Kazuhide Takahashi

Summary

Affiliation: Yokohama City Institute of Health
Country: Japan

Publications

  1. pmc WAVE2 Protein Complex Coupled to Membrane and Microtubules
    Kazuhide Takahashi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama 241 0815, Japan
    J Oncol 2012:590531. 2012
  2. ncbi request reprint Involvement of protein phosphatase 2A in the maintenance of E-cadherin-mediated cell-cell adhesion through recruitment of IQGAP1
    Kazuhide Takahashi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    J Cell Physiol 206:814-20. 2006
  3. doi request reprint Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/Op18 to Pak1-WAVE2-kinesin complex
    Kazuhide Takahashi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama 241 0815, Japan
    Cell Signal 21:695-703. 2009
  4. pmc The linkage between beta1 integrin and the actin cytoskeleton is differentially regulated by tyrosine and serine/threonine phosphorylation of beta1 integrin in normal and cancerous human breast cells
    K Takahashi
    Laboratory of Biochemistry, Kanagawa Cancer Center Research Institute 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    BMC Cell Biol 2:23. 2001
  5. doi request reprint Directional control of WAVE2 membrane targeting by EB1 and phosphatidylinositol 3,4,5-triphosphate
    Kazuhide Takahashi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama 241 0815, Japan
    Cell Signal 22:510-8. 2010
  6. doi request reprint WAVE2 targeting to phosphatidylinositol 3,4,5-triphosphate mediated by insulin receptor substrate p53 through a complex with WAVE2
    Kazuhide Takahashi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama 241 0815, Japan
    Cell Signal 22:1708-16. 2010
  7. doi request reprint WAVE2, N-WASP, and Mena facilitate cell invasion via phosphatidylinositol 3-kinase-dependent local accumulation of actin filaments
    Kazuhide Takahashi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama 241 0815, Japan
    J Cell Biochem 112:3421-9. 2011
  8. ncbi request reprint Regulation of protein phosphatase 2A-mediated recruitment of IQGAP1 to beta1 integrin by EGF through activation of Ca2+/calmodulin-dependent protein kinase II
    Kazuhide Takahashi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    J Cell Physiol 208:213-9. 2006
  9. ncbi request reprint Requirement of protein phosphatase 2A for recruitment of IQGAP1 to Rac-bound beta1 integrin
    Katsuo Suzuki
    Department of Biochemistry, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    J Cell Physiol 203:487-92. 2005
  10. ncbi request reprint Reduced expression of the regulatory A subunit of serine/threonine protein phosphatase 2A in human breast cancer MCF-7 cells
    Katsuo Suzuki
    Department of Biochemistry, Kanagawa Cancer Center Research Institute, Asahi ku, Yokohama 241 0815, Japan
    Int J Oncol 23:1263-8. 2003

Collaborators

  • Shigeru Morimura
  • K Ikeda
  • Katsuo Suzuki
  • Keiji Kikuchi
  • Eri Nakajima
  • K Suzuki
  • Yasuhiro Chikamatsu
  • H Nishina
  • T Katada
  • K Inageda
  • S Hoshino
  • M Tohkin
  • T Iiri
  • N Morishima
  • M Ui

Detail Information

Publications23

  1. pmc WAVE2 Protein Complex Coupled to Membrane and Microtubules
    Kazuhide Takahashi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama 241 0815, Japan
    J Oncol 2012:590531. 2012
    ..These findings might have important implications for the development of effective therapeutic agents against cancer cell migration and invasion...
  2. ncbi request reprint Involvement of protein phosphatase 2A in the maintenance of E-cadherin-mediated cell-cell adhesion through recruitment of IQGAP1
    Kazuhide Takahashi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    J Cell Physiol 206:814-20. 2006
    ..We therefore propose that PP2A plays a crucial role in the maintenance of cell-cell adhesion through recruitment of IQGAP1 to the Rac-bound E-cadherin-catenins complex...
  3. doi request reprint Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/Op18 to Pak1-WAVE2-kinesin complex
    Kazuhide Takahashi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama 241 0815, Japan
    Cell Signal 21:695-703. 2009
    ....
  4. pmc The linkage between beta1 integrin and the actin cytoskeleton is differentially regulated by tyrosine and serine/threonine phosphorylation of beta1 integrin in normal and cancerous human breast cells
    K Takahashi
    Laboratory of Biochemistry, Kanagawa Cancer Center Research Institute 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    BMC Cell Biol 2:23. 2001
    ..In this study, we examined the reason for the reduced surface expression of beta1 integrin in human breast cancer MCF-7 cells compared to normal human breast epithelial (HBE) cells, both of which adhered to collagen type IV...
  5. doi request reprint Directional control of WAVE2 membrane targeting by EB1 and phosphatidylinositol 3,4,5-triphosphate
    Kazuhide Takahashi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama 241 0815, Japan
    Cell Signal 22:510-8. 2010
    ....
  6. doi request reprint WAVE2 targeting to phosphatidylinositol 3,4,5-triphosphate mediated by insulin receptor substrate p53 through a complex with WAVE2
    Kazuhide Takahashi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama 241 0815, Japan
    Cell Signal 22:1708-16. 2010
    ....
  7. doi request reprint WAVE2, N-WASP, and Mena facilitate cell invasion via phosphatidylinositol 3-kinase-dependent local accumulation of actin filaments
    Kazuhide Takahashi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama 241 0815, Japan
    J Cell Biochem 112:3421-9. 2011
    ..These results indicate that by mediating intensive F-actin accumulation at the sites of cell infiltration, WAVE2, N-WASP, and Mena are crucial for PI3K-dependent cell invasion induced by PDGF...
  8. ncbi request reprint Regulation of protein phosphatase 2A-mediated recruitment of IQGAP1 to beta1 integrin by EGF through activation of Ca2+/calmodulin-dependent protein kinase II
    Kazuhide Takahashi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    J Cell Physiol 208:213-9. 2006
    ....
  9. ncbi request reprint Requirement of protein phosphatase 2A for recruitment of IQGAP1 to Rac-bound beta1 integrin
    Katsuo Suzuki
    Department of Biochemistry, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    J Cell Physiol 203:487-92. 2005
    ..We therefore propose that PP2A, especially PP2A-A, functions to maintain F-actin assembly to which beta1 integrin is anchored by recruitment of IQGAP1 to Rac-beta1 integrin...
  10. ncbi request reprint Reduced expression of the regulatory A subunit of serine/threonine protein phosphatase 2A in human breast cancer MCF-7 cells
    Katsuo Suzuki
    Department of Biochemistry, Kanagawa Cancer Center Research Institute, Asahi ku, Yokohama 241 0815, Japan
    Int J Oncol 23:1263-8. 2003
    ..The results suggest that the failure of beta1 integrin dephosphorylation at threonines 788 and 789 may be due to a significant reduction in the PP2A-A expression in MCF-7 cells...
  11. doi request reprint Requirement of kinesin-mediated membrane transport of WAVE2 along microtubules for lamellipodia formation promoted by hepatocyte growth factor
    Kazuhide Takahashi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Exp Cell Res 314:2313-22. 2008
    ..Therefore, we propose here that the promotion of lamellipodia formation by HGF in MDA-MB-231 cells is Rac1-dependent and requires KIF5B-mediated transport of WAVE2 and IQGAP1 to the cell periphery along microtubules...
  12. ncbi request reprint Induction of E-cadherin endocytosis by loss of protein phosphatase 2A expression in human breast cancers
    Katsuo Suzuki
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Biochem Biophys Res Commun 349:255-60. 2006
    ..Therefore, we propose that the dysfunction of E-cadherin due to its endocytosis may occur in some proportion of human breast carcinomas in which the PP2A-A protein is lost or significantly reduced...
  13. doi request reprint Regulation of lamellipodia formation and cell invasion by CLIP-170 in invasive human breast cancer cells
    Katsuo Suzuki
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Biochem Biophys Res Commun 368:199-204. 2008
    ....
  14. ncbi request reprint Mitotic dissociation of IQGAP1 from Rac-bound beta1-integrin is mediated by protein phosphatase 2A
    Eri Nakajima
    Department of Biochemistry, Kanagawa Cancer Center Research Institute, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Biochem Biophys Res Commun 326:249-53. 2005
    ..The results suggest that the mitotic loss of F-actin assembly to which beta1-integrin anchors is due to PP2A-mediated dissociation of IQGAP1 from Rac-bound beta1-integrin...
  15. ncbi request reprint Reduced cell adhesion during mitosis by threonine phosphorylation of beta1 integrin
    Katsuo Suzuki
    Department of Biochemistry, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    J Cell Physiol 197:297-305. 2003
    ....
  16. doi request reprint BetaPIX and GIT1 regulate HGF-induced lamellipodia formation and WAVE2 transport
    Shigeru Morimura
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Biochem Biophys Res Commun 382:614-9. 2009
    ..Collectively, we suggest that betaPIX releases cells from the GIT1-mediated suppression of HGF-independent responses and recruits GIT1 to WAVE2, thereby facilitating HGF-induced WAVE2 transport and lamellipodia formation...
  17. doi request reprint Nonmuscle myosin IIA is required for lamellipodia formation through binding to WAVE2 and phosphatidylinositol 3,4,5-triphosphate
    Shigeru Morimura
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama 241 0815, Japan
    Biochem Biophys Res Commun 404:834-40. 2011
    ....
  18. doi request reprint WAVE2- and microtubule-dependent formation of long protrusions and invasion of cancer cells cultured on three-dimensional extracellular matrices
    Keiji Kikuchi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    Cancer Sci 99:2252-9. 2008
    ..These results suggest that long protrusions formed in a WAVE2- and microtubule-dependent manner may identify the cells at the later stage of invasion, possibly after the formation of invadopodia in the 3-D cultures...
  19. ncbi request reprint Actin filament assembly and actin-myosin contractility are necessary for anchorage- and EGF-dependent activation of phospholipase Cgamma
    K Suzuki
    Department of Biochemistry, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    J Cell Physiol 189:64-71. 2001
    ..The present results suggest that anchorage-dependent EGF signaling in HME cells may require both actin filament assembly and actin-myosin contractility for the PLCgamma activation...
  20. ncbi request reprint Induction of tyrosine phosphorylation and association of beta-catenin with EGF receptor upon tryptic digestion of quiescent cells at confluence
    K Takahashi
    Department of Biochemistry, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    Oncogene 15:71-8. 1997
    ..beta-Catenin thus phosphorylated at tyrosine is suggested to play the role in preventing alpha-catenin once dissociated from reassociating with E-cadherin until cells reach confluence...
  21. pmc Rac1 and Stathmin but Not EB1 Are Required for Invasion of Breast Cancer Cells in Response to IGF-I
    Shigeru Morimura
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama 241 0815, Japan
    Int J Cell Biol 2011:615912. 2011
    ..The signaling pathway leading to cell invasion may not be identical but shares some common molecules, leading to cell migration through lamellipodia formation...
  22. ncbi request reprint Cell surface antigen CD38 identified as ecto-enzyme of NAD glycohydrolase has hyaluronate-binding activity
    H Nishina
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    Biochem Biophys Res Commun 203:1318-23. 1994
    ..By contrast, no binding activity was found in Aplysia ADP-ribosyl cyclase. Thus CD38 antigen, like CD44 antigen characterized as a HA-receptor (or binding) protein, may function as an adhesion molecule...
  23. ncbi request reprint Interaction of guanine-nucleotide-binding regulatory proteins with chemotactic peptide receptors in differentiated human leukemic HL-60 cells
    M Tohkin
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    Eur J Biochem 195:527-33. 1991
    ....