Kazuhiro Ogata

Summary

Affiliation: Yokohama City University
Country: Japan

Publications

  1. ncbi request reprint Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar
    Kazuhiro Ogata
    Department of Biochemistry, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Curr Opin Struct Biol 13:40-8. 2003
  2. ncbi request reprint [Biochemistry and structural biology in the post-genome era: search for the underlying mechanisms of biological molecules]
    Kazuhiro Ogata
    Department of Biochemistry Gene Regulation, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Seikagaku 76:1305-19. 2004
  3. ncbi request reprint Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter
    Tahir H Tahirov
    Kanagawa Academy of Science and Technology, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Cell 108:57-70. 2002
  4. doi request reprint Rational approach to the synthesis, evaluation, and (68)ga labeling of a novel 4-anilinoquinoline epidermal growth factor receptor inhibitor as a new imaging agent that selectively targets the epidermal growth factor receptor tyrosine kinase
    Chumpol Theeraladanon
    Department of Radiology, Yokohama City University, Japan
    Cancer Biother Radiopharm 25:479-85. 2010
  5. doi request reprint De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy
    Hirotomo Saitsu
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Nat Genet 40:782-8. 2008
  6. pmc Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy
    Hirotomo Saitsu
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Am J Hum Genet 89:644-51. 2011
  7. pmc De Novo Mutations in GNAO1, Encoding a Gαo Subunit of Heterotrimeric G Proteins, Cause Epileptic Encephalopathy
    Kazuyuki Nakamura
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan Department of Pediatrics, Yamagata University Faculty of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Am J Hum Genet 93:496-505. 2013
  8. pmc Dominant-negative mutations in alpha-II spectrin cause West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay
    Hirotomo Saitsu
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Am J Hum Genet 86:881-91. 2010
  9. doi request reprint NLRP4 negatively regulates autophagic processes through an association with beclin1
    Nao Jounai
    Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Immunol 186:1646-55. 2011
  10. doi request reprint The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b
    Kazunari Yamashita
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Biochem Biophys Res Commun 391:812-7. 2010

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar
    Kazuhiro Ogata
    Department of Biochemistry, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Curr Opin Struct Biol 13:40-8. 2003
    ..g. the Runx1-CBFbeta-DNA, NFAT-Fos-Jun-DNA, GABPalpha-GABPbeta-DNA, Ets-1-Pax-5-DNA and PU.1-IRF-4-DNA complexes) and afar with DNA looping (e.g. the c-Myb-C/EBPbeta-DNA complex), and their regulatory mechanisms...
  2. ncbi request reprint [Biochemistry and structural biology in the post-genome era: search for the underlying mechanisms of biological molecules]
    Kazuhiro Ogata
    Department of Biochemistry Gene Regulation, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Seikagaku 76:1305-19. 2004
  3. ncbi request reprint Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter
    Tahir H Tahirov
    Kanagawa Academy of Science and Technology, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Cell 108:57-70. 2002
    ....
  4. doi request reprint Rational approach to the synthesis, evaluation, and (68)ga labeling of a novel 4-anilinoquinoline epidermal growth factor receptor inhibitor as a new imaging agent that selectively targets the epidermal growth factor receptor tyrosine kinase
    Chumpol Theeraladanon
    Department of Radiology, Yokohama City University, Japan
    Cancer Biother Radiopharm 25:479-85. 2010
    ..68)Ga-GAP-YCU accumulated in the receptor-positive tumors, with uptake values of 1.50% +/- 0.09% and 2.36% +/- 0.36% of injected activity per gram tissue at 30 and 90 minutes, respectively...
  5. doi request reprint De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy
    Hirotomo Saitsu
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Nat Genet 40:782-8. 2008
    ..Furthermore, binding of the mutant protein to syntaxin was impaired. These findings suggest that haploinsufficiency of STXBP1 causes EIEE...
  6. pmc Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy
    Hirotomo Saitsu
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Am J Hum Genet 89:644-51. 2011
    ..We hypothesize that perturbation of Pol III target transcription, especially of tRNAs, could be a common pathological mechanism underlying POLR3A and POLR3B mutations...
  7. pmc De Novo Mutations in GNAO1, Encoding a Gαo Subunit of Heterotrimeric G Proteins, Cause Epileptic Encephalopathy
    Kazuyuki Nakamura
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan Department of Pediatrics, Yamagata University Faculty of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Am J Hum Genet 93:496-505. 2013
    ..These data suggest that aberrant Gαo signaling can cause multiple neurodevelopmental phenotypes, including epileptic encephalopathy and involuntary movements. ..
  8. pmc Dominant-negative mutations in alpha-II spectrin cause West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay
    Hirotomo Saitsu
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Am J Hum Genet 86:881-91. 2010
    ..These findings suggest that pathological aggregation of alpha/beta spectrin heterodimers and abnormal AIS integrity resulting from SPTAN1 mutations were involved in pathogenesis of infantile epilepsy...
  9. doi request reprint NLRP4 negatively regulates autophagic processes through an association with beclin1
    Nao Jounai
    Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Immunol 186:1646-55. 2011
    ....
  10. doi request reprint The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b
    Kazunari Yamashita
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Biochem Biophys Res Commun 391:812-7. 2010
    ..These results reveal a novel function of the rod domain of utrophin beyond that of a passive structural linker connecting the N- and C-terminal domain...
  11. pmc Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways
    Nobumoto Watanabe
    Antibiotics Laboratory, Discovery Research Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 102:11663-8. 2005
    ..Using a specific inhibitor of CK2, we showed that the phosphorylation-dependent degradation of Wee1A is important for the proper onset of mitosis...
  12. ncbi request reprint Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay
    Tomoko Morita
    Department of Life Sciences, Graduate School of Arts and Science, The University of Tokyo 153 8902, Japan
    J Biol Chem 282:7799-808. 2007
    ..These results indicated an unexpected feature of SMG-1, i.e. that distantly located N- and C-terminal sequences were essential for the intrinsic kinase activity...