Y Nagashima

Summary

Affiliation: Yokohama City University
Country: Japan

Publications

  1. ncbi request reprint Cytostatic effect of inostamycin, an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, on oral squamous cell carcinoma cell lines
    Y Baba
    Department of Otolaryngology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan
    Cell Biol Int 25:613-20. 2001
  2. ncbi request reprint Pathological and molecular biological aspects of the renal epithelial neoplasms, up-to-date
    Yoji Nagashima
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Pathol Int 54:377-86. 2004
  3. pmc Decreased Semaphorin3A expression correlates with disease activity and histological features of rheumatoid arthritis
    Shu Takagawa
    Department of Orthopaedic Surgery, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    BMC Musculoskelet Disord 14:40. 2013
  4. doi request reprint Transition of organizational category on renal cancer
    Yoji Nagashima
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Japan
    Jpn J Clin Oncol 43:233-42. 2013
  5. doi request reprint FLCN gene-mutated renal cell neoplasms: mother and daughter cases with a novel germline mutation
    Yoji Nagashima
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Int J Urol 19:468-70. 2012
  6. ncbi request reprint Renal oncocytosis
    Yoji Nagashima
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Pathol Int 55:210-5. 2005
  7. ncbi request reprint Chromophobe renal cell carcinoma with sarcomatoid change. A case report
    Y Nagashima
    Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
    Pathol Res Pract 196:647-51; discussion 652. 2000
  8. ncbi request reprint Chromophobe renal cell carcinoma: clinical, pathological and molecular biological aspects
    Y Nagashima
    Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
    Pathol Int 50:872-8. 2000
  9. ncbi request reprint Low-grade renal cell carcinoma arising from the lower nephron: a case report with immunohistochemical, histochemical and ultrastructural studies
    M Otani
    Department of Pathology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Pathol Int 51:954-60. 2001
  10. ncbi request reprint Identification and characterization of Birt-Hogg-Dubé associated renal carcinoma
    T Murakami
    Department of Urology and Molecular Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Pathol 211:524-31. 2007

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Cytostatic effect of inostamycin, an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, on oral squamous cell carcinoma cell lines
    Y Baba
    Department of Otolaryngology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan
    Cell Biol Int 25:613-20. 2001
    ..Moreover, flow cytometric analysis showed that inostamycin induced an increase in G1/G0 cells (1.2--3.2 fold) over 24 h. These results suggest that inostamycin is a useful agent for tumour dormant cytostatic therapy for oral SCC...
  2. ncbi request reprint Pathological and molecular biological aspects of the renal epithelial neoplasms, up-to-date
    Yoji Nagashima
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Pathol Int 54:377-86. 2004
    ..This review aims to present recent classification of renal parenchymal neoplasms based on their molecular biological characteristics, and future problems yet to be clarified...
  3. pmc Decreased Semaphorin3A expression correlates with disease activity and histological features of rheumatoid arthritis
    Shu Takagawa
    Department of Orthopaedic Surgery, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    BMC Musculoskelet Disord 14:40. 2013
    ..This study investigated whether Sema3A is expressed in synovial tissues, and is associated with disease activity and the histological features of synovial tissues from RA patients...
  4. doi request reprint Transition of organizational category on renal cancer
    Yoji Nagashima
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Japan
    Jpn J Clin Oncol 43:233-42. 2013
    ..In future, the classification of renal cell carcinoma should be reorganized on the basis of molecular biological characteristics to establish personalized therapeutic strategies...
  5. doi request reprint FLCN gene-mutated renal cell neoplasms: mother and daughter cases with a novel germline mutation
    Yoji Nagashima
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Int J Urol 19:468-70. 2012
    ..332_349del/p.H111_Q116del), predicting an alteration of the amino acid sequence of "HPSHPQ" replaced by a single amino acid, "L". This is a novel germline mutation of the FCLN gene that has not been previously reported...
  6. ncbi request reprint Renal oncocytosis
    Yoji Nagashima
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Pathol Int 55:210-5. 2005
    ..Despite the rare occurrence pathologists and urologists should be aware of renal oncocytosis, as a precursor lesion of renal oncocytoma and chromophobe renal cell carcinoma...
  7. ncbi request reprint Chromophobe renal cell carcinoma with sarcomatoid change. A case report
    Y Nagashima
    Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
    Pathol Res Pract 196:647-51; discussion 652. 2000
    ..It is necessary to perform careful postoperative investigation of chromophobe RCC due to its possible histological progression to the sarcomatoid subtype...
  8. ncbi request reprint Chromophobe renal cell carcinoma: clinical, pathological and molecular biological aspects
    Y Nagashima
    Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
    Pathol Int 50:872-8. 2000
    ..In order to adopt the most appropriate treatment, including gene therapy, recognition and correct pathological diagnosis of chromophobe RCC are extremely important...
  9. ncbi request reprint Low-grade renal cell carcinoma arising from the lower nephron: a case report with immunohistochemical, histochemical and ultrastructural studies
    M Otani
    Department of Pathology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Pathol Int 51:954-60. 2001
    ..0 and 1.7%, respectively. Considering its morphological and histochemical natures, this tumor is considered to have originated from the lower nephron, which is unique for a tumor of low-grade malignancy...
  10. ncbi request reprint Identification and characterization of Birt-Hogg-Dubé associated renal carcinoma
    T Murakami
    Department of Urology and Molecular Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Pathol 211:524-31. 2007
    ..The BHD-mutated RCC identified in this study, which exhibits heterogeneous biological features in both morphology and gene expression signatures, seems to deviate from our current understanding of renal tumour classification...
  11. pmc aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6
    Hitoshi Ishiguro
    Department of Urology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    Proc Natl Acad Sci U S A 106:16369-74. 2009
    ..Further, aPKClambda/iota expression might be a biomarker for prostate cancer progression...
  12. doi request reprint Prostaglandin E1 prevents liver failure after excessive hepatectomy in the rat by up-regulating Cyclin C, Cyclin D1, and Bclxl
    Atsushi Ishibe
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Wound Repair Regen 17:62-70. 2009
    ..Our results suggest that pretreatment with PGE1 may increase survival following hepatectomy by salvaging the remaining liver tissue, which it does by inhibiting apoptosis and stimulating hepatocyte proliferation...
  13. ncbi request reprint Matrilysin as a target for chemotherapy for colon cancer: use of antisense oligonucleotides as antimetastatic agents
    K Miyazaki
    Division of Cell Biology, Kihara Institute for Biological Research, Yokohama City University, Yokohama, Japan
    Cancer Chemother Pharmacol 43:S52-5. 1999
    ..These results suggest that matrilysin has an important role in the liver metastasis of human colon cancer and that matrilysin antisense oligonucleotides have therapeutic potential for the prevention of metastasis...
  14. ncbi request reprint High alkaline phosphatase activity in 3p-induced human renal cancer cells
    S Noguchi
    Department of Urology, Yokohama City University, School of Medicine, Yokohama, Japan
    Cancer Lett 131:223-7. 1998
    ....
  15. ncbi request reprint Mutation of von Hippel-Lindau tumor suppressor gene in a sporadic endolymphatic sac tumor
    S Hamazaki
    Department of Pathology, Okayama University Hospital, Okayama, Japan
    Hum Pathol 32:1272-6. 2001
    ..Sequencing studies of the tumor DNA disclosed a G to T substitution of nucleotide 564, which resulted in an amino acid substitution (Trp to Cys). This is the first report of the VHL gene mutation in a sporadic Japanese case of ELST...
  16. ncbi request reprint Desmoplastic small round-cell tumor of the paratesticular region: report of an adult case with demonstration of EWS and WT1 gene fusion using paraffin-embedded tissue
    N Kawano
    Division of Anatomic and Surgical Pathology, Hospital of Yokohama City University, Yokohama, Japan
    Mod Pathol 12:729-34. 1999
    ....
  17. ncbi request reprint Role of transforming growth factor-beta1 (TGF-beta1) in endotoxin-induced hepatic failure after extensive hepatectomy in rats
    Noboru Yoshimoto
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Endotoxin Res 11:33-9. 2005
    ..TGF-beta1 enhanced by LPS plays an important role in the mechanism of hepatic failure by infections after hepatectomy, especially in inhibition of liver regeneration, and induction of hepatocyte apoptosis and perisinusoidal fibrosis...
  18. ncbi request reprint Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: relationship to clinicopathological parameters
    Keiichi Kondo
    Department of Urology, Yokohama City University School of Medicine, Yokohama, Japan
    Genes Chromosomes Cancer 34:58-68. 2002
    ....
  19. ncbi request reprint Vascular cell adhesion molecule 1 predicts cancer-free survival in clear cell renal carcinoma patients
    Ko ichi Shioi
    Department of Urology and Molecular Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Clin Cancer Res 12:7339-46. 2006
    ..We measured VCAM1 expression levels in tumor tissues and evaluated its significance and prognostic use in renal cell carcinoma (RCC)...
  20. ncbi request reprint Pseudomonas aeruginosa-induced neutrophilic lung inflammation is attenuated by adenovirus-mediated transfer of the heme oxygenase 1 cDNA in mice
    Takahiro Tsuburai
    First Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama City 236 0004, Japan
    Hum Gene Ther 15:273-85. 2004
    ..It is thus suggested that HO-1 overexpression is useful for treating P. aeruginosa-associated lung inflammation by attenuating neutrophil influx and apoptotic cell death...
  21. ncbi request reprint Somatic von Hippel-Lindau disease gene mutation in clear-cell renal carcinomas associated with end-stage renal disease/acquired cystic disease of the kidney
    Minoru Yoshida
    Department of Urology, Yokohama City University School of Medicine, Yokohama, Japan
    Genes Chromosomes Cancer 35:359-64. 2002
    ..However, mutations of the MET oncogene could not be found in the seven ESRD/ACDK-associated papillary RCCs examined...
  22. ncbi request reprint Role of nitric oxide in human gastric cancer cells treated with 5-fluorouracil
    T Oshima
    First Department of Surgery, Yokohama City University, School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama City, Kanagawa ken 236 0004, Japan
    Oncol Rep 8:847-9. 2001
    ..5-FU induces NO production by gastric cancer cells, and NO participates in antitumor activity in gastric cancer cells. These effects may be mediated by TNF-alpha production...
  23. ncbi request reprint Marked increase of trypsin(ogen) in serum of linitis plastica (gastric cancer, borrmann 4) patients
    Y Ichikawa
    Second Department of Surgery, Yokohoma City University School of Medicine, Yokohama, Japan
    Clin Cancer Res 6:1385-8. 2000
    ..Therefore, serum concentration of trypsin(ogen) might be a good marker of gastric cancer of linitis plastica...
  24. ncbi request reprint Correlation of immunohistochemical p53 labeling index with inhibition rate in chemosensitivity test in gastric and colon cancer
    N Hosaka
    Second Department of Surgery and Department of Pathology, Yokohama City University, School of Medicine, 3-9 Fukuura Kanazawa-ku, Yokohama, Japan
    Anticancer Res 21:229-35. 2001
    ..We therefore concluded that immunohistochemical studies for p53 and p21 were useful for predicting the chemosensitivities of colon and gastric cancer to MMC and 5-FU...
  25. ncbi request reprint A good model of hepatic failure after excessive hepatectomy in mice
    Hirochika Makino
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Surg Res 127:171-6. 2005
    ..This study was intended to establish in mice: 1) a safety limit for the extent of hepatectomy and 2) the extent of hepatectomy invariably causing fatal hepatic failure, to facilitate gene expression analysis...
  26. doi request reprint Expression of laminin gamma2 chain monomer enhances invasive growth of human carcinoma cells in vivo
    Yoshiaki Tsubota
    Division of Cell Biology, Kihara Institute for Biological Research, Yokohama City University, Totsuka ku, Yokohama, Japan
    Int J Cancer 127:2031-41. 2010
    ..These findings imply that the gamma2 monomer is induced in human cancers by inflammatory and stromal cytokines and promotes their invasive growth in vivo...
  27. ncbi request reprint A rat model of a repeat 70% major hepatectomy
    Shuji Saito
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Surg Res 134:322-6. 2006
    ..This study investigated the effects of a repeat 70% major hepatectomy in a rat model...
  28. ncbi request reprint VEGF receptor antisense therapy inhibits angiogenesis and peritoneal dissemination of human gastric cancer in nude mice
    Masako Kamiyama
    Department of Surgery II, Yokohama City University, School of Medicine, Yokohama, Japan
    Cancer Gene Ther 9:197-201. 2002
    ..Microvessel density was significantly reduced in the KDR/Flk-1-ASO-treated tumor nodules. The KDR/Flk-1 antisense strategy, therefore, decreases tumor dissemination apparently by inhibiting angiogenesis...
  29. ncbi request reprint Inhibition of growth of human prostate cancer xenograft by transfection of p53 gene: gene transfer by electroporation
    Kunihisa Mikata
    Department of Urology, Department of Pathology, Yokohama City University School of Medicine, Yokohama, 236 0004, Japan
    Mol Cancer Ther 1:247-52. 2002
    ....
  30. doi request reprint Renal collecting duct carcinoma in a dog
    N Kobayashi
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, B252, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Vet Pathol 45:489-94. 2008
    ..To our knowledge, this is the first case report of CDC in animals...
  31. ncbi request reprint Intrarenal mature cystic teratoma associated with renal dysplasia: case report and literature review
    M Otani
    Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan
    Pathol Int 51:560-4. 2001
    ..Extragonadal teratoma occurs predominantly along the median line of the body. Intrarenal teratoma is extremely rare; however, it should be distinguished from teratoid Wilms' tumor and other renal cystic lesions...
  32. ncbi request reprint Pigmented intraosseous odontogenic carcinoma of the maxilla: a pediatric case report and differential diagnosis
    R Ijiri
    Division of Pathology, Kanagawa Children's Medical Center, Yokohama, Japan
    Hum Pathol 32:880-4. 2001
    ..We consider that the present tumor suggests a close association of ectoderm, mesenchyma, and neuroectoderm in embryogenesis of the tooth, and can raise a diagnostic confusion with melanotic neuroectodermal tumor...
  33. ncbi request reprint Prostaglandin E1 improves survival rate after 95% hepatectomy in rats
    Shinji Togo
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Surg Res 146:66-72. 2008
    ..In this study, we examined the effect of a nontoxic HSP-inducer, PGE1, on acute liver failure after 95% hepatectomy in rats...
  34. ncbi request reprint Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma
    Masahiro Yao
    Department of Urology and Molecular Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Pathol 205:377-87. 2005
    ..Moreover ADFP expression status may provide useful prognostic information as a biomolecular marker in patients with clear-cell RCC...
  35. ncbi request reprint Inactivation of von Hippel-Lindau gene induces constitutive phosphorylation of MET protein in clear cell renal carcinoma
    Noboru Nakaigawa
    Departments of Urology and Molecular Pathology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura Kanazawaku, Yokohama 236 0004, Japan
    Cancer Res 66:3699-705. 2006
    ..This is one of the mechanisms of CCRC oncogenesis, and MET protein has potential as a molecular target for novel CCRC therapies...
  36. ncbi request reprint An immunohistochemical scoring system of prolyl isomerase Pin1 for predicting relapse of prostate carcinoma after radical prostatectomy
    Takeshi Sasaki
    Division of Surgical Pathology, Yokohama City University Medical Center, Urafunecho, Minami Ku, Yokohama, Kanagawa 232 0024, Japan
    Pathol Res Pract 202:357-64. 2006
    ..0001). This suggests that, at the common laboratory level, our Pin1 scoring system could be a useful tool for predicting the prognosis of PCa patients after surgery...
  37. doi request reprint A three-gene expression signature model to predict clinical outcome of clear cell renal carcinoma
    Masahiro Yao
    Department of Urology and Molecular Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Int J Cancer 123:1126-32. 2008
    ....
  38. ncbi request reprint Expression of adipose differentiation-related protein: a predictor of cancer-specific survival in clear cell renal carcinoma
    Masahiro Yao
    Department of Urology and Molecular Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Clin Cancer Res 13:152-60. 2007
    ..To further evaluate the correlation between ADFP expression levels and clinicopathologic characteristics and patient outcome, we retrospectively examined patients with clear cell RCC...
  39. ncbi request reprint Antiproliferative activity of angiotensin II receptor blocker through cross-talk between stromal and epithelial prostate cancer cells
    Hiroji Uemura
    Department of Urology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Mol Cancer Ther 4:1699-709. 2005
    ..Because prostate stromal cells are thought to be involved in the initiation and development of prostate cancer, the present data suggest the possibility that ARBs are a novel therapeutic class of agents for prostate cancer...
  40. ncbi request reprint Heme oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injury
    Takashi Sato
    Department of Internal Medicine and Clinical Immunology, Yokohama City University, and Rosai Hospital for Silicosis, Tochigi, Japan
    Am J Respir Crit Care Med 174:906-14. 2006
    ..Heme oxygenase-1 (HO-1), a rate-limiting enzyme in heme catabolism, has antioxidative, antiapoptotic, and antiinflammatory activities. We examined whether HO-1 might be involved in silicosis...
  41. doi request reprint Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome
    Noriko Miyake
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Hum Mutat 31:966-74. 2010
    ..These findings indicate the important role of decorin DS in the extracellular matrix and a novel pathomechanism in EDS...
  42. ncbi request reprint MMP-7 (matrilysin) accelerated growth of human umbilical vein endothelial cells
    Nailin Huo
    Department of Surgery 2, Yokohama City University School of Medicine, 3 9 Fukuura Kanazawa ku, Yokohama 236 0004, Japan
    Cancer Lett 177:95-100. 2002
    ..From this study, we conclude that MMP-7 directly induces angiogenesis, and that therefore MMP-7 would be a good target of cancer therapy...
  43. doi request reprint The topoisomerase II alpha gene status in primary breast cancer is a predictive marker of the response to anthracycline-based neoadjuvant chemotherapy
    Kae Kawachi
    Division of Anatomic and Surgical Pathology, Yokohama City University Medical Center, Minami Ku, Yokohama, Japan
    Pathol Res Pract 206:156-62. 2010
    ..TOP2A overexpression was not significantly associated with response (p=0.580). Our results thus suggest that the TOP2A/CEP17 ratio may be a useful predictor of the effects of anthracycline-based neoadjuvant chemotherapy in breast cancer...
  44. ncbi request reprint Reduction of in vivo tumor growth by MMI-166, a selective matrix metalloproteinase inhibitor, through inhibition of tumor angiogenesis in squamous cell carcinoma cell lines of head and neck
    Hideaki Katori
    Department of Otolaryngology, Yokohama City University School of Medicine, 3 9 Fukuuna, Kanazawa Ku, Yokohama 236 0004, Japan
    Cancer Lett 178:151-9. 2002
    ..Therefore, MMI-166 seems to be useful for tumor dormancy therapy of SCCHN...
  45. ncbi request reprint Label-free biomedical imaging of hydrodynamics in single human cells
    Hisanori Fukunaga
    Yokohama City University School of Medicine, Yokohama, Japan
    Biomed Res 31:177-81. 2010
    ....
  46. ncbi request reprint Aberrant nuclear localization and gene mutation of beta-catenin in low-grade adenocarcinoma of fetal lung type: up-regulation of the Wnt signaling pathway may be a common denominator for the development of tumors that form morules
    Yukio Nakatani
    Division of Anatomic and Surgical Pathology, Hospital of Yokohama City University, Yokohama City University School of Medicine, Japan
    Mod Pathol 15:617-24. 2002
    ....
  47. doi request reprint Sebaceous carcinoma of the breast
    Ayumi Murakami
    Department of Pathology, Yokohama City University Medical Center, Yokohama, Japan
    Pathol Int 59:188-92. 2009
    ..This is the first case of an androgen receptor-positive mammary SC to be reported, and therefore contributes to the understanding of the clinicopathological features of SC of the breast...
  48. ncbi request reprint VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma
    Masahiro Yao
    Department of Urology, Yokohama City University School of Medicine, Japan
    J Natl Cancer Inst 94:1569-75. 2002
    ..However, the prognostic utility of VHL mutations has not been examined. The purpose of this study was to explore the association between VHL mutations and the risk of death from sporadic clear-cell RCC...
  49. ncbi request reprint Von Hippel-Lindau tumor suppressor protein transforms human neuroblastoma cells into functional neuron-like cells
    Hidetoshi Murata
    Departments of Neurosurgery, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    Cancer Res 62:7004-11. 2002
    ....
  50. doi request reprint Transfection of NF-kappaB decoy oligodeoxynucleotides into macrophages reduces murine fatal liver failure after excessive hepatectomy
    Takuji Takahashi
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Surg Res 154:179-86. 2009
    ..This study was aimed at evaluating whether the selective suppression of nuclear factor kappa B (NF-kappaB) in macrophages by decoy oligodeoxynucleotides (ODN) could prevent liver failure after excessive hepatectomy...
  51. ncbi request reprint Angiotensin II receptor blocker shows antiproliferative activity in prostate cancer cells: a possibility of tyrosine kinase inhibitor of growth factor
    Hiroji Uemura
    Department of Urology, First Department of Physiology, and Second Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Mol Cancer Ther 2:1139-47. 2003
    ..These results suggest the possibility that ARB is a novel therapeutic class of agents for prostate cancer, especially hormone-independent tumors...
  52. ncbi request reprint Chromophobe renal cell carcinoma with sarcomatoid transformation in a dog
    Naohito Kobayashi
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, B252, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    J Vet Diagn Invest 22:983-7. 2010
    ..Because these histopathologic features are identical to those of human chromophobe renal cell carcinoma, the present case was diagnosed as canine chromophobe renal cell carcinoma...
  53. ncbi request reprint Effect of lung-protective ventilation on severe Pseudomonas aeruginosa pneumonia and sepsis in rats
    Kiyoyasu Kurahashi
    Department of Anesthesiology and Critical Care Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 236 0004
    Am J Physiol Lung Cell Mol Physiol 287:L402-10. 2004
    ..Furthermore, low V(T) ventilation cannot protect the involved lung, and high PEEP did not significantly alter lung injury over a short time course...
  54. pmc Immune response induced by airway sensitization after influenza A virus infection depends on timing of antigen exposure in mice
    N Yamamoto
    Departments of Internal Medicine, Yokohama City University School of Medicine, Kanazawa Ku, Yokohama 236 0004, Japan
    J Virol 75:499-505. 2001
    ..These results indicate that the timing of antigen sensitization after viral infection determines the type of immune response...
  55. ncbi request reprint Development of an orthotopic transplantation model in nude mice that simulates the clinical features of human lung cancer
    Yun Kang
    Department of Radiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan
    Cancer Sci 97:996-1001. 2006
    ..The SQ5 solid tumors invaded bronchioles and occupied the alveoli. This reproducible orthotopic transplantation model produced tumor growth that simulated the clinical features of human lung cancer...
  56. doi request reprint Expression of aquaporin 1 in primary renal tumors: a prognostic indicator for clear-cell renal cell carcinoma
    Ying Huang
    Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Eur Urol 56:690-8. 2009
    ..Aquaporin 1 (AQP1) is a water channel expressed in many epithelial tissues and endothelium, including the proximal nephron of the kidney...
  57. ncbi request reprint PAI-1 plays an important role in liver failure after excessive hepatectomy in the rat
    Kazuteru Watanabe
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Surg Res 143:13-9. 2007
    ....
  58. doi request reprint High expression of atypical protein kinase C lambda/iota in gastric cancer as a prognostic factor for recurrence
    Ryo Takagawa
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Ann Surg Oncol 17:81-8. 2010
    ..This study aimed to clarify the relationship between aPKClambda/iota expression and the clinicopathological features of gastric cancer...
  59. doi request reprint Antitumour effect of electrochemotherapy with bleomycin on human prostate cancer xenograft
    Tei ichiro Ueki
    Department of Urology, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
    BJU Int 102:1467-71. 2008
    ..To investigate the antitumour effect of electroporation (EP), a drug delivery system that has been shown to be effective synergistically with antitumour drugs, with bleomycin on the growth of prostate cancer xenografts in nude mice...
  60. doi request reprint Collecting duct carcinoma of the kidney: an immunohistochemical evaluation of the use of antibodies for differential diagnosis
    Naohito Kobayashi
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Hum Pathol 39:1350-9. 2008
    ....
  61. doi request reprint The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors
    Yasuyuki Kojima
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Hum Pathol 39:824-31. 2008
    ..This is also the first evidence to show aPKC lambda/iota overexpression in breast cancer and demonstrates that its localization is associated with the trend of pathologic type of the tumor...
  62. doi request reprint Role of nitric oxide synthesized by nitric oxide synthase 2 in liver regeneration
    Takafumi Kumamoto
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Liver Int 28:865-77. 2008
    ..However, the role of NOS2-synthesized NO in post-PHx liver regeneration remains unclear. We investigated the role of NOS2-synthesized NO in liver regeneration...
  63. ncbi request reprint Adenovirus-mediated transfer and overexpression of heme oxygenase 1 cDNA in lungs attenuates elastase-induced pulmonary emphysema in mice
    Takeshi Shinohara
    Department of Internal Medicine and Clinical Immunology, Yokohama City University School of Medicine, Kanazawa, Yokohama, Kanagawa 236 0004, Japan
    Hum Gene Ther 16:318-27. 2005
    ..These results suggest that Ad.HO-1-induced HO-1 overexpression suppressed PPE-induced emphysema by attenuating neutrophilic inflammation via modulating cytokine and chemokine profiles in mouse lungs...
  64. ncbi request reprint Adenovirus-mediated transfer and overexpression of heme oxygenase 1 cDNA in lung prevents bleomycin-induced pulmonary fibrosis via a Fas-Fas ligand-independent pathway
    Takahiro Tsuburai
    First Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Hum Gene Ther 13:1945-60. 2002
    ....
  65. ncbi request reprint Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation
    Tomonori Hirose
    Department of Molecular Biology, Yokohama City University School of Medicine, Kanazawa Ku, Japan
    J Cell Sci 115:2485-95. 2002
    ..Together, our present data suggest that ASIP/PAR-3 regulates epithelial tight junction formation positively through interaction with aPKC...
  66. ncbi request reprint Reduced expression of p16 and p27 proteins in nasopharyngeal carcinoma
    Y Baba
    Department of Otolaryngology, Yokohama City University School of Medicine, Japan
    Cancer Detect Prev 25:414-9. 2001
    ..022), suggesting that the reduction of p27 protein is an important event for the multi-step process of NPC development...
  67. ncbi request reprint Expression of serine proteinase inhibitor PP5/TFPI-2/MSPI decreases the invasive potential of human choriocarcinoma cells in vitro and in vivo
    M Jin
    Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Yokohama, 241-0815, Japan
    Gynecol Oncol 83:325-33. 2001
    ..It is suggested that loss or suppression of PP5/TFPI-2/MSPI expression may result in the acquisition of invasiveness in choriocarcinoma cells...
  68. ncbi request reprint Transfer of heme oxygenase 1 cDNA by a replication-deficient adenovirus enhances interleukin 10 production from alveolar macrophages that attenuates lipopolysaccharide-induced acute lung injury in mice
    S Inoue
    First Department of Internal Medicine, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama, Kanagawa, 236-0004, Japan
    Hum Gene Ther 12:967-79. 2001
    ....
  69. ncbi request reprint PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines
    K Kondo
    Department of Urology, Yokohama City University School of Medicine, Yokohama, Japan
    Int J Cancer 91:219-24. 2001
    ..Our data suggest that PTEN mutation is observed in a subset of RCCs and that, especially in clear-cell RCCs, it occurs as a late-stage event and may contribute to the invasive and/or metastatic tumor phenotype...
  70. doi request reprint Epithelioid angiomyolipoma of the kidney
    Ikuma Kato
    Division of Anatomical and Surgical Pathology, Yokohama City University Hospital, Yokohama, Japan
    Pathol Int 59:38-43. 2009
    ..The possibility of eAMLoma should be evaluated as a diagnostic candidate, especially in cases of renal tumors (i) in young patients; (ii) associated with TSC; or (iii) with an epithelioid morphology and a high nuclear grade...
  71. ncbi request reprint The expression of vascular endothelial growth factor-A and -C, and receptors 1 and 3: correlation with lymph node metastasis and prognosis in tongue squamous cell carcinoma
    Yuji Tanigaki
    Department of Biology and Function in the Head and Neck, Yokohama City University Graduate School of Medicine, Kanazawa Ku, Yokohama 236 0004, Japan
    Int J Mol Med 14:389-95. 2004
    ..VEGF-C expression may be a predictive factor of regional lymph node recurrence and prognosis in patients with tongue carcinoma...
  72. doi request reprint Inhibition of peroxisome proliferator-activated receptor gamma activity suppresses pancreatic cancer cell motility
    Atsushi Nakajima
    Division of Gastroenterology, Yokohama City University School of Medicine, Yokohama, Japan
    Cancer Sci 99:1892-900. 2008
    ..Based on these findings, PPARgamma could function as a novel target for the therapeutic control of cancer cell invasion or metastasis...
  73. ncbi request reprint Mucinous tubular and spindle cell carcinoma of the kidney: Report of a case with imprint cytologic features
    Masako Otani
    Department of Pathology, Shinshu University School of Medicine, Shinshu, Japan
    Acta Cytol 50:680-2. 2006
    ..The tumor has a good prognosis, and its diagnosis is clinically important. However, there are no reports of its cytologic features. Here we report the cytologic findings of this rare tumor...
  74. ncbi request reprint Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit
    Yohei Miyagi
    Departments of Pathology and Bacteriology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    J Neurosci 22:803-14. 2002
    ..Thus, Delphilin is a postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GluRdelta2 with actin cytoskeleton and various signaling molecules...
  75. ncbi request reprint Prognostic value of integrin beta1-ILK-pAkt signaling pathway in non-small cell lung cancer
    Mayumi Okamura
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Hum Pathol 38:1081-91. 2007
    ..Thus, further studies of the integrin beta1-integrin-linked kinase-pAkt signaling pathway may provide a novel prognostic marker and therapeutic target for non-small cell lung cancer...
  76. ncbi request reprint Lung pathology of pale ear mouse (model of Hermansky-Pudlak syndrome 1) and beige mouse (model of Chediak-Higashi syndrome): severity of giant lamellar body degeneration of type II pneumocytes correlates with interstitial inflammation
    Xiaoyan Tang
    Department of Pathology, Tokyo Hospital, Tokai University School of Medicine, Tokyo, Japan
    Pathol Int 55:137-43. 2005
    ..The results of the present study support the hypothesis that GLBD may play an important role in the development of HPSIP. Ep and bg mice, especially the latter, may be useful mouse models of HPSIP...
  77. doi request reprint Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease
    Yuichi Nozaki
    Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Hepatol 51:548-56. 2009
    ..In this study, we propose a novel combination therapy for NAFLD comprising ezetimibe (EZ), a cholesterol absorption inhibitor, and acarbose (AC), an alpha-glucosidase inhibitor...
  78. ncbi request reprint Prolactin inhibits apoptosis of ovarian carcinoma cells induced by serum starvation or cisplatin treatment
    Mikiko Asai-Sato
    Department of Obstetrics, Gynecology and Molecular Reproductive Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Int J Cancer 115:539-44. 2005
    ..These findings indicate a responsiveness of ovarian carcinomas to prolactin and suggest that the prolactin/prolactin receptor system may be a new therapeutic target of ovarian carcinomas...
  79. ncbi request reprint Extramammary Paget's disease: analysis of growth signal pathway from the human epidermal growth factor receptor 2 protein
    Toru Ogawa
    Department of Environmental Immunodermatology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Hum Pathol 36:1273-80. 2005
    ....
  80. ncbi request reprint Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue
    Kyoko Yoneda
    Gastroenterology Division, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama, Japan
    Oncol Rep 20:479-83. 2008
    ..Further studies are required to elucidate the function of the AdipoRs activated by adiponectin and the downstream mechanisms of AdipoRs in colon cancer cells...
  81. doi request reprint Metformin suppresses intestinal polyp growth in ApcMin/+ mice
    Ayako Tomimoto
    Division of Gastroenterology, Yokohama City School of Medicine, Kanazawa, Yokohama, Japan
    Cancer Sci 99:2136-41. 2008
    ..Metformin suppressed the polyp growth in Apc(Min/+) mice, suggesting that it may be a novel candidate as a chemopreventive agent for colorectal cancer...
  82. ncbi request reprint Expression of SPARC in tongue carcinoma of stage II is associated with poor prognosis: an immunohistochemical study of 86 cases
    Yasumasa Kato
    Department of Biology and Function in the Head and Neck, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Int J Mol Med 16:263-8. 2005
    ..7%) (p < 0.01, chi2 test). Together with these results, SPARC can be a beneficial prognostic marker for the stage II tongue carcinoma, of which clinical outcomes are sometimes difficult to predict...
  83. doi request reprint Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice: implications for human disease
    Mio Kirino
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Allergy Clin Immunol 122:290-7, 297.e1-8. 2008
    ..Oxidative stress has been implicated in the exacerbation of atopic dermatitis (AD)...
  84. ncbi request reprint Composite distal nephron-derived renal cell carcinoma with chromophobe and collecting duct carcinomatous elements
    Naomi Kawano
    Division of Anatomical and Surgical Pathology, Yokohama City University Hospital, Yokohama, Japan
    Pathol Int 55:360-5. 2005
    ..Along with the previous reports, the present case seemed to be composite RCC derived from the collecting duct, which might present clues to elucidate carcinogenesis in the distal nephron...
  85. ncbi request reprint 5-aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated cancer in a mouse colitis model
    Ikuko Ikeda
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Clin Cancer Res 13:6527-31. 2007
    ..We therefore investigated the possible inhibition by peroxisome proliferator-activated receptor-gamma (PPARgamma) ligands and 5-ASA of colitis-associated colon carcinogenesis in a mouse model...
  86. ncbi request reprint Specific expression of PP5/TFPI2 mRNA by syncytiotrophoblasts in human placenta as revealed by in situ hybridization
    K Udagawa
    Department of Obstetrics, Yokohama City University School of Medicine, Yokohama, Japan
    Placenta 19:217-23. 1998
    ..Also, Northern analysis demonstrated no or little expression of PP5/TFPI-2 in four choriocarcinoma cell lines, in contrast to its abundant expression in syncytiotrophoblast...
  87. ncbi request reprint The expression of corticotropin-releasing hormone in melanoma
    Hirofumi Sato
    Department of Dermatology, Kobe University School of Medicine, Japan
    Pigment Cell Res 15:98-103. 2002
    ..CRH induced POMC mRNA expression, an effect that was inhibited by a CRH antagonist. These results provide evidence for the existence of the CRH/POMC axis in pigmented lesions...
  88. ncbi request reprint Collecting duct (Bellini duct) renal cell carcinoma: a nationwide survey in Japan
    Noriaki Tokuda
    Department of Urology, Saga Prefectural Koseikan Hospital, 1 12 9 Mizugae, Saga 840 8571, Japan
    J Urol 176:40-3; discussion 43. 2006
    ..Collecting duct carcinoma, a rare type of renal cell carcinoma, remains poorly understood. To analyze the nature of collecting duct carcinoma a retrospective survey was performed in Japan...
  89. ncbi request reprint Prior induction of heme oxygenase-1 with glutathione depletor ameliorates the renal ischemia and reperfusion injury in the rat
    Saburo Horikawa
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Japan
    FEBS Lett 510:221-4. 2002
    ..Administration of zinc-protoporphyrin IX, an inhibitor of HO activity, reduced the efficacy of BSO pretreatment on the renal IR injury. Our findings suggest that the prior induction of HO-1 ameliorates the subsequent renal IR injury...
  90. ncbi request reprint Promotion of bladder cancer development and progression by androgen receptor signals
    Hiroshi Miyamoto
    Department of Pathology, University of Rochester Medical Center, 601 Elmwood Ave, Box 626, Rochester, NY 14642, USA
    J Natl Cancer Inst 99:558-68. 2007
    ..Unlike prostate cancer, human bladder cancer is not generally considered to be dependent on hormone activity. We investigated the possible involvement of androgens and the androgen receptor (AR) in bladder cancer...
  91. ncbi request reprint ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomas
    Kohei Shomori
    Division of Organ Pathology, Department of Microbiology and Pathology, Tottori University, Yonago, Tottori, Japan
    Mod Pathol 20:199-207. 2007
    ....
  92. ncbi request reprint Negative growth control of renal cell carcinoma cell by connexin 32: possible involvement of Her-2
    Eriko Fujimoto
    Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Mol Carcinog 40:135-42. 2004
    ..These data suggest that Cx32 has negative growth control of Caki-2 cells, partly due to the inhibition of the Her-2 activation...
  93. ncbi request reprint [Chromophobe renal cell carcinoma: a clinicopathological study of 16 cases]
    Noboru Nakaigawa
    Department of Urology, Yokohama City University Graduate School of Medicine
    Hinyokika Kiyo 52:1-6. 2006
    ..The increase in CRP or IAP could predict poor prognosis in such cases...
  94. ncbi request reprint Connexin32 as a tumor suppressor gene in a metastatic renal cell carcinoma cell line
    Eriko Fujimoto
    Department of Food Science Research for Health, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku, 162 8636 Tokyo, Japan
    Oncogene 24:3684-90. 2005
    ..These data suggest that Cx32 acts as a tumor suppressor gene in Caki-1 cells and that the tumor-suppressive effect partly depends on the inhibition of Src-Stat3-VEGF signal pathway...
  95. ncbi request reprint Hemolysate pretreatment ameliorates ischemic acute renal injury in rats
    Rika Yoneya
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Nephron 92:407-13. 2002
    ..Prior injection of self-hemolysate would be clinically useful for the protection against the renal IR injury induced by kidney transplantation and kidney surgery without immunological and infectious problems...
  96. ncbi request reprint A Src family inhibitor (PP1) potentiates tumor-suppressive effect of connexin 32 gene in renal cancer cells
    Eriko Fujimoto
    Department of Food Science Research for Health, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan Faculty of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Life Sci 76:2711-20. 2005
    ..These results suggest that PP1 potentiates tumor-suppressive effect of connexin 32 gene in renal cancer cells through the reduction of anti-apoptotic molecules...
  97. ncbi request reprint The inhibitory effect of connexin 32 gene on metastasis in renal cell carcinoma
    Hiromi Sato
    Project for Complementary Factors, National Institute of Health and Nutrition, Shinjuku ku, Tokyo, Japan
    Mol Carcinog 47:403-9. 2008
    ..These results suggest that Cx32 inhibits hypoxia adaptation governed by HIF-2alpha, and this may help to reduce the metastasis of RCC cells...
  98. ncbi request reprint Mutations of c-kit gene in bilateral testicular germ cell tumours in Japan
    Yuji Sakuma
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Nakao 1 1 2, Asahi ku, Yokohama 241 0815, Japan
    Cancer Lett 259:119-26. 2008
    ..No mutations, however, were observed in bilateral TGCTs. Thus, the presence of c-kit gene mutations in TGCTs may not be associated with bilateral diseases, at least in Japan...
  99. ncbi request reprint Contribution of the Src family of kinases to the appearance of malignant phenotypes in renal cancer cells
    Yuko Yonezawa
    Department of Food Science Research for Health, National Institute of Health and Nutrition, Tokyo, Japan
    Mol Carcinog 43:188-97. 2005
    ..These results suggested that Src contributed to the appearance of malignant phenotypes in renal cancer cells, particularly due to the resistance against apoptosis by Bcl-xL and angiogenesis stimulated by Src-Stat3-VEGF signaling...
  100. ncbi request reprint Forced expression of antisense 14-3-3beta RNA suppresses tumor cell growth in vitro and in vivo
    Akinori Sugiyama
    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Yamazaki 2641, Noda shi, Chiba 278 8510, Japan
    Carcinogenesis 24:1549-59. 2003
    ..In addition, over-expression of 14-3-3beta mRNA was observed in various murine tumor cell lines. These results suggest that 14-3-3beta gene plays a pivotal role in abnormal growth of tumor cells in vitro and in vivo...
  101. ncbi request reprint [A case of recurrent renal cell carcinoma which recurred after fourth surgical resection and survived for about 2 years by medroxyporgesterone acetate administration]
    Koji Izumi
    The Department of Urology, Toshiba Rinkan Hospital
    Hinyokika Kiyo 53:623-6. 2007
    ..After that, medroxyprogesterone acetate (MPA) and UFT were administered; the patient lived 20 months with relatively good performance status and died in February 2004. MPA might be considered as a drug for advanced renal cell carcinoma...