Masayuki Yoshikawa

Summary

Country: Japan

Publications

  1. ncbi request reprint Bioactive constituents from Chinese natural medicines. XXIII. Absolute structures of new megastigmane glycosides, sedumosides A(4), A(5), A(6), H, and I, and hepatoprotective megastigmanes from Sedum sarmentosum
    Kiyofumi Ninomiya
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 55:1185-91. 2007
  2. ncbi request reprint Bioactive constituents from chinese natural medicines. XXIV. Hypoglycemic effects of Sinocrassula indica in sugar-loaded rats and genetically diabetic KK-A(y) mice and structures of new acylated flavonol glycosides, sinocrassosides A(1), A(2), B(1), and B
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 55:1308-15. 2007
  3. doi request reprint Protective effects of amide constituents from the fruit of Piper chaba on D-galactosamine/TNF-alpha-induced cell death in mouse hepatocytes
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 18:2038-42. 2008
  4. ncbi request reprint Bioactive constituents from chinese natural medicines. XXIX. Monoterpene and monoterpene glycosides from the roots of Rhodiola sachalinensis
    Xuezheng Li
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:612-5. 2008
  5. ncbi request reprint Structures of acetylated oleanane-type triterpene saponins, rarasaponins IV, V, and VI, and anti-hyperlipidemic constituents from the pericarps of Sapindus rarak
    Yasunobu Asao
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Japan
    Chem Pharm Bull (Tokyo) 57:198-203. 2009
  6. ncbi request reprint Megastigmanes and their glucosides from the whole plant of Sedum sarmentosum
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 70:575-83. 2007
  7. ncbi request reprint Medicinal flowers. XXIV. Chemical structures and hepatoprotective effects of constituents from flowers of Hedychium coronarium
    Seikou Nakamura
    Kyoto Pharmaceutical University, Yamashina ku, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:1704-9. 2008
  8. ncbi request reprint Medicinal flowers. XXI. Structures of perennisaponins A, B, C, D, E, and F, acylated oleanane-type triterpene oligoglycosides, from the flowers of Bellis perennis
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:559-68. 2008
  9. ncbi request reprint Bioactive constituents from Chinese natural medicines. XIV. New glycosides of beta-carboline-type alkaloid, neolignan, and phenylpropanoid from Stellaria dichotoma L. var. lanceolata and their antiallergic activities
    Toshio Morikawa
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 52:1194-9. 2004
  10. ncbi request reprint Medicinal flowers. XXII. Structures of chakasaponins V and VI, chakanoside I, and chakaflavonoside A from flower buds of Chinese tea plant (Camellia sinensis)
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:1297-303. 2008

Collaborators

  • Masayuki Yamashita
  • Tao Wang
  • Toshio Morikawa
  • Osamu Muraoka
  • Yi Zhang
  • Hiroshi Shimoda
  • Ning Li
  • Dan Yuan
  • Xian Li
  • Supinya Tewtrakul
  • Ikuko Kimura
  • Jiang Liu
  • Gang Chen
  • Tomoko Matsumoto
  • Yoshiyasu Fukuyama
  • Yuehu Pei
  • Hiroaki Kojima
  • Yoshiyuki Kimura
  • Hisashi Matsuda
  • Seikou Nakamura
  • Kiyofumi Ninomiya
  • Souichi Nakashima
  • Sachiko Sugimoto
  • Shin Ando
  • Yutana Pongpiriyadacha
  • Fengming Xu
  • Katsuyoshi Fujimoto
  • Makoto Hamao
  • Haihui Xie
  • Yoshimi Oda
  • Yasunobu Asao
  • Ying Kun Qiu
  • Qilong Wang
  • Jing Tao
  • Osama Bashir Abdel-Halim
  • Li Kun Han
  • Tomoe Ohta
  • Tomoko Miura
  • Kaoru Uno
  • Norihisa Nishida
  • Ghazi Mohamed Eisa Hussein
  • Junko Iwami
  • Hiromi Managi
  • Hailong Zhang
  • Chihiro Yamashita
  • Itadaki Yamaguchi
  • Masako Hongo
  • Yoshie Okazaki
  • Daisuke Yasuda
  • Yang Qu
  • Jiang Ning Hu
  • Koudai Matsuhira
  • Yi Nan Zheng
  • Momotaro Ochi
  • Ying Jie Chen
  • Shinya Kataoka
  • Bohang Sun
  • Toshiyuki Murakami
  • Hideo Oominami
  • De Qiang Dou
  • Iwao Toguchida
  • Nami Yokota
  • Keiko Ogawa
  • Sayuri Maeda
  • Shino Nishida
  • Megumi Murata
  • Haruka Kon'i
  • Miwa Kubo
  • Megumi Nakai
  • Toshihito Akiyama
  • Kouhei Tamura
  • Yuanyuan Xie
  • Sachie Kiyohara
  • Masaki Okamoto
  • Makoto Tamesada
  • Sachiyo Yamamoto
  • Yasuyo Kato
  • Guihua Chi
  • Junji Akaki
  • Hiroko Wakayama
  • Lijun Wu
  • Masato Saito
  • Yin Shi Sun
  • Xue Mei Zhu
  • Akifumi Nagatomo
  • Mizuho Kubo
  • Kikuji Yamaguti
  • Tomoko Kato
  • Tadato Tani
  • Hiromichi Okuda

Detail Information

Publications99

  1. ncbi request reprint Bioactive constituents from Chinese natural medicines. XXIII. Absolute structures of new megastigmane glycosides, sedumosides A(4), A(5), A(6), H, and I, and hepatoprotective megastigmanes from Sedum sarmentosum
    Kiyofumi Ninomiya
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 55:1185-91. 2007
    ..Among them, sedumoside F(1) (IC(50)=47 microM), (3S,5R,6S,9R)-megastigmane-3,9-diol (61 microM), and myrsinionosides A (52 microM) and D (62 microM) were found to show the strong hepatoprotective activity...
  2. ncbi request reprint Bioactive constituents from chinese natural medicines. XXIV. Hypoglycemic effects of Sinocrassula indica in sugar-loaded rats and genetically diabetic KK-A(y) mice and structures of new acylated flavonol glycosides, sinocrassosides A(1), A(2), B(1), and B
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 55:1308-15. 2007
    ..The absolute stereostructures of the four new compounds were elucidated on the basis of chemical and physicochemical evidence...
  3. doi request reprint Protective effects of amide constituents from the fruit of Piper chaba on D-galactosamine/TNF-alpha-induced cell death in mouse hepatocytes
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 18:2038-42. 2008
    ..5-10 mg/kg (p.o.) in D-GalN/LPS-treated mice, and this inhibitory effect was suggested to depend on the reduced sensitivity of hepatocytes to TNF-alpha...
  4. ncbi request reprint Bioactive constituents from chinese natural medicines. XXIX. Monoterpene and monoterpene glycosides from the roots of Rhodiola sachalinensis
    Xuezheng Li
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:612-5. 2008
    ..The absolute stereostructures of new monoterpenes were elucidated on the basis of chemical and physicochemical evidence including the application of the modified Mosher's method...
  5. ncbi request reprint Structures of acetylated oleanane-type triterpene saponins, rarasaponins IV, V, and VI, and anti-hyperlipidemic constituents from the pericarps of Sapindus rarak
    Yasunobu Asao
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Japan
    Chem Pharm Bull (Tokyo) 57:198-203. 2009
    ....
  6. ncbi request reprint Megastigmanes and their glucosides from the whole plant of Sedum sarmentosum
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 70:575-83. 2007
    ..The absolute stereostructures of 1-8 were elucidated on the basis of chemical and physicochemical evidence, including the application of the modified Mosher's method...
  7. ncbi request reprint Medicinal flowers. XXIV. Chemical structures and hepatoprotective effects of constituents from flowers of Hedychium coronarium
    Seikou Nakamura
    Kyoto Pharmaceutical University, Yamashina ku, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:1704-9. 2008
    ..In addition, the principal constituents, coronaririn C and 15-hydroxylabda-8(17),11,13-trien-16,15-olide, displayed hepatoprotective effects, which were stronger than that of the hepatoprotective agent, silybin...
  8. ncbi request reprint Medicinal flowers. XXI. Structures of perennisaponins A, B, C, D, E, and F, acylated oleanane-type triterpene oligoglycosides, from the flowers of Bellis perennis
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:559-68. 2008
    ..The structures of 1-6 were elucidated on the basis of chemical and physicochemical evidence...
  9. ncbi request reprint Bioactive constituents from Chinese natural medicines. XIV. New glycosides of beta-carboline-type alkaloid, neolignan, and phenylpropanoid from Stellaria dichotoma L. var. lanceolata and their antiallergic activities
    Toshio Morikawa
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 52:1194-9. 2004
    ..These findings suggest that dichotomoside D is more effective against the late-phase reactions in type I allergy than in the immediate phase...
  10. ncbi request reprint Medicinal flowers. XXII. Structures of chakasaponins V and VI, chakanoside I, and chakaflavonoside A from flower buds of Chinese tea plant (Camellia sinensis)
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:1297-303. 2008
    ..O. KUNTZE]. The chemical structures of those new glycosides were elucidated on the basis of chemical and physicochemical evidence...
  11. ncbi request reprint [Biological activities of Salacia chinensis originating in Thailand: the quality evaluation guided by alpha-glucosidase inhibitory activity]
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Yakugaku Zasshi 123:871-80. 2003
    ..reticulata. In addition, we isolated the principal alpha-glucosidase inhibitor, salacinol, from the stems of S. chinensis and examined alpha-glucosidase inhibitory activities of eleven samples of S. chinensis collected in Thailand...
  12. ncbi request reprint Bioactive saponins and glycosides. XXVIII. New triterpene saponins, foliatheasaponins I, II, III, IV, and V, from Tencha (the leaves of Camellia sinensis)
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 55:293-8. 2007
    ..Among the new saponins, foliatheasaponins II and III, were found to inhibit release of beta-hexosaminidase, as a marker of antigen-induced degranulation, in RBL-2H3 cells...
  13. ncbi request reprint Absolute structures of new megastigmane glycosides, foliasalaciosides E(1), E(2), E(3), F, G, H, and I from the leaves of Salacia chinensis
    Yi Zhang
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:547-53. 2008
    ..collected in Thailand. The absolute stereostructures of the new compounds were characterized on the basis of chemical and physicochemical evidence, including the application of the modified Mosher's method...
  14. doi request reprint Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells
    Souichi Nakashima
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem 18:2337-45. 2010
    ....
  15. doi request reprint Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: structures of karapinchamines A and B
    Seikou Nakamura
    Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Kyoto 607 8412, Japan
    Bioorg Med Chem 21:1043-9. 2013
    ..The principal alkaloid constituents were found to display potent melanogenesis inhibitory activity. The structural requirements of the carbazole alkaloids for melanogenesis inhibitory activity were discussed...
  16. ncbi request reprint Bioactive constituents from Chinese natural medicines. XI. inhibitors on NO production and degranulation in RBL-2H3 from Rubia yunnanensis: structures of rubianosides II, III, and IV, rubianol-g, and rubianthraquinone
    Jing Tao
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 51:654-62. 2003
    ..In addition, an anthraquinone constituent, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone, was found to show inhibitory effects on the release of beta-hexosaminidase in RBL-2H3 cells...
  17. ncbi request reprint Gastroprotective effects of phenylpropanoids from the rhizomes of Alpinia galanga in rats: structural requirements and mode of action
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Eur J Pharmacol 471:59-67. 2003
    ..These findings suggest that endogenous prostaglandins and sulfhydryl compounds are involved in the protective effect of 1'S-1'-acetoxychavicol acetate...
  18. ncbi request reprint Reinvestigation of absolute stereostructure of (-)-rosiridol: structures of monoterpene glycosides, rosiridin, rosiridosides A, B, and C, from Rhodiola sachalinensis
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:695-700. 2008
    ....
  19. ncbi request reprint Structures of new cyclic diarylheptanoids and inhibitors of nitric oxide production from Japanese folk medicine Acer nikoense
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 66:86-91. 2003
    ..In addition, the principal diarylheptanoid constituents were found to exhibit inhibitory activity on nitric oxide production in lipopolysaccharide-activated macrophages...
  20. ncbi request reprint Bioactive saponins and glycosides. XXIII. Triterpene saponins with gastroprotective effect from the seeds of Camellia sinensis--theasaponins E3, E4, E5, E6, and E7
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Japan
    Chem Pharm Bull (Tokyo) 53:1559-64. 2005
    ....
  21. ncbi request reprint Nigellamines A3, A4, A5, and C, new dolabellane-type diterpene alkaloids, with lipid metabolism-promoting activities from the Egyptian medicinal food black cumin
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Japan
    Chem Pharm Bull (Tokyo) 52:494-7. 2004
    ..Nigellamines were found to lower triglyceride levels in primary cultured mouse hepatocytes, and in particular, the activity of nigellamine A(5) was equivalent to that of the hypolipidemic agent, clofibrate...
  22. ncbi request reprint Bioactive constituents from Chinese natural medicines. XV. Inhibitory effect on aldose reductase and structures of Saussureosides A and B from Saussurea medusa
    Haihui Xie
    Kyoto Pharmaceutical University, Japan
    Chem Pharm Bull (Tokyo) 53:1416-22. 2005
    ..In addition, some isolates were found to show an inhibitory effect on aldose reductase...
  23. ncbi request reprint Medicinal flowers. XII.(1)) New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 55:308-16. 2007
    ..In addition, the principal steroid saponin, dioscin (13), inhibited the increase of serum glucose levels in sucrose-loaded rats at a dose of 50 mg/kg, p.o...
  24. ncbi request reprint Medicinal flowers. XXXIII. Anti-hyperlipidemic and anti-hyperglycemic effects of chakasaponins I-III and structure of chakasaponin IV from flower buds of Chinese tea plant (Camellia sinensis)
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 60:674-80. 2012
    ..In addition, the chemical structure of a new acylated oleanane-type triterpene oligoglycoside, chakasaponin IV, was elucidated on the basis of chemical and physicochemical evidence...
  25. ncbi request reprint Medicinal flowers. XXXVI.1) Acylated oleanane-type triterpene saponins with inhibitory effects on melanogenesis from the flower buds of Chinese Camellia japonica
    Seikou Nakamura
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Japan
    Chem Pharm Bull (Tokyo) 60:752-8. 2012
    ..The inhibitory effects of the triterpene oligoglycoside constituents on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells were investigated...
  26. ncbi request reprint Mate tea (Ilex paraguariensis) promotes satiety and body weight lowering in mice: involvement of glucagon-like peptide-1
    Ghazi Mohamed Eisa Hussein
    Kyoto Pharmaceutical University, Japan
    Biol Pharm Bull 34:1849-55. 2011
    ..These findings suggest that mate may induce anorexic effects by direct induction of satiety and by stimulation of GLP-1 secretion and modulation of serum leptin levels...
  27. ncbi request reprint Inhibitory effects of coumarin and acetylene constituents from the roots of Angelica furcijuga on D-galactosamine/lipopolysaccharide-induced liver injury in mice and on nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem 14:456-63. 2006
    ..Furthermore, hyuganin A, anomalin, and isopteryxin inhibited the decrease in cell viability by TNF-alpha in L929 cells...
  28. ncbi request reprint Medicinal Flowers. XXVI. structures of acylated oleanane-type triterpene oligoglycosides, yuchasaponins A, B, C, and D, from the flower buds of Camellia oleifera-gastroprotective, aldose reductase inhibitory, and radical scavenging effects-
    Sachiko Sugimoto
    Kyoto Pharmaceutical University, Yamashitaa ku, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 57:269-75. 2009
    ....
  29. ncbi request reprint Medicinal flowers. XVI. New dammarane-type triterpene tetraglycosides and gastroprotective principles from flower buds of Panax ginseng
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 55:1034-8. 2007
    ..Ginsenoside Rd (protopanaxadiol 3,20-O-bisdesmoside) exhibited inhibitory effects on ethanol- and indomethacin-induced gastric mucosal lesions in rats...
  30. ncbi request reprint Inhibitory effects of thunberginols A and B isolated from Hydrangeae Dulcis Folium on mRNA expression of cytokines and on activation of activator protein-1 in RBL-2H3 cells
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Phytomedicine 15:177-84. 2008
    ..In addition, the profile of gene expression by thunberginol B was similar to that by luteolin, a natural flavone with a potent anti-allergic effect...
  31. doi request reprint Perennisosides I-VII, acylated triterpene saponins with antihyperlipidemic activities from the flowers of Bellis perennis
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    J Nat Prod 71:828-35. 2008
    ..Among these saponins, perennisosides I (1) and II (2) showed inhibitory effects on serum triglyceride elevation at doses of 25-50 mg/kg, po...
  32. ncbi request reprint Brazilian natural medicines. IV. New noroleanane-type triterpene and ecdysterone-type sterol glycosides and melanogenesis inhibitors from the roots of Pfaffia glomerata
    Seikou Nakamura
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 58:690-5. 2010
    ..The inhibitory effects were stronger than that of reference compound, arbutin (IC(50)=174 microM)...
  33. ncbi request reprint Structures of new sesquiterpenes from Curcuma comosa
    Fengming Xu
    Kyoto Pharmaceutical University, Yamashina ku, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:1710-6. 2008
    ..Their structures were elucidated on the basis of chemical and physicochemical evidence...
  34. doi request reprint Acylated oleanane-type triterpene saponins with acceleration of gastrointestinal transit and inhibitory effect on pancreatic lipase from flower buds of chinese tea plant (Camellia sinensis)
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Chem Biodivers 6:903-15. 2009
    ..Compounds 1-3 showed accelerating effects on gastrointestinal transit in mice and inhibitory effects against porcine pancreatic lipase (IC(50)=150-530 microM)...
  35. ncbi request reprint Brazilian natural medicines. III. structures of triterpene oligoglycosides and lipase inhibitors from mate, leaves of ilex paraguariensis
    Sachiko Sugimoto
    Kyoto Pharmaceutical University, Yamashina ku, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 57:257-61. 2009
    ..The chemical structures of new oligoglycosides were elucidated on the basis of chemical and physicochemical evidence. Several constituents showed inhibitory activities on pancreatic lipase...
  36. ncbi request reprint Antidiabetogenic constituents from the Thai traditional medicine Cotylelobium melanoxylon
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 57:487-94. 2009
    ..In addition, vaticanols A, E, and/or G inhibited the enzyme activities of rat intestinal alpha-glucosidase, porcine pancreatic lipase, and rat lens aldose reductase...
  37. ncbi request reprint Absolute stereostructures of new arborinane-type triterpenoids and inhibitors of nitric oxide production from Rubia yunnanensis
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Japan
    J Nat Prod 66:638-45. 2003
    ..The effects of the isolated constituents on nitric oxide production in lipopolysaccharide-activated macrophages were examined, and several triterpenes were found to show inhibitory activity...
  38. ncbi request reprint Antiallergic principles from Alpinia galanga: structural requirements of phenylpropanoids for inhibition of degranulation and release of TNF-alpha and IL-4 in RBL-2H3 cells
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 13:3197-202. 2003
    ....
  39. ncbi request reprint Structure-activity relationships of 1'S-1'-acetoxychavicol acetate for inhibitory effect on NO production in lipopolysaccharide-activated mouse peritoneal macrophages
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 15:1949-53. 2005
    ..4) The substitution of acetyl groups with propionyl or methyl groups reduced the activity. (5) Lengthening of the carbon chain between the 1'- and 2'-positions reduced the activity...
  40. ncbi request reprint Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 66:922-7. 2003
    ..The principal dammarane-type triterpene saponins from the roots and flower buds of Panax notoginseng were found to show potent hepatoprotective effects...
  41. ncbi request reprint Carnosic acid, a new class of lipid absorption inhibitor from sage
    Kiyofumi Ninomiya
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 14:1943-6. 2004
    ..o.). Furthermore, carnosic acid (20 mg/kg/day, p.o.) reduced the gain of body weight and the accumulation of epididymal fat weight in high fat diet-fed mice after 14 days...
  42. ncbi request reprint Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): structure requirement and mode of action
    Hiroshi Shimoda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 13:223-8. 2003
    ..In addition, inhibition of gastric emptying was shown to be partly involved in anti-hyperlipidemic activity...
  43. ncbi request reprint Bioactive constituents from Chinese natural medicines. XXVIII. Chemical structures of acyclic alcohol glycosides from the roots of Rhodiola crenulata
    Seikou Nakamura
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:536-40. 2008
    ..The chemical structures of new constituents were elucidated on the basis of chemical and physicochemical evidence...
  44. ncbi request reprint Effects of allyl isothiocyanate from horseradish on several experimental gastric lesions in rats
    Hisashi Matsuda
    Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Eur J Pharmacol 561:172-81. 2007
    ..These findings suggest that endogenous prostaglandins play an important role in the protective effect of allyl isothiocyanate in ethanol-induced gastric lesions different from capsaicin, piperine, and omeprazole...
  45. ncbi request reprint Structures of new monoterpenes from Thai herbal medicine Curcuma comosa
    Seikou Nakamura
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:1604-6. 2008
    ..Their structures were elucidated on the basis of chemical and physicochemical evidence...
  46. ncbi request reprint Structures of new beta-carboline-type alkaloids with antiallergic effects from Stellaria dichotoma(1,2)
    Bohang Sun
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 67:1464-9. 2004
    ..Moreover, 3 also inhibited the releases of antigen-IgE-mediated TNF-alpha and IL-4 (19 and 15 microM, respectively) in RBL-2H3 cells, both of which participate in the late phase of type I allergic reactions...
  47. ncbi request reprint Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 66:1191-6. 2003
    ..In addition, six constituents, 3beta,22beta-dihydroxyolean-12-en-29-oic acid, tingenone, tingenine B, regeol A, triptocalline A, and mangiferin, were found to show an inhibitory effect on rat lens aldose reductase...
  48. doi request reprint Hydrangeic acid from the processed leaves of Hydrangea macrophylla var. thunbergii as a new type of anti-diabetic compound
    Hailong Zhang
    Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Eur J Pharmacol 606:255-61. 2009
    ..Furthermore, hydrangeic acid significantly lowered blood glucose, triglyceride, and free fatty acid levels after its administration for 2 weeks at a dose of 200 mg/kg/day (p.o.) in KK-A(y) mice...
  49. ncbi request reprint Monoterpene constituents from Cistanche tubulosa--chemical structures of kankanosides A-E and kankanol-
    Haihui Xie
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 54:669-75. 2006
    ..WIGHT (Orobanchaceae) together with 16 known compounds. The structures of these new compounds (1-6) were determined on the basis of the chemical and physicochemical evidence...
  50. ncbi request reprint Bioactive saponins and glycosides. XXV. Acylated oleanane-type triterpene saponins from the seeds of tea plant (Camellia sinensis)
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 55:57-63. 2007
    ..The structures of 1-7 were elucidated on the basis of chemical and physicochemical evidence...
  51. ncbi request reprint Cucurbitane-type triterpenes with anti-proliferative effects on U937 cells from an egyptian natural medicine, Bryonia cretica: structures of new triterpene glycosides, bryoniaosides A and B
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 58:747-51. 2010
    ..2 and 16 nM after 72 h, and their IC(50) values were equivalent to that of camptothecin. An alpha,beta-conjugated ketone moiety at the 22-24-positions and an acetoxy group at the 25-position are essential for the strong activity...
  52. ncbi request reprint Medicinal flowers. XXXV. Nor-oleanane-type and acylated oleanane-type triterpene saponins from the flower buds of Chinese Camellia japonica and their inhibitory effects on melanogenesis
    Katsuyoshi Fujimoto
    Kyoto Pharmaceutical University, Misasagi, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 60:1188-94. 2012
    ..The inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells and structure-activity relationships of the saponins were investigated...
  53. ncbi request reprint Bioactive constituents from Chinese natural medicines. XVII. constituents with radical scavenging effect and new glucosyloxybenzyl 2-isobutylmalates from Gymnadenia conopsea
    Toshio Morikawa
    Kyoto Pharmaceutical University, Japan
    Chem Pharm Bull (Tokyo) 54:506-13. 2006
    ....
  54. ncbi request reprint Triterpene saponins with gastroprotective effects from tea seed (the seeds of Camellia sinensis)
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 69:185-90. 2006
    ....
  55. ncbi request reprint Bioactive constituents from Chinese natural medicines. XXVI. Chemical structures and hepatoprotective effects of constituents from roots of Rhodiola sachalinensis
    Seikou Nakamura
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 55:1505-11. 2007
    ..In addition, the principal constituents, sachalosides III and IV, rhodiosin, and trans-caffeic acid, displayed hepatoprotective effects...
  56. ncbi request reprint Bioactive constituents from Chinese natural medicines. XXXII. aminopeptidase N and aldose reductase inhibitors from Sinocrassula indica: structures of sinocrassosides B(4), B(5), C(1), and D(1)-D(3)
    Toshio Morikawa
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:1438-44. 2008
    ..The structures of 1-6 were elucidated on the basis of chemical and physicochemical evidence. In addition, several constituents were found to show inhibitory effects on aminopeptidase N and aldose reductase...
  57. ncbi request reprint [Functional saponins in tea flower (flower buds of Camellia sinensis): gastroprotective and hypoglycemic effects of floratheasaponins and qualitative and quantitative analysis using HPLC]
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, shityono cho, Misasagi, Yamashina ku, Kyoto, Japan
    Yakugaku Zasshi 128:141-51. 2008
    ..Additionally, the contents of caffeine in the tea flowers were examined using HPLC...
  58. ncbi request reprint Medicinal flowers. XV. The structures of noroleanane- and oleanane-type triterpene oligoglycosides with gastroprotective and platelet aggregation activities from flower buds of Camellia japonica
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Japan
    Chem Pharm Bull (Tokyo) 55:606-12. 2007
    ..The principal oligoglycosides, camelliosides A and B, showed platelet aggregation activity in addition to the gastroprotective effects on ethanol- or indomethacin-induced gastric mucosal lesions in rats...
  59. ncbi request reprint Structures of new phenylbutanoids and nitric oxide production inhibitors from the rhizomes of Zingiber cassumunar
    Seikou Nakamura
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 57:1267-72. 2009
    ..Among them, phlain III (IC50=24 microM), (E)-1-(3,4-dimethoxyphenyl)buta-1,3-diene (69 microM), (E)-1-(2,4,5-trimethoxyphenyl)buta-1,3-diene (83 microM), and cassumunaquinone 1 (47 microM) were found to show the inhibitory effects...
  60. ncbi request reprint Absolute stereostructures of polypodane-type triterpenes, myrrhanol A and myrrhanone A, from guggul-gum resin (the resin of Balsamodendron mukul)
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 52:1200-3. 2004
    ..The structures of the new constituents, including their absolute configurations, were determined on the basis of chemical and physicochemical evidence...
  61. ncbi request reprint Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Org Lett 6:869-72. 2004
    ..Nigellamines A(1) (1), B(1) (3), and B(2) (4) were found to show potent lipid metabolism promoting activity in primary cultured mouse hepatocytes, and their activities were equivalent to that of a PPAR-alpha agonist, clofibrate...
  62. ncbi request reprint Absolute stereostructures of polypodane- and octanordammarane-type triterpenes with nitric oxide production inhibitory activity from guggul-gum resins
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem 12:3037-46. 2004
    ..The several constituents showed inhibitory effects on nitric oxide production and induction of inducible nitric oxide synthase...
  63. ncbi request reprint Structures of new flavonoids, erycibenins D, E, and F, and NO production inhibitors from Erycibe expansa originating in Thailand
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 54:1530-4. 2006
    ..Among the principal constituents, two isoflavones, clycosin (IC50 = 13 microM) and erythrinin B (18 microM), and two rotenoids, deguelin (26 microM) and rotenone (27 microM), were found to show potent inhibitory activity...
  64. ncbi request reprint Bioactive constituents from Chinese natural medicines. XXII. Absolute structures of new megastigmane glycosides, sedumosides E1, E2, E3, F1, F2, and G, from Sedum sarmentosum (Crassulaceae)
    Toshio Morikawa
    Kyoto Pharmaceutical University, Yamashina ku, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 55:435-41. 2007
    ..The structures of new constituents including the absolute configuration were elucidated on the basis of chemical and physicochemical evidence...
  65. ncbi request reprint Phenylethanoid oligoglycosides and acylated oligosugars with vasorelaxant activity from Cistanche tubulosa
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem 14:7468-75. 2006
    ..In addition, principal constituents, kankanoside F, kankanose, echinacoside, acteoside, and cistanoside F, showed vasorelaxant activity, and several structural requirements for the activity were clarified...
  66. ncbi request reprint Potent anti-obese principle from Rosa canina: structural requirements and mode of action of trans-tiliroside
    Kiyofumi Ninomiya
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 17:3059-64. 2007
    ..Furthermore, a single oral administration of trans-tiliroside at a dose of 10 mg/kg increased the expression of PPAR-alpha mRNA of liver tissue in mice...
  67. ncbi request reprint Invasion inhibitors of human fibrosarcoma HT 1080 cells from the rhizomes of Zingiber cassumunar: structures of phenylbutanoids, cassumunols
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 59:365-70. 2011
    ..Interestingly, (E)-1-(2,4,5-trimethoxyphenyl)buta-1,3-diene [inhibition (%) 46.8 ± 7.2 (p<0.05) at 30 µM] significantly inhibited the invasion, and only a weak cytotoxic effect was observed...
  68. ncbi request reprint Inhibitory effects of thunberginols A, B, and F on degranulations and releases of TNF-alpha and IL-4 in RBL-2H3 cells
    Qilong Wang
    Kyoto Pharmaceutical University, Japan
    Biol Pharm Bull 30:388-92. 2007
    ..These results suggested that these active compounds inhibited the degranulation processes both before and after increase in intracellular free Ca2+ levels...
  69. ncbi request reprint New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Prunus mume
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Japan
    J Nat Prod 65:1151-5. 2002
    ..The flavonol glycosides and prunose I were found to inhibit aldose reductase, while prunoses I and II inhibited platelet aggregation induced by thrombin...
  70. ncbi request reprint Inhibitors of nitric oxide production from the bark of Myrica rubra: structures of new biphenyl type diarylheptanoid glycosides and taraxerane type triterpene
    Jing Tao
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto, Japan
    Bioorg Med Chem 10:4005-12. 2002
    ..Furthermore, diarylheptanoids, myricanol and myricanone, were found to inhibit induction of inducible nitric oxide synthase...
  71. ncbi request reprint Glucosyloxybenzyl 2-Isobutylmalates from the tubers of Gymnadenia conopsea
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 69:881-6. 2006
    ..Seven new glucosyloxybenzyl 2-isobutylmalates, gymnosides I-VII (1-7), were isolated from the tubers of Gymnadenia conopsea. The structures of 1-7 were determined on the basis of chemical and physicochemical evidence...
  72. doi request reprint Steroidal saponins and pseudoalkaloid oligoglycoside from Brazilian natural medicine, "fruta do lobo" (fruit of Solanum lycocarpum)
    Seikou Nakamura
    Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Phytochemistry 69:1565-72. 2008
    ..Hil.). The chemical structures of these compounds were elucidated on the basis of analysis of chemical and physicochemical evidence...
  73. ncbi request reprint Structures of new sesquiterpenes and hepatoprotective constituents from the Egyptian herbal medicine Cyperus longus
    Fengming Xu
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 67:569-76. 2004
    ..In addition, the principal constituents were found to exhibit inhibitory activity on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes...
  74. ncbi request reprint Floratheasaponins A-C, acylated oleanane-type triterpene oligoglycosides with anti-hyperlipidemic activities from flowers of the tea plant (Camellia sinensis)
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 68:1360-5. 2005
    ..Floratheasaponins (1-3) showed inhibitory effects on serum triglyceride elevation, with their activities being more potent than those of theasaponins E1 (4) and E2 (5) obtained previously from the seeds of C. sinensis...
  75. ncbi request reprint Medicinal flowers. XI. Structures of new dammarane-type triterpene diglycosides with hydroperoxide group from flower buds of Panax ginseng
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 55:571-6. 2007
    ..A. MEYER, together with seven known dammarane-type triterpene oligoglycosides. The structures of new floralginsenosides were elucidated on the basis of chemical and physicochemical evidence...
  76. ncbi request reprint Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 70:210-4. 2007
    ..It was concluded that these steroidal alkaloid oligoglycosides, 1 and 3, inhibited the increase of rat serum glucose levels by suppressing the transfer of sucrose from the stomach to the small intestine...
  77. ncbi request reprint Inhibitors from the rhizomes of Alpinia officinarum on production of nitric oxide in lipopolysaccharide-activated macrophages and the structural requirements of diarylheptanoids for the activity
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem 14:138-42. 2006
    ..To clarify structure-activity relationships of diarylheptanoids, related diarylheptanoids from Curcuma zedoaria were examined. Results indicate that the double bond or enone moiety at the 1-7 positions is important for the activity...
  78. ncbi request reprint Anastatins A and B, new skeletal flavonoids with hepatoprotective activities from the desert plant Anastatica hierochuntica
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 13:1045-9. 2003
    ..Anastatins A and B were found to show hepatoprotective effects on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes and their activities were stronger than those of related flavonoids and commercial silybin...
  79. doi request reprint Hepatoprotective amide constituents from the fruit of Piper chaba: Structural requirements, mode of action, and new amides
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem 17:7313-23. 2009
    ..Moreover, a principal constituent, piperine, exhibited strong in vivo hepatoprotective effects at doses of 5 and 10 mg/kg, po and its mode of action was suggested to depend on the reduced sensitivity of hepatocytes to TNF-alpha...
  80. ncbi request reprint Apoptosis-inducing effects of sterols from the dried powder of cultured mycelium of Cordyceps sinensis
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 57:411-4. 2009
    ..To the best of our knowledge, this is the first report of the isolation of sterol constituents (1-5) from cultured C. sinensis mycelium...
  81. ncbi request reprint Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Japan
    J Nutr 132:1819-24. 2002
    ..01). In conclusion, polyphenolic compounds may be involved in the antiobesity effects of SRHW in rats through inhibition of fat metabolizing enzymes (PL, LPL and GPDH) and enhanced lipolysis...
  82. ncbi request reprint Labdane-type diterpenes with inhibitory effects on increase in vascular permeability and nitric oxide production from Hedychium coronarium
    Hisashi Matsuda
    Kyoto Pharmaceutical University, 1 Shichono cho, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem 10:2527-34. 2002
    ..The diterpene constituents showed inhibitory effects on the increase in vascular permeability, nitric oxide production, and inducible nitric oxide synthase induction...
  83. ncbi request reprint Absolute stereostructure of potent alpha-glucosidase inhibitor, Salacinol, with unique thiosugar sulfonium sulfate inner salt structure from Salacia reticulata
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, 607 8412, Kyoto, Japan
    Bioorg Med Chem 10:1547-54. 2002
    ....
  84. ncbi request reprint Hepatoprotective and antioxidative properties of Salacia reticulata: preventive effects of phenolic constituents on CCl4-induced liver injury in mice
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Japan
    Biol Pharm Bull 25:72-6. 2002
    ..These results suggest that the antioxidative activity of the principal phenolic compounds is involved in the hepatoprotective activity of S. reticulata...
  85. ncbi request reprint Bioactive saponins and glycosides. XXVII. Structures of new cucurbitane-type triterpene glycosides and antiallergic constituents from Citrullus colocynthis
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Yamashina ku, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 55:428-34. 2007
    ..In addition, the principal cucurbitane-type triterpene glycoside, cucurbitacin E 2-O-beta-D-glucopyranoside, and its aglycon, cucurbitacin E, exhibited the antiallergic activity at a dose of 100 and 1.25 mg/kg, p.o., respectively...
  86. ncbi request reprint Structural requirements of flavonoids for inhibition of protein glycation and radical scavenging activities
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, 2Kyoto 607 8412, Japan
    Bioorg Med Chem 11:5317-23. 2003
    ..In addition, various flavonoids with strong AGEs formation inhibitory activity tended to exhibit strong scavenging activity for 1,1-diphenyl-2-picrylhydrazyl and superoxide anion radicals, with several exceptions...
  87. ncbi request reprint Medicinal flowers. VIII. Radical scavenging constituents from the flowers of Prunus mume: structure of prunose III
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Japan
    Chem Pharm Bull (Tokyo) 51:440-3. 2003
    ..In addition, the scavenging effects of the principal constituents on DPPH radical and superoxide were examined...
  88. ncbi request reprint Protective effects of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 12:477-82. 2002
    ....
  89. ncbi request reprint Medicinal flowers. XIV. New acylated oleanane-type triterpene oligoglycosides with antiallergic activity from flower buds of chinese tea plant (Camellia sinensis)
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Japan
    Chem Pharm Bull (Tokyo) 55:598-605. 2007
    ..The principal constituents, floratheasaponins A-F, were found to show the inhibitory activity on the release of beta-hexosaminidase from RBL-2H3 cells...
  90. ncbi request reprint Protective effects of steroid saponins from Paris polyphylla var. yunnanensis on ethanol- or indomethacin-induced gastric mucosal lesions in rats: structural requirement for activity and mode of action
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 13:1101-6. 2003
    ..Compounds 1 and 3 weakly inhibited acid secretions in pylorus-ligated rats. These findings suggested that endogenous prostaglandins and sulfhydryl compounds were involved in the protective activity...
  91. ncbi request reprint Medicinal foodstuffs. XXXI. Structures of new aromatic constituents and inhibitors of degranulation in RBL-2H3 cells from a Japanese folk medicine, the stem bark of Acer nikoense
    Toshio Morikawa
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 51:62-7. 2003
    ..The principle cyclic diarylheptanoids were found to show inhibitory effects on the release of beta-hexosaminidase in RBL-2H3 cells...
  92. ncbi request reprint Bioactive constituents from Chinese natural medicines. XXXIII. Inhibitors from the seeds of Psoralea corylifolia on production of nitric oxide in lipopolysaccharide-activated macrophages
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Japan
    Biol Pharm Bull 32:147-9. 2009
    ..Bakuchiol, which is mainly contained in the extract, also showed weak activity at 10 microM, but cytotoxic effects were observed more than 30 microM...
  93. ncbi request reprint Characterization of new sweet triterpene saponins from Albizia myriophylla
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 65:1638-42. 2002
    ..In addition, when sensory tests were performed on sweetness, albiziasaponin B (2), with a carbonyl group at the C-30 position, was found to show a potent sweetness intensity relative to sucrose (600 times)...
  94. ncbi request reprint Antidiabetic principles of natural medicines. V. Aldose reductase inhibitors from Myrcia multiflora DC. (2): Structures of myrciacitrins III, IV, and V
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Japan
    Chem Pharm Bull (Tokyo) 50:429-31. 2002
    ..The structures of new myrciacitrins were elucidated on the basis of physicochemical and chemical evidence. Myrciacitrins were found to show potent inhibitory activity on aldose reductase...
  95. pmc Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes
    Li Kun Han
    Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Tsukide, Kumamoto 862 8502, Japan
    BMC Complement Altern Med 5:9. 2005
    ..Obesity is closely associated with life-style-related diseases. This study was performed to clarify whether chikusetsusaponins prevent obesity induced in mice by a high-fat diet for 9 weeks...
  96. ncbi request reprint [Study on chemical constituents from Opuntia dillenii]
    Ying Kun Qiu
    School of Pharmacy, Yaitai University, China
    Zhongguo Zhong Yao Za Zhi 30:1824-6. 2005
    ..To study the chemical composition of Opuntia dillenii...
  97. ncbi request reprint New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense
    Osama Bashir Abdel-Halim
    Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
    J Nat Prod 67:1119-24. 2004
    ..g. 1, (+)-bulbispermine (6), (+)-crinamine (7), (+)-6-hydroxycrinamine (8), and (-)-lycorine (9), showed inhibitory effects on nitric oxide production and induction of inducible nitric oxide synthase...
  98. ncbi request reprint Anti-obesity effects of escins extracted from the seeds of Aesculus turbinata BLUME (Hippocastanaceae)
    Jiang Ning Hu
    Department of Food Science and Technology, Chungnam National University, Republic of Korea
    Chem Pharm Bull (Tokyo) 56:12-6. 2008
    ..The reason for this may be due to a delay in the intestinal absorption of dietary fat by inhibiting PL activity...
  99. ncbi request reprint [The isolation and identification of a new alpha-pyrone from Opuntia dillenii]
    Ying Kun Qiu
    Shenyang Pharmaceutical University, Shenyang 110016, China
    Yao Xue Xue Bao 38:523-5. 2003
    ..To study the chemical composition of Opuntia dillenii Haw...