Shumpei Yokota

Summary

Affiliation: Yokohama City University
Country: Japan

Publications

  1. ncbi request reprint Hypothetical pathophysiology of acute encephalopathy and encephalitis related to influenza virus infection and hypothermia therapy
    S Yokota
    Department of Pediatrics, Yokohama City University School of Medicine, Kanagawa, Japan
    Pediatr Int 42:197-203. 2000
  2. doi request reprint Juvenile fibromyalgia: Guidance for management
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Japan
    Pediatr Int 55:403-9. 2013
  3. doi request reprint Guidance on the use of canakinumab in patients with cryopyrin-associated periodic syndrome in Japan
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University School of Medicine, 3 9, Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Mod Rheumatol 23:425-9. 2013
  4. doi request reprint Guidance on the use of adalimumab for juvenile idiopathic arthritis in Japan
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa, 236 0004, Japan
    Mod Rheumatol 22:491-7. 2012
  5. pmc Efficacy of thalidomide in a girl with inflammatory calcinosis, a severe complication of juvenile dermatomyositis
    Takako Miyamae
    Department of Pediatrics, Yokohama City University, 3 9 Fukuura, Kanazawaku, Yokohama 236 0004, Japan
    Pediatr Rheumatol Online J 8:6. 2010
  6. pmc Effect of anakinra on arthropathy in CINCA/NOMID syndrome
    Takako Miyamae
    Department of Pediatrics, Yokohama City University, Yokohama, Japan
    Pediatr Rheumatol Online J 8:9. 2010
  7. pmc A molecular epidemiological study of respiratory viruses detected in Japanese children with acute wheezing illness
    Asako Fujitsuka
    Department of Pediatrics, National Hospital Organization Yokohama Medical Center, 3 60 2 Harajuku, Totsuka ku, Yokohama, Kanagawa 245 8575, Japan
    BMC Infect Dis 11:168. 2011
  8. pmc Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy
    Takako Miyamae
    Division of Rheumatology, Children s Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arthritis Res Ther 7:R746-55. 2005
  9. doi request reprint Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial
    Shumpei Yokota
    Department of Paediatrics, Yokohama City University School of Medicine, Yokohama, Japan
    Lancet 371:998-1006. 2008
  10. doi request reprint Guidance on using tocilizumab for juvenile idiopathic arthritis
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Mod Rheumatol 21:563-71. 2011

Detail Information

Publications128 found, 100 shown here

  1. ncbi request reprint Hypothetical pathophysiology of acute encephalopathy and encephalitis related to influenza virus infection and hypothermia therapy
    S Yokota
    Department of Pediatrics, Yokohama City University School of Medicine, Kanagawa, Japan
    Pediatr Int 42:197-203. 2000
    ..To establish a treatment strategy for acute encephalopathy and encephalitis associated with influenza virus infection, the pathophysiology of the disease was investigated through manifestations and laboratory findings of patients...
  2. doi request reprint Juvenile fibromyalgia: Guidance for management
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Japan
    Pediatr Int 55:403-9. 2013
    ..This guideline describes how to diagnose JFM in children and how to treat them appropriately. ..
  3. doi request reprint Guidance on the use of canakinumab in patients with cryopyrin-associated periodic syndrome in Japan
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University School of Medicine, 3 9, Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Mod Rheumatol 23:425-9. 2013
    ..This guidance describes the use of canakinumab in Japan for CAPS in relation to exclusion criteria, method of use, evaluation criteria, and adverse drug reactions...
  4. doi request reprint Guidance on the use of adalimumab for juvenile idiopathic arthritis in Japan
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa, 236 0004, Japan
    Mod Rheumatol 22:491-7. 2012
    ..The guidance presented here define the indications, exclusion criteria, usage, and evaluation criteria of adalimumab for the treatment of polyarticular JIA...
  5. pmc Efficacy of thalidomide in a girl with inflammatory calcinosis, a severe complication of juvenile dermatomyositis
    Takako Miyamae
    Department of Pediatrics, Yokohama City University, 3 9 Fukuura, Kanazawaku, Yokohama 236 0004, Japan
    Pediatr Rheumatol Online J 8:6. 2010
    ..08 mg/dL. Recent examination by whole-body 18F-FDG-PET-CT over the 15 months of thalidomide treatment demonstrated fewer hot spots around the subcutaneous calcified lesions...
  6. pmc Effect of anakinra on arthropathy in CINCA/NOMID syndrome
    Takako Miyamae
    Department of Pediatrics, Yokohama City University, Yokohama, Japan
    Pediatr Rheumatol Online J 8:9. 2010
    ..Furthermore, longitudinal growth of the femur and tibia was identified during 20 months of observation...
  7. pmc A molecular epidemiological study of respiratory viruses detected in Japanese children with acute wheezing illness
    Asako Fujitsuka
    Department of Pediatrics, National Hospital Organization Yokohama Medical Center, 3 60 2 Harajuku, Totsuka ku, Yokohama, Kanagawa 245 8575, Japan
    BMC Infect Dis 11:168. 2011
    ..Recent studies strongly suggest that some respiratory viruses are associated with the induction of acute wheezing and/or exacerbation of bronchial asthma. However, molecular epidemiology of these viruses is not exactly known...
  8. pmc Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy
    Takako Miyamae
    Division of Rheumatology, Children s Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arthritis Res Ther 7:R746-55. 2005
    ....
  9. doi request reprint Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial
    Shumpei Yokota
    Department of Paediatrics, Yokohama City University School of Medicine, Yokohama, Japan
    Lancet 371:998-1006. 2008
    ..We investigated the efficacy and safety of tocilizumab, an anti-interleukin-6-receptor monoclonal antibody, in children with this disorder...
  10. doi request reprint Guidance on using tocilizumab for juvenile idiopathic arthritis
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Mod Rheumatol 21:563-71. 2011
    ....
  11. ncbi request reprint Interleukin 6 as a therapeutic target in systemic-onset juvenile idiopathic arthritis
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University School of Medicine, Kanagawa, Japan
    Curr Opin Rheumatol 15:581-6. 2003
    ....
  12. ncbi request reprint Clinical study of tocilizumab in children with systemic-onset juvenile idiopathic arthritis
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Clin Rev Allergy Immunol 28:231-8. 2005
    ..A confirmation of the role of tocilizumab in the treatment of sJIA will be provided by the results of the ongoing phase III study in Japan...
  13. ncbi request reprint Inflammatory cytokines and systemic-onset juvenile idiopathic arthritis
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University School of Medicines, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Mod Rheumatol 14:12-7. 2004
    ..MRA could be a therapeutic modality for children with systemic-onset JIA intractable to high-dose corticosteroids...
  14. ncbi request reprint Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis
    Shumpei Yokota
    Yokohama City University School of Medicine, Kanagawa, Japan
    Arthritis Rheum 52:818-25. 2005
    ....
  15. doi request reprint Tocilizumab: molecular intervention therapy in children with systemic juvenile idiopathic arthritis
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University School of Medicine, Kanazawa Ku, Yokohama, Kanagawa, Japan
    Expert Rev Clin Immunol 6:735-43. 2010
    ..Thus, tocilizumab is generally safe and well tolerated. It might be a suitable treatment in the control of this disorder, which has so far been difficult to manage...
  16. doi request reprint Guidelines on the use of etanercept for juvenile idiopathic arthritis in Japan
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa, 236 0004, Japan
    Mod Rheumatol 20:107-13. 2010
    ..The guidelines presented here define the indications, exclusion criteria, usage, and evaluation criteria of etanercept for the treatment of polyarticular JIA...
  17. ncbi request reprint Foreword--Mizoribine: a new immunosuppressive drug for kidney diseases and rheumatic diseases
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Pediatr Int 44:195. 2002
  18. ncbi request reprint Proposal for juvenile idiopathic arthritis guidance on diagnosis and treatment for primary care pediatricians and nonpediatric rheumatologists (2007)
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Mod Rheumatol 17:353-63. 2007
    ..Finally, we hope that this guidance will trigger exploration for further information by referring to the textbooks and literature listed at the end of these guidelines...
  19. ncbi request reprint Mizoribine: mode of action and effects in clinical use
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Pediatr Int 44:196-8. 2002
    ..Thus, mizoribine is superior to azathioprine, in that it may not cause damages to normal cells and normal nucleic acid...
  20. doi request reprint Safety and efficacy of long-term etanercept in the treatment of methotrexate-refractory polyarticular-course juvenile idiopathic arthritis in Japan
    Masaaki Mori
    Department of Pediatrics, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Mod Rheumatol 22:720-6. 2012
    ..The aim of this study was to evaluate the long-term safety and efficacy of etanercept in Japanese children with JIA...
  21. doi request reprint Association of IRF5 polymorphisms with susceptibility to hemophagocytic lymphohistiocytosis in children
    Masakatsu Yanagimachi
    Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Clin Immunol 31:946-51. 2011
    ..IRF5 acts as a master transcription factor in the activation of pro-inflammatory cytokines. We assessed associations of IRF5 gene polymorphisms with susceptibility to secondary HLH...
  22. doi request reprint Influence of CYP3A5 and ABCB1 gene polymorphisms on calcineurin inhibitor-related neurotoxicity after hematopoietic stem cell transplantation
    Masakatsu Yanagimachi
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Tokyo, Japan
    Clin Transplant 24:855-61. 2010
    ..CNIs are substrates for CYP3A5 and P-glycoprotein (P-gp), encoded by ABCB1 gene. In the present study, we hypothesized that genetic variability in CYP3A5 and ABCB1 genes may be associated with CNI-related neurotoxicity...
  23. doi request reprint Comparison of markers for fetal inflammatory response syndrome: fetal blood interleukin-6 and neonatal urinary beta(2)-microglobulin
    Shigeru Nishimaki
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    J Obstet Gynaecol Res 35:472-6. 2009
    ..The aim of the present study was to compare the value of measuring neonatal urinary beta(2)-microglobulin (beta(2)-MG) levels with fetal blood interleukin (IL)-6 levels in premature infants at risk of developing CLD...
  24. ncbi request reprint [Effects of therapies on childhood systemic lupus erythematosus]
    Rumiko Kurosawa
    Department of Pediatrics, Yokohama City University School of Medicine
    Ryumachi 43:632-7. 2003
    ..In conclusion, the combination of immunosuppressants and IVCY appeared to offer great benefits in childhood systemic lupus erythematosus...
  25. ncbi request reprint [Three cases of childhood-onset male systemic lupus erythematosus (SLE) successfully treated with a combination of pulse methylprednisolone and pulse cyclophosphamide]
    Shoko Nakajima
    Department of Pediatrics, Yokohama City University School of Medicine
    Nihon Rinsho Meneki Gakkai Kaishi 28:343-8. 2005
    ..We suggest a combination of pulse mPSL and IVCY is effective for the patients who are suffering with severe lupus nephritis complicated with the other collagen diseases...
  26. pmc Analysis of gender differences in genetic risk: association of TNFAIP3 polymorphism with male childhood-onset systemic lupus erythematosus in the Japanese population
    Keisuke Kadota
    Department of Pediatrics, Yokohama City University School of Medicine, Kanazawa Ku, Yokohama, Kanagawa, Japan
    PLoS ONE 8:e72551. 2013
    ..In particular, we focused on gender differences in allelic frequencies...
  27. doi request reprint Clinical analysis of 50 children with juvenile dermatomyositis
    Takayuki Kishi
    Department of Pediatrics, Tokyo Women s Medical University, School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Mod Rheumatol 23:311-7. 2013
    ..We performed a retrospective review of medical records to assess the clinical characteristics of 50 Japanese children with juvenile dermatomyositis (JDM)...
  28. doi request reprint Safety and efficacy of tocilizumab, an anti-IL-6-receptor monoclonal antibody, in patients with polyarticular-course juvenile idiopathic arthritis
    Tomoyuki Imagawa
    Department of Pediatrics, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    Mod Rheumatol 22:109-15. 2012
    ..In conclusion, tocilizumab showed early and sustained efficacy and tolerability for treating intractable pJIA, which suggests that it is a promising new treatment for this disease...
  29. ncbi request reprint [Clinical features and laboratory findings in children with both anti-dsDNA and anti-U1-RNP antibody]
    Takako Miyamae
    Department of Pediatrics, Yokohama City University
    Nihon Rinsho Meneki Gakkai Kaishi 31:405-14. 2008
    ....
  30. doi request reprint Suppressed neutrophil function in children with acute lymphoblastic leukemia
    Fumiko Tanaka
    Department of Pediatrics, Yokohama City University Hospital, 3 9 Fukuura Kanazawa ku, Yokohama, Japan
    Int J Hematol 90:311-7. 2009
    ..Impaired oxidative burst of neutrophils may be one risk factor for infections in children with ALL, especially in the initial periods of treatment...
  31. ncbi request reprint Interleukin-6 inhibits early differentiation of ATDC5 chondrogenic progenitor cells
    Shoko Nakajima
    Department of Pediatrics, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    Cytokine 47:91-7. 2009
    ....
  32. doi request reprint Mizoribine for renal sarcoidosis: effective steroid tapering and prevention of recurrence
    Shuichi Ito
    Children s Medical Center, Yokohama City University Medical Center, 4 57, Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    Pediatr Nephrol 24:411-4. 2009
    ..Our treatment of this patient shows that treatment with MZR can allow steroid sparing and prevent recurrence in a patient with sarcoidosis...
  33. pmc Methotrexate for the treatment of juvenile idiopathic arthritis: process to approval for JIA indication in Japan
    Masaaki Mori
    Department of Pediatrics, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa, 236 0004, Japan
    Mod Rheumatol 19:1-11. 2009
    ..It also merits attention that the maximum dose (10 mg/m2) was set on the basis of pharmacokinetic data from children, rather than relying on the dosing method and dose for adults...
  34. doi request reprint Radiologic analysis of the effect of tocilizumab on hands and large joints in children with systemic juvenile idiopathic arthritis
    Yutaka Inaba
    Department of Orthopaedic Surgery, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Mod Rheumatol 23:667-73. 2013
    ....
  35. ncbi request reprint Interleukin-6, interleukin-8, and soluble tumor necrosis factor receptor-I in the cord blood as predictors of chronic lung disease in premature infants
    Hiromi An
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Japan
    Am J Obstet Gynecol 191:1649-54. 2004
    ..In order to predict the late-development of chronic lung disease of prematurity (CLD), cytokines in the cord blood were assessed in this study...
  36. doi request reprint Improvement of reduced serum cartilage oligomeric matrix protein levels in systemic juvenile idiopathic arthritis patients treated with the anti-interleukin-6 receptor monoclonal antibody tocilizumab
    Shoko Nakajima
    Department of Pediatrics, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa, 236 0004, Japan
    Mod Rheumatol 19:42-6. 2009
    ....
  37. doi request reprint Association of HLA-A*02:06 and HLA-DRB1*04:05 with clinical subtypes of juvenile idiopathic arthritis
    Masakatsu Yanagimachi
    Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Hum Genet 56:196-9. 2011
    ..We also found an association between HLA-DRB1(*)04:05 and polyarticular JIA. Thus, clinical subtypes of JIA can be classified by the presence of the specific HLA alleles, HLA-A(*)02:06 and DRB1(*)04:05...
  38. pmc Influence of polymorphisms within the methotrexate pathway genes on the toxicity and efficacy of methotrexate in patients with juvenile idiopathic arthritis
    Masakatsu Yanagimachi
    Department of Pediatrics, Yokohama City University Graduate School of Medicine, Kanazawa Ku, Yokohama 236 0004, Japan
    Br J Clin Pharmacol 71:237-43. 2011
    ..We investigated whether several polymorphisms within the methotrexate (MTX) pathway genes were related to the toxicity and efficacy of MTX in 92 Japanese patients with articular-type juvenile idiopathic arthritis (JIA)...
  39. ncbi request reprint Risk factors for poor outcome in congenital cytomegalovirus infection and neonatal herpes on the basis of a nationwide survey in Japan
    Yoshinori Ito
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Int 55:566-71. 2013
    ..Congenital cytomegalovirus (CMV) infection and neonatal herpes are major mother-to-child infections, and analyses of the important clinical issues, including risk factors for prognosis, are essential...
  40. ncbi request reprint Interleukin-15 inhibits smooth muscle cell proliferation and hyaluronan production in rat ductus arteriosus
    Shiho Iwasaki
    Department of Pediatrics, Yokohama City University, Yokohama 236 0004, Japan
    Pediatr Res 62:392-8. 2007
    ..Accordingly, IL-15 might have an inhibitory effect on the physiologic vascular remodeling processes in closing the DA...
  41. ncbi request reprint Safety and efficacy of canakinumab in Japanese patients with phenotypes of cryopyrin-associated periodic syndrome as established in the first open-label, phase-3 pivotal study (24-week results)
    Tomoyuki Imagawa
    Department of Paediatrics, Yokohama City University, Yokohama, Japan
    Clin Exp Rheumatol 31:302-9. 2013
    ..This is the first study to evaluate the safety and efficacy of canakinumab in Japanese patients with CAPS...
  42. ncbi request reprint [A case of systemic scleroderma complicating pulmonary hypertension]
    Rumiko Kurosawa
    Department of Pediatrics, Yokohama City University School of Medicine
    Nihon Rinsho Meneki Gakkai Kaishi 29:378-83. 2006
    ..The dermal symptoms improved, and it was possible to maintain a state of remission...
  43. ncbi request reprint Chemo-sensitivity in a panel of B-cell precursor acute lymphoblastic leukemia cell lines, YCUB series, derived from children
    Hiroaki Goto
    Department of Pediatrics, Yokohama City University Hospital, 3 9 Fukuura Kanazawa ku, Yokohama 236 0044, Japan
    Leuk Res 33:1386-91. 2009
    ..22-1.8 microg/ml and 0.57-3.6 ng/ml, respectively. This cell line panel offers an in vitro model for the development of new therapies for childhood BCP-ALL...
  44. ncbi request reprint [Cutaneous non-tuberculous mycobacterial infection following cord blood stem cell transplantation]
    Masakatsu Yanagimachi
    Department of Pediatrics, Yokohama City University School of Medicine
    Rinsho Ketsueki 49:99-103. 2008
    ..The cutaneous lesions gradually improved after continuous administration of CAM. Cutaneous NTM infection is rare, but it may occur in immunocompromised patients after SCT...
  45. ncbi request reprint Soluble tumor necrosis factor receptor-1 in preterm infants with chronic lung disease
    Miho Sato
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Pediatr Int 52:268-72. 2010
    ..The purpose of the present study is to investigate changes of serum soluble tumor necrosis factor receptor-1 levels over time in infants with chronic lung disease...
  46. ncbi request reprint [Cyclophosphamide pulse therapy for pediatric systemic sclerosis]
    Naomi Iwata
    Department of Pediatrics and Dermatology, Yokohama City University School of Medicine, Yokohama, Japan
    Ryumachi 43:660-6. 2003
    ..We further observed that their total skin score was decreasing while the clinical manifestations improved...
  47. ncbi request reprint [A case of autoimmune hepatitis needed to be differentiated from EBV hepatitis, in that the histology of liver biopsy specimen was useful for diagnosis]
    Shoko Nakajima
    Department of Pediatrics, Yokohama City University of Medicine, Yokohama, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 28:154-8. 2005
    ..The histology of liver biopsy specimen was useful for the diagnosis of AIH in such a difficult case needed to be differentiated from EBV hepatitis...
  48. doi request reprint Association of IRF5 polymorphisms with susceptibility to macrophage activation syndrome in patients with juvenile idiopathic arthritis
    Masakatsu Yanagimachi
    Department of Pediatrics, Yokohama City University Graduate School of Medicine and the CNV Laboratory, DNA Chip Research Institute, Yokohama, Japan
    J Rheumatol 38:769-74. 2011
    ..Our aim was to assess associations of IRF5 gene polymorphisms with susceptibility to systemic JIA and MAS...
  49. doi request reprint Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis
    Hiroyuki Machida
    Department of Pediatrics, Yokohama City University, Japan
    Nephrol Dial Transplant 25:2530-537. 2010
    ..We conducted a study to elucidate the association between TLR9 and LN in childhood-onset SLE...
  50. ncbi request reprint Longterm safety and effectiveness of the anti-interleukin 6 receptor monoclonal antibody tocilizumab in patients with systemic juvenile idiopathic arthritis in Japan
    Shumpei Yokota
    From the Department of Pediatrics, Yokohama City University School of Medicine, and Department of Pediatrics, Yokohama City University Medical Center Yokohama School of Health Science, Faculty of Medicine, Kagoshima University, Kagoshima Aichi Children s Health and Medical Center, Aichi Miyagi Children s Hospital, Miyagi Department of Pediatrics, Osaka Medical College, Osaka Kobe Children s Hospital, Kobe Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba Department of Molecular Regulation for Intractable Diseases, Institute of Medical Science, Tokyo Medical University, Osaka Immunology Frontier Research Center, Osaka University, Osaka, Japan
    J Rheumatol 41:759-67. 2014
    ..To assess the longterm safety and effectiveness of tocilizumab (TCZ) in systemic-onset juvenile idiopathic arthritis (sJIA)...
  51. doi request reprint Methylated chrysin reduced cell proliferation, but antagonized cytotoxicity of other anticancer drugs in acute lymphoblastic leukemia
    Hiroaki Goto
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Japan
    Anticancer Drugs 23:417-25. 2012
    ..However, combination therapy with DMF and other anticancer drugs is not recommended...
  52. doi request reprint Urinary ß2-microglobulin in very preterm neonates with chorioamnionitis
    Shigeru Nishimaki
    Department of Pediatrics, Yokohama City University School of Medicine, 3 9, Fukuura, Kanazawa Ku, Yokohama, Kanagawa, 236 0004, Japan
    Pediatr Nephrol 26:2185-91. 2011
    ..It is suggested that the urinary β(2)-MG level during the early postnatal period can identify prenatal inflammation...
  53. doi request reprint Whole blood interferon-gamma assay for tuberculosis in children in Japan
    Rumiko Higuchi
    Department of Pediatrics, Yokohama City University, Yokohama, Kanagawa, Japan
    Pediatr Int 51:97-102. 2009
    ..The aim of the present study was to assess the usefulness of QFT-2G as an indicator, both for diagnosing childhood TB and for assessing therapeutic effectiveness...
  54. ncbi request reprint Graft versus leukemia effect against juvenile myelomonocytic leukemia after unrelated cord blood transplantation
    Reo Tanoshima
    Department of Pediatrics, Yokohama City University, Yokohama, Kanagawa, Japan
    Pediatr Blood Cancer 50:665-7. 2008
    ..She has been in complete remission for 1 year after transplantation. This case illustrates that CBT can provide a potent graft versus leukemia (GVL) effect against JMML...
  55. ncbi request reprint [Juvenile rheumatoid arthritis]
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University School of Medicine
    Nihon Rinsho 63:274-80. 2005
  56. ncbi request reprint [Gastrointestinal involvement and renal infarction in a boy with classic polyarteritis nodosa diagnosed with 3D-computed tomography angiography]
    Fumie Sano
    Department of Pediatrics, Yokohama City University
    Nihon Rinsho Meneki Gakkai Kaishi 31:415-21. 2008
    ....
  57. doi request reprint Acute pancreatitis associated with systemic lupus erythematosus: Successful treatment with plasmapheresis followed by aggressive immunosuppressive therapy
    Norio Tominaga
    Department of Pediatrics, Nagasaki University School of Medicine, Nagasaki, Japan
    Pediatr Int 50:109-11. 2008
  58. doi request reprint Influence of pre-hydration and pharmacogenetics on plasma methotrexate concentration and renal dysfunction following high-dose methotrexate therapy
    Masakatsu Yanagimachi
    Department of Pediatrics, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Int J Hematol 98:702-7. 2013
    ..We found the influence of MTHFR C677T polymorphism on prolonged high MTX concentration. We reconfirmed the importance of adequate pre-hydration before HD-MTX to prevent prolonged high MTX concentration and MTX-related renal dysfunction. ..
  59. pmc T-type Ca2+ channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation
    Toru Akaike
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Biol Chem 284:24025-34. 2009
    ....
  60. pmc Efficacy, pharmacokinetics, and safety of adalimumab in pediatric patients with juvenile idiopathic arthritis in Japan
    Tomoyuki Imagawa
    Yokohama City University, Japan
    Clin Rheumatol 31:1713-21. 2012
    ..In pediatric patients with polyarticular JIA in Japan, adalimumab was safe and effective for reducing disease activity for up to 60 weeks...
  61. doi request reprint Efficacy and limitation of infliximab treatment for children with Kawasaki disease intractable to intravenous immunoglobulin therapy: report of an open-label case series
    Masaaki Mori
    Department of Pediatrics, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    J Rheumatol 39:864-7. 2012
    ..Plasma exchange (PE) was available as a rescue therapy for patients refractory to infliximab...
  62. doi request reprint Definitive differences in laboratory and radiological characteristics between two subtypes of juvenile idiopathic arthritis: systemic arthritis and polyarthritis
    Remi Ozawa
    Department of Pediatrics, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Mod Rheumatol 22:558-64. 2012
    ....
  63. doi request reprint Acquisition of expanded indications for intravenous cyclophosphamide in the management of childhood rheumatic disease in general
    Masaaki Mori
    Department of Pediatrics, Yokohama City University Medical Center, 4 57, Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    Mod Rheumatol 21:449-57. 2011
    ..Consequently, IVCY is now available for the treatment of both childhood and adult rheumatic diseases in general...
  64. ncbi request reprint [Infliximab therapy for three adolescent patients with refractory Takayasu's arteritis]
    Utako Kaneko
    Department of Pediatrics, Yokohama City University School of Medicines, Yokohama, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 33:317-23. 2010
    ..Infliximab would be a good choice for adolescent patients with TA refractory to conventional treatments. However, we should carefully monitor safety and efficacy of this agent considering its peculiarity...
  65. ncbi request reprint [Two female siblings with childhood-onset systemic lupus erythematosus]
    Fumie Sano
    Department of Pediatrics, Yokohama City University School of Medicine, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 31:172-7. 2008
    ..HLA typing was performed and the siblings were noted to have the same haplotype; A(*)0207, A(*)2402, B(*)4601, B(*)5201, B(*)5201, Cw(*)0102, Cw(*)1202, DRB1(*)0101, DRB1(*)0803...
  66. doi request reprint The role of heme oxygenase-1 in systemic-onset juvenile idiopathic arthritis
    Akitaka Takahashi
    Department of Pediatrics, Yokohama City University School of Medicine, Kanazawa Ku, Yokohama, Kanagawa, Japan
    Mod Rheumatol 19:302-8. 2009
    ..Further study will be necessary to elucidate the mechanism of HO-1 production and to clarify the role of HO-1 in the disease process...
  67. ncbi request reprint Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection
    Motohiko Okano
    Department of Pediatrics, Hokkaido University Hospital, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Hematol 80:64-9. 2005
    ..Guidelines, derived mainly from the current literature and recent experiences with CAEBV in Japan, for diagnosing CAEBV are proposed to clarify this enigmatic disease...
  68. ncbi request reprint Dynamic movement of cytochrome c from mitochondria into cytosol and peripheral circulation in massive hepatic cell injury
    Yoshinori Kobayashi
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Japan
    Pediatr Int 46:685-92. 2004
    ..But in the state of hypercytokine induced by D-galactosamine (D-GaIN)/Lipopolysaccharide (LPS), the localization of cytochrome c is little known...
  69. ncbi request reprint [Reduced-intensity stem cell transplantation using allogeneic peripheral blood stem cells from the same donor for relapsed leukemia after bone marrow transplantation]
    Fumiko Kuroki
    Department of Pediatrics, Yokohama City University School of Medicine
    Rinsho Ketsueki 47:639-44. 2006
    ..In both these cases, the results suggest that using PBSC as a stem cell source and abrupt cessation of GVHD prophylaxis provided a potent graft-versus-leukemia effect...
  70. ncbi request reprint [Biologic response modifiers for juvenile idiopathic arthritis]
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University School of Medicine
    Nihon Rinsho 65:1331-5. 2007
    ..Recently, IL-1Ra was reported to be effective for these children. Moreover, tocilizumab, anti-IL-6 receptor monoclonal antiboby developed in Japan, was revealed to be effective and safe...
  71. ncbi request reprint Maternal vitamin A alters gene profiles and structural maturation of the rat ductus arteriosus
    Utako Yokoyama
    Department of Physiology, Yokohama City University, Yokohama, Japan
    Physiol Genomics 31:139-57. 2007
    ..The present study indicates that MVA-mediated alteration in gene profile was associated with early structural maturation of DA, although MVA-mediated maturation may differ from normal vascular remodeling of DA...
  72. ncbi request reprint [A case report of childhood systemic lupus erythematosus complicated with lupus cystitis]
    Rumiko Kurosawa
    Department of Pediatrics, Yokohama City University School of Medicine
    Nihon Rinsho Meneki Gakkai Kaishi 29:154-9. 2006
    ..We reported a case of childhood SLE complicated with lupus cystitis and successfully treated by IVCY-pulse therapy and maintenance predonisolone and azathioprin...
  73. ncbi request reprint Plasma exchange for refractory Kawasaki disease
    Tomoyuki Imagawa
    Department of Paediatrics, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, 236 0004 Yokohama, Japan
    Eur J Pediatr 163:263-4. 2004
  74. doi request reprint Hyper-IgD syndrome with novel mutation in a Japanese girl
    Takuya Naruto
    Department of Pediatrics, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa, 236 0004, Japan
    Mod Rheumatol 19:96-9. 2009
    ..This is the first case in which homozygosity for the mutation of the MVK gene has been reported in an Asian patient, and indicated a need for differentiation...
  75. ncbi request reprint Efficacy of plasma exchange therapy for Kawasaki disease intractable to intravenous gamma-globulin
    Masaaki Mori
    Department of Pediatrics, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Mod Rheumatol 14:43-7. 2004
    ..PE should be performed at an early stage, as soon as fractional increases in inflammatory markers are found after IVGG therapy...
  76. doi request reprint Survey of psychological support for bereaved families in Japan
    Shigeru Nishimaki
    Department of Pediatrics, Yokohama City University, School of Medicine, Kanagawa, Japan
    Pediatr Int 51:626-9. 2009
    ..The aim of the present study was to investigate the current conditions of psychological support for the families of children who died suddenly of disease or accident...
  77. ncbi request reprint HLA-DRB1*15021 is the predominant allele in Japanese patients with juvenile dermatomyositis
    Noriaki Tomono
    Division of Immunology and Rheumatology, Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Japan
    J Rheumatol 31:1847-50. 2004
    ..To investigate HLA molecules and genes in Japanese patients with juvenile dermatomyositis (JDM)...
  78. ncbi request reprint A CpG-containing oligodeoxynucleotide as an efficient adjuvant counterbalancing the Th1/Th2 immune response in diphtheria-tetanus-pertussis vaccine
    Toshiyuki Sugai
    Department of Pediatrics, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    Vaccine 23:5450-6. 2005
    ..These data suggested new applications of CpG-ODN as adjuvants in DPT vaccine...
  79. ncbi request reprint Lack of mitochondrial depolarization by oxidative stress is associated with resistance to buthionine sulfoximine in acute lymphoblastic leukemia cells
    Hiroaki Goto
    Department of Pediatrics, Yokohama City University Hospital, 3 9 Fukuura Kanazawa ku, Yokohama 236 0044, Japan
    Leuk Res 31:1293-301. 2007
    ..BSO up-regulated Bcl-2 protein, and antagonized the anti-ALL effect of prednisolone in BSO-resistant cells. A lack of mitochondrial death-signal activation by oxidative stress seemed to be associated with BSO-resistance in ALL...
  80. doi request reprint Cross-cultural adaptation and validation of the Japanese version of the Childhood Health Assessment Questionnaire (CHAQ)
    Takako Miyamae
    Department of Pediatrics, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawaku, Yokohama 236 0004, Japan
    Mod Rheumatol 18:336-43. 2008
    ..Functional ability, as assessed by the CHAQ, may not be the main consideration of sJIA patients' parents when assessing their child's status...
  81. doi request reprint A report of two cases of Kawasaki disease treated with plasma exchange
    Tomonori Harada
    Children s Medical Center, Yokohama City University Medical Center, Yokohama, Japan
    Ther Apher Dial 12:176-9. 2008
    ..In both cases, plasma exchange may have reduced the risk of coronary artery lesions and proved effective against acute heart failure with catecholamine-refractory shock; yet the mechanism of this improvement remains unclear...
  82. ncbi request reprint [Sjögren's syndrome associated with childhood-onset systemic lupus erythematosus]
    Naomi Iwata
    Department of Pediatrics, Yokohama City University, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 31:166-71. 2008
    ..The revised criteria is useful for diagnosis of SS in early stage before the development of exocrine gland damage and appears to be helpful for long term follow-up in childhood-onset SLE associated with SS...
  83. ncbi request reprint Long-term follow-up of busulfan, etoposide, and nimustine hydrochloride (ACNU) or melphalan as conditioning regimens for childhood acute leukemia and lymphoma
    Sakurako Izaki
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Japan
    Int J Hematol 86:253-60. 2007
    ..The effectiveness of the BVL regimen requires further study...
  84. doi request reprint Early discharge from a neonatal intensive care unit and rates of readmission
    Kazuo Seki
    Perinatal Center for Maternity and Neonate, Yokohama City University Medical Center, Yokohama, Japan
    Pediatr Int 53:7-12. 2011
    ..We studied the real state of this strategy...
  85. ncbi request reprint Toxic epidermal necrolysis in a child successfully treated with cyclosporin A and methylprednisolone
    Yukoh Aihara
    Department of Pediatrics, Yokohama City University Medical Center, Yokohama, Japan
    Pediatr Int 49:659-62. 2007
  86. ncbi request reprint Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus
    Yukoh Aihara
    Department of Pediatrics, Yokohama City University Medical Center, Yokohama, Japan
    Pediatr Int 44:199-204. 2002
    ..Therefore, we have been attempting to improve the maintenance therapy of child-onset SLE...
  87. ncbi request reprint Successful bone marrow transplantation for severe aplastic anemia in a patient with persistent human parvovirus B19 infection
    Hiroaki Goto
    Department of Pediatrics, Yokohama City University School of Medicine, Japan
    Int J Hematol 79:384-6. 2004
    ..B19 DNA disappeared from the serum 2 months after BMT, suggesting that a normal immune response was restored by BMT and terminated the B19 viremia. During BMT, use of high-titer IVIg for B19 might prevent B19-associated organ failure...
  88. ncbi request reprint Urinary beta 2-microglobulin in premature infants with chorioamnionitis and chronic lung disease
    Shigeru Nishimaki
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    J Pediatr 143:120-2. 2003
    ..We propose that an elevated urinary beta(2)-MG can indicate a fetal inflammatory response and identify neonates at risk for the development of CLD...
  89. ncbi request reprint N-(4-Hydroxyphenyl)retinamide (4-HPR) induces leukemia cell death via generation of reactive oxygen species
    Hiroaki Goto
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Japan
    Int J Hematol 78:219-25. 2003
    ..Our findings suggest that ROS play a significant role in the antileukemia effect of 4-HPR and that the glutathione level in leukemias may be associated the sensitivity of the cells to 4-HPR...
  90. doi request reprint PET assessment of disease activity in children with juvenile idiopathic arthritis
    Ukihide Tateishi
    Department of Radiology, Yokohama City University Graduate School of Medicine, 3 9, Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Pediatr Radiol 40:1781-8. 2010
    ..The clinical validity of (18)F-FDG positron emission tomography (PET) has not been evaluated in juvenile idiopathic arthritis (JIA)...
  91. ncbi request reprint Hemimegalencephaly misdiagnosed as a congenital brain tumor by fetal cerebral ultrasonography
    Shigeru Nishimaki
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Prenat Diagn 24:257-9. 2004
    ..To describe a case of hemimegalencephaly misdiagnosed prenatally...
  92. doi request reprint Nationwide survey of severe respiratory syncytial virus infection in children who do not meet indications for palivizumab in Japan
    Masaaki Mori
    Department of Pediatrics, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    J Infect Chemother 17:254-63. 2011
    ....
  93. ncbi request reprint Kawasaki disease after burns
    Shuichi Ito
    Department of Pediatrics, Yokohama City University Medical Center, 4 57, Urafune cho, Minami Ku, Yokohama, Japan
    Eur J Pediatr 165:340-1. 2006
  94. ncbi request reprint Different patterns of cytokines, ECP and immunoglobulin profiles at two adverse drug reactions in a patient
    Yukoh Aihara
    Department of Pediatrics, Yokohama City University Medical Center, Yokohama, Japan
    Pediatr Int 47:616-21. 2005
    ..We experienced carbamazepine-induced HS in a 14-year-old boy, who had cefaclor-induced cutaneous eruptions 15 months later. To clarify the mechanisms of HS and the differences between two diseases we studied this case in detail...
  95. ncbi request reprint Amelioration of steroids and cyclosporine-resistant nephrotic syndrome by pravastatin
    Shuichi Ito
    Children s Medical Center, Yokohama City University Medical Center, Yokohama 232 0024, Japan
    Pediatr Nephrol 22:603-6. 2007
    ..Furthermore, the anti-inflammatory and immuno-modulatory effects, recently attributed to statins, may also have been involved in the improvement experienced by our patient...
  96. ncbi request reprint Intravenous gamma globulin for thrombotic microangiopathy of unknown etiology
    Shuichi Ito
    Children s Medical Center, Yokohama City University Medical Center, 4 57, Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    Pediatr Nephrol 22:301-5. 2007
    ..He has not suffered a relapse of TMA or an allograft rejection for 4 years. IVIG might be an option for some patients with TMA of unknown etiology refractory to conventional treatment...
  97. ncbi request reprint Blood flow velocities in the anterior cerebral artery and basilar artery in asphyxiated infants
    Shigeru Nishimaki
    Department of Pediatrics, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    J Ultrasound Med 27:955-60. 2008
    ....
  98. ncbi request reprint Norovirus-associated encephalopathy
    Shuichi Ito
    Children s Medical Center, Yokohama City University Medical Center, Yokohama, Japan
    Pediatr Infect Dis J 25:651-2. 2006
    ..This is the first report of encephalopathy potentially caused by norovirus as indicated by the presence of the virus genome in CSF...
  99. ncbi request reprint Latent cerebral hypoperfusion in a boy with persistent nephrotic syndrome
    Shu Ichi Ito
    Department of Pediatrics, Yokohama City University Medical Center, 4 57, Urafune cho, Minami Ku, 232 0024 Yokohama, Japan
    Brain Dev 24:780-3. 2002
    ..In our patient, cerebral hypoperfusion might have been associated with his mental problems, physical problems, and delayed development of speech...
  100. ncbi request reprint The influence of methicillin-resistant Staphylococcus aureus (MRSA) carriers in a nursery and transmission of MRSA to their households
    T Mitsuda
    Department of Pediatrics, School of Medicine, Yokohama City University, Japan
    J Hosp Infect 42:45-51. 1999
    ..We recommend that healthcare providers should be examined for MRSA if an MRSA epidemic occurs in a hospital. The families of any such carriers should also be examined for MRSA...
  101. pmc Molecular epidemiological study of Haemophilus influenzae serotype b strains obtained from children with meningitis in Japan
    T Mitsuda
    Division of Clinical Laboratory Medicine, School of Medicine, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama City, 236 0004, Japan
    J Clin Microbiol 37:2548-52. 1999
    ..The genotyping of clinically isolated Hib strains may help to elucidate transmission routes in community infections, endemicity, and the reasons for vaccine failure...