Susumu Minamisawa

Summary

Affiliation: Yokohama City University
Country: Japan

Publications

  1. ncbi Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling
    Susumu Minamisawa
    Department of Pediatric Cardiology, Institute of Advanced Biomedical Engineering and Science, Graduate School of Medicine, Tokyo Women s Medical University, Tokyo 162 8666, Japan
    J Biol Chem 278:9570-5. 2003
  2. ncbi Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies
    Susumu Minamisawa
    Department of Physiology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Biochem Biophys Res Commun 325:852-6. 2004
  3. ncbi Post-transcriptional downregulation of sarcolipin mRNA by triiodothyronine in the atrial myocardium
    Susumu Minamisawa
    Department of Physiology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    FEBS Lett 580:2247-52. 2006
  4. ncbi Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy
    Susumu Minamisawa
    Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, 162 8666, Tokyo, Japan
    Biochem Biophys Res Commun 304:1-4. 2003
  5. ncbi Calcium cycling proteins in heart failure, cardiomyopathy and arrhythmias
    Susumu Minamisawa
    Department of Physiology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    Exp Mol Med 36:193-203. 2004
  6. pmc Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration
    Utako Yokoyama
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Am J Physiol Heart Circ Physiol 295:H1547-55. 2008
  7. pmc Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus
    Utako Yokoyama
    Department of Life Science and Medical Bioscience, Waseda University Graduate School of Advanced Science and Engineering, 2 2, Wakamatsu cho, TWIns, Shinjuku ku, Tokyo 162 8480, Japan
    Circ Res 106:1882-92. 2010
  8. pmc Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A
    Utako Yokoyama
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Kanagawa, Japan
    J Biol Chem 283:28702-9. 2008
  9. doi Caveolin gene transfer improves glucose metabolism in diabetic mice
    Koji Otsu
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Am J Physiol Cell Physiol 298:C450-6. 2010
  10. doi Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice
    Hiromichi Wakui
    Dept of Medical Science and Cardiorenal Medicine, Yokohama City Univ Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Am J Physiol Renal Physiol 299:F991-F1003. 2010

Detail Information

Publications45

  1. ncbi Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling
    Susumu Minamisawa
    Department of Pediatric Cardiology, Institute of Advanced Biomedical Engineering and Science, Graduate School of Medicine, Tokyo Women s Medical University, Tokyo 162 8666, Japan
    J Biol Chem 278:9570-5. 2003
    ..Taken together, sarcolipin is likely to be an atrial chamber-specific regulator of Ca2+ cycling in heart...
  2. ncbi Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies
    Susumu Minamisawa
    Department of Physiology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Biochem Biophys Res Commun 325:852-6. 2004
    ..The expression levels of JP-2 may be associated with the development of T-tubules and impaired Ca(2+)-induced Ca(2+) release in the heart...
  3. ncbi Post-transcriptional downregulation of sarcolipin mRNA by triiodothyronine in the atrial myocardium
    Susumu Minamisawa
    Department of Physiology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    FEBS Lett 580:2247-52. 2006
    ..The atrium-specific effect of thyroid hormone may occur in part through the regulation of atrial sarcolipin gene expression...
  4. ncbi Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy
    Susumu Minamisawa
    Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, 162 8666, Tokyo, Japan
    Biochem Biophys Res Commun 304:1-4. 2003
    ..No nucleotide change in the phospholamban coding region was found in 99 patients with cardiomyopathy. We suspect that the mutation plays an important role in the development of hypertrophic cardiomyopathy...
  5. ncbi Calcium cycling proteins in heart failure, cardiomyopathy and arrhythmias
    Susumu Minamisawa
    Department of Physiology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    Exp Mol Med 36:193-203. 2004
    ..The regulation of Ca2+ homeostasis via the SR proteins may have potential therapeutic value for heart diseases such as cardiomyopathy, heart failure and arrhythmias...
  6. pmc Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration
    Utako Yokoyama
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Am J Physiol Heart Circ Physiol 295:H1547-55. 2008
    ..Our findings suggest that Epac1, in opposition to PKA, increases vascular smooth muscle cell migration. Epac may thus play an important role in advancing vascular remodeling and restenosis upon vascular injury...
  7. pmc Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus
    Utako Yokoyama
    Department of Life Science and Medical Bioscience, Waseda University Graduate School of Advanced Science and Engineering, 2 2, Wakamatsu cho, TWIns, Shinjuku ku, Tokyo 162 8480, Japan
    Circ Res 106:1882-92. 2010
    ..After birth, however, differential regulation of vasodilation and IT is preferable for treatment of patients with patent DA and DA-dependent congenital cardiac malformations...
  8. pmc Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A
    Utako Yokoyama
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Kanagawa, Japan
    J Biol Chem 283:28702-9. 2008
    ..O-Me-cAMP did not change hyaluronan production, although it decreased proliferation of DA SMCs. The present study demonstrated that Epac, especially Epac1, plays an important role in promoting SMC migration and thereby ICF in the rat DA...
  9. doi Caveolin gene transfer improves glucose metabolism in diabetic mice
    Koji Otsu
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Am J Physiol Cell Physiol 298:C450-6. 2010
    ..In conclusion, our results suggest that caveolin is an important regulator of glucose metabolism that can enhance insulin signals...
  10. doi Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice
    Hiromichi Wakui
    Dept of Medical Science and Cardiorenal Medicine, Yokohama City Univ Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Am J Physiol Renal Physiol 299:F991-F1003. 2010
    ..These results suggest that the plasma membrane AT1R level in the kidney is modulated by intrarenal ATRAP expression under physiological and pathophysiological conditions in vivo...
  11. pmc Sarcalumenin is essential for maintaining cardiac function during endurance exercise training
    Qibin Jiao
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Am J Physiol Heart Circ Physiol 297:H576-82. 2009
    ..SAR may be a primary target for exercise-related adaptation of the Ca(2+) storage system in the SR to preserve cardiac function...
  12. pmc Type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight
    Satoshi Okumura
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    J Appl Physiol (1985) 105:173-9. 2008
    ..In all, AC5 plays a major role in stabilizing heat rate under microgravity...
  13. ncbi Sarcalumenin alleviates stress-induced cardiac dysfunction by improving Ca2+ handling of the sarcoplasmic reticulum
    Miei Shimura
    Department of Internal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Cardiovasc Res 77:362-70. 2008
    ..Although its Ca(2+)-binding property is similar to that of calsequestrin, its role in the regulation of Ca(2+) cycling remains unclear...
  14. pmc T-type Ca2+ channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation
    Toru Akaike
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Biol Chem 284:24025-34. 2009
    ....
  15. doi Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity
    Qibin Jiao
    Department of Life Science and Medical Bioscience, Waseda University, Wakamatsu cho, Shinjuku ku, Tokyo, Japan
    Cell Calcium 51:31-9. 2012
    ..Thus we uncovered the important role of SAR in maintaining Ca(2+) transport activity of SERCA2a and cardiac function in the senescent population...
  16. ncbi Interleukin-15 inhibits smooth muscle cell proliferation and hyaluronan production in rat ductus arteriosus
    Shiho Iwasaki
    Department of Pediatrics, Yokohama City University, Yokohama 236 0004, Japan
    Pediatr Res 62:392-8. 2007
    ..Accordingly, IL-15 might have an inhibitory effect on the physiologic vascular remodeling processes in closing the DA...
  17. ncbi Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy
    Coskun Ulucan
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Am J Physiol Heart Circ Physiol 293:H1662-72. 2007
    ..Furthermore, our results suggest the importance of the stoichiometry of Epac over that of Rap in cellular biological effects...
  18. doi DNA microarray profiling identified a new role of growth hormone in vascular remodeling of rat ductus arteriosus
    Mei Hua Jin
    Cardiovascular Research Institute, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    J Physiol Sci 61:167-79. 2011
    ..Thus, the present study revealed that GH-GHR signal played a role in the vascular remodeling of the DA...
  19. ncbi Mechanical stress-dependent transcriptional regulation of sarcolipin gene in the rodent atrium
    Miei Shimura
    Department of Internal Medicine, Yokohama City University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 334:861-6. 2005
    ..The two independent complementary experiments unequivocally demonstrated that mechanical stress down-regulates the transcription of the sarcolipin gene...
  20. ncbi Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration
    Kousaku Iwatsubo
    Department of Physiology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    J Biol Chem 279:40938-45. 2004
    ....
  21. pmc Insulin resistance in skeletal muscles of caveolin-3-null mice
    Jin Oshikawa
    Departments of Physiology and Medicine, Yokohama City University School of Medicine, 3 9 Fukuura Kanazawa, Yokohama 236 0004, Japan
    Proc Natl Acad Sci U S A 101:12670-5. 2004
    ..Our findings suggest that Cav3 is an enhancer of insulin signaling in skeletal muscles but does not act as a scaffolding molecule for insulin receptors...
  22. ncbi Maternal vitamin A alters gene profiles and structural maturation of the rat ductus arteriosus
    Utako Yokoyama
    Department of Physiology, Yokohama City University, Yokohama, Japan
    Physiol Genomics 31:139-57. 2007
    ..The present study indicates that MVA-mediated alteration in gene profile was associated with early structural maturation of DA, although MVA-mediated maturation may differ from normal vascular remodeling of DA...
  23. ncbi Ischemic preconditioning prevents ischemia-induced beta-adrenergic receptor sequestration
    Kousaku Iwatsubo
    Departments of Physiology and Medicine, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    J Mol Cell Cardiol 35:923-9. 2003
    ..Pre-conditioning may play a role in preserving the cell surface beta ARs by inhibiting the sequestration that is usually induced by an ischemic event or beta adrenergic stimulation...
  24. ncbi Prostaglandin E2 inhibits elastogenesis in the ductus arteriosus via EP4 signaling
    Utako Yokoyama
    Cardiovascular Research Institute, Yokohama City University, Yokohama, Japan U Y, S M, A s, R I, M H J, Y I the Department of Life Science and Medical Bioscience, Waseda University Graduate School of Advanced Science and Engineering, Tokyo, Japan S M, R I the Department of Cell Physiology, Jikei University School of Medicine, Tokyo, Japan S M the Department of Surgery, Yokohama City University, Yokohama, Japan M M the Department of Cardiovascular Surgery, Kanagawa Children s Medical Center, Yokohama, Japan T A the Department of Pharmaceutical Biochemistry, Kumamoto University, Kumamoto, Japan Y S Cardiovascular Research Institute, Kurume University, Kurume, Japan H A and the Department of Pharmacology, Kansai Medical University, Osaka, Japan T N
    Circulation 129:487-96. 2014
    ..The molecular mechanisms for this inhibited elastogenesis in the DA, which is necessary for the establishment of adult circulation, remain largely unknown...
  25. ncbi Multiple transcripts of Ca2+ channel alpha1-subunits and a novel spliced variant of the alpha1C-subunit in rat ductus arteriosus
    Utako Yokoyama
    Dept of Pediatrics, Yokohama City University, Kanazawa Ku, Yokohama 236 0004, Japan
    Am J Physiol Heart Circ Physiol 290:H1660-70. 2006
    ..A novel spliced variant of the alpha(1C)-subunit gene may play a distinct role in neointimal cushion formation in the DA...
  26. pmc Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43)
    Motohiko Sato
    Cardiovascular Research Institute, Yokohama City University School of Medicine, Fukuura, Yokohama 236 0004, Japan
    J Biol Chem 284:31431-40. 2009
    ..Under hypoxic stress, this unrecognized response program plays a critical role in the fate of NCM...
  27. doi Metabolomic profiling analysis reveals chamber-dependent metabolite patterns in the mouse heart
    Daisuke Shimura
    Department of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 305:H494-505. 2013
    ..The present study provides a basis for understanding the chamber-specific metabolism underlining pathophysiology in the heart. ..
  28. doi Cardiac-specific activation of angiotensin II type 1 receptor-associated protein completely suppresses cardiac hypertrophy in chronic angiotensin II-infused mice
    Hiromichi Wakui
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Hypertension 55:1157-64. 2010
    ....
  29. pmc Thromboxane A(2) receptor stimulation promotes closure of the rat ductus arteriosus through enhancing neointima formation
    Tomohiro Yokota
    Department of Life Science and Medical Bioscience, Waseda University Graduate School of Advanced Science and Engineering, Tokyo, Japan
    PLoS ONE 9:e94895. 2014
    ....
  30. doi Three-dimensional multilayers of smooth muscle cells as a new experimental model for vascular elastic fiber formation studies
    Ryo Ishiwata
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    Atherosclerosis 233:590-600. 2014
    ..Since fibronectin is known to assemble and activate elastic fiber-related molecules, we further optimized culture conditions...
  31. ncbi Low-dose thromboxane A2 receptor stimulation promotes closure of the rat ductus arteriosus with minimal adverse effects
    Tomohiro Yokota
    Department of Life Science and Medical Bioscience, Waseda University Graduate School of Advanced Science and Engineering, Tokyo, Japan
    Pediatr Res 72:129-36. 2012
    ..As thromboxane A(2) (TXA(2)) induces vascular contraction via the TXA(2) receptor (TP), we hypothesized that TP stimulation would promote DA closure...
  32. doi Acupuncture ameliorated skeletal muscle atrophy induced by hindlimb suspension in mice
    Akiko Onda
    Graduate School of Sport Sciences, Waseda University, Tokyo, Japan
    Biochem Biophys Res Commun 410:434-9. 2011
    ..05 in MA) and TRPV4 (p<0.05 in MA) mRNAs. We concluded that acupuncture partially prevented skeletal muscle atrophy. This effect might be due to an increase in protein synthesis and a decrease in protein degradation...
  33. ncbi Regulation of vascular tone and remodeling of the ductus arteriosus
    Utako Yokoyama
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine
    J Smooth Muscle Res 46:77-87. 2010
    ..Both EP4-cAMP downstream targets, Epac and PKA, regulate vascular remodeling in the DA...
  34. ncbi [Sarcoplasmic reticulum function and heart failure: a novel therapeutic target for heart failure]
    Susumu Minamisawa
    Department of Physiology, Yokohama City University Graduate School of Medicine
    Clin Calcium 16:37-44. 2006
    ..The improvement of the SR function has ameliorated effects on cardiac pump function and it has potential therapeutic value for heart failure...
  35. ncbi Blood flow velocities in the anterior cerebral artery and basilar artery in asphyxiated infants
    Shigeru Nishimaki
    Department of Pediatrics, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    J Ultrasound Med 27:955-60. 2008
    ....
  36. pmc Transcription profiles of endothelial cells in the rat ductus arteriosus during a perinatal period
    Norika Mengchia Liu
    Department of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan
    PLoS ONE 8:e73685. 2013
    ..Newly identified DA endothelium-dominant genes may play an important role in DA-specific functional and morphologic characteristics. ..
  37. ncbi Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy
    Eiko Ikoma
    Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan
    J Cardiovasc Pharmacol 42:S27-32. 2003
    ..It was concluded that the AA group may be at risk of developing left ventricular hypertrophy independent of increased blood pressure...
  38. ncbi Ectopic expression of an embryonic skeletal myosin heavy chain in human fetal and Syrian hamster hearts
    Susumu Minamisawa
    Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    J Muscle Res Cell Motil 24:399-406. 2003
    ..Our data provide a new insight into the regulatory mechanisms of MHCs in the cardiomyopathic hamster heart...
  39. ncbi Characterization of beta-adrenergic receptor sequestration by newly developed whole cell binding assays
    Kousaku Iwatsubo
    Department of Physiology, Yokohama City University School of Medicine, Kanazawa Ku, Yokohama, Japan
    J Cardiovasc Pharmacol 41:S53-6. 2003
    ..Thus, beta1-adrenergic receptor sequestrates upon agonist stimulation but the same agonist stimulation does not induce beta3-adrenergic receptor sequestration, as demonstrated by our whole cell binding assays...
  40. ncbi Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice
    Morikatsu Yoshida
    Medical Chemistry and Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8575, Japan
    J Biol Chem 280:3500-6. 2005
    ..The results obtained demonstrate that SAR plays important roles in improving the Ca2+ handling functions of the SR in striated muscle...
  41. ncbi Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery
    Masahiko Hoshijima
    University of California, San Diego Institute of Molecular Medicine, La Jolla, California, USA
    Nat Med 8:864-71. 2002
    ..Thus, transcoronary gene transfer of S16EPLN via rAAV vector is a potential therapy for progressive dilated cardiomyopathy and associated heart failure...
  42. ncbi Caveolin-3 inhibits growth signal in cardiac myoblasts in a Ca2+-dependent manner
    Takayuki Fujita
    Cardiovascular Research Institute, Department of Pathology and Department of Medicine, Yokohama City University Graduate School of Medical Science, Fukuura, Yokohama, Japan
    J Cell Mol Med 10:216-24. 2006
    ..Our findings suggest that caveolin exhibits growth inhibition in a Ca2+-dependent manner, most likely through PKC, in cardiac myoblasts...
  43. pmc Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon
    Makoto Tadano
    Division of Molecular Biology, Department of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Mol Cell Biol 25:2191-9. 2005
    ..These results suggest a crucial role of phospholipase Cepsilon downstream of the epidermal growth factor receptor in controlling semilunar valvulogenesis through inhibition of bone morphogenetic protein signaling...
  44. ncbi ErbB2 is essential in the prevention of dilated cardiomyopathy
    Steven A Crone
    The Salk Institute, La Jolla, California, USA
    Nat Med 8:459-65. 2002
    ..Additionally, cardiomyocytes isolated from these conditional mutants were more susceptible to anthracycline toxicity. ErbB2 signaling in cardiomyocytes is therefore essential for the prevention of dilated cardiomyopathy...
  45. pmc Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus
    Utako Yokoyama
    Cardiovascular Research Institute, Yokohama City University, Yokohama, Japan
    J Clin Invest 116:3026-34. 2006
    ..e., inhibition of PGE signaling by cyclooxygenase inhibitors, which might delay PGE-mediated ICF in immature infants...