Research Topics
| Harinder JasejaSummaryAffiliation: G R Medical College Location: Gwalior, India Summary: Dr Jaseja has proposed an additional novel guideline in the management protocol of patients with Cerebral Palsy for their improved prognosis and quality of life and also shown the efficacy of Vagal Nerve Stimulation (VNS) in such patients. Cerebral Palsy is a neurological disorder of immense national socio-economic concern with several spastic societies, both in Government and non-Government sectors. He has initiated an International debate on the relation between Meditation and Epilepsy evidenced by the large number of publications in recent years. He has also initiated debate on the dilemma on treatment of the EEG and has published papers on resolution of the issue. He has shed significant light on Purpose of Sleep in Man and Vigabatrin administration in West Syndrome. He has re-defined Meditation and Epilepsy in context to current scenario. Interestingly, he has shown that the Indian traditional application of Shoe-smell in Epilepsy has a sound scientific basis, thus highlighting the scientific approach in Indian traditional remedial measures. Recently, he has proposed the utility of Global Positioning System (GPS) in safeguarding women’s dignity and has also published a novel approach to search for Alien-existence and suggested a telepathic mode of communication with Aliens. Publications: Jaseja H, Jaseja B, Badaya S, Tonpay P. Treatment of interictal epileptiform discharges in patients with cerebral palsy for an improved prognostic outcome and quality of life: Emerging evidence. Epilepsy Behav (in Press) DOI 10.1016/j.yebeh.2012.08.016 Jaseja H, Jaseja B, Badaya S, Tonpay P. Superior therapeutic efficacy of adrenocorticotrophic hormone (ACTH) in infantile spasms: Emerging evidence. Epilepsy Behav. 2012 Oct 1;25(2):250. Jaseja H, Jaseja B. EEG spike versus EEG sharp wave: Differential clinical significance in epilepsy. Epilepsy Behav. 2012 Jul 17. [Epub ahead of print] Jaseja H. Controversy over misinterpretation of EEG with subsequent misdiagnosis of epilepsy.Epilepsy Behav. 2012 Jun;24(2):290. Jaseja H. The EEG: Warranting proper reading or diagnosing epilepsy? Epilepsy Behav. 2011;20(4):737. Jaseja H. Efficacy of vagal nerve stimulation in patients with cerebral palsy: Emerging corroborative evidence. Clin Neurol Neurosurg. 2011;113(7):603. Jaseja H. Vigabatrin administration in patients with infantile spasms: the risks. Clin Neurol Neurosurg. 2010 Nov;112(9):835 Jaseja H.EEG fast oscillations and epileptogenesis during meditation: corroborative empirical evidence.Epilepsy Behav. 2010 May;18(1-2):133. Goyal M, Jaseja H, Verma N.Increased parasympathetic tone as the underlying cause of asthma: a hypothesis. Med Hypotheses. 2010 Apr;74(4):661-4. Jaseja H. EEG-desynchronization as the major mechanism of anti-epileptic action of vagal nerve stimulation in patients with intractable seizures: clinical neurophysiological evidence. Med Hypotheses. 2010 May;74(5):855-6 Jaseja H. Potential role of self-induced EEG fast oscillations in predisposition to seizures in meditators. Epilepsy Behav. 2010 Jan;17(1):124-5. Jaseja H. The dilemma on treatment of the EEG: A justified perspective. Epilepsy Behav. 2009 Nov;16(3):561-2. Jaseja H. Significance of the EEG in the decision to initiate antiepileptic treatment in patients with epilepsy: A perspective on recent evidence. Epilepsy Behav. 2009 Oct;16(2):345-6. Jaseja H. Application of shoe-smell in controlling epileptic attacks: Its origin. Med Hypotheses. 2010 Jan;74(1):210. Jaseja H. Meditation: Epileptogenic versus antiepileptic influence. Epilepsy Behav. 2009;16(1):187. Jaseja H. Multidimensional significance of self-perception of seizure-precipitants in patients with epilepsy. Med Hypotheses. 2009;73(3):458-459. Jaseja H. Endogenous anti-epileptogenic purpose of REM sleep in man: corroborative clinical neurophysiological evidence. Clin Neurophysiol. 2009 Apr;120(4):840. Jaseja H. Is meditation associated with a potential risk of addiction? Warranting a greater insight. Epilepsy Behav. 2009 Apr;14(4):709. Jaseja H. Definition of epilepsy: significance of its revision on clinical neurophysiological basis to improve prognosis and quality of life of patients with epilepsy. Med Hypotheses. 2009 Jun;72(6):756-7. Jaseja H. Evidence in support of treating interictal epileptiform discharges in cerebral palsy patients without clinical epilepsy for an improved prognostic outcome and quality of life. Clin Neurol Neurosurg. 2009 May;111(4):396-7. Jaseja H. Definition of meditation: Seeking a consensus. Jaseja H. Med Hypotheses. 2009 Apr;72(4):483. Jaseja H. Influence of psychological/anxiety level on self-perception of precipitants in patients with epilepsy: Assessment by clinical neurophysiological studies. Epilepsy Behav 2009 Jan;14(1):271. Jaseja H. Justification of vigabatrin administration in West syndrome patients? Warranting a re-consideration for improvement in their quality of life. Clin Neurol Neurosurg. 2009 Feb;111(2):111-4. Jaseja H. Can transcendental meditation exercise a miraculous control over long standing epilepsy? Med Hypotheses. 2009 Jan;72(1):106. Jaseja H. Vagal nerve stimulation: exploring its efficacy and success for an improved prognosis and quality of life in cerebral palsy patients. Clin Neurol Neurosurg. 2008 Sep;110(8):755-62. Jaseja H. Scientific basis behind traditional practice of application of "shoe-smell" in controlling epileptic seizures in the eastern countries. Clin Neurol Neurosurg. 2008 Jun;110(6):535-8. Jaseja H. Cerebral palsy: Is it truly absolutely non-progressive in nature? Clin Neurol Neurosurg. 2008 Feb;110(2):211-2. Jaseja H. Drug-choice in management of West syndrome (infantile spasms): Early ACTH treatment may offer a better prognostic outcome. Med Hypotheses. 2008;70(1):197-8. Jaseja H. Cerebral palsy: Interictal epileptiform discharges and cognitive impairment. Clin Neurol Neurosurg. 2007 Sep;109(7):549-52 Jaseja H. Treatment of interictal epileptiform discharges in cerebral palsy patients without clinical epilepsy: hope for a better outcome in prognosis. Clin Neurol Neurosurg. 2007 Apr;109(3):221-4. Jaseja H. Functional components of REM sleep programmed to exert natural anti- epileptogenic influence. Med Hypotheses. 2007;68(5):1186-7. Jaseja H. Meditation and epilepsy: the ongoing debate. Med Hypotheses. 2007;68(4):916-7. Jaseja H. Does phenytoin play any role in prevention of Alzheimers disease? Med Hypotheses. 2007;68(3):718-9. Jaseja H. A plausible explanation for superiority of adreno-cortico-trophic hormone (ACTH) over oral corticosteroids in management of infantile spasms (West syndrome). Med Hypotheses. 2006;67(4):721-4 Jaseja H. A brief study of a possible relation of epilepsy association with meditation. Med Hypotheses. 2006;66(5):1036-7 Jaseja H. Meditation potentially capable of increasing susceptibility to epilepsy - a follow-up hypothesis. Med Hypotheses. 2006;66(5):925-8. Jaseja H. Mechanism of endogenous anti-epileptogenesis during rapid eye movement sleep. Med Hypotheses. 2006;66(4):866. Jaseja H. Mechanism of vagal nerve stimulation (VNS) anti-convulsant action. Med Hypotheses. 2006;66(3):680-1. Jaseja H. Meditation may predispose to epilepsy: an insight into the alteration in brain environment induced by meditation. Med Hypotheses. 2005;64(3):464-7. Jaseja H. Vagal nerve stimulation technique: enhancing its efficacy and acceptability by augmentation with auto activation and deactivation mode of operation. Med Hypotheses. 2004;63(1):76-9. Jaseja H. Purpose of REM sleep: endogenous anti-epileptogenesis in man -- a hypothesis. Med Hypotheses. 2004;62(4):546-8. Jaseja H. Intractable epilepsy management: an EEG-oriented approach. Med Hypotheses. 2003 Aug;61(2):231-4. Jaseja H. Electrical resection: new concept in management of focal epilepsy. Med Hypotheses. 2002 Nov;59(5):498-500. Publications
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Detail Information
Publications
Purpose of REM sleep: endogenous anti-epileptogenesis in man -- a hypothesisHarinder Jaseja
Physiology Department, G R Medical College, Gwalior, MP 474001, India
Med Hypotheses 62:546-8. 2004..This hypothesis-article highlights and conceptualizes the primary function of REM-sleep as endogenous anti-epileptogenic system in the body akin to the endogenous analgesia and immune systems man is born with...
Mechanism of vagal nerve stimulation (VNS) anti-convulsant actionHarinder Jaseja
Med Hypotheses 66:680-1. 2006
Mechanism of endogenous anti-epileptogenesis during rapid eye movement sleepHarinder Jaseja
Med Hypotheses 66:866. 2006
Meditation potentially capable of increasing susceptibility to epilepsy - a follow-up hypothesisHarinder Jaseja
Physiology Department, GR Medical College, Gwalior, MP, India
Med Hypotheses 66:925-8. 2006..These studies thus do highlight and underscore the strong influence of meditation in increasing susceptibility to epilepsy...
Electrical resection: new concept in management of focal epilepsyHarinder Jaseja
G R Medical College, Gwalior, India
Med Hypotheses 59:498-500. 2002..Preliminary trials in the form of scalp application of positivity have markedly improved EEG picture in terms of occurrence of epileptiform activity...
EEG-desynchronization as the major mechanism of anti-epileptic action of vagal nerve stimulation in patients with intractable seizures: clinical neurophysiological evidenceHarinder Jaseja
Physiology Department, G R Medical College, Gwalior, MP, India
Med Hypotheses 74:855-6. 2010..This brief paper attempts to support the proposed mechanism with clinical neurophysiological evidence that has emerged in recent times...
Potential role of self-induced EEG fast oscillations in predisposition to seizures in meditatorsHarinder Jaseja
Physiology Department, G R Medical College, 8, C Block, Near Paliwal Health Club, Harishanker puram, Lashkar, Gwalior 474009, MP, India
Epilepsy Behav 17:124-5. 2010..This brief article attempts to study the potential role of meditation-induced EEG fast oscillations in the predisposition to seizures in meditation practitioners with epilepsy...
The dilemma on treatment of the EEG: a justified perspectiveHarinder Jaseja
Physiology Department, G R Medical College, Gwalior, India
Epilepsy Behav 16:561-2. 2009..In this brief article an attempt is made to justify the significance of treatment of the EEG and its impact on the overall prognostic outcome and quality of life of patients with abnormal EEGs...
Significance of the EEG in the decision to initiate antiepileptic treatment in patients with epilepsy: a perspective on recent evidenceHarinder Jaseja
Physiology Department, G R Medical College, 8, C Block, Near Paliwal Health Club, Harishanker puram, Lashkar, Gwalior 474009, MP, India
Epilepsy Behav 16:345-6. 2009....
Cerebral palsy: is it truly absolutely non-progressive in nature?Harinder Jaseja
Clin Neurol Neurosurg 110:211-2. 2008
Cerebral palsy: Interictal epileptiform discharges and cognitive impairmentHarinder Jaseja
Physiology Department, G R Medical College, Gwalior 474001, MP, India
Clin Neurol Neurosurg 109:549-52. 2007..At cellular level, since epileptiform discharge generating neurons exhibit increased proneness to premature death, an early detection of IEDs and appropriate intervention can also check further neuronal damage in CP patients...
Increased parasympathetic tone as the underlying cause of asthma: a hypothesisManish Goyal
Department of Physiology, All India Institute of Medical Sciences, New Delhi 110 029, India
Med Hypotheses 74:661-4. 2010....
Meditation and epilepsy: the ongoing debateHarinder Jaseja
Med Hypotheses 68:916-7. 2007
Intractable epilepsy management: an EEG-oriented approachHarinder Jaseja
Physiology Department, G R Medical College, Gwalior, Madhya Pradesh, India
Med Hypotheses 61:231-4. 2003....
A brief study of a possible relation of epilepsy association with meditationHarinder Jaseja
Med Hypotheses 66:1036-7. 2006
A plausible explanation for superiority of adreno-cortico-trophic hormone (ACTH) over oral corticosteroids in management of infantile spasms (West syndrome)Harinder Jaseja
Physiology Department, G R Medical College, Gwalior 474001, Madhya Pradesh, India
Med Hypotheses 67:721-4. 2006..Thus, this difference in feedback mechanism may be the major factor responsible for the superior therapeutic efficacy of ACTH over oral steroids in the management of West syndrome...
Vagal nerve stimulation technique: enhancing its efficacy and acceptability by augmentation with auto activation and deactivation mode of operationHarinder Jaseja
G R Medical College, Gwalior 474009, M P, India
Med Hypotheses 63:76-9. 2004..This mode should enhance its acceptability, efficacy and success...
Meditation may predispose to epilepsy: an insight into the alteration in brain environment induced by meditationHarinder Jaseja
Physiology Department, G R Medical College, 8, 10 C Block, Near Paliwal Health Club, Harishanker puram, Lashkar, Gwalior 474009, MP, India
Med Hypotheses 64:464-7. 2005....
Justification of vigabatrin administration in West syndrome patients? Warranting a re-consideration for improvement in their quality of lifeHarinder Jaseja
Physiology Department, G R Medical College, Gwalior 474001, M P, India
Clin Neurol Neurosurg 111:111-4. 2009..Therefore, based on the enhancement of handicap by VGB administration it is recommended that a comprehensive review be performed on its continuation in WS patients in order to prevent further deterioration of their quality of life (QOL)...
Vagal nerve stimulation: exploring its efficacy and success for an improved prognosis and quality of life in cerebral palsy patientsHarinder Jaseja
Physiology Department, G R Medical College, Gwalior 474001, MP, India
Clin Neurol Neurosurg 110:755-62. 2008....
Scientific basis behind traditional practice of application of "shoe-smell" in controlling epileptic seizures in the eastern countriesHarinder Jaseja
Physiology Department, GR Medical College, Gwalior 474001, MP, India
Clin Neurol Neurosurg 110:535-8. 2008....
Treatment of interictal epileptiform discharges in cerebral palsy patients without clinical epilepsy: hope for a better outcome in prognosisHarinder Jaseja
Physiology Department, G R Medical College, Gwalior 474001, Madhya Pradesh, India
Clin Neurol Neurosurg 109:221-4. 2007..Based on these studies, the author proposes inclusion of EEG investigation in the management protocol of CP patients and treatment of IEDs (when detected even in absence of clinical epilepsy) for a better outcome in their prognosis...
Drug-choice in management of West syndrome (infantile spasms): Early ACTH treatment may offer a better prognostic outcomeHarinder Jaseja
Med Hypotheses 70:197-8. 2008
Functional components of REM sleep programmed to exert natural anti-epileptogenic influenceHarinder Jaseja
Med Hypotheses 68:1186-7. 2007
Does phenytoin play any role in prevention of Alzheimer's disease?Harinder Jaseja
Med Hypotheses 68:718-9. 2007
