Affiliation: Yokohama City University
Yamashita A. Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay. Genes Cells. 2013;18:161-75 pubmed publisher
..At present, a variety of tools are available that can specifically suppress NMD, and it has become possible to examine the contribution of NMD in a variety of physiological and pathological conditions. ..
Yamashita A, Izumi N, Kashima I, Ohnishi T, Saari B, Katsuhata Y, et al
. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev. 2009;23:1091-105 pubmed publisher
Melero R, Uchiyama A, Castaño R, Kataoka N, Kurosawa H, Ohno S, et al
. Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD. Structure. 2014;22:1105-1119 pubmed publisher
LÃ³pez Perrote A, CastaÃ±o R, Melero R, Zamarro T, Kurosawa H, Ohnishi T, et al
. Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex. Nucleic Acids Res. 2016;44:1909-23 pubmed publisher
..Together, our results highlight the role of UPF2 as a platform for the transient interactions of several NMD factors, including several components of SURF. ..
Ohki K, Wakui H, Azushima K, Uneda K, Haku S, Kobayashi R, et al
. ATRAP Expression in Brown Adipose Tissue Does Not Influence the Development of Diet-Induced Metabolic Disorders in Mice. Int J Mol Sci. 2017;18: pubmed publisher
..Future studies that modulate ATRAP in WAT are necessary to assess its in vivo functions in the development of obesity-related metabolic disorders. ..