Research TopicsSpecies | Keisuke OkadaSummaryAffiliation: Yokohama City University Country: Japan Publications
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Detail Information
Publications
Human leukocyte antigen may predict outcome of primary recurrent spontaneous abortion treated with paternal lymphocyte alloimmunization therapyTakashi Kano
Kano Medical Cooperation Clinic, Osaka, Japan
Am J Reprod Immunol 58:383-7. 2007..Paternal lymphocyte alloimmunization therapy (PLAT) is an effective therapy for RSA in some cases, but there are no predictive markers about the effectiveness of PLAT...- Pattern-stimulated visual evoked potential in dog: changes in elicited response with pattern size and calculation of visual acuityYoshiki Itoh
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Japan
J Vet Med Sci 72:1449-53. 2010..We suggest that, with further study, pVEP with different check sizes would be applicable for canine visual acuity examination... - High-throughput DNA typing of HLA-A, -B, -C, and -DRB1 loci by a PCR-SSOP-Luminex method in the Japanese populationYoshiki Itoh
Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
Immunogenetics 57:717-29. 2005..It takes only approximately 5 h from DNA extraction to the definition of HLA four-digit alleles at the HLA-A, HLA-B, HLA-C, and HLA-DRB1 loci for 96 samples when handled by a single typist... - The association between HLA-A alleles and young Alu dimorphisms near the HLA-J, -H, and -F genes in workshop cell lines and Japanese and Australian populationsDavid S Dunn
Centre for Bioinformatics and Biological Computing, School for Information Technology, Murdoch University, Murdoch, Western Australia, Australia
J Mol Evol 55:718-26. 2002.... - High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanismTakakazu Kawase
Division of Immunology, Aichi Cancer Center, Nagoya, Japan
Blood 110:2235-41. 2007..Furthermore, the identification of high-risk mismatch, that is, nonpermissive mismatch, would be beneficial for the selection of a suitable donor... - Rapid assignment of the swine major histocompatibility complex (SLA) class I and II genotypes in Clawn miniature swine using PCR-SSP and PCR-RFLP methodsAsako Ando
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
Xenotransplantation 12:121-6. 2005..CONCLUSIONS: The combination of PCR-SSP and PCR-RFLP methods facilitate the rapid identification of the three haplotypes and SLA class I and II homozygotes in individual Clawn miniature swine... - Effects of HLA allele and killer immunoglobulin-like receptor ligand matching on clinical outcome in leukemia patients undergoing transplantation with T-cell-replete marrow from an unrelated donorYasuo Morishima
Aichi Cancer Center Hospital, Department of Hematology and Cell Therapy, Nagoya, Japan
Biol Blood Marrow Transplant 13:315-28. 2007..Furthermore, KIR-L-MM induced adverse effects on acute GVHD (aGVHD) and rejection, and brought no survival benefits to patients with T-cell-replete UR-BMT... - Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patientsYukihiro Horie
Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Mol Vis 12:1601-5. 2006..The aim of the present study was to examine the genetic background of Vogt-Koyanagi-Harada (VKH) disease in a Japanese population by analyzing the tyrosinase gene family (TYR, TYRP1, and dopachrome tautomerase (DCT))... - Genetic linkage map of medaka with polymerase chain reaction length polymorphismsTetsuaki Kimura
Department of Molecular Life Science, Course of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Kanagawa 259-1193, Japan
Gene 363:24-31. 2005..Together with the genotyping data of six medaka inbred strains, our new marker set provides a powerful tool for genome-wide analysis of complex biological phenomena found widely in medaka populations... - Combination of HLA-A24, -DQA1*03, and -DR9 contributes to acute-onset and early complete beta-cell destruction in type 1 diabetes: longitudinal study of residual beta-cell functionKoji Nakanishi
Department of Endocrinology and Metabolism, Toranomon Hospital, 2 2 2 Toranomon, Minato ku, Tokyo 105 8470, Japan
Diabetes 55:1862-8. 2006.... - Single nucleotide polymorphism detection by polymerase chain reaction-restriction fragment length polymorphismMasao Ota
Department of Legal Medicine, Shinshu University School of Medicine, Nagano 390 8621, Japan
Nat Protoc 2:2857-64. 2007..This convenient and simple method is inexpensive and accurate for SNP genotyping and especially useful in small basic research studies of complex genetic diseases. The whole protocol takes only a day to carry out... - The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donorsYasuo Morishima
Department of Hematology and Chemotherapy, the Division of Epidemiology and Prevention, Aichi Cancer Center, Japan
Blood 99:4200-6. 2002..Thus, the role of the HLA class I allele in unrelated bone marrow transplantation was elucidated. Notably, HLA-C alleles had a different mode from HLA-A or -B alleles for acute GVHD and survival... - [Four-digit allele genotyping of HLA-A and HLA-B genes in Japanese patients with Behçet's disease (BD) by a PCR-SSOP-luminex method and stratification analysis according to each major symptom of BD]Tomoko Kamiishi
Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Japan
Nihon Ganka Gakkai Zasshi 112:451-8. 2008..We also analyzed our results for the association of these alleles with the individual clinical features of BD... - Sequencing-based typing of HLA-B*51 alleles and the significant association of HLA-B*5101 and -B*5108 with Behçet's disease in Greek patientsN Mizuki
Department of Ophthalmology, Yokohama City University School of Medicine, Japan
Tissue Antigens 59:118-21. 2002..This study revealed a strong association between Greeks with BD, both B*5101, B*5108, provided important insights into the molecular mechanism underlying the association between HLA status, this disease... 
Human endogenous retrovirus (HERVK9) structural polymorphism with haplotypic HLA-A allelic associationsJerzy K Kulski
Centre for Forensic Science, The University of Western Australia, Nedlands, Western Australia, Australia
Genetics 180:445-57. 2008....- Association of autoimmune disease-related gene polymorphisms with chronic graft-versus-host diseaseMasako Shimada
Department of Haematology and Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Br J Haematol 139:458-63. 2007..As FCRL3 is expressed by B cells and might have an important role in immunoregulation, this significant protective genetic effect raises the question of whether FCRL3 might also be involved in the pathogenesis of chronic GVHD... - Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitisMasao Ota
Department of Legal Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
Immunogenetics 59:45-52. 2007..The two critical HLA regions for susceptibility to AIP are limited to the HLA-DRB1*0405-DQB1*0401 in the class II and the ABCF1 proximal to C3-2-11, telomeric of HLA-E, in the class I regions... - One-step generation of recombineering constructs by asymmetric-end ligation and negative selectionMasato Ohtsuka
Division of Basic Molecular Science and Molecular Medicine, School of Medicine, Tokai University, Bohseidai, Isehara, Kanagawa 259-1193, Japan
Anal Biochem 360:306-8. 2007 - The major histocompatibility complex (Mhc) class IIB region has greater genomic structural flexibility and diversity in the quail than the chickenKazuyoshi Hosomichi
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1143, Japan
BMC Genomics 7:322. 2006.... - Alternative splicing due to an intronic SNP in HMSD generates a novel minor histocompatibility antigenTakakazu Kawase
Division of Immunology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
Blood 110:1055-63. 2007..These findings suggest that the HMSD-v-encoded mHA (designated ACC-6) could serve as a target antigen for immunotherapy against hematologic malignancies... - Mapping of susceptibility and protective loci for acute GVHD in unrelated HLA-matched bone marrow transplantation donors and recipients using 155 microsatellite markers on chromosome 22Tomoki Kikuchi
Department of Pathology, Sapporo Medical University School of Medicine, Hokkaido, Japan
Immunogenetics 59:99-108. 2007..This screening analysis suggests that several aGVHD-associated susceptible and protective loci exist on chromosome 22, which may encompass novel gene regions that need to be elucidated for their role in aGVHD... - High-resolution mapping for essential hypertension using microsatellite markersKeisuke Yatsu
Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Yokohama, Japan
Hypertension 49:446-52. 2007..We identified 19 allelic loci that were significantly different between the cases of essential hypertension and the controls... - Paternity determination of captive bottlenose dolphins (Tursiops truncatus) using microsatellite DNA analysisDaisuke Sumiyama
Department of Molecular Life Science, School of Medicine, Tokai University, Bouseidai, Kanagawa, Japan
J Vet Med Sci 70:711-3. 2008.... 
Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucomaEtsuko Shibuya
Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
Invest Ophthalmol Vis Sci 49:4453-7. 2008..This study was undertaken to investigate whether TLR4 polymorphisms are associated with NTG...- Exclusion of transforming growth factor-beta1 as a candidate gene for myopia in the JapaneseTakahiko Hayashi
Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Japan
Jpn J Ophthalmol 51:96-9. 2007..Previous studies have indicated that the gene expression products, regulators of the TGF-beta1 gene, are involved in high myopia... - Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in MongoliansTetsuaki Kimura
Department of Molecular Life Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
Hum Genet 123:655-60. 2008..000016). In the LD block at 15q22.32, SNP rs8038652 located in intron 1 of IQCH was strongly associated (P = 0.0003), especially the AA genotype of the SNP under a recessive model was strongly associated with adult height (P = 0.000046)... - The COL1A1 gene and high myopia susceptibility in JapaneseYumiko Inamori
Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
Hum Genet 122:151-7. 2007..6) and associated with high myopia (P = 0.028, Pc< 0.084). Together our results provide the first evidence for COL1A1 as a gene associated with high myopia... - Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada diseaseYukihiro Horie
Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Mol Vis 13:2334-8. 2007..Elevated aqueous and serum levels of IFN-gamma levels have been reported to be elevated in patients with Vogt-Koyanagi-Harada (VKH) disease. The aim of this study was to determine the IFN-gamma gene polymorphisms in VKH disease... - Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's diseaseIkuko Mizuta
Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan
Hum Mol Genet 15:1151-8. 2006..SNCA expression levels tended to be positively correlated with the number of the associated allele in autopsied frontal cortices. These findings establish SNCA as a definite susceptibility gene for sporadic PD... - Serotonin transporter gene promoter polymorphism and autism: a family-based genetic association study in Japanese populationShinko Koishi
Department of Psychiatry, Course of Specialized Clinical Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
Brain Dev 28:257-60. 2006..Therefore, further investigations by haplotype analyses are necessary to confirm the implications of genetic variants of the serotonin transporter in the etiology of autism... - Notch4 gene polymorphisms are not associated with autism in Japanese populationShinko Koishi
Am J Med Genet B Neuropsychiatr Genet 125:61-2. 2004 - Identification of NAD+-dependent isocitrate dehydrogenase 3 gamma-like (IDH3GL) gene and its genetic polymorphismsKoichi Okamoto
Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Kanagawa 259 1193, Isehara, Japan
Gene 323:141-8. 2003..We conclude that the IDH3GL gene sequence is a splice variant of the NELL1 gene and that it probably evolved from a transposed pseudogene of the IDH3 gene... - Genetic polymorphism of the swine major histocompatibility complex ( SLA) class I genes, SLA-1, -2 and -3Asako Ando
Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, 259 1193 Kanagawa, Japan
Immunogenetics 55:583-93. 2003.... - Toward identification of susceptibility genes for sporadic Parkinson's diseaseTatsushi Toda
Division of Functional Genomics, Department of Post Genomics and Diseases, Osaka University Graduate School of Medicine, 2 2 B9 Yamadaoka, Suita, 565 0871, Osaka, Japan
J Neurol 250:III40-3. 2003..9 x 10(-6)) on chromosome 1 where other studies showed a linkage. Genes in linkage disequilibrium with these markers may be associated with pathogenesis of PD... - A clinical feature associated with polymorphisms of the TNF region in Japanese patients with palmoplantar pustulosisKazuhiro Hashigucci
Department of Otolaryngology K H, Kitasato Institute Hospital, Tokyo, Japan
Hum Immunol 64:530-7. 2003..These results indicate that detection of polymorphisms at the TNF locus may be a marker for determination of the heterogeneity of the disease, and that the allelic variation may influence the susceptibility... - Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritisKoichi Okamoto
Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan
Am J Hum Genet 72:303-12. 2003..Therefore, the MHC may harbor RA genetic determinants affecting the innate and adaptive arms of the immune system... - Alu polymorphism within the MICB gene and association with HLA-B allelesJerzy K Kulski
Centre for Bioinformatics and Biological Computing, School of Information Technology, Murdoch University, Murdoch, 6150 Western Australia, Australia
Immunogenetics 53:975-9. 2002..157) [corrected] but was strongly associated with HLA-B17 (HLA-B57,HLA-B58) and HLA-B13. The AluyMICB locus provides a useful dimorphic marker for investigations on the level of linkage disequilibrium between MICB, MICA, and HLA-B loci... - Genetic association analysis using microsatellite markers in atopic dermatitisMariko Iizuka
Department of Dermatology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Tokai J Exp Clin Med 27:51-6. 2002..This distribution in close proximity to candidate loci for AD is very similar to that of atopic genes, therefore implying that an atopic trait is genetically responsible for the development of AD... - Association of HLA-DQ genotype in autoantibody-negative and rapid-onset type 1 diabetesShoichiro Tanaka
Third Department of Internal Medicine, Yamanashi Medical University, Japan
Diabetes Care 25:2302-7. 2002..However, little is known about genetic factors of this distinct subtype of diabetes (fulminant autoantibody-negative type 1 diabetes)... - MHC class IIB gene sequences and expression in quails (Coturnix japonica) selected for high and low antibody responsesSayoko Shimizu
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Bohseidai, Isehara-shi, 259-1193 Kanagawa, Japan
Immunogenetics 56:280-91. 2004..The antibody and class IIB gene expression data obtained in response to SRBC immunization provide further evidence that quails within the L line had reduced immunocompetence compared with those in the H line... - hRDH-E2 gene polymorphisms, variable transcriptional start sites, and psoriasisYasunari Matsuzaka
Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
Mamm Genome 15:668-75. 2004..On this basis, we conclude that the polymorphisms that we detected for the hRDH-E2 gene do not contribute to the etiology of psoriasis but may be important in diseases of other tissues... - Autoreactive CD8+ cytotoxic T lymphocytes to major histocompatibility complex class I chain-related gene A in patients with Behçet's diseaseHidekata Yasuoka
Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Arthritis Rheum 50:3658-62. 2004..Finally, MICA-stimulated T cell lines lysed the HLA-B51-expressing B cell line in the presence of MICA-TM. CONCLUSION: HLA-B51-restricted cytotoxic T lymphocytes autoreactive to MICA may be involved in the pathogenesis of BD... - The rise and fall of the CR1 subfamily in the lineage leading to penguinsMaiko Watanabe
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan
Gene 365:57-66. 2006..Hence, this work will be a cornerstone for elucidating the phylogenetic relationships in penguin evolution using the retroposon method... - Donor fibroblast chimerism in the pathogenic fibrotic lesion of human chronic graft-versus-host diseaseYoko Ogawa
Institute for Advanced Medical Research, Keio University School of Medicine, Shinanomachi, Tokyo, Japan
Invest Ophthalmol Vis Sci 46:4519-27. 2005..Fibroblasts originating from circulating donor-derived precursors may participate in the excessive fibrosis in these patients... - Gene expression profiling of Japanese psoriatic skin reveals an increased activity in molecular stress and immune response signalsJerzy K Kulski
Centre for Bioinformatics and Biological Computing, Murdoch University, South Street, Murdoch, Western Australia, 6150, Australia
J Mol Med (Berl) 83:964-75. 2005.... - [HLA typing and transplantation]Makoto Onizuka
Department of Molecular Life Science, Tokai University School of Medicine
Nippon Rinsho 63:1945-9. 2005..In order to have good survival of transplanted organ, HLA, cytokine promoter lesion and immunoglobulin like receptor genotyping might be helpful. We focused on this review at HLA genotyping, especially new SSO methods... - Genetic features of Khoton Mongolians revealed by SNP analysis of the X chromosomeToru Katoh
Molecular Life Science, School of Medicine, Tokai University, Bohseidai, Isehara, Kanagawa, 259-1193, Japan
Gene 357:95-102. 2005..However, the population structure analysis produced an additional finding, namely, that the Khoton population is likely to be an admixed population... - Whole genome association study of rheumatoid arthritis using 27 039 microsatellitesGen Tamiya
Department of Molecular Life Science, Course of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Bohseidai, Kanagawa, Japan
Hum Mol Genet 14:2305-21. 2005..Hence, microsatellite-based genome-wide association analysis complemented by end stage SNP typing provides a new tool for genetic dissection of multifactorial pathologies including common diseases... - Genomic evolution of MHC class I region in primatesKaoru Fukami-Kobayashi
RIKEN BioResource Center, RIKEN Tsukuba Institute, Tsukuba 305-0074, Japan
Proc Natl Acad Sci U S A 102:9230-4. 2005..These results support our inference that MHC-B and MHC-C duplicated after the divergence between apes and Old World monkeys... - Analysis of the sequence variations in the Mhc DRB1-like gene of the endangered Humboldt penguin (Spheniscus humboldti)Eri F Kikkawa
Department of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Kanagawa, Japan
Immunogenetics 57:99-107. 2005.... - Novel algorithm for automated genotyping of microsatellitesToshiko Matsumoto
Japan Biological Information Research Center, Japan Biological Informatics Consortium, Tokyo, Japan
Nucleic Acids Res 32:6069-77. 2004..Our algorithm is crucial for a high-throughput genotyping system for microsatellite markers by reducing manual editing and human errors... - Identification of novel candidate genes in the diffuse panbronchiolitis critical region of the class I human MHCYasunari Matsuzaka
Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
Immunogenetics 54:301-9. 2002..Taken together, these results, especially the abundant expression in lung, indicate that C6orf37 and C6orf37OS are excellent candidate genes for DPB...