Genomes and Genes


Hiromichi Wakui


Affiliation: Yokohama City University
Country: Japan


  1. Uneda K, Wakui H, Maeda A, Azushima K, Kobayashi R, Haku S, et al. Angiotensin II Type 1 Receptor-Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin. J Am Heart Assoc. 2017;6: pubmed publisher
    ..These results indicate that ATRAP plays an important role in inhibiting kidney aging, possibly through sirtuin1-mediated mechanism independent of blocking AT1R signaling, and further protecting normal life span. ..
  2. Azushima K, Uneda K, Wakui H, Ohki K, Haruhara K, Kobayashi R, et al. Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice. Sci Rep. 2019;9:6201 pubmed publisher
    ..These findings suggest that RKT potentially has a renal anti-inflammatory effect in the development of renal injury, and this effect could be mediated by the ghrelin signaling pathway. ..
  3. Ohsawa M, Tamura K, Wakui H, Kanaoka T, Azushima K, Uneda K, et al. Effects of pitavastatin add-on therapy on chronic kidney disease with albuminuria and dyslipidemia. Lipids Health Dis. 2015;14:161 pubmed publisher
  4. Haruhara K, Wakui H, Azushima K, Kurotaki D, Kawase W, Uneda K, et al. Angiotensin receptor-binding molecule in leukocytes in association with the systemic and leukocyte inflammatory profile. Atherosclerosis. 2018;269:236-244 pubmed publisher
    ..These results suggest that leukocyte ATRAP is an emerging marker capable of reflecting the systemic and leukocyte inflammatory profile, and plays a role as an anti-inflammatory factor in the pathophysiology of NCDs. ..
  5. Ohki K, Wakui H, Kishio N, Azushima K, Uneda K, Haku S, et al. Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue. Sci Rep. 2018;8:2846 pubmed publisher
    ..Hyperactivity of AT1 receptor could be related to formation of insulin resistance related to metabolic syndrome. ..
  6. Kobayashi R, Wakui H, Azushima K, Uneda K, Haku S, Ohki K, et al. An angiotensin II type 1 receptor binding molecule has a critical role in hypertension in a chronic kidney disease model. Kidney Int. 2017;91:1115-1125 pubmed publisher
    ..Thus, renal ATRAP downregulation is involved in the onset and progression of blood pressure elevation caused by renal mass reduction, and implicates ATRAP as a therapeutic target for hypertension in chronic kidney disease. ..
  7. Ohki K, Wakui H, Azushima K, Uneda K, Haku S, Kobayashi R, et al. ATRAP Expression in Brown Adipose Tissue Does Not Influence the Development of Diet-Induced Metabolic Disorders in Mice. Int J Mol Sci. 2017;18: pubmed publisher
    ..Future studies that modulate ATRAP in WAT are necessary to assess its in vivo functions in the development of obesity-related metabolic disorders. ..
  8. Wakui H, Hosokawa Y, Oshikawa J, Tamura K, Toya Y, Yabana M, et al. Endovascular treatment of renal artery stenosis improves contralateral renal hypertrophy with nephrotic syndrome. CEN Case Rep. 2014;3:53-55 pubmed publisher
    ..In addition, her stenotic-side renal atrophy was resolved, concomitant with an improvement in her renal function. The contralateral renal hypertrophy was also resolved. ..
  9. Kino T, Ishigami T, Murata T, Doi H, Nakashima Sasaki R, Chen L, et al. Eplerenone-Resistant Salt-Sensitive Hypertension in Nedd4-2 C2 KO Mice. Int J Mol Sci. 2017;18: pubmed publisher
    ..Our results from Nedd4-2 C2 KO mice suggest that enhanced ENaC gene expression is critically involved in salt-sensitive hypertension under certain conditions of specific enzyme isoforms for their ubiquitination. ..

More Information


  1. Wakui H, Sumida K, Fujita M, Ohtomo Y, Ohsawa M, Kobayashi R, et al. Enhancement of intrarenal plasma membrane calcium pump isoform 1 expression in chronic angiotensin II-infused mice. Physiol Rep. 2017;5: pubmed publisher
    ..These results suggest that renal PMCA1 has a role as one of the molecules involved in angiotensin II-induced hypertension and kidney injury. ..
  2. Minegishi S, Ishigami T, Kawamura H, Kino T, Chen L, Nakashima Sasaki R, et al. An Isoform of Nedd4-2 Plays a Pivotal Role in Electrophysiological Cardiac Abnormalities. Int J Mol Sci. 2017;18: pubmed publisher