Yohei Miyagi

Summary

Affiliation: Yokohama City Institute of Health
Country: Japan

Publications

  1. pmc Annexin A4 is involved in proliferation, chemo-resistance and migration and invasion in ovarian clear cell adenocarcinoma cells
    Tae Mogami
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan Department of Obstetrics and Gynecology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    PLoS ONE 8:e80359. 2013
  2. pmc HIF2α-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells
    Shiro Koizume
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Nucleic Acids Res 40:5389-401. 2012
  3. pmc Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells
    N Yokota
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 1 1 2 Nakao Asahi ku, 241 0815 Yokohama, Japan
    Br J Cancer 101:2023-9. 2009
  4. doi request reprint ETS family-associated gene fusions in Japanese prostate cancer: analysis of 194 radical prostatectomy samples
    Yohei Miyagi
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    Mod Pathol 23:1492-8. 2010
  5. pmc Plasma free amino acid profiling of five types of cancer patients and its application for early detection
    Yohei Miyagi
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center, Yokohama, Japan
    PLoS ONE 6:e24143. 2011
  6. pmc Hepatocyte nuclear factor-4-independent synthesis of coagulation factor VII in breast cancer cells and its inhibition by targeting selective histone acetyltransferases
    Shiro Koizume
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Mol Cancer Res 7:1928-36. 2009
  7. doi request reprint Enhanced autophagy is required for survival in EGFR-independent EGFR-mutant lung adenocarcinoma cells
    Yuji Sakuma
    1 Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan 2 Laboratory for Molecular Diagnostics, Kanagawa Cancer Center Hospital, Yokohama, Japan 3 Department of Pathology, Jichi Medical University, Tochigi, Japan
    Lab Invest 93:1137-46. 2013
  8. doi request reprint WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors
    Yuji Sakuma
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Asahi ku, Yokohama, Japan
    Lab Invest 92:371-83. 2012
  9. ncbi request reprint Epidermal growth factor receptor gene mutations in atypical adenomatous hyperplasias of the lung
    Yuji Sakuma
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Kanagawa Cancer Center Hospital, Asahi ku, Yokohama, Japan
    Mod Pathol 20:967-73. 2007
  10. ncbi request reprint Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII
    Shiro Koizume
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Asahi ku, Yokohama 241 0815, Japan
    Cancer Res 66:9453-60. 2006

Detail Information

Publications69

  1. pmc Annexin A4 is involved in proliferation, chemo-resistance and migration and invasion in ovarian clear cell adenocarcinoma cells
    Tae Mogami
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan Department of Obstetrics and Gynecology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    PLoS ONE 8:e80359. 2013
    ..Further investigation to clarify the mechanism that produces the subtypes is needed to clarify the function of ANXA4 in CCC, and might allow stratification and improved treatment strategies for patients with CCC. ..
  2. pmc HIF2α-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells
    Shiro Koizume
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Nucleic Acids Res 40:5389-401. 2012
    ..These results suggest the presence of a stress-responsive transcription mediated by the HIF2α/Sp1/HDAC4 network and explain how CCC shed their procoagulant activity under hypoxia...
  3. pmc Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells
    N Yokota
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 1 1 2 Nakao Asahi ku, 241 0815 Yokohama, Japan
    Br J Cancer 101:2023-9. 2009
    ..These findings led us to hypothesise that ovarian cancer cells are intrinsically associated with TF-fVIIa coagulation activity, which could result in thrombosis...
  4. doi request reprint ETS family-associated gene fusions in Japanese prostate cancer: analysis of 194 radical prostatectomy samples
    Yohei Miyagi
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    Mod Pathol 23:1492-8. 2010
    ..Because we identified a relatively low frequency of TMPRSS2:ERG and other fusions, further evaluation is required before this promising molecular marker should be introduced into the management of Japanese prostate cancer patients...
  5. pmc Plasma free amino acid profiling of five types of cancer patients and its application for early detection
    Yohei Miyagi
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center, Yokohama, Japan
    PLoS ONE 6:e24143. 2011
    ..Therefore, the purpose of the present study was to determine the characteristics of the PFAA profiles in cancer patients and the possibility of using this information for early detection...
  6. pmc Hepatocyte nuclear factor-4-independent synthesis of coagulation factor VII in breast cancer cells and its inhibition by targeting selective histone acetyltransferases
    Shiro Koizume
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Mol Cancer Res 7:1928-36. 2009
    ..These results suggest a strategy to inhibit ectopic fVII-induced tumor progression without impairment of the physiologic hemostatic process...
  7. doi request reprint Enhanced autophagy is required for survival in EGFR-independent EGFR-mutant lung adenocarcinoma cells
    Yuji Sakuma
    1 Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan 2 Laboratory for Molecular Diagnostics, Kanagawa Cancer Center Hospital, Yokohama, Japan 3 Department of Pathology, Jichi Medical University, Tochigi, Japan
    Lab Invest 93:1137-46. 2013
    ..Together, our results indicate that autophagy inhibitors alone or in combination with EGFR TKIs may be an effective approach for the treatment of EGFR-mutant lung cancers, where basal autophagy of some cancer cells is upregulated. ..
  8. doi request reprint WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors
    Yuji Sakuma
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Asahi ku, Yokohama, Japan
    Lab Invest 92:371-83. 2012
    ..The tumor cells circulating in vessels, which express mutant-specific EGFR, would be highly susceptible to the combination therapy of WZ4002, ABT-263, and TSA...
  9. ncbi request reprint Epidermal growth factor receptor gene mutations in atypical adenomatous hyperplasias of the lung
    Yuji Sakuma
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Kanagawa Cancer Center Hospital, Asahi ku, Yokohama, Japan
    Mod Pathol 20:967-73. 2007
    ....
  10. ncbi request reprint Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII
    Shiro Koizume
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Asahi ku, Yokohama 241 0815, Japan
    Cancer Res 66:9453-60. 2006
    ..This study shows that ectopic synthesis of fVII by cancer cells is sufficient to support proinvasive factor Xa-mediated protease-activated receptor-1 signaling and that this pathway is inducible under hypoxia...
  11. doi request reprint MDM2 gene amplification in colorectal cancer is associated with disease progression at the primary site, but inversely correlated with distant metastasis
    Nobuhiro Sugano
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center Hospital, Yokohama, Japan
    Genes Chromosomes Cancer 49:620-9. 2010
    ..Further understanding of the significance of MDM2 and MDM2 amplification in CRC is required to facilitate personalized treatment for CRC patients...
  12. ncbi request reprint Genomewide cDNA microarray screening of genes related to benefits and toxicities of platinum-based chemotherapy in patients with advanced lung cancer
    Fumihiro Oshita
    Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan
    Am J Clin Oncol 28:367-70. 2005
    ..01). It is concluded that not only the benefits but also the toxicities of chemotherapy can be predicted by cDNA microarray using tumor specimens obtained before chemotherapy...
  13. pmc The clinical significance of SWI/SNF complex in pancreatic cancer
    Masakatsu Numata
    Department of Gastroenterological Surgery, Kanagawa Cancer Center, Asahi ku, Yokohama, Kanagawa 241 0815, Japan
    Int J Oncol 42:403-10. 2013
    ..These results suggest that the specific cofactors of SWI/SNF chromatin remodeling complex certainly have roles in pancreatic cancer. High BRM, and low BAF180 are useful biomarkers for poor prognosis in pancreatic cancer...
  14. ncbi request reprint Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas: confirmation of the correlations with histologic subtypes and gene mutations
    Yuji Sakuma
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Kanagawa Cancer Center Hospital, Yokohama, Japan
    Am J Clin Pathol 128:100-8. 2007
    ..Because EGFR mutations were detected even in most pure nonmucinous BACs, ie, lung adenocarcinoma in situ, EGFR mutation is considered a critical event in the pathogenesis of nonmucinous BAC tumors...
  15. doi request reprint Rare MDM4 gene amplification in colorectal cancer: The principle of a mutually exclusive relationship between MDM alteration and TP53 inactivation is not applicable
    Tetsuji Suda
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama 241 0815, Japan
    Oncol Rep 26:49-54. 2011
    ..We speculate that MDM4 might play a role in colorectal carcinogenesis that is not limited to negative regulation of p53 in combination with MDM2. The functional significance of MDM4 is still unclear and further studies are needed...
  16. doi request reprint Lung adenocarcinoma cells floating in lymphatic vessels resist anoikis by expressing phosphorylated Src
    Yuji Sakuma
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    J Pathol 220:574-85. 2010
    ..These results indicate that Src, but not Abl or Kit, plays an essential role in the development of anoikis resistance in lung adenocarcinomas...
  17. ncbi request reprint Human epidermal growth factor receptor 2 (Her-2) and S-1 adjuvant chemotherapy in stage 2/3 gastric cancer patients who underwent D2 gastrectomy
    Toru Aoyama
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    Surg Today 43:1390-7. 2013
    ..However, there is currently no information available on the rate of Her-2 positivity and the relapse-free survival (RFS) stratified by Her-2 status in stage 2/3 patients...
  18. doi request reprint NF-κB signaling is activated and confers resistance to apoptosis in three-dimensionally cultured EGFR-mutant lung adenocarcinoma cells
    Yuji Sakuma
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    Biochem Biophys Res Commun 423:667-71. 2012
    ..These results suggest that inhibition of NF-κB signaling would render ECM-adherent EGFR-mutant lung adenocarcinoma cells in vivo more susceptible to EGFR TKI-induced cell death...
  19. doi request reprint Differential detection of KRAS mutations in codons 12 and 13 with a modified loop-hybrid (LH) mobility shift assay using an insert-type LH-generator
    Shoichi Matsukuma
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    Clin Chim Acta 412:1874-8. 2011
    ..Recently, clinical importance of determining KRAS mutations has been demonstrated in colorectal tumors as tumors harboring mutated KRAS genes were not responsive to therapy with EGFR-targeted antibodies such as cetuximab...
  20. pmc Identification of colorectal cancer patients with tumors carrying the TP53 mutation on the codon 72 proline allele that benefited most from 5-fluorouracil (5-FU) based postoperative chemotherapy
    Ten i Godai
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center Hospital, 1 1 2 Nakao, Asahi ku, Yokohama, Japan
    BMC Cancer 9:420. 2009
    ..In addition, the polymorphic status at p53 codon 72, which results in arginine or proline residues (R72P) and is thought to influence the function of the protein significantly, was not examined...
  21. doi request reprint Immunohistochemical analysis of human equilibrative nucleoside transporter-1 (hENT1) predicts survival in resected pancreatic cancer patients treated with adjuvant gemcitabine monotherapy
    Soichiro Morinaga
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Ann Surg Oncol 19:S558-64. 2012
    ..The aim of this study was to retrospectively determine the relationship between the outcome of pancreatic cancer after surgery followed by postoperative gemcitabine monotherapy and the expression of hENT1...
  22. ncbi request reprint Proteomic screening of completely resected tumors in relation to survival in patients with stage I non-small cell lung cancer
    Fumihiro Oshita
    Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama 241 0815, Japan
    Oncol Rep 24:637-45. 2010
    ..A further study is required to confirm the utility of these biomarkers...
  23. doi request reprint Heterogeneity in binding and gene-expression regulation by HIF-2alpha
    Shiro Koizume
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Biochem Biophys Res Commun 371:251-5. 2008
    ..These results demonstrate that, unlike HIF-1alpha, HIF-2alpha differentially binds and regulates transcription under hypoxia...
  24. pmc SNP (-617C>A) in ARE-like loci of the NRF2 gene: a new biomarker for prognosis of lung adenocarcinoma in Japanese non-smoking women
    Yasuko Okano
    Omics Science Center, RIKEN Yokohama Institute, Yokohama, Japan Department of Clinical Oncology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    PLoS ONE 8:e73794. 2013
    ..We aimed to investigate the single nucleotide polymorphisms in the NRF2 gene as a prognostic biomarker in lung cancer...
  25. ncbi request reprint Prospective study of second-line chemotherapy for non-small cell lung cancer selected according to EGFR gene status
    Fumihiro Oshita
    Department of Thoracic Oncology, Kanagawa Cancer Center Nakao 1 1 2, Asahi ku, Yokohama 241 0815, Japan
    J Exp Ther Oncol 8:313-9. 2010
    ..003 and p = 0.003, respectively). Selection of second-line treatment according to EGFR gene status may be useful for patients with NSCLC...
  26. doi request reprint SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients
    Akira Noguchi
    Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol 115:385-92. 2013
    ..Therefore, we investigated SIRT1 expression to clarify its biological behavior and identify its usefulness as a biomarker for head and neck squamous cell carcinoma (HNSCC)...
  27. doi request reprint The associations between RAS mutations and clinical characteristics in follicular thyroid tumors: new insights from a single center and a large patient cohort
    Michiko Fukahori
    Division of Endocrine Surgery, Kanagawa Cancer Center Hospital, Yokohama, Japan
    Thyroid 22:683-9. 2012
    ..To clarify the significance of RAS mutations, we examined a large number of follicular adenomas and carcinomas obtained from a single institute using established methods for the analysis of RAS...
  28. doi request reprint The global histone modification pattern correlates with overall survival in metachronous liver metastasis of colorectal cancer
    Hiroshi Tamagawa
    Department of Gastro intestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Oncol Rep 27:637-42. 2012
    ..011). We suggest that the pattern of histone modification as detected by immunohistochemistry may be an independent prognostic factor for metachronous liver metastasis of colorectal carcinomas...
  29. doi request reprint ABT-263, a Bcl-2 inhibitor, enhances the susceptibility of lung adenocarcinoma cells treated with Src inhibitors to anoikis
    Yuji Sakuma
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Oncol Rep 25:661-7. 2011
    ..These findings provide a biological rationale to test combination therapy with ABT-263 and Src inhibitors in patients with lung adenocarcinoma...
  30. ncbi request reprint Predictive advantage of a cell type classification for pulmonary adenocarcinoma coupled with data for p53, K-ras and EGFR alterations
    Akira Okada
    Laboratory of Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    Cancer Sci 101:1745-53. 2010
    ..The FCT combined with multiple gene mutation status appears to be useful in indicating pathogenesis and predicting the biological nature of pulmonary adenocarcinomas, and it could facilitate development of new therapies for each subtype...
  31. ncbi request reprint Genome-wide cDNA microarray screening of genes related to the benefits of paclitaxel and irinotecan chemotherapy in patients with advanced non-small cell lung cancer
    Fumihiro Oshita
    Department of Thoracic Oncology, Kanagawa Cancer Center, Nakao 1 1 2, Asahi ku, Yokohama 241 0815, Japan
    J Exp Ther Oncol 6:49-53. 2006
    ..In conclusion, the expression of certain genes was able to predict the benefits of this Pac and CPT chemotherapy regimen...
  32. ncbi request reprint Mutations of c-kit gene in bilateral testicular germ cell tumours in Japan
    Yuji Sakuma
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Nakao 1 1 2, Asahi ku, Yokohama 241 0815, Japan
    Cancer Lett 259:119-26. 2008
    ..No mutations, however, were observed in bilateral TGCTs. Thus, the presence of c-kit gene mutations in TGCTs may not be associated with bilateral diseases, at least in Japan...
  33. pmc Allelic Imbalance in the miR-31 Host Gene Locus in Lung Cancer - Its Potential Role in Carcinogenesis
    Koji Okudela
    Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    PLoS ONE 9:e100581. 2014
    ..To the best of our knowledge, this is the first study to show the potential causative mechanism of the altered expression of miR-31 and suggest its potentially diverse significance in the different histological types of lung cancers. ..
  34. pmc Impaired CXCL4 expression in tumor-associated macrophages (TAMs) of ovarian cancers arising in endometriosis
    Mitsuko Furuya
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Cancer Biol Ther 13:671-80. 2012
    ..Suppression of CXCL4 in cancer lesions is likely to be attributable to TAMs in part...
  35. pmc Stromal micropapillary component as a novel unfavorable prognostic factor of lung adenocarcinoma
    Miki Ohe
    Department of Pathology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan
    Diagn Pathol 7:3. 2012
    ..We evaluated the incidence and clinicopathological characteristics of SMPC in lung adenocarcinoma cases...
  36. ncbi request reprint Comparison of the chemosensitivity of the primary lesion and a pancreatic metastasis of colon cancer: a case report
    Hiroshi Tamagawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Asahi ku, Yokohama, Japan
    Anticancer Res 32:1457-61. 2012
    ....
  37. doi request reprint Simple and precise detection of UGT1A1 polymorphisms with a modified loop-hybrid mobility shift assay using Cy5-labeled loop probes
    Shoichi Matsukuma
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Asahi ku, Yokohama, Japan
    Clin Chim Acta 412:1668-72. 2011
    ..Deleterious effects of the drug in hypersensitive patients are known to be associated with genetic polymorphisms of the UGT1A1 gene, namely the polymorphic variants, *28 and *6...
  38. ncbi request reprint Differential expression patterns of CXCR3 variants and corresponding CXC chemokines in clear cell ovarian cancers and endometriosis
    Mitsuko Furuya
    Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Gynecol Oncol 122:648-55. 2011
    ..Currently, little is known about the roles of CXCR3 variants in these ovarian diseases. In this study, we investigated the expression of CXCR3 variants and their corresponding ligands in endometriosis and ovarian cancers...
  39. doi request reprint Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L
    Naomi Araki
    Yokohama City University Graduate School of Medicine, Department of Medical Science and Cardio renal Medicine, Yokohama City, Kanagawa ken 236 0004, Japan
    Biochem Biophys Res Commun 388:290-6. 2009
    ..NPC2 might regulate sodium reabsorption in the terminal nephron by interacting with ENaC-Nedd4L system...
  40. ncbi request reprint The synaptic scaffolding protein Delphilin interacts with monocarboxylate transporter 2
    Keiko Watanabe-Kaneko
    Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Neuroreport 18:489-93. 2007
    ....
  41. doi request reprint Pilot research for the correlation between the expression pattern of E-cadherin-β-catenin complex and lymph node metastasis in early gastric cancer
    Takako Yoshii
    Division of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan
    Tumori 99:234-8. 2013
    ..This was a pilot research evaluating the usefulness of combined analysis of these molecules in predicting lymph node metastasis in early gastric cancer...
  42. doi request reprint Lymphatic invasion identified with D2-40 immunostaining as a risk factor of nodal metastasis in T1 colorectal cancer
    Hiroo Wada
    Kanagawa Cancer Center Hospital Digestive Surgery, 1 1 2 Nakao, Asahi ku, Yokohama, Kanagawa, 241 8515, Japan
    Int J Clin Oncol 18:1025-31. 2013
    ....
  43. doi request reprint Small bud of probable gastrointestinal stromal tumor within a laparoscopically-resected gastric schwannoma
    Haruhiko Cho
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center Hospital, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    Int J Clin Oncol 17:294-8. 2012
    ..Our observations raised the significance of genotyping for diagnosis of GI tract SMTs...
  44. doi request reprint Elevated expression of angiomodulin (AGM/IGFBP-rP1) in tumor stroma and its roles in fibroblast activation
    Eriko Komiya
    Graduate School of Integrated Sciences, Yokohama City University, Yokohama, Japan
    Cancer Sci 103:691-9. 2012
    ..These findings also suggest that AGM and TGF-β1 cooperatively or complementarily contribute to the stromal activation and connective tissue formation in human cancer tissues, contributing to tumor progression...
  45. ncbi request reprint Expression of MMP-7 and MT1-MMP in peritoneal dissemination of gastric cancer
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama Kowan Hospital, Yokohama, Japan
    Hepatogastroenterology 53:964-7. 2006
    ....
  46. ncbi request reprint Genome-wide cDNA microarray screening of genes related to survival in patients after curative resection of non-small cell lung cancer
    Fumihiro Oshita
    Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama 241 0815, Japan
    Oncol Rep 16:817-21. 2006
    ..01). In conclusion, these survival-related genes are considered to be possible targets of adjuvant therapy after surgical resection of NSCLC...
  47. doi request reprint A logistic regression predictive model and the outcome of patients with resected lung adenocarcinoma of 2 cm or less in size
    Yuji Sakuma
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Lung Cancer 65:85-90. 2009
    ..Consequently, using a logistic predictive model consisting of the five clinicopathological factors might enable us to predict the recurrence of resected small-sized lung adenocarcinomas in male patients...
  48. pmc Pulmonary tumors associated with the JC virus T-antigen in a transgenic mouse model
    Akira Noguchi
    Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa 241 0815, Japan
    Oncol Rep 30:2603-8. 2013
    ..We propose that the pulmonary tumors were derived from the JCV T-antigen in a TG mouse model. These findings shed light on pulmonary carcinogenesis...
  49. pmc Downregulation of ALDH1A1 expression in non-small cell lung carcinomas--its clinicopathologic and biological significance
    Koji Okudela
    Department of Pathology, Yokohama City University Graduate School of Medicine 3 9, Fukuura, Kanazawa Ku, 236 0004, Yokohama, Japan
    Int J Clin Exp Pathol 6:1-12. 2013
    ..Taken together, loss of ALDH1A1 expression is suggested to promote carcinogenesis especially in the smoking-related ADCs...
  50. ncbi request reprint Secretome-based identification of TFPI2, a novel serum biomarker for detection of ovarian clear cell adenocarcinoma
    Noriaki Arakawa
    Department of Medical Life Science, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Kanagawa, Japan
    J Proteome Res 12:4340-50. 2013
    ..93 for TFPI2 versus 0.80 for CA125). This is the first evidence for TFPI2 as a serum biomarker of CCA. We propose that this biomarker may be useful for detection of CCA and for monitoring the transformation from endometriosis into CCA. ..
  51. ncbi request reprint Angiomodulin, a marker of cancer vasculature, is upregulated by vascular endothelial growth factor and increases vascular permeability as a ligand of integrin αvβ3
    Eriko Komiya
    Department of Genome Science, Graduate School of Integrated Science and Nanobioscience, Yokohama City University, 641 12 Maioka cho, Totsuka ku, Yokohama, Kanagawa, 244 0813, Japan Division of Cell Biology, Kihara Institute for Biological Research, Yokohama City University, 641 12 Maioka cho, Totsuka ku, Yokohama, Kanagawa, 244 0813, Japan
    Cancer Med 3:537-49. 2014
    ..Furthermore, AGM and integrin αvβ3 were highly expressed and colocalized in cancer vasculature. These results suggest that AGM cooperates with VEGF to induce the aberrant functions of cancer vasculature as a ligand of integrin αvβ3...
  52. pmc Specific expression of human intelectin-1 in malignant pleural mesothelioma and gastrointestinal goblet cells
    Kota Washimi
    Department of Pathology, Kanagawa Cancer Center, Yokohama, Japan
    PLoS ONE 7:e39889. 2012
    ..Pleural intelectin-1 could be a useful diagnostic marker for MPM with applications in histopathological identification of MPM...
  53. doi request reprint Gastrointestinal stromal tumor with two genetic abnormalities on different alleles: report of a case
    Yasushi Ichikawa
    Department of Gastroenterological Surgery, Yokohama City University Postgraduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Surg Today 40:262-6. 2010
    ..Cloning analysis indicated that the point mutation and the deletion were present on different alleles...
  54. pmc Rapid and simple detection of hot spot point mutations of epidermal growth factor receptor, BRAF, and NRAS in cancers using the loop-hybrid mobility shift assay
    Shoichi Matsukuma
    Division of Molecular Pathology and Genetics, Kanagawa Cancer Center Research Institute, Nakao 1 1 2, Asahi ku, Yokohama 241 0815, Japan
    J Mol Diagn 8:504-12. 2006
    ..5% of the total DNA. As a simple and straightforward mutation detection technique, loop-hybrid mobility shift assay may be useful for the molecular diagnosis of certain types of clinical cancers. Other applications are also discussed...
  55. doi request reprint Endometrial adenocarcinoma without myometrial invasion metastasizing to the pancreas and masquerading as primary pancreatic neoplasm
    Hisashi Oshiro
    Department of Pathology, Yokohama City University Hospital, Yokohama, Japan
    Pathol Int 58:456-61. 2008
    ..Histopathological comparison study and genetic analysis are important for the correct diagnosis of metastasis...
  56. doi request reprint Inflammation in background cirrhosis evokes malignant progression in HCC development from HCV-associated liver cirrhosis
    Kazuo Tarao
    Tarao s Gastroenterological Clinic, Yokohama, Japan
    Scand J Gastroenterol 48:729-35. 2013
    ..We examined the relationship between the inflammatory histology activity index (HAI) in the background liver cirrhosis (LC) and the histological grading of the HCC in the hepatectomized HCC patients with HCV-associated LC...
  57. ncbi request reprint Up-regulation of hypoxia-inducible factor-1 alpha and VEGF mRNAs in peritoneal dissemination of patients with gastric cancer
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Anticancer Res 26:3849-53. 2006
    ..Hypoxia-inducible factor-1 (HIF-1) and its target gene, vascular endothelial growth factor (VEGF), may play a role in the development of peritoneal metastases...
  58. doi request reprint Downregulation of a newly identified laminin, laminin-3B11, in vascular basement membranes of invasive human breast cancers
    Taizo Mori
    Graduate School of Integrated Sciences, Yokohama City University, Yokohama, Japan
    Cancer Sci 102:1095-100. 2011
    ..These results suggest that Lm3B11/3B21 may be required for normal mature vessels and interfere with tumor angiogenesis...
  59. ncbi request reprint Metastatic gastrointestinal stromal tumor with an exon 11 c-kit mutation responding to the tyrosine kinase inhibitor imatinib
    Haruhiko Cho
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Dig Surg 21:74-7. 2004
  60. ncbi request reprint Detection of occult tumor cells in peripheral blood from patients with small cell lung cancer by promoter methylation and silencing of the retinoic acid receptor-beta
    Fumihiro Oshita
    Department of Thoracic Oncology, Kanagawa Cancer Center, Nakao, Asahi ku, Yokohama 241 0815, Japan
    Oncol Rep 10:105-8. 2003
    ..044). In conclusion, occult tumor cells can be detected in the peripheral blood of patients with SCLC using methylation of RARbeta, and long-term survival appears to be better in LD-SCLC patients with occult tumor cells in their blood...
  61. doi request reprint Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension
    Naomi Araki
    Department of Medical Science and Cardio renal Medicine, Yokohama City University Graduate School of Medicine, Kanagawa Ken, Japan
    Hypertension 51:773-7. 2008
    ..Such interactions might abnormally increase sodium reabsorption. Taken together, our analyses suggest that the human Nedd4L gene, especially the evolutionarily new isoform I, is a candidate gene for hypertension...
  62. ncbi request reprint Binding of glutamate receptor delta2 to its scaffold protein, Delphilin, is regulated by PKA
    Tomoko Sonoda
    Department of Molecular Biodefence Research, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Biochem Biophys Res Commun 350:748-52. 2006
    ..Thus, phosphorylation of -2T and/or -1S of GluRdelta2 C-terminus by PKA may regulate the binding of GluRdelta2 to its scaffolding protein, Delphilin...
  63. doi request reprint Identification of phosphorylated proteins involved in the oncogenesis of prostate cancer via Pin1-proteomic analysis
    Kanji Endoh
    Drug Discovery Research Center, Taiho Pharmaceutical Co, Ltd, Tsukuba, Japan
    Prostate 72:626-37. 2012
    ..Although Pin1 has been shown to be involved in cell transformation and the maintenance of the malignant phenotype in prostate cancer, its specific substrates during these processes have not yet been determined...
  64. ncbi request reprint Genomic-wide cDNA microarray screening to correlate gene expression profile with chemoresistance in patients with advanced lung cancer
    Fumihiro Oshita
    Department of Thoracic Oncology, Laboratory for Molecular Diagnostics and Pathology, Kanagawa Cancer Center, Nakao 1 1 2, Asahi ku, Yokohama 241 0815, Japan
    J Exp Ther Oncol 4:155-60. 2004
    ..A prospective study is required to confirm whether expression levels of these genes reflect chemosensitivity...
  65. ncbi request reprint Diagnosis of B-cell lymphoma. Utility of the polymerase chain reaction for detecting clonality from archival cytologic smears
    Miho Kikuchi
    Division of Anatomic and Surgical Pathology, Department of Pathology, Hospital of Yokohama City University, Yokohama City University School of Medicine, Kanagawa Cancer Center Research Institute, Yokohama, Japan
    Acta Cytol 46:349-56. 2002
    ..To apply the polymerase chain reaction (PCR) to detect clonality for potentially helping to establish a definitive diagnosis of lymphoma in cytologic material...
  66. ncbi request reprint Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma
    Yukio Nakatani
    Department of Pathology, Yokohama City University Medical Center, Yokohama, Japan
    Am J Surg Pathol 28:921-7. 2004
    ..Although CPB and BCS have often been grouped together as biphasic PB, they are different entities based on immunohistochemical and molecular analysis of beta-catenin. Immunostaining for beta-catenin is useful for the discrimination...
  67. ncbi request reprint VEGF receptor antisense therapy inhibits angiogenesis and peritoneal dissemination of human gastric cancer in nude mice
    Masako Kamiyama
    Department of Surgery II, Yokohama City University, School of Medicine, Yokohama, Japan
    Cancer Gene Ther 9:197-201. 2002
    ..Microvessel density was significantly reduced in the KDR/Flk-1-ASO-treated tumor nodules. The KDR/Flk-1 antisense strategy, therefore, decreases tumor dissemination apparently by inhibiting angiogenesis...
  68. ncbi request reprint Genome-wide cDNA microarray screening to correlate gene expression profile with survival in patients with advanced lung cancer
    Mizuki Ikehara
    Department of Thoracic Oncology, Kanagawa Cancer Center, Asahi ku, Yokohama 241 0815, Japan
    Oncol Rep 11:1041-4. 2004
    ..A prospective study is required to confirm whether expression levels of these genes can be used for prognosis...
  69. ncbi request reprint Protein levels of tissue inhibitor of metalloproteinase-1 in tumor extracts as a marker for prognosis and recurrence in patients with gastric cancer
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Gastric Cancer 9:106-13. 2006
    ..Tissue inhibitor of metalloproteinase-1 (TIMP-1) correlates with tumor progression in patients with gastric cancer; however, the clinical significance of TIMP-1 as a marker for prognosis and recurrence has not been fully clarified...