Affiliation: Yokohama City University
- Tamura K, Chen Y, Tanaka Y, Sakai M, Tsurumi Y, Koide Y, et al. Nuclear receptor LXRalpha is involved in cAMP-mediated human renin gene expression. Mol Cell Endocrinol. 2004;224:11-20 pubmed..These results suggest that LXRalpha plays an important role in the cAMP-mediated regulation of human renin gene transcription by binding to CNRE. ..
- Kobayashi R, Wakui H, Azushima K, Uneda K, Haku S, Ohki K, et al. An angiotensin II type 1 receptor binding molecule has a critical role in hypertension in a chronic kidney disease model. Kidney Int. 2017;91:1115-1125 pubmed publisher..Thus, renal ATRAP downregulation is involved in the onset and progression ofÂ blood pressure elevation caused by renal mass reduction,Â and implicates ATRAP as a therapeutic target forÂ hypertension in chronic kidney disease. ..
- Ohki K, Wakui H, Azushima K, Uneda K, Haku S, Kobayashi R, et al. ATRAP Expression in Brown Adipose Tissue Does Not Influence the Development of Diet-Induced Metabolic Disorders in Mice. Int J Mol Sci. 2017;18: pubmed publisher..Future studies that modulate ATRAP in WAT are necessary to assess its in vivo functions in the development of obesity-related metabolic disorders. ..
- Ishii T, Taguri M, Tamura K, Oyama K. Evaluation of the Effectiveness of Xanthine Oxidoreductase Inhibitors on Haemodialysis Patients using a Marginal Structural Model. Sci Rep. 2017;7:14004 pubmed publisher..24 (95% confidence interval: 0.15-0.38) in all cohorts. These results suggest that XORi improved all-cause mortality in end-stage renal disease, irrespective of the serum UA level. ..