Takako Yokozawa

Summary

Country: Japan

Publications

  1. ncbi request reprint Protective activity of green tea against free radical- and glucose-mediated protein damage
    Takako Nakagawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930 0194, Japan
    J Agric Food Chem 50:2418-22. 2002
  2. ncbi request reprint Antioxidative activity of green tea polyphenol in cholesterol-fed rats
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Agric Food Chem 50:3549-52. 2002
  3. ncbi request reprint The beneficial effects of morroniside on the inflammatory response and lipid metabolism in the liver of db/db mice
    Chan Hum Park
    Institute of Natural Medicine, University of Toyama, Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 32:1734-40. 2009
  4. ncbi request reprint Increase in the free radical scavenging activities of American ginseng by heat processing and its safety evaluation
    Ki Sung Kang
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Ethnopharmacol 113:225-32. 2007
  5. ncbi request reprint Protective effects of morroniside isolated from Corni Fructus against renal damage in streptozotocin-induced diabetic rats
    Takako Yokozawa
    Institute of Natural Medicine, University of Toyama, Toyama, Japan
    Biol Pharm Bull 31:1422-8. 2008
  6. ncbi request reprint Glycerol-induced renal damage improved by 7-O-galloyl-D-sedoheptulose treatment through attenuating oxidative stress
    Chan Hum Park
    Institute of Natural Medicine, University of Toyama, Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 35:34-41. 2012
  7. ncbi request reprint Effects of heat-processed ginseng and its active component ginsenoside 20(S)-Rg3 on the progression of renal damage and dysfunction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats
    Ki Sung Kang
    Institute of Natural Medicine, University of Toyama, Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 33:1077-81. 2010
  8. doi request reprint Evaluation of loganin, iridoid glycoside from Corni Fructus, on hepatic and renal glucolipotoxicity and inflammation in type 2 diabetic db/db mice
    Noriko Yamabe
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Eur J Pharmacol 648:179-87. 2010
  9. doi request reprint Matcha, a powdered green tea, ameliorates the progression of renal and hepatic damage in type 2 diabetic OLETF rats
    Noriko Yamabe
    Institute of Natural Medicine, University of Toyama, Toyama, Japan
    J Med Food 12:714-21. 2009
  10. ncbi request reprint 7-O-galloyl-D-sedoheptulose is a novel therapeutic agent against oxidative stress and advanced glycation endproducts in the diabetic kidney
    Noriko Yamabe
    Institute of Natural Medicine, University of Toyama, Japan
    Biol Pharm Bull 32:657-64. 2009

Collaborators

Detail Information

Publications93

  1. ncbi request reprint Protective activity of green tea against free radical- and glucose-mediated protein damage
    Takako Nakagawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930 0194, Japan
    J Agric Food Chem 50:2418-22. 2002
    ..These findings demonstrate the mechanisms of the usefulness of green tea in protein oxidation- and glycation-associated diseases...
  2. ncbi request reprint Antioxidative activity of green tea polyphenol in cholesterol-fed rats
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Agric Food Chem 50:3549-52. 2002
    ..Thus, green tea polyphenol may exert an antiatherosclerotic action by virtue of its antioxidant properties and by increasing HDL cholesterol levels...
  3. ncbi request reprint The beneficial effects of morroniside on the inflammatory response and lipid metabolism in the liver of db/db mice
    Chan Hum Park
    Institute of Natural Medicine, University of Toyama, Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 32:1734-40. 2009
    ..These results suggest that morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice...
  4. ncbi request reprint Increase in the free radical scavenging activities of American ginseng by heat processing and its safety evaluation
    Ki Sung Kang
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Ethnopharmacol 113:225-32. 2007
    ..Therefore, heat processing, as in KG, is a useful method to enhance the free radical scavenging activities of AG by the increases in total phenolic contents and MRP levels...
  5. ncbi request reprint Protective effects of morroniside isolated from Corni Fructus against renal damage in streptozotocin-induced diabetic rats
    Takako Yokozawa
    Institute of Natural Medicine, University of Toyama, Toyama, Japan
    Biol Pharm Bull 31:1422-8. 2008
    ..These results indicate that morroniside is one component partly responsible for the protective effects of Corni Fructus and Hachimi-jio-gan against diabetic renal damage...
  6. ncbi request reprint Glycerol-induced renal damage improved by 7-O-galloyl-D-sedoheptulose treatment through attenuating oxidative stress
    Chan Hum Park
    Institute of Natural Medicine, University of Toyama, Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 35:34-41. 2012
    ..The present study indicates that GS exerts a protective effect against ARF through the recovery of renal dysfunction and attenuation of renal oxidative stress by regulating related protein expression...
  7. ncbi request reprint Effects of heat-processed ginseng and its active component ginsenoside 20(S)-Rg3 on the progression of renal damage and dysfunction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats
    Ki Sung Kang
    Institute of Natural Medicine, University of Toyama, Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 33:1077-81. 2010
    ..This study provides scientific evidence that 20(S)-Rg(3) prevents the progression of renal damage and dysfunction in type 2 diabetic rats via inhibiting oxidative stress and advanced glycation endproduct formation...
  8. doi request reprint Evaluation of loganin, iridoid glycoside from Corni Fructus, on hepatic and renal glucolipotoxicity and inflammation in type 2 diabetic db/db mice
    Noriko Yamabe
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Eur J Pharmacol 648:179-87. 2010
    ..Loganin exhibits protective effects against hepatic injury and other diabetic complications associated with abnormal metabolic states and inflammation caused by oxidative stress and advanced glycation endproduct formation...
  9. doi request reprint Matcha, a powdered green tea, ameliorates the progression of renal and hepatic damage in type 2 diabetic OLETF rats
    Noriko Yamabe
    Institute of Natural Medicine, University of Toyama, Toyama, Japan
    J Med Food 12:714-21. 2009
    ....
  10. ncbi request reprint 7-O-galloyl-D-sedoheptulose is a novel therapeutic agent against oxidative stress and advanced glycation endproducts in the diabetic kidney
    Noriko Yamabe
    Institute of Natural Medicine, University of Toyama, Japan
    Biol Pharm Bull 32:657-64. 2009
    ..Together, our data help to elucidate its potential therapeutic value against diabetic kidney disease...
  11. ncbi request reprint Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice
    Chan Hum Park
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 34:1559-65. 2011
    ..Taking these into consideration, our findings support the therapeutic evidence for morroniside ameliorating the development of diabetic hepatic complications via regulating oxidative stress, inflammation, and apoptosis...
  12. ncbi request reprint Amla (Emblica officinalis Gaertn.) prevents dyslipidaemia and oxidative stress in the ageing process
    Takako Yokozawa
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Br J Nutr 97:1187-95. 2007
    ..These results indicate that amla may prevent age-related hyperlipidaemia through attenuating oxidative stress in the ageing process...
  13. ncbi request reprint Protective role of gamma-aminobutyric acid against chronic renal failure in rats
    Sumiyo Sasaki
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, Japan
    J Pharm Pharmacol 58:1515-25. 2006
    ....
  14. doi request reprint Beneficial effect of 7-O-galloyl-D-sedoheptulose on oxidative stress and hepatic and renal changes in type 2 diabetic db/db mice
    Chan Hum Park
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Eur J Pharmacol 640:233-42. 2010
    ..In conclusion, GS could have hepato- and reno-protective effects against abnormal lipid metabolism and the reactive oxygen species-related formation of advanced glycation endproducts with inflammation in type 2 diabetes...
  15. doi request reprint Hypolipidaemic and antioxidative effects of oligonol, a low-molecular-weight polyphenol derived from lychee fruit, on renal damage in type 2 diabetic mice
    Jeong Sook Noh
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Br J Nutr 104:1120-8. 2010
    ..The present results suggest that oligonol could have renoprotective effects against abnormal lipid metabolism and ROS-related AGE formation in type 2 diabetes...
  16. doi request reprint 7-O-galloyl-D-sedoheptulose ameliorates renal damage triggered by reactive oxygen species-sensitive pathway of inflammation and apoptosis
    Chan Hum Park
    Institute of Natural Medicine, University of Toyama, Toyama Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    J Pharm Pharmacol 64:1730-40. 2012
    ..This study was carried out to verify the preventive effects of 7-O-galloyl-d-sedoheptulose (GS), a phenolic compound isolated from Corni Fructus, underlying diabetic renal damage in type 2 diabetes...
  17. ncbi request reprint Protective effects of the Chinese prescription Hachimi-jio-gan against diabetic oxidative stress
    Hyun Young Kim
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Pharmacol 56:1299-305. 2004
    ..These results indicate that Hachimi-jio-gan is a potential therapeutic agent that will reduce the damage caused by oxidative stress involved in diabetes...
  18. ncbi request reprint Glycyrrhizae Radix attenuates peroxynitrite-induced renal oxidative damage through inhibition of protein nitration
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Free Radic Res 39:203-11. 2005
    ..The present study suggests that Glycyrrhizae Radix extract could protect the kidneys against ONOO- through scavenging ONOO- and/or its precursor NO, inhibiting protein nitration and improving renal dysfunction caused by ONOO-...
  19. doi request reprint Role of maltol in advanced glycation end products and free radicals: in-vitro and in-vivo studies
    Ki Sung Kang
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Pharmacol 60:445-52. 2008
    ..These beneficial effects of maltol against STZ-diabetic renal damage were thought to result from its free radical scavenging and AGE inhibitory effects...
  20. ncbi request reprint Effects of the Chinese prescription Kangen-karyu and its crude drug Tanjin on ageing process in rats
    Takako Yokozawa
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Pharmacol 58:1591-9. 2006
    ..Furthermore, Kangen-karyu showed a stronger protective effect against ageing by oxidative stress than Tanjin, probably through synergistic and/or additive effects...
  21. doi request reprint Treatment with oligonol, a low-molecular polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism
    Jeong Sook Noh
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Br J Nutr 106:1013-22. 2011
    ..The present results suggest that oligonol has protective effects against ROS-related inflammation and excess lipid deposition in the type 2 diabetic liver...
  22. ncbi request reprint Protective effects of keishibukuryogan on the kidney of spontaneously diabetic WBN/Kob rats
    Takako Nakagawa
    Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Ethnopharmacol 110:311-7. 2007
    ..These results suggest that keishibukuryogan reduces oxidative stress by hyperglycemia, and that it protects renal function and suppresses fibronectin deposition induced by TGF-beta(1) production in WBN/Kob rats...
  23. doi request reprint Protection against hypercholesterolemia by Corni fructus extract and its related protective mechanism
    Chan Hum Park
    Institute of Natural Medicine, University of Toyama, Toyama, Japan
    J Med Food 12:973-81. 2009
    ..In conclusion, Corni Fructus may protect against CVD by regulating blood pressure, cholesterol levels, and expression of proteins related to lipid metabolism...
  24. ncbi request reprint The protective role of Kangen-karyu against fructose-induced metabolic syndrome in a rat model
    Takako Yokozawa
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Pharmacol 59:1271-8. 2007
    ....
  25. ncbi request reprint Long-term treatment with Hachimi-jio-gan attenuates kidney damage in spontaneously diabetic WBN/Kob rats
    Takako Nakagawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Pharmacol 57:1205-12. 2005
    ....
  26. ncbi request reprint Protective effect of heat-processed American ginseng against diabetic renal damage in rats
    Hyun Young Kim
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Agric Food Chem 55:8491-7. 2007
    ..These findings indicate that H-AG may have beneficial effect on pathological conditions associated with diabetic nephropathy...
  27. ncbi request reprint Protective activity of (-)-epicatechin 3-O-gallate against peroxynitrite-mediated renal damage
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Free Radic Res 37:561-71. 2003
    ..This study provides evidence that ECg has protective activity against the renal damage induced by excessive ONOO- in cellular and in vivo systems...
  28. ncbi request reprint Protective effect of persimmon peel polyphenol against high glucose-induced oxidative stress in LLC-PK(1) cells
    Takako Yokozawa
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Food Chem Toxicol 45:1979-87. 2007
    ..These findings indicate the potential benefits of persimmon peel as a valuable source of antioxidants in the diabetic condition which will reduce the oxidative stress induced by hyperglycemia...
  29. ncbi request reprint Protective effect of the Chinese prescription Kangen-karyu against high glucose-induced oxidative stress in LLC-PK1 cells
    Takako Yokozawa
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Ethnopharmacol 109:113-20. 2007
    ..These findings indicate that Kangen-karyu is a potential therapeutic agent that will reduce the damage caused by hyperglycemia-induced oxidative stress associated with diabetes...
  30. ncbi request reprint Rosa rugosa attenuates diabetic oxidative stress in rats with streptozotocin-induced diabetes
    Eun Ju Cho
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University 2630 Sugitani, Toyama 930 0194, Japan
    Am J Chin Med 32:487-96. 2004
    ..This study provides evidence that Rosa rugosa has potential as a treatment for diabetes through attenuating oxidative stress induced by the diabetic condition...
  31. ncbi request reprint The protective role of Chinese prescription Kangen-karyu extract on diet-induced hypercholesterolemia in rats
    Takako Yokozawa
    Institute of Natural Medicine, University of Toyama, Sugitani, Japan
    Biol Pharm Bull 29:760-5. 2006
    ..The present study suggests that Kangen-karyu could play a protective role against hypercholesterolemia through the regulation of cholesterol levels and inhibition of lipid peroxidation...
  32. ncbi request reprint Comparison of the effects of Korean ginseng and heat-processed Korean ginseng on diabetic oxidative stress
    Hyun Young Kim
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, Japan
    Am J Chin Med 36:989-1004. 2008
    ..This study provides scientific evidence that H-KG may be a potential therapeutic agent for pathological conditions associated with diabetic complications including diabetic nephropathy...
  33. ncbi request reprint A study on the effects to diabetic nephropathy of Hachimi-jio-gan in rats
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Nephron Exp Nephrol 97:e38-48. 2004
    ..This study suggests that Hachimi-jio-gan may be a novel therapeutic approach to improving diabetic nephropathy...
  34. ncbi request reprint (-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Pharmacol 56:231-9. 2004
    ....
  35. doi request reprint Therapeutic potential of 20(S)-ginsenoside Rg(3) against streptozotocin-induced diabetic renal damage in rats
    Ki Sung Kang
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Eur J Pharmacol 591:266-72. 2008
    ..These beneficial effects on diabetic renal damage were related to the inhibitory effect of 20(S)-Rg(3) against NMDA receptor-mediated nitrosative stress...
  36. ncbi request reprint Effect of Chinese prescription Kangen-karyu on lipid metabolism in type 2 diabetic db/db mice
    Noriko Yamabe
    Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan
    J Ethnopharmacol 129:299-305. 2010
    ..The present study was investigated to evaluate the hypolipidemic effect of Kangen-karyu in type 2 diabetic db/db mice which has not been explored yet...
  37. doi request reprint Effects of morroniside isolated from Corni Fructus on renal lipids and inflammation in type 2 diabetic mice
    Chan Hum Park
    Institute of Natural Medicine, University of Toyama, Toyama, Japan
    J Pharm Pharmacol 62:374-80. 2010
    ..The effects of morroniside isolated from Corni Fructus on renal lipids and inflammation provoked by hyperglycaemia were investigated using type 2 diabetic mice...
  38. ncbi request reprint In vitro and in vivo antioxidant effects of mustard leaf (Brassica juncea)
    Hyun Young Kim
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Phytother Res 17:465-71. 2003
    ..These results indicate that the BuOH fraction of mustard leaf controls glucose metabolism and reduces lipid peroxidation as well as the level of oxygen radicals, ameliorating the damage caused by oxidative stress in diabetes...
  39. ncbi request reprint Coptidis Rhizoma: protective effects against peroxynitrite-induced oxidative damage and elucidation of its active components
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Pharmacol 56:547-56. 2004
    ..This study is the first to demonstrate an antioxidative effect of alkaloids, including berberine, against ONOO(-)-induced damage...
  40. ncbi request reprint Chinese prescription kangen-karyu ameliorates the development of diabetic hepatic damages via regulating oxidative stress and inflammation in the liver of db/db mice
    Chan Hum Park
    Institute of Natural Medicine, University of Toyama, Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 34:383-8. 2011
    ..Taking these into consideration, our findings support the therapeutic evidence for kangen-karyu ameliorating the development of diabetic hepatic damages via regulating oxidative stress and inflammation...
  41. doi request reprint Novel action of 7-O-galloyl-D-sedoheptulose isolated from Corni Fructus as a hypertriglyceridaemic agent
    Takako Yokozawa
    Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan
    J Pharm Pharmacol 61:653-61. 2009
    ..We investigated the lipid-lowering activity of 7-O-galloyl-D-sedoheptulose, an active component of Corni Fructus, and related mechanisms...
  42. ncbi request reprint Influence of green tea polyphenol in rats with arginine-induced renal failure
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Agric Food Chem 51:2421-5. 2003
    ..These results suggest that green tea polyphenol would ameliorate renal failure induced by excessive dietary arginine by decreasing uremic toxin, and NO production and increasing radical-scavenging enzyme activity...
  43. ncbi request reprint Protective effect of persimmon (Diospyros kaki) peel proanthocyanidin against oxidative damage under H2O2-induced cellular senescence
    Young A Lee
    Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan
    Biol Pharm Bull 31:1265-9. 2008
    ....
  44. ncbi request reprint Influence of amla (Emblica officinalis Gaertn.) on hypercholesterolemia and lipid peroxidation in cholesterol-fed rats
    Hyun Ju Kim
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:413-8. 2005
    ..These results suggest that amla may be effective for hypercholesterolemia and prevention of atherosclerosis...
  45. ncbi request reprint Green tea polyphenols and dietary fibre protect against kidney damage in rats with diabetic nephropathy
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Pharmacol 57:773-80. 2005
    ..A significant reduction in the total cholesterol concentration was also observed in the PHGG-treated group. These results suggest that GTP and PHGG could be beneficial as additional therapy in the management of diabetic nephropathy...
  46. ncbi request reprint Therapeutic potential of (-)-epigallocatechin 3-O-gallate on renal damage in diabetic nephropathy model rats
    Noriko Yamabe
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharmacol Exp Ther 319:228-36. 2006
    ..These results suggest that EGCg ameliorates glucose toxicity and renal injury, thus alleviating renal damage caused by abnormal glucose metabolism-associated oxidative stress involved in renal lesions of diabetic nephropathy...
  47. ncbi request reprint The effects of corni fructus extract and its fractions against α-glucosidase inhibitory activities in vitro and sucrose tolerance in normal rats
    Chan Hum Park
    Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan
    Am J Chin Med 39:367-80. 2011
    ..These results indicate that Fr. 4S-1 from corni fructus has a potential to control postprandial hyperglycemia by α-glucosidase inhibition...
  48. ncbi request reprint Protective effects of mustard leaf (Brassica juncea) against diabetic oxidative stress
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930 0194, Japan
    J Nutr Sci Vitaminol (Tokyo) 49:87-93. 2003
    ..These findings suggest that the EtOAc fraction from mustard leaf might be beneficial in attenuating the damage caused by oxidative stress involved in diabetes and its complications...
  49. ncbi request reprint Protective effects of Acanthopanax Radix extract against endotoxemia induced by lipopolysaccharide
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Phytother Res 17:353-7. 2003
    ..These results suggested that scavenging of reactive oxygen radicals is part of the mechanism by which Acanthopanax Radix extract works as an effective agent in preventing multiple organ dysfunction...
  50. ncbi request reprint Attenuation of renal ischemia-reperfusion injury by proanthocyanidin-rich extract from grape seeds
    Takako Nakagawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:283-6. 2005
    ..These results suggest that proanthocyanidin-rich extract has protective effects against ischemia-reperfusion-induced renal damage associated with oxidative stress...
  51. ncbi request reprint Protective effects of gamma-aminobutyric acid in rats with streptozotocin-induced diabetes
    Takako Nakagawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:278-82. 2005
    ..These results suggest that GABA treatment protects against the development of diabetic complications resulting from impaired glucose metabolism and enhanced oxidative stress...
  52. doi request reprint Chinese prescription Kangen-karyu prevents dyslipidaemia and oxidative stress in mouse model of type 2 diabetes
    Jeong Sook Noh
    Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan
    J Pharm Pharmacol 63:111-9. 2011
    ..We have investigated the effects of Kangen-karyu, a Chinese prescription, on the lipid metabolism and oxidative stress in a type 2 diabetes model...
  53. ncbi request reprint Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930 0194, Japan
    J Agric Food Chem 50:5490-5. 2002
    ..These results suggest that isorhamnetin diglucoside is metabolized in vivo by intestinal bacteria to isorhamnetin and that isorhamnetin plays an important role as an antioxidant...
  54. doi request reprint Hepato-/reno-protective activity of Chinese prescription Kangen-karyu through inhibition of AGE formation and fibrosis-related protein expression in type 2 diabetes
    Takuya Okamoto
    Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan
    J Pharm Pharmacol 63:952-9. 2011
    ....
  55. doi request reprint Hepato-protective effects of loganin, iridoid glycoside from Corni Fructus, against hyperglycemia-activated signaling pathway in liver of type 2 diabetic db/db mice
    Chan Hum Park
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Toxicology 290:14-21. 2011
    ....
  56. ncbi request reprint Preventive effect of 20(S)-ginsenoside Rg3 against lipopolysaccharide-induced hepatic and renal injury in rats
    Ki Sung Kang
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Free Radic Res 41:1181-8. 2007
    ....
  57. ncbi request reprint Identification of antidiabetic effect of iridoid glycosides and low molecular weight polyphenol fractions of Corni Fructus, a constituent of Hachimi-jio-gan, in streptozotocin-induced diabetic rats
    Noriko Yamabe
    Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan
    Biol Pharm Bull 30:1289-96. 2007
    ..The main active components of these fractions are discussed...
  58. ncbi request reprint Protective effect of Hachimi-jio-gan against the development of pancreatic fibrosis and oxidative damage in Otsuka Long-Evans Tokushima Fatty rats
    Noriko Yamabe
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Ethnopharmacol 113:91-9. 2007
    ..Therefore, this may provide evidence that Hachimi-jio-gan is a therapeutic target for preventing the development of pancreatic damage concomitant with hyperglycemia in type 2 diabetes...
  59. ncbi request reprint Amla (Emblica officinalis Gaertn.) attenuates age-related renal dysfunction by oxidative stress
    Takako Yokozawa
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Agric Food Chem 55:7744-52. 2007
    ..These results indicate that amla would be a very useful antioxidant for the prevention of age-related renal disease...
  60. ncbi request reprint Protective role of Coptidis Rhizoma alkaloids against peroxynitrite-induced damage to renal tubular epithelial cells
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Pharmacol 57:367-74. 2005
    ..Furthermore, the data suggest that among the Coptidis Rhizoma alkaloids, coptisine is the most effective for protection against SIN-1-induced cellular injury in terms of its potency and content...
  61. ncbi request reprint Study on the hydroxyl radical scavenging activity changes of ginseng and ginsenoside-Rb2 by heat processing
    Ki Sung Kang
    Institute of Natural Medicine, University of Toyama, Japan
    Biol Pharm Bull 30:724-8. 2007
    ..OH scavenging activity was thought to be more closely related to the generation of .OH scavenging ginsenosides such as 20(S)-Rg3 and Rg5 by heat processing than MRPs...
  62. ncbi request reprint Protective effects of the BuOH fraction from mustard leaf in a renal ischemia-reperfusion model
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930 0194, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:384-9. 2002
    ....
  63. ncbi request reprint Gamma-aminobutyric acid specifically inhibits progression of tubular fibrosis and atrophy in nephrectomized rats
    Sumiyo Sasaki
    Institute of Natural Medicine, University of Toyama, Japan
    Biol Pharm Bull 30:687-91. 2007
    ..These results suggest that GABA may have a beneficial effect on renal function in nephrectomized rats by inhibiting fibrosis and atrophy primarily in tubuli, and that it ameliorates losses of renal function in renal failure...
  64. ncbi request reprint Increase in the free radical scavenging activity of ginseng by heat-processing
    Ki Sung Kang
    Institute of Natural Medicine, University of Toyama, Sugitani, Japan
    Biol Pharm Bull 29:750-4. 2006
    ..These findings indicate that SG may act as a free radical scavenger and protect against damage caused by oxidative stress related with these radicals...
  65. ncbi request reprint Inhibitory activities of proanthocyanidins from persimmon against oxidative stress and digestive enzymes related to diabetes
    Young A Lee
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:287-92. 2007
    ..Moreover, oligomers rather than polymers from proanthocyanidins of persimmon peel may be expected to be a more promising antioxidative and antidiabetic agent in relation to utilization in biological systems...
  66. ncbi request reprint Protective effect of lipoic acid against methylglyoxal-induced oxidative stress in LLC-PK(1) cells
    Hyun Young Kim
    Institute of Natural Medicine, University of Toyama, Toyama, Japan
    J Nutr Sci Vitaminol (Tokyo) 54:99-104. 2008
    ..These findings indicate that lipoic acid has potential as a therapeutic agent against the development of diabetic complications related to MG-induced oxidative stress in diabetes...
  67. ncbi request reprint Activity of (-)-epigallocatechin 3-O-gallate against oxidative stress in rats with adenine-induced renal failure
    Takako Nakagawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Agric Food Chem 52:2103-7. 2004
    ..Our findings suggest that EGCg, an excellent antioxidant from green tea, exerts protective activity in rats with chronic renal failure, resulting in suppression of Cr oxidation influenced by *OH...
  68. ncbi request reprint Erythritol attenuates the diabetic oxidative stress through modulating glucose metabolism and lipid peroxidation in streptozotocin-induced diabetic rats
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Agric Food Chem 50:5485-9. 2002
    ..These results suggest that erythritol affects glucose metabolism and reduces lipid peroxidation, thereby improving the damage caused by oxidative stress involved in the pathogenesis of diabetes...
  69. ncbi request reprint Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Pharmacol 56:107-13. 2004
    ....
  70. ncbi request reprint Ameliorative effects of proanthocyanidin on oxidative stress and inflammation in streptozotocin-induced diabetic rats
    Young A Lee
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930 0194, Japan
    J Agric Food Chem 55:9395-400. 2007
    ..The present study supports the beneficial effect of proanthocyanidin against diabetes and oxidative stress-related inflammatory processes...
  71. ncbi request reprint Prevention of peroxynitrite-induced renal injury through modulation of peroxynitrite production by the Chinese prescription Wen-Pi-Tang
    Dong Young Rhyu
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Free Radic Res 36:1261-9. 2002
    ..The present study indicates that Wen-Pi-Tang extract contributes to the regulation of ONOO- formation and plays a beneficial role against ONOO(-) -induced oxidative injury and renal dysfunction in vivo...
  72. ncbi request reprint Protective effect of sun ginseng against diabetic renal damage
    Ki Sung Kang
    Institute of Natural Medicine, University of Toyama, Japan
    Biol Pharm Bull 29:1678-84. 2006
    ..These findings indicate that oxidative stress is increased in the diabetic rat kidney and that SG can prevent renal damage associated with diabetes by attenuating the oxidative stress...
  73. ncbi request reprint Piceatannol inhibits melanogenesis by its antioxidative actions
    Takako Yokozawa
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, Japan
    Biol Pharm Bull 30:2007-11. 2007
    ..In conclusion, our results indicated that the antimelanogenic action of PICE is likely exhibited by the combined effect of PICE's antioxidative property and its ability to suppress RS generation while increasing the GSH/GSSG ratio...
  74. ncbi request reprint Site of methylguanidine production and factors that influence production levels
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitami, Toyama 930 0194, Japan
    Nephron 92:356-62. 2002
    ..These findings indicate that the accumulation of creatinine due to DHOA, combined with oxidative stress, resulted in increased MG production...
  75. ncbi request reprint Potential of sanguiin H-6 against oxidative damage in renal mitochondria and apoptosis mediated by peroxynitrite in vivo
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Nephron 92:133-41. 2002
    ..These beneficial effects of sanguiin H-6 against oxidative damage in mitochondria and apoptosis contributed to the improvement in renal function by reversing the elevated levels of blood urea nitrogen and creatinine caused by ONOO(-)...
  76. ncbi request reprint Attenuating effects of wen-pi-tang treatment in rats with diabetic nephropathy
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Am J Chin Med 34:307-21. 2006
    ..This study suggests that wen-pi-tang treatment could be beneficial in reducing the risk of developing diabetic nephropathy...
  77. ncbi request reprint Protective effect of gamma-aminobutyric acid against glycerol-induced acute renal failure in rats
    Hyun Young Kim
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Food Chem Toxicol 42:2009-14. 2004
    ..These results indicate that GABA has potential as a therapeutic agent against the renal damage involved in acute renal failure...
  78. doi request reprint Effects of proanthocyanidin preparations on hyperlipidemia and other biomarkers in mouse model of type 2 diabetes
    Young A Lee
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Agric Food Chem 56:7781-9. 2008
    ..The present study results suggest that proanthocyanidin administration, especially the oligomeric form, may improve oxidative stress via the regulation of hyperlipidemia than hyperglycemia in type 2 diabetes...
  79. ncbi request reprint Effects of Choto-san and hooks and stems of Uncaria sinensis on antioxidant enzyme activities in the gerbil brain after transient forebrain ischemia
    Koichi Yokoyama
    Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Ethnopharmacol 95:335-43. 2004
    ..These results suggest that one of the mechanisms of the protective effects of CSE and USE against transient brain ischemia-induced neuronal damage may be their enhancing effect on CAT activity in the brain...
  80. doi request reprint Gravinol ameliorates high-fructose-induced metabolic syndrome through regulation of lipid metabolism and proinflammatory state in rats
    Takako Yokozawa
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Agric Food Chem 56:5026-32. 2008
    ....
  81. ncbi request reprint Interventions in aging and age-associated pathologies by means of nutritional approaches
    Kenichi Kitani
    National Institute for Longevity Sciences, 36 3 Gengo, Morioka cho, Obu shi, Aichi 474 8522, Japan
    Ann N Y Acad Sci 1019:424-6. 2004
    ..As a challenge against this dogma, we attempted to examine the effect of two potent antioxidants, one tetrahydrocurcumin (a biotransformed metabolite of curcumin contained in turmeric of Indian curry) and the other green tea polyphenols...
  82. ncbi request reprint Preparation, characterization, and antioxidative effects of oligomeric proanthocyanidin-L-cysteine complexes
    Hajime Fujii
    Amino Up Chemical Company Ltd, High Tech Hill Shin ei, 363 32 Kiyota, Sapporo 004 0839, Japan
    J Agric Food Chem 55:1525-31. 2007
    ..In addition, it is suggested that the oligomeric complexes may help to prevent oxidative stress and may reduce free radical production...
  83. ncbi request reprint The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice
    Kenichi Kitani
    National Institute for Longevity Sciences, 36 3, Gengo, Moriokacho, Obu shi, Aichi 474 8522, Japan
    Biogerontology 8:567-73. 2007
    ....
  84. ncbi request reprint Protective effects of broccoli (Brassica oleracea) against oxidative damage in vitro and in vivo
    Eun Ju Cho
    Department of Food Science and Nutrition, and Research Institute of Ecology for the Elderly, Pusan National University, 30 Jangjeon dong, Geumjeong Gu, Busan 609 735, Korea
    J Nutr Sci Vitaminol (Tokyo) 52:437-44. 2006
    ..The present study demonstrates that the BuOH fraction has an antioxidative effect in vitro and it protects against oxidative stress induced by diabetes in an in vivo model...
  85. ncbi request reprint Antioxidant effect of Wen-Pi-Tang and its component crude drugs on oxidative stress
    Dong Young Rhyu
    Department of Medicinal Plant Resources, Mokpo National University, 61 Dorim Ri, Chonggye Myon, Muan gun, Jeonnam, Korea
    Am J Chin Med 35:127-37. 2007
    ..Thus, the present data suggest that Wen-Pi-Tang and its component crude drugs effectively prevent biological toxicity on oxidative stress through potent antioxidant and anti-lipid peroxidation activities...
  86. ncbi request reprint Hypolipidemic effects of Sophora flavescens and its constituents in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats
    Hyun Young Kim
    College of Pharmacy, Seoul National University, Shillim Dong, Kwanak gu, Seoul 151 742, Korea
    Biol Pharm Bull 31:73-8. 2008
    ..These results suggest that S. flavescens and its constituents may be effective cholesterol-lowering agents and useful for preventing hypercholesterolemic atherosclerosis...
  87. ncbi request reprint Effects of energy restriction and fish oil supplementation on renal guanidino levels and antioxidant defences in aged lupus-prone B/W mice
    You Jung Kim
    Department of Cosmetology, Pusan Women s College, Pusanjin gu, Pusan, Korea
    Br J Nutr 93:835-44. 2005
    ..In conclusion, our data strongly indicate that ER and FO maintain antioxidant status and GSH:GSSG ratio, thereby protecting against renal deterioration from oxidative insults during ageing...
  88. ncbi request reprint Suppression of oxidative stress in aging NZB/NZW mice: effect of fish oil feeding on hepatic antioxidant status and guanidino compounds
    You Jung Kim
    Pusan Women s College, Department of Cosmetology, Pusanjin gu, Pusan, South Korea
    Free Radic Res 39:1101-10. 2005
    ..Based on these results, we propose that dietary FO exerts beneficial effects in aged, nephritic mice by suppressing RS, superoxide and lipid peroxidation, and by maintaining a higher GSH/GSSG ratio and antioxidant enzyme activities...
  89. ncbi request reprint Protective effect of grape seed polyphenols against high glucose-induced oxidative stress
    Hajime Fujii
    Institute of Natural Medicine, University of Toyama
    Biosci Biotechnol Biochem 70:2104-11. 2006
    ....
  90. ncbi request reprint Peroxynitrite scavenging activity of lithospermate B from Salvia miltiorrhiza
    Do You Soung
    Department of Pharmacy, Pusan National University, Busan, Korea
    J Pharm Pharmacol 55:1427-32. 2003
    ..This study demonstrated that lithospermate B with hydroxyl groups and double bonds exerts an anti-nitration effect by scavenging ONOO-...
  91. ncbi request reprint The anti-melanogenic effect of pycnogenol by its anti-oxidative actions
    You Jung Kim
    Department of Dental Hygiene, Busan Women s College, Busanjin Gu, Busan 617 734, South Korea
    Food Chem Toxicol 46:2466-71. 2008
    ..O2, and NO., while up-regulating the reduced glutathione/oxidized glutathione ratio in B16 cells. Based on the findings, we propose that pycnogenol exerts anti-melanogenic activity via its anti-oxidative actions...
  92. doi request reprint Antioxidant potential of dimethyl lithospermate isolated from Salvia miltiorrhiza (red sage) against peroxynitrite
    Ji Young Kim
    College of Pharmacy, Aging Tissue Bank, Pusan National University, Busan, Republic of Korea
    J Med Food 11:21-8. 2008
    ..DML also manifested cytoprotection from cell damage induced by ONOO(-). The present study suggests that DML is an effective ONOO(-) scavenger and promotes cellular defense activity in the protection against ONOO(-)-involved diseases...
  93. ncbi request reprint Protective effects of broccoli (Brassica oleracea) and its active components against radical-induced oxidative damage
    Xiang Lan Piao
    College of Pharmacy, Seoul National University, Seoul 1 51 742, Korea
    J Nutr Sci Vitaminol (Tokyo) 51:142-7. 2005
    ....