Masanari Umemura

Summary

Affiliation: Yokohama City University
Country: Japan

Publications

  1. ncbi request reprint Implication of base heart rate in autonomic nervous function, blood pressure and health-related QOL
    Yasuko Okano
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama City, Japan
    Clin Exp Hypertens 27:169-78. 2005
  2. doi request reprint Ambulatory blood pressure variability is increased in diabetic hypertensives
    Motoko Ozawa
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Clin Exp Hypertens 30:213-24. 2008
  3. ncbi request reprint Angiotensin II Type 1 Receptor Binding Molecule ATRAP as a Possible Modulator of Renal Sodium Handling and Blood Pressure in Pathophysiology
    K Tamura
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Curr Med Chem 22:3210-6. 2015
  4. pmc Bofu-tsu-shosan, an oriental herbal medicine, exerts a combinatorial favorable metabolic modulation including antihypertensive effect on a mouse model of human metabolic disorders with visceral obesity
    Kengo Azushima
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    PLoS ONE 8:e75560. 2013
  5. pmc Angiotensin receptor-binding protein ATRAP/Agtrap inhibits metabolic dysfunction with visceral obesity
    Akinobu Maeda
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Am Heart Assoc 2:e000312. 2013
  6. pmc Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein
    Miyuki Matsuda
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, USA
    J Biol Chem 288:19238-49. 2013
  7. pmc L/N-type calcium channel blocker cilnidipine added to renin-angiotensin inhibition improves ambulatory blood pressure profile and suppresses cardiac hypertrophy in hypertension with chronic kidney disease
    Tomohiko Kanaoka
    Department of Medical Science and Cardiorenal Medicine, Graduate School of Medicine, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Int J Mol Sci 14:16866-81. 2013
  8. pmc Addition of aliskiren to Angiotensin receptor blocker improves ambulatory blood pressure profile and cardiorenal function better than addition of benazepril in chronic kidney disease
    Masato Ohsawa
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Int J Mol Sci 14:15361-75. 2013
  9. doi request reprint Therapeutic potential of low-density lipoprotein apheresis in the management of peripheral artery disease in patients with chronic kidney disease
    Kouichi Tamura
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokosuka, Japan
    Ther Apher Dial 17:185-92. 2013
  10. pmc Enhanced angiotensin receptor-associated protein in renal tubule suppresses angiotensin-dependent hypertension
    Hiromichi Wakui
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Hypertension 61:1203-10. 2013

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Implication of base heart rate in autonomic nervous function, blood pressure and health-related QOL
    Yasuko Okano
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama City, Japan
    Clin Exp Hypertens 27:169-78. 2005
    ..Using multivariate analysis, HRo is related to LF/HF, body mass index, and the score of social functioning (HRQOL). HRo may be a useful indicator for assessing sympathetic nervous activity and HRQOL in normotensive healthy subjects...
  2. doi request reprint Ambulatory blood pressure variability is increased in diabetic hypertensives
    Motoko Ozawa
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Clin Exp Hypertens 30:213-24. 2008
    ..Taken together, these results demonstrate that BP variability is increased in diabetic hypertensives. Furthermore, it is possible that an elevation of fasting blood glucose may contribute to the enhanced BP variability in hypertensives...
  3. ncbi request reprint Angiotensin II Type 1 Receptor Binding Molecule ATRAP as a Possible Modulator of Renal Sodium Handling and Blood Pressure in Pathophysiology
    K Tamura
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Curr Med Chem 22:3210-6. 2015
    ....
  4. pmc Bofu-tsu-shosan, an oriental herbal medicine, exerts a combinatorial favorable metabolic modulation including antihypertensive effect on a mouse model of human metabolic disorders with visceral obesity
    Kengo Azushima
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    PLoS ONE 8:e75560. 2013
    ....
  5. pmc Angiotensin receptor-binding protein ATRAP/Agtrap inhibits metabolic dysfunction with visceral obesity
    Akinobu Maeda
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Am Heart Assoc 2:e000312. 2013
    ..Adipose tissue dysfunction has been proposed as the cause of visceral obesity-related metabolic disorders, moving the tissue toward a proinflammatory phenotype...
  6. pmc Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein
    Miyuki Matsuda
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, USA
    J Biol Chem 288:19238-49. 2013
    ..The results also demonstrate a functional E-box-USF1/USF2 interaction in the human AGTRAP promoter, thereby suggesting that a strategy of modulating the E-box-USF1/USF2 binding has novel therapeutic potential. ..
  7. pmc L/N-type calcium channel blocker cilnidipine added to renin-angiotensin inhibition improves ambulatory blood pressure profile and suppresses cardiac hypertrophy in hypertension with chronic kidney disease
    Tomohiko Kanaoka
    Department of Medical Science and Cardiorenal Medicine, Graduate School of Medicine, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Int J Mol Sci 14:16866-81. 2013
    ....
  8. pmc Addition of aliskiren to Angiotensin receptor blocker improves ambulatory blood pressure profile and cardiorenal function better than addition of benazepril in chronic kidney disease
    Masato Ohsawa
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Int J Mol Sci 14:15361-75. 2013
    ..These results suggest that aliskiren add-on therapy may be beneficial for suppression of renal deterioration and pathological cardiac remodeling through an improvement that is effected in ambulatory BP and HR profiles. ..
  9. doi request reprint Therapeutic potential of low-density lipoprotein apheresis in the management of peripheral artery disease in patients with chronic kidney disease
    Kouichi Tamura
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokosuka, Japan
    Ther Apher Dial 17:185-92. 2013
    ....
  10. pmc Enhanced angiotensin receptor-associated protein in renal tubule suppresses angiotensin-dependent hypertension
    Hiromichi Wakui
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Hypertension 61:1203-10. 2013
    ....
  11. ncbi request reprint The physiology and pathophysiology of a novel angiotensin receptor-binding protein ATRAP/Agtrap
    Kouichi Tamura
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Curr Pharm Des 19:3043-8. 2013
    ..These results suggest the clinical potential benefit of an ATRAP activation strategy in the treatment of hypertension and related organ injury...
  12. doi request reprint Ambulatory blood pressure and heart rate in hypertensives with renal failure: comparison between diabetic nephropathy and non-diabetic glomerulopathy
    Kouichi Tamura
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Clin Exp Hypertens 30:33-43. 2008
    ....
  13. ncbi request reprint The role of angiotensin AT1 receptor-associated protein in renin-angiotensin system regulation and function
    Kouichi Tamura
    Department of Cardiorenal Medicine, Yokohama City University School of Medicine, 3 9 Fukuura, Yokohama, Japan
    Curr Hypertens Rep 9:121-7. 2007
    ..We would expect ATRAP to become a new therapeutic target molecule to treat and prevent cardiovascular remodeling in hypertension...
  14. ncbi request reprint A possible relationship of nocturnal blood pressure variability with coronary artery disease in diabetic nephropathy
    Kouichi Tamura
    Department of Medicine II, Yokohama City University School of Medicine, Yokohama, Japan
    Clin Exp Hypertens 29:31-42. 2007
    ..Elevated short-term BP variability combined with relative sympathetic prevalence during the night might represent an important risk factor for cardiovascular events in the diabetic population...
  15. ncbi request reprint Nuclear receptor LXRalpha is involved in cAMP-mediated human renin gene expression
    Kouichi Tamura
    Department of Medicine II, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Mol Cell Endocrinol 224:11-20. 2004
    ..These results suggest that LXRalpha plays an important role in the cAMP-mediated regulation of human renin gene transcription by binding to CNRE...
  16. ncbi request reprint Acute renal failure due to cholesterol crystal embolism treated with LDL apheresis followed by corticosteroid and candesartan
    Kouichi Tamura
    Second Department of Medicine, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Clin Exp Nephrol 7:67-71. 2003
    ..Therefore, a combination therapy of LDL-A, low-dose corticosteroid, and an ARB is a possible treatment for CCE, although the possibility of spontaneous recovery of renal function cannot be eliminated for this patient...
  17. doi request reprint Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L
    Naomi Araki
    Yokohama City University Graduate School of Medicine, Department of Medical Science and Cardio renal Medicine, Yokohama City, Kanagawa ken 236 0004, Japan
    Biochem Biophys Res Commun 388:290-6. 2009
    ..NPC2 might regulate sodium reabsorption in the terminal nephron by interacting with ENaC-Nedd4L system...
  18. doi request reprint Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension
    Naomi Araki
    Department of Medical Science and Cardio renal Medicine, Yokohama City University Graduate School of Medicine, Kanagawa Ken, Japan
    Hypertension 51:773-7. 2008
    ..Such interactions might abnormally increase sodium reabsorption. Taken together, our analyses suggest that the human Nedd4L gene, especially the evolutionarily new isoform I, is a candidate gene for hypertension...
  19. doi request reprint Renin angiotensin antagonists normalize aberrant activation of epithelial sodium channels in sodium-sensitive hypertension
    Hisako Ushio-Yamana
    Department of Medical Science and Cardio renal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Nephron Exp Nephrol 122:95-102. 2012
    ..These effects would act to suppress sodium reabsorption via ENaC and normalize molecular mechanisms that elevate blood pressure in response to increased salt intake...
  20. doi request reprint Identification of bona fide alternative renin transcripts expressed along cortical tubules and potential roles in promoting insulin resistance in vivo without significant plasma renin activity elevation
    Tomoaki Ishigami
    From the Department of Medical Science and Cardio Renal Medicine, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
    Hypertension 64:125-33. 2014
    ....
  21. ncbi request reprint The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy
    Yutaka Tanaka
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    FEBS Lett 579:1579-86. 2005
    ..These results indicate that ATRAP significantly promotes downregulation of the AT1R and further attenuates certain Ang II-mediated hypertrophic responses in cardiomyocytes...
  22. doi request reprint Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through β1- and α1-Adrenergic Receptor-Mediated Signaling in Mice
    Kenji Suita
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    PLoS ONE 10:e0133664. 2015
    ..However, investigation of its pathogenesis and potential treatment has been hampered by the lack of suitable AF models in experimental animals...
  23. ncbi request reprint Transcriptional diversity and expression of NEDD4L gene in distal nephron
    Masanari Umemura
    Department of Internal Medicine and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Biochem Biophys Res Commun 339:1129-37. 2006
    ..This response was impaired in genetically sodium-sensitive animals. These findings suggested that Nedd4L gene products were involved in the development of salt-sensitive hypertension...
  24. doi request reprint Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation
    Yuko Kato
    From the Cardiovascular Research Institute Y K, U Y, C Y, M U, T F, Y I and Department of Immunology D K, T T, Yokohama City University, Graduate School of Medicine, Yokohama, Japan Department of Microbiology and Immunology, Tokyo Medical and Dental University Graduate School of Health Care Sciences, Tokyo, Japan Y K, R I, T K Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan S O and Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan M S
    Arterioscler Thromb Vasc Biol 35:2617-25. 2015
    ..In this study, we examined the molecular mechanisms of Epac1-induced SMC migration and the effect of Epac1 deficiency on vascular remodeling in vivo...
  25. doi request reprint Decreased serum osmolality promotes ductus arteriosus constriction
    Rika Aoki
    Cardiovascular Research Institute, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan Department of Pediatrics, Yokohama City University, Yokohama, Japan
    Cardiovasc Res 104:326-36. 2014
    ..However, the significance of this transient decrease in osmolality has never been addressed. The objective of the present study was to examine the role of changes in serum osmolality after birth in DA closure...
  26. doi request reprint Hyperthermia generated with ferucarbotran (Resovist®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells
    Itaru Sato
    Cardiovascular Research Institute, Yokohama City University, Graduate School of Medicine, 3 9 Fukuura, Yokohama, 236 0004, Japan
    J Physiol Sci 64:177-83. 2014
    ..Further work seems justified to evaluate simultaneous thermo-chemotherapy as a new approach to anticancer therapy. ..
  27. doi request reprint The prostanoid EP4 receptor and its signaling pathway
    Utako Yokoyama
    Cardiovascular Research Institute, Yokohama City University, Yokohama, Kanagawa, Japan
    Pharmacol Rev 65:1010-52. 2013
    ..The aim of this review is to present current findings on the biologic functions of the EP4 receptor. In particular, we will discuss its diversity from the standpoint of EP4-mediated signaling...
  28. doi request reprint Coupling of β1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes
    Takashi Tsunematsu
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Biochem Biophys Res Commun 458:531-5. 2015
    ..We believe these results are helpful for understanding the mechanisms underlying the different roles of AR subtypes in healthy and diseased hearts. ..
  29. pmc Store-operated Ca2+ entry (SOCE) regulates melanoma proliferation and cell migration
    Masanari Umemura
    Cardiovascular Research Institute, Yokohama City University School of Medicine, Yokohama, Japan
    PLoS ONE 9:e89292. 2014
    ..Our findings indicate that SOCE contributes to melanoma progression, and therefore may be a new potential target for treatment of melanoma, irrespective of whether or not Braf mutation is present. ..
  30. doi request reprint Three-dimensional multilayers of smooth muscle cells as a new experimental model for vascular elastic fiber formation studies
    Ryo Ishiwata
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    Atherosclerosis 233:590-600. 2014
    ..Since fibronectin is known to assemble and activate elastic fiber-related molecules, we further optimized culture conditions...
  31. pmc A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging
    Haruki Eguchi
    1 Cardiovascular Research Institute, Yokohama City University, Graduate School of Medicine, Yokohama, Japan 2 Advanced Applied Science Department, Research Laboratory, IHI Corporation, Yokohama, Japan
    Sci Rep 5:9194. 2015
    ..We believe such magnetic anti-cancer drugs have the potential to greatly advance cancer chemotherapy for new theranostics and drug-delivery strategies. ..
  32. ncbi request reprint Analysis of factors that affect short-term blood pressure variability in patients with chronic renal failure
    Masashi Sakai
    Department of Medicine II, Yokohama City University School of Medicine, Yokohama, Japan
    Clin Exp Hypertens 27:139-47. 2005
    ..Furthermore, sympathetic nerve overactivity may be involved in cardiovascular complications in CRF patients through the increase in nighttime systolic BP variability...
  33. ncbi request reprint Relationships between diurnal blood pressure variation, physical activity, and health-related QOL
    Yasuko Okano
    Second Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama City, Japan
    Clin Exp Hypertens 26:145-55. 2004
    ..05, p < 0.05, respectively). In conclusion, physical activity is associated with the nocturnal dip in blood pressure. Moreover, physical activity correlates with some of the factors of HRQOL...