Affiliation: Yokohama College of Pharmacy
- Ohrui H, Kohgo S, Hayakawa H, Kodama E, Matsuoka M, Nakata T, et al. 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma. Nucleosides Nucleotides Nucleic Acids. 2007;26:1543-6 pubmed..The nucleoside will prevent or delay the emergence of drug-resistant HIV-1 variants and be an ideal therapeutic agent for both HIV-1 and HBV infections. ..
- Ohrui H. A proposed structure of modified nucleosides expected to have high antiviral activity and low toxicity. Nucleosides Nucleotides Nucleic Acids. 2009;28:772-5 pubmed publisher..This article describes modified nucleosides with deactivated 3'-OH and modified at two or more positions. These are expected to have high antiviral activity as well as have low toxicity. ..