Akio Yamashita

Summary

Affiliation: Yokohama City University
Country: Japan

Publications

  1. Yamashita A. Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay. Genes Cells. 2013;18:161-75 pubmed publisher
    ..At present, a variety of tools are available that can specifically suppress NMD, and it has become possible to examine the contribution of NMD in a variety of physiological and pathological conditions. ..
  2. Yamashita A, Izumi N, Kashima I, Ohnishi T, Saari B, Katsuhata Y, et al. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev. 2009;23:1091-105 pubmed publisher
  3. Melero R, Uchiyama A, Castaño R, Kataoka N, Kurosawa H, Ohno S, et al. Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD. Structure. 2014;22:1105-1119 pubmed publisher
  4. López Perrote A, Castaño R, Melero R, Zamarro T, Kurosawa H, Ohnishi T, et al. Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex. Nucleic Acids Res. 2016;44:1909-23 pubmed publisher
    ..Together, our results highlight the role of UPF2 as a platform for the transient interactions of several NMD factors, including several components of SURF. ..
  5. Ohki K, Wakui H, Azushima K, Uneda K, Haku S, Kobayashi R, et al. ATRAP Expression in Brown Adipose Tissue Does Not Influence the Development of Diet-Induced Metabolic Disorders in Mice. Int J Mol Sci. 2017;18: pubmed publisher
    ..Future studies that modulate ATRAP in WAT are necessary to assess its in vivo functions in the development of obesity-related metabolic disorders. ..