Motohiko Sato

Summary

Affiliation: Yokohama City University
Location: Yokohama, Japan

Publications

  1. ncbi Transforming growth factor-beta 1 proliferated vascular smooth muscle cells from spontaneously hypertensive rats
    M Sato
    First Department of Internal Medicine, Asahikawa Medical College, Japan
    Am J Hypertens 8:160-6. 1995
  2. pmc Identification of transcription factor E3 (TFE3) as a receptor-independent activator of Gα16: gene regulation by nuclear Gα subunit and its activator
    Motohiko Sato
    Cardiovascular Research Institute, Yokohama City University School of Medicine, Fukuura, Yokohama 236 0004, Japan
    J Biol Chem 286:17766-76. 2011
  3. pmc Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus
    Utako Yokoyama
    Department of Life Science and Medical Bioscience, Waseda University Graduate School of Advanced Science and Engineering, 2 2, Wakamatsu cho, TWIns, Shinjuku ku, Tokyo 162 8480, Japan
    Circ Res 106:1882-92. 2010
  4. pmc Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43)
    Motohiko Sato
    Cardiovascular Research Institute, Yokohama City University School of Medicine, Fukuura, Yokohama 236 0004, Japan
    J Biol Chem 284:31431-40. 2009
  5. ncbi Accessory proteins for heterotrimeric G-protein: Implication in the cardiovascular system
    Motohiko Sato
    Cardiovascular Research Institute, Yokohama City University, School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Pathophysiology 17:89-99. 2010
  6. ncbi Signaling by a non-dissociated complex of G Protein betagamma and alpha subunits stimulated by a receptor-independent activator of G protein signaling, AGS8
    Chujun Yuan
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 282:19938-47. 2007
  7. ncbi Identification and characterization of a G-protein regulatory motif in WAVE1
    Kyoung Seob Song
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    FEBS Lett 580:1993-8. 2006
  8. pmc Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gbetagamma
    Motohiko Sato
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 103:797-802. 2006
  9. ncbi Accessory proteins for G proteins: partners in signaling
    Motohiko Sato
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Annu Rev Pharmacol Toxicol 46:151-87. 2006
  10. ncbi AGS proteins: receptor-independent activators of G-protein signaling
    Joe B Blumer
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Trends Pharmacol Sci 26:470-6. 2005

Collaborators

Detail Information

Publications19

  1. ncbi Transforming growth factor-beta 1 proliferated vascular smooth muscle cells from spontaneously hypertensive rats
    M Sato
    First Department of Internal Medicine, Asahikawa Medical College, Japan
    Am J Hypertens 8:160-6. 1995
    ..This abnormal responsiveness to TGF-beta 1 is involved in the proliferative characteristics of SHR-VSMC. Therefore, TGF-beta 1 could contribute to the development of hypertension or vascular hypertrophy in SHR...
  2. pmc Identification of transcription factor E3 (TFE3) as a receptor-independent activator of Gα16: gene regulation by nuclear Gα subunit and its activator
    Motohiko Sato
    Cardiovascular Research Institute, Yokohama City University School of Medicine, Fukuura, Yokohama 236 0004, Japan
    J Biol Chem 286:17766-76. 2011
    ..These findings indicate that TFE3 and Gα(16) are up-regulated under pathologic conditions and are involved in a novel mechanism of transcriptional regulation via the relocalization and activation of Gα(16)...
  3. pmc Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus
    Utako Yokoyama
    Department of Life Science and Medical Bioscience, Waseda University Graduate School of Advanced Science and Engineering, 2 2, Wakamatsu cho, TWIns, Shinjuku ku, Tokyo 162 8480, Japan
    Circ Res 106:1882-92. 2010
    ..After birth, however, differential regulation of vasodilation and IT is preferable for treatment of patients with patent DA and DA-dependent congenital cardiac malformations...
  4. pmc Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43)
    Motohiko Sato
    Cardiovascular Research Institute, Yokohama City University School of Medicine, Fukuura, Yokohama 236 0004, Japan
    J Biol Chem 284:31431-40. 2009
    ..Under hypoxic stress, this unrecognized response program plays a critical role in the fate of NCM...
  5. ncbi Accessory proteins for heterotrimeric G-protein: Implication in the cardiovascular system
    Motohiko Sato
    Cardiovascular Research Institute, Yokohama City University, School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Pathophysiology 17:89-99. 2010
    ..Such information may contribute to uncovering mechanisms underlying cardiovascular disease as well as the development of novel therapeutic approaches to human disease...
  6. ncbi Signaling by a non-dissociated complex of G Protein betagamma and alpha subunits stimulated by a receptor-independent activator of G protein signaling, AGS8
    Chujun Yuan
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 282:19938-47. 2007
    ..These data implicate a mechanism for AGS8, and potentially other Gbetagamma binding proteins, for directing Gbetagamma signaling through alternative effector activation sites on Gbetagamma in the absence of subunit dissociation...
  7. ncbi Identification and characterization of a G-protein regulatory motif in WAVE1
    Kyoung Seob Song
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    FEBS Lett 580:1993-8. 2006
    ..The docking of Gialpha within a WAVE1 scaffolding complex may facilitate dynamic cycling and/or targeting for efficient and localized control of actin polymerization...
  8. pmc Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gbetagamma
    Motohiko Sato
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 103:797-802. 2006
    ..Mechanistically, AGS8 appears to promote G protein signaling by a previously unrecognized mechanism that involves direct interaction with Gbetagamma...
  9. ncbi Accessory proteins for G proteins: partners in signaling
    Motohiko Sato
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Annu Rev Pharmacol Toxicol 46:151-87. 2006
    ..AGS and related accessory proteins reveal unexpected diversity in G protein subunits as signal transducers within the cell...
  10. ncbi AGS proteins: receptor-independent activators of G-protein signaling
    Joe B Blumer
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Trends Pharmacol Sci 26:470-6. 2005
    ..Thus, these proteins and the concepts advanced with their discovery highlight the diversity associated with G-protein signaling and present new avenues for the development of therapeutics that target G-protein signaling...
  11. ncbi Identification and characterization of AGS4: a protein containing three G-protein regulatory motifs that regulate the activation state of Gialpha
    Xiaoqing Cao
    The Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    J Biol Chem 279:27567-74. 2004
    ....
  12. ncbi AGS3 and signal integration by Galpha(s)- and Galpha(i)-coupled receptors: AGS3 blocks the sensitization of adenylyl cyclase following prolonged stimulation of a Galpha(i)-coupled receptor by influencing processing of Galpha(i)
    Motohiko Sato
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 279:13375-82. 2004
    ....
  13. ncbi Pertussis toxin-insensitive activation of the heterotrimeric G-proteins Gi/Go by the NG108-15 G-protein activator
    Catalina Ribas
    Centro de Biologia Molecular, Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Biol Chem 277:50223-5. 2002
    ..These data indicate the presence of unexpected regulatory domains on G(i)/G(o) proteins and suggest the existence of pertussis toxin-insensitive modes of signal input to G(i)/G(o) signaling systems...
  14. ncbi Analysis of signal transfer from receptor to Go/Gi in different membrane environments and receptor-independent activators of brain G protein
    Catalina Ribas
    Centro de Biología Molecular Severo Ochoa C51C UAM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Methods Enzymol 344:140-52. 2002
  15. ncbi Adenylyl cyclase isoforms and vasopressin enhancement of agonist-stimulated cAMP in vascular smooth muscle cells
    J Zhang
    Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston 29425, USA
    Am J Physiol 273:H971-80. 1997
    ....
  16. ncbi Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. Integration of stimulatory and inhibitory input to the effector adenylyl cyclase
    A Marjamaki
    Department of Pharmacology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 272:16466-73. 1997
    ..These data indicate that the integration of multiple signals by adenylyl cyclases is a dynamic process depending upon the enzyme type and phosphorylation status...
  17. ncbi Characterization of a G-protein activator in the neuroblastoma-glioma cell hybrid NG108-15
    M Sato
    Department of Pharmacology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 271:30052-60. 1996
    ..The G-protein activator was distinct from other proteins (neuromodulin, tubulin, and beta-amyloid precursor protein) that influence nucleotide binding to G-protein, indicating the existence of a novel signal accelerator...
  18. ncbi Factors determining specificity of signal transduction by G-protein-coupled receptors. Regulation of signal transfer from receptor to G-protein
    M Sato
    Department of Pharmacology, Medical University of South Carolina, Charleston 29425, USA
    J Biol Chem 270:15269-76. 1995
    ..These data indicate that the transfer of signal from R to G is regulated by a cell type-specific, membrane-associated protein that enhances the agonist-induced activation of G...
  19. ncbi The roles of cytochrome p450 in ischemic heart disease
    Motohiko Sato
    Cardiovascular Research Institute, Yokohama City University School of Medicine, Fukuura, Kanazawa Ku, Japan
    Curr Drug Metab 12:526-32. 2011
    ..In this review, we summarize current knowledge of this enzyme family and discuss the roles of CYP in ischemia-reperfusion injury of the heart...