Hiroshi Ohrui

Summary

Affiliation: Yokohama College of Pharmacy
Country: Japan

Publications

  1. request reprint
    Ohrui H, Kohgo S, Hayakawa H, Kodama E, Matsuoka M, Nakata T, et al. 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma. Nucleosides Nucleotides Nucleic Acids. 2007;26:1543-6 pubmed
    ..The nucleoside will prevent or delay the emergence of drug-resistant HIV-1 variants and be an ideal therapeutic agent for both HIV-1 and HBV infections. ..
  2. Ohrui H. A proposed structure of modified nucleosides expected to have high antiviral activity and low toxicity. Nucleosides Nucleotides Nucleic Acids. 2009;28:772-5 pubmed publisher
    ..This article describes modified nucleosides with deactivated 3'-OH and modified at two or more positions. These are expected to have high antiviral activity as well as have low toxicity. ..

Detail Information

Publications2

  1. request reprint
    Ohrui H, Kohgo S, Hayakawa H, Kodama E, Matsuoka M, Nakata T, et al. 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma. Nucleosides Nucleotides Nucleic Acids. 2007;26:1543-6 pubmed
    ..The nucleoside will prevent or delay the emergence of drug-resistant HIV-1 variants and be an ideal therapeutic agent for both HIV-1 and HBV infections. ..
  2. Ohrui H. A proposed structure of modified nucleosides expected to have high antiviral activity and low toxicity. Nucleosides Nucleotides Nucleic Acids. 2009;28:772-5 pubmed publisher
    ..This article describes modified nucleosides with deactivated 3'-OH and modified at two or more positions. These are expected to have high antiviral activity as well as have low toxicity. ..