Genomes and Genes


Denis Leonardo Fontes Jardim


Affiliation: Hospital Sirio Libanes
Location: Sao Paulo, Brazil
Clinical Oncologista at Sirio Libanes Hospital.
Researcher at Sirio Libanes Hospital and State University of Campinas, interested in mechanisms of drug resistance and development of new drugs for cancer treatment


  1. Jardim D, da Cunha A, Duarte A, dos Santos C, Saad S, Costa F. Expression of Sara2 human gene in erythroid progenitors. J Biochem Mol Biol. 2005;38:328-33 pubmed
    ..Our results suggest that Sara2 is an important gene in processes involving proliferation and differentiation and could be valuable for understanding the vesicular transport system during erythropoiesis. ..
  2. Schutz F, Jardim D, Je Y, Choueiri T. Haematologic toxicities associated with the addition of bevacizumab in cancer patients. Eur J Cancer. 2011;47:1161-74 pubmed publisher
    ..22; 95%CI 1.00-1.48; p = .047) and febrile neutropenia (RR = 1.31; 95%CI 1.08-1.58; p = .006). Bevacizumab is associated with a lower risk of anaemia and increased risks of neutropenia, thrombocytopenia and febrile neutropenia. ..
  3. Jardim D, Tsukumo D, Angerami R, Carvalho Filho M, Saad M. Autoimmune features caused by dengue fever: a case report. Braz J Infect Dis. 2012;16:92-5 pubmed
    ..Therefore, dengue should be suspected in patients with hematological disorders and autoimmune features in endemic regions or those who have travelled to those regions. ..
  4. Jardim D, Groves E, Breitfeld P, Kurzrock R. Factors associated with failure of oncology drugs in late-stage clinical development: A systematic review. Cancer Treat Rev. 2017;52:12-21 pubmed publisher
    ..For drugs that reached Phase III, lack of a biomarker-driven strategy and failure to attain proof of concept in phase II are potential risk factors for later discontinuation, especially for targeted agents. ..
  5. Jardim D, de Melo Gagliato D, Giles F, Kurzrock R. Analysis of Drug Development Paradigms for Immune Checkpoint Inhibitors. Clin Cancer Res. 2018;24:1785-1794 pubmed publisher
    ..i>Clin Cancer Res; 24(8); 1785-94. ©2017 AACR. ..

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