Chikara Kunisaki

Summary

Affiliation: Yokohama City University
Country: Japan

Publications

  1. ncbi request reprint Clinical significance of the metastatic lymph-node ratio in early gastric cancer
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University Graduate School of Medicine, 4 57 Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    J Gastrointest Surg 12:542-9. 2008
  2. pmc The clinicopathological features of colorectal mucinous adenocarcinoma and a therapeutic strategy for the disease
    Masakatsu Numata
    Department of Gastroenterological Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, Kanagawa, 241 0815, Japan
    World J Surg Oncol 10:109. 2012
  3. ncbi request reprint Biweekly Docetaxel and S-1 combination chemotherapy as first-line treatment for elderly patients with advanced gastric cancer
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57 Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    Anticancer Res 33:697-704. 2013
  4. doi request reprint Low-dose docetaxel and cisplatin combination chemotherapy for stage II/III gastric cancer showing resistance to S-1 adjuvant chemotherapy: a phase I study
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, Yokohama, Japan
    J Chemother 24:364-8. 2012
  5. ncbi request reprint Inflammation-based prognostic score predicts survival in patients with advanced gastric cancer receiving biweekly docetaxel and s-1 combination chemotherapy
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, Japan
    Oncology 83:183-91. 2012
  6. ncbi request reprint Relevance of reduced-port laparoscopic distal gastrectomy for gastric cancer: a pilot study
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, Yokohama, Japan
    Dig Surg 29:261-8. 2012
  7. doi request reprint Surgical outcomes of laparoscopy-assisted gastrectomy versus open gastrectomy for gastric cancer: a case-control study
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57, Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    Surg Endosc 26:804-10. 2012
  8. pmc Effect of obesity on intraoperative bleeding volume in open gastrectomy with D2 lymph-node dissection for gastric cancer
    Hirochika Makino
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57, Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    Patient Saf Surg 2:7. 2008
  9. ncbi request reprint Clinicopathological properties of poorly-differentiated adenocarcinoma of the stomach: comparison of solid- and non-solid-types
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Japan
    Anticancer Res 26:639-46. 2006
  10. ncbi request reprint Comparison of results of surgery in the upper third and more distal stomach
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Gastrointest Surg 10:718-26. 2006

Collaborators

Detail Information

Publications98

  1. ncbi request reprint Clinical significance of the metastatic lymph-node ratio in early gastric cancer
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University Graduate School of Medicine, 4 57 Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    J Gastrointest Surg 12:542-9. 2008
    ..The metastatic lymph-node ratio may be a superior method of classification, which provides also accurate prognostic stratification for early gastric cancer patients...
  2. pmc The clinicopathological features of colorectal mucinous adenocarcinoma and a therapeutic strategy for the disease
    Masakatsu Numata
    Department of Gastroenterological Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, Kanagawa, 241 0815, Japan
    World J Surg Oncol 10:109. 2012
    ..In this study, we described the clinicopathological features of mucinous adenocarcinoma in Japan, to identify optimal therapeutic strategies...
  3. ncbi request reprint Biweekly Docetaxel and S-1 combination chemotherapy as first-line treatment for elderly patients with advanced gastric cancer
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57 Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    Anticancer Res 33:697-704. 2013
    ..This study assessed the toxicity and activity of biweekly docetaxel and S-1 combination therapy in elderly patients with advanced gastric cancer...
  4. doi request reprint Low-dose docetaxel and cisplatin combination chemotherapy for stage II/III gastric cancer showing resistance to S-1 adjuvant chemotherapy: a phase I study
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, Yokohama, Japan
    J Chemother 24:364-8. 2012
    ..The recommended dose (RD) of DOC was therefore defined as 25 mg/m². There is a need for a phase II clinical trial using this regimen in patients with S-1-refractory stage II/III gastric cancer...
  5. ncbi request reprint Inflammation-based prognostic score predicts survival in patients with advanced gastric cancer receiving biweekly docetaxel and s-1 combination chemotherapy
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, Japan
    Oncology 83:183-91. 2012
    ..This study was conducted to determine the prognostic value of the Glasgow Prognostic Score (GPS), an inflammation-based prognostic score composed of C-reactive protein and albumin, for patients with advanced cancer...
  6. ncbi request reprint Relevance of reduced-port laparoscopic distal gastrectomy for gastric cancer: a pilot study
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, Yokohama, Japan
    Dig Surg 29:261-8. 2012
    ....
  7. doi request reprint Surgical outcomes of laparoscopy-assisted gastrectomy versus open gastrectomy for gastric cancer: a case-control study
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57, Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    Surg Endosc 26:804-10. 2012
    ..The aim of this study was to clarify the technical feasibility and oncological efficacy of laparoscopy-assisted gastrectomy (LAG) for gastric cancer compared with open gastrectomy (OG)...
  8. pmc Effect of obesity on intraoperative bleeding volume in open gastrectomy with D2 lymph-node dissection for gastric cancer
    Hirochika Makino
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57, Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    Patient Saf Surg 2:7. 2008
    ..To investigate the effect of obesity on open gastrectomy with D2 lymph-node dissection...
  9. ncbi request reprint Clinicopathological properties of poorly-differentiated adenocarcinoma of the stomach: comparison of solid- and non-solid-types
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Japan
    Anticancer Res 26:639-46. 2006
    ..The purpose of this study was to clarify the clinicopathological and biological properties of the poorly-differentiated types of gastric carcinoma (solid-type and non-solid-type)...
  10. ncbi request reprint Comparison of results of surgery in the upper third and more distal stomach
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Gastrointest Surg 10:718-26. 2006
    ..Treatments for T2 or deeper and pN1 tumors in the upper third of the stomach, particularly for hematogenous metastasis, require further investigation...
  11. ncbi request reprint Clinicopathologic characteristics and surgical outcomes of mucinous gastric carcinoma
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, 3 9, Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Ann Surg Oncol 13:836-42. 2006
    ..The clinicopathologic characteristics of mucinous gastric carcinoma (MGC), an uncommon subtype of gastric carcinoma, were examined by comparing 45 MGC and 1255 non-MGC (NGC) cases...
  12. ncbi request reprint Comparison of surgical results of D2 versus D3 gastrectomy (para-aortic lymph node dissection) for advanced gastric carcinoma: a multi-institutional study
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Ann Surg Oncol 13:659-67. 2006
    ..The surgical results of D2 and D3 gastrectomy (para-aortic lymph node dissection) were retrospectively compared...
  13. ncbi request reprint Phase I study of biweekly docetaxel and S-1 combination chemotherapy for advanced gastric cancer
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57 Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Anticancer Res 28:2473-8. 2008
    ..Docetaxel and S-1 are novel antitumour chemotherapeutic agents with distinct toxicities. Here a phase I study of combined docetaxel and S-1 therapy for advanced gastric cancer is reported...
  14. ncbi request reprint Comparison of surgical outcomes of gastric cancer in elderly and middle-aged patients
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University, Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Am J Surg 191:216-24. 2006
    ..We compared clinicopathological features and results of surgery for gastric carcinoma in elderly and middle-aged patients to develop appropriate treatment for elderly patients with gastric carcinoma...
  15. ncbi request reprint Outcomes of mass screening for gastric carcinoma
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University, Graduate School of Medicine, 3 9 Fukuura Kanazawaku, Yokohama 236 0004, Japan
    Ann Surg Oncol 13:221-8. 2006
    ..The objective of our study was to assess the efficacy of mass screening for gastric cancer by using a barium meal...
  16. ncbi request reprint The influence of stage migration on the comparison of surgical outcomes between D2 gastrectomy and D3 gastrectomy (para-aortic lymph node dissection): a multi-institutional retrospective study
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, 3 9, Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Am J Surg 196:358-63. 2008
    ..The aim of this study was to determine the influence of stage migration on the outcomes of D2 gastrectomy compared with D3 gastrectomy in advanced gastric cancer...
  17. ncbi request reprint Prospective randomized controlled trial comparing the use of 3.5-mm and 4.8-mm staples in gastric surgery
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57, Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    Hepatogastroenterology 55:1943-7. 2008
    ..The purpose of this study was to evaluate and compare the use of 4.8-mm and 3.8-mm staples in gastric resection...
  18. ncbi request reprint Phase II study of docetaxel plus cisplatin as a second-line combined therapy in patients with advanced gastric carcinoma
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
    Anticancer Res 25:2973-7. 2005
    ..We conducted a pilot phase II study to evaluate the efficacy and safety of docetaxel and cisplatin as a combination second-line therapy for advanced gastric cancer...
  19. ncbi request reprint Predictive factors for surgical complications of laparoscopy-assisted distal gastrectomy for gastric cancer
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57, Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    Surg Endosc 23:2085-93. 2009
    ..To determine the predictive factors for the surgical complications of laparoscopic gastric surgery, surgical outcomes were evaluated...
  20. ncbi request reprint Prognostic factors after chemoradiotherapy for patients with inoperable esophageal squamous cell carcinoma
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Hepatogastroenterology 53:366-71. 2006
    ..It is important to clarify the predictive and prognostic factors for chemoradiotherapy (CRT) in patients with inoperable esophageal cancer...
  21. ncbi request reprint Distribution of lymph node metastasis in gastric carcinoma
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, 3 9, Fukuura Kanazawa ku, Yokohama, 236 0004, Japan
    Hepatogastroenterology 53:468-72. 2006
    ..In gastric cancer, appropriate lymph node dissection increases survival, and hence it is of value to determine lymph node metastasis distribution in the early phase of progression...
  22. ncbi request reprint Therapeutic outcomes of continuous hyperthermic peritoneal perfusion against advanced gastric cancer with peritoneal carcinomatosis
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa ku Yokohama 236 0004, Japan
    Hepatogastroenterology 53:473-8. 2006
    ..To clarify the efficacy of therapeutic continuous hyperthermic peritoneal perfusion in peritoneal carcinomatosis of gastric cancer...
  23. doi request reprint Efficacy of laparoscopy-assisted distal gastrectomy for gastric cancer in the elderly
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57 Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    Surg Endosc 23:377-83. 2009
    ..This study retrospectively compared surgical outcomes between elderly and nonelderly patients with gastric cancer...
  24. doi request reprint Tumor diameter as a prognostic factor in patients with gastric cancer
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57, Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    Ann Surg Oncol 15:1959-67. 2008
    ..The aim of this study was to evaluate the prognostic value of tumor diameter in gastric cancer...
  25. ncbi request reprint Appropriate routes of reconstruction following transthoracic esophagectomy
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, Minami Ku, Yokohama, 232 0024, Japan
    Hepatogastroenterology 54:1997-2002. 2007
    ..The effectiveness of reconstructive methods after esophagectomy remains controversial...
  26. ncbi request reprint Surgical outcomes in esophageal cancer patients with tumor recurrence after curative esophagectomy
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57, Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    J Gastrointest Surg 12:802-10. 2008
    ..Randomized controlled trials should be used to develop effective modalities for each recurrence pattern to improve therapeutic outcomes...
  27. ncbi request reprint Impact of palliative gastrectomy in patients with incurable advanced gastric cancer
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, Minami Ku, Yokohama, Japan
    Anticancer Res 28:1309-15. 2008
    ..The efficacy of palliative gastrectomy for incurable advanced gastric cancer remains debatable...
  28. ncbi request reprint Predictive factors for anastomotic leakage in the neck after retrosternal reconstruction for esophageal cancer
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center Yokohama City University, Minami Ku, Yokohama 232 0024, Japan
    Hepatogastroenterology 55:98-102. 2008
    ..Anastomotic leakage after transthoracic esophagectomy for esophageal cancer can induce life-threatening morbidity. This study investigated the predictive factors for anastomotic leakage in the neck after retrosternal reconstruction...
  29. ncbi request reprint Impact of splenectomy in patients with gastric adenocarcinoma of the cardia
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57, Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    J Gastrointest Surg 11:1039-44. 2007
    ..Splenectomy should be limited in those patients with gastric cardia tumors invading the spleen or with metastatic bulky lymph nodes extending to the spleen...
  30. ncbi request reprint Lymph node status in patients with submucosal gastric cancer
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Ann Surg Oncol 13:1364-71. 2006
    ..The aim of this study was to clarify the lymph node status in patients with submucosal gastric cancer...
  31. ncbi request reprint Therapeutic strategy for patients with pN0 gastric carcinoma
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University, Yokohama, Japan
    J Surg Oncol 94:212-9. 2006
    ..The prognosis for patients with pN0 gastric cancer is moderately hopeful (expected 5-year survival: 80%). However, the relevant prognostic factors and most appropriate surveillance protocol have not been identified...
  32. ncbi request reprint Learning curve for laparoscopy-assisted distal gastrectomy with regional lymph node dissection for early gastric cancer
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, Urafunecho, Minami Ku, Yokohama, Japan
    Surg Laparosc Endosc Percutan Tech 18:236-41. 2008
    ..LADG is a technically feasible surgical procedure, depending on the surgeon's technical proficiency. Experience of at least 60 cases of LADG seems to result in satisfactory patient outcomes...
  33. ncbi request reprint Clinical impact of metastatic lymph node ratio in advanced gastric cancer
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University, Graduate School of Medicine, Fukuura Kanazawa ku, Yokohama 236 0004, Japan
    Anticancer Res 25:1369-75. 2005
    ..We examined the prognostic value of metastatic lymph node ratio (the ratio of the number of metastatic lymph nodes to the number of lymph nodes removed) after curative resection...
  34. ncbi request reprint Surgical outcome in superficially spreading early gastric cancer
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Oncology 68:52-7. 2005
    ..Superficially spreading early gastric cancer is characterized by wide horizontal extension without deep vertical invasion. This study aimed to clarify the clinicopathological characteristics and prognosis of this rare disease...
  35. ncbi request reprint Survival benefit of palliative gastrectomy in advanced incurable gastric cancer
    Chikara Kunisaki
    Second Department of Surgery, Yokohama City Uniersity School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Anticancer Res 23:1853-8. 2003
    ..In such gastrectomy, lymph node dissection is limited to a little more than D1, which eradicates only macroscopically identifiable metastatic lymph nodes near the stomach...
  36. doi request reprint Application of the transorally inserted anvil (OrVil) after laparoscopy-assisted total gastrectomy
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57, Urafunecho, Minami Ku, Yokohama 232 0024, Japan
    Surg Endosc 25:1300-5. 2011
    ..In this study, we compared the short-term outcomes of LATG reconstructed by mini-laparotomy and by the newly developed transorally inserted anvil (OrVil)...
  37. doi request reprint Significance of thoracoscopy-assisted surgery with a minithoracotomy and hand-assisted laparoscopic surgery for esophageal cancer: the experience of a single surgeon
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57 Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    J Gastrointest Surg 15:1939-51. 2011
    ..This retrospective study evaluated the surgical learning curve and outcomes of thoracolaparoscopic esophagectomy...
  38. ncbi request reprint Lymph node dissection in surgical treatment for remnant stomach cancer
    Chikara Kunisaki
    Second Department of Surgery, Yokohama City University School of Medicine, 3 49, Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Hepatogastroenterology 49:580-4. 2002
    ..Lymphatic flow and the incidence of lymph node metastasis in remnant stomach cancer after distal gastrectomy are obscure. There is consequent controversy about appropriate lymph node dissection in such cases...
  39. ncbi request reprint Clinicopathological features of gastric carcinoma in younger and middle-aged patients: a comparative study
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
    J Gastrointest Surg 10:1023-32. 2006
    ....
  40. ncbi request reprint Indications for pancreaticosplenectomy in advanced gastric cancer
    K Chikara
    Second Department of Surgery, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Hepatogastroenterology 48:908-12. 2001
    ..Pancreaticosplenectomy is performed to achieve complete D2 dissection, but its efficacy remains controversial. To clarify the indications for pancreaticosplenectomy in gastric cancer, surgical results were investigated...
  41. doi request reprint Therapeutic strategy for esophageal cancer based on solitary lymph node metastasis
    Chikara Kunisaki
    Department of Surgery, Yokohama City University, Yokohama, Japan
    Hepatogastroenterology 58:1561-5. 2011
    ..It is essential to perform appropriate lymph node dissection in esophageal cancer. However, it may be beneficial if lymph node dissection could be minimized to reduce the surgical stress...
  42. ncbi request reprint Prognostic factors in early gastric cancer
    C Kunisaki
    Second Department of Surgery, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Hepatogastroenterology 48:294-8. 2001
    ..Assessment of prognostic factors for the recurrence of early gastric cancer is important for determining adequate strategies for managing early gastric cancer...
  43. ncbi request reprint Prognostic factors in esophageal cancer
    Chikara Kunisaki
    Second Department of Surgery, Yokohama City University School of Medicine, Yokohama, Japan
    Hepatogastroenterology 51:736-40. 2004
    ..This paper deals with the prognostic factors in esophageal cancer after potentially curative resection. Furthermore, correlation of the genetic alteration obtained from biopsy specimens with the prognostic factor was determined...
  44. ncbi request reprint Indications for paraaortic lymph node dissection in gastric cancer patients with paraaortic lymph node involvement
    C Kunisaki
    Second Department of Surgery, Yokohama City University, Faculty of Medicine, Japan
    Hepatogastroenterology 47:586-9. 2000
    ....
  45. ncbi request reprint Significance of para-aortic lymph node dissection in advanced gastric cancer
    C Kunisaki
    Second Department of Surgery, Yokohama City University, Faculty of Medicine, Japan
    Hepatogastroenterology 46:2635-42. 1999
    ..Since surgical results in advanced gastric cancer remain poor and para-aortic lymph node dissection may contribute to survival, it is useful to determine the significance of para-aortic lymph node dissection...
  46. ncbi request reprint Clinicopathological features in N0 oesophageal cancer patients
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University 4 57 Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Anticancer Res 30:3063-9. 2010
    ..The prognosis for patients with N0 oesophageal cancer is favourable, but relevant prognostic factors and appropriate surveillance protocols have not been identified for these patients...
  47. ncbi request reprint Implication of extended lymph node dissection stratified for advanced gastric cancer
    Chikara Kunisaki
    Second Department of Surgery, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Anticancer Res 23:4181-6. 2003
    ..What extent of lymph node dissection for advanced gastric cancer is appropriate is a matter of controversy...
  48. ncbi request reprint Comparative evaluation of gastric carcinoma staging: Japanese classification versus new american joint committee on cancer/international union against cancer classification
    Chikara Kunisaki
    Second Department of Surgery, Yokohama City University School of Medicine, Yokohama, Japan
    Ann Surg Oncol 11:203-6. 2004
    ..This study was designed to compare these staging systems and devise a more rational system for gastric carcinoma...
  49. doi request reprint Impact of lymphovascular invasion in patients with stage I gastric cancer
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
    Surgery 147:204-11. 2010
    ..Patients with stage I gastric cancer often suffer from tumor recurrence despite a generally favorable operative outcome. It is therefore important to determine the prognostic factors in order to improve such outcomes...
  50. ncbi request reprint Video-assisted thoracoscopic esophagectomy with a voice-controlled robot: the AESOP system
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, School of Medicine, Japan
    Surg Laparosc Endosc Percutan Tech 14:323-7. 2004
    ..Laparoscopic and thoracoscopic surgery with the AESOP system has the potential to enable a single surgeon to perform a complex surgical procedure like esophagectomy...
  51. ncbi request reprint Association of the number of metastatic perigastric lymph nodes with long-term survival in gastric cancer
    Kunisaki Chikara
    Second Department of Surgery, Yokohama City University, School of Medicine, Yokohama, Japan
    Hepatogastroenterology 52:277-80. 2005
    ..Currently, the total number of metastatic lymph nodes (MLN) is thought to be more prognostically significant than the anatomical distribution of MLN...
  52. ncbi request reprint Surgical outcome of serosa-negative advanced gastric carcinoma
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
    Anticancer Res 24:3169-75. 2004
    ..Prophylactic therapeutic strategy should be advised for patients with many metastatic lymph nodes, for peritoneal or lymphatic recurrence and in patients with "medullary" stroma for hematogenous recurrence...
  53. ncbi request reprint Therapeutic strategy for signet ring cell carcinoma of the stomach
    C Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
    Br J Surg 91:1319-24. 2004
    ..Reports of clinicopathological characteristics and prognosis in patients with signet ring cell carcinoma (SRC) of the stomach are conflicting...
  54. doi request reprint Impact of lymph-node metastasis site in patients with thoracic esophageal cancer
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57 Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    J Surg Oncol 101:36-42. 2010
    ..We retrospectively compared surgical outcomes between patients with intra-thoracic and extra-thoracic (cervical and abdominal) lymph-node metastasis...
  55. ncbi request reprint Immunonutrition risk factors of respiratory complications after esophagectomy
    Chikara Kunisaki
    Second Department of Surgery, Yokohama City University School of Medicine, Yokohama, Japan
    Nutrition 20:364-7. 2004
    ..There are many reports suggesting predictive factors for respiratory complications after esophagectomy, but few studies have focused on this problem from the aspect of immunonutrition...
  56. ncbi request reprint Therapeutic strategy for scirrhous type gastric cancer
    Chikara Kunisaki
    Second Department of Surgery, Yokohama City University School of Medicine 3 9 Fukuura Kanazawa ku, Yokohama, Japan
    Hepatogastroenterology 52:314-8. 2005
    ..As no appropriate therapeutic strategy has yet been established in scirrhous type gastric cancer, we retrospectively analyzed the therapeutic outcomes in patients with this type of cancer...
  57. ncbi request reprint Yearly alterations in prognostic factors in gastric cancer during the post-operative period
    Chikara Kunisaki
    Second Department of Surgery, Yokohama City University School of Medicine, Yokohama, Japan
    Anticancer Res 24:377-83. 2004
    ..Ascertaining prognostic factors appropriate for each post-operative year should contribute to the establishment of better therapeutic strategies and ultimately to the improvement of their long-term results...
  58. doi request reprint Risk factors for lymph node metastasis in histologically poorly differentiated type early gastric cancer
    C Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, Yokohama, Japan
    Endoscopy 41:498-503. 2009
    ....
  59. pmc Upper abdominal body shape is the risk factor for postoperative pancreatic fistula after splenectomy for advanced gastric cancer: a retrospective study
    Naoto Yamamoto
    Yokohama City University Medical Center, Gastroenterological Surgery, Yokohama, Japan
    World J Surg Oncol 6:109. 2008
    ..Postoperative pancreas fistula (POPF) is a major complication after total gastrectomy with splenectomy. We retrospectively studied the effects of upper abdominal shape on the development of POPF after gastrectomy...
  60. ncbi request reprint Predictive factors for pancreatic fistula after pancreaticosplenectomy for advanced gastric cancer in the upper third of the stomach
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Japan
    J Gastrointest Surg 10:132-7. 2006
    ..If this operative procedure must be used (e.g., in patients with extensive tumor presence), careful manipulation and appropriate drainage are essential, particularly in cases showing predictive factors of pancreatic fistula...
  61. ncbi request reprint Usefulness of multidisciplinary therapy combining neoadjuvant chemotherapy with S-1 plus cisplatin and postoperative sequential chemotherapy in patients with scirrhous gastric cancer
    Takashi Oshima
    Yokohama City University Medical Center, Yokohama, Japan
    Hepatogastroenterology 59:1638-42. 2012
    ..We retrospectively compared outcomes according to historically different treatments for SGC and studied the therapeutic usefulness of NAC with S-1 plus cisplatin followed by postoperative sequential chemotherapy...
  62. doi request reprint Phase II study of biweekly docetaxel and S-1 combination chemotherapy as first-line treatment for advanced gastric cancer
    Chikara Kunisaki
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57 Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Cancer Chemother Pharmacol 67:1363-8. 2011
    ..We evaluated the efficacy and toxicity of biweekly S-1 and docetaxel combination therapy in patients with advanced gastric cancer...
  63. ncbi request reprint Preoperative S-1 and docetaxel combination chemotherapy in patients with locally advanced gastric cancer
    Takashi Kosaka
    Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Cancer Chemother Pharmacol 73:281-5. 2014
    ..This study was held to evaluate the efficacy and safety of DS followed by surgery...
  64. doi request reprint Evaluation of intraperitoneal lavage cytology before colorectal cancer resection
    Shoichi Fujii
    Department of Surgery, Gastroenterological Center, Yokohama City University, Yokohama, Japan
    Int J Colorectal Dis 24:907-14. 2009
    ..The aim of this study was to assess the usefulness of intraperitoneal lavage cytology (lavage Cy) status before the resection of colorectal cancer as a predictive factor of peritoneal recurrence...
  65. doi request reprint Prognostic factors after resection of pancreatic cancer
    Michio Ueda
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    World J Surg 33:104-10. 2009
    ..The purpose of this study was to identify important prognostic factors related to the status of a pancreatic tumor, its treatment, and the patient's general condition...
  66. ncbi request reprint Preoperative serum carcinoembryonic antigen level as a predictive factor of recurrence after curative resection of colorectal cancer
    Ryo Takagawa
    Department of Surgery, Gastroenterological Center, Yokohama City University, Yokohama, Japan
    Ann Surg Oncol 15:3433-9. 2008
    ..We evaluated the prognostic value of the preoperative serum carcinoembryonic antigen (CEA) level in patients with colorectal cancer (CRC)...
  67. ncbi request reprint The expression of bone matrix protein mRNAs around beta-TCP particles implanted into bone
    K Ohsawa
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Biomed Mater Res 52:460-6. 2000
    ..The latter cells may be macrophages and reflect foreign body reactions. Expression of these OPN mRNAs induced by implantation of beta-TCP may play a role in bone formation on the materials and in determining their biocompatibility...
  68. doi request reprint Laparoscopic colorectal cancer surgery by a colon lifting-up technique that decreases the number of access ports: comparison by propensity scoring of short-term and long-term outcomes with standard multiport laparoscopic surgery
    Shoichi Fujii
    Department of Surgery, Gastroenterological Center, Graduate School of Medicine, Yokohama City University, Minami Ku, Yokohama, Japan
    Surg Laparosc Endosc Percutan Tech 22:38-45. 2012
    ..The main mesenteric vessels are under tension, and lymph node dissection is performed easily by a medial approach. The working space is more stable because the colon is fixed to the abdominal wall...
  69. ncbi request reprint Significance of long-term follow-up of early gastric cancer
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Ann Surg Oncol 13:363-9. 2006
    ..Improvements in therapeutic outcomes are being sought by studying the timing and causes of death. Here, the results of surgery were evaluated to assess the appropriate treatment and follow-up schedule for early gastric cancer...
  70. ncbi request reprint Effect of obesity on laparoscopy-assisted distal gastrectomy compared with open distal gastrectomy for gastric cancer
    Hirochika Makino
    Department of Surgery, Yokohama City University, Gastroenterological Center, Minami Ku, Yokohama, Japan
    J Surg Oncol 102:141-7. 2010
    ..This study compared surgical outcomes between patients undergoing laparoscopy-assisted distal gastrectomy (LADG) and those undergoing open distal gastrectomy (ODG) from the viewpoint of obesity...
  71. ncbi request reprint [A case of advanced gastric cancer effectively treated on an outpatient basis by biweekly S-1 and docetaxel combination chemotherapy]
    Ryo Takagawa
    Dept of Surgery, Gastroenterological Center, Yokohama City University
    Gan To Kagaku Ryoho 36:1749-51. 2009
    ..The biweekly docetaxel and S-1 combination chemotherapy was thought to be an effective method as chemotherapy for an outpatient with advanced gastric cancer...
  72. ncbi request reprint The effect of alkali- and heat-treated titanium and apatite-formed titanium on osteoblastic differentiation of bone marrow cells
    K Nishio
    Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Kawahara cho 54, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Biomed Mater Res 52:652-61. 2000
    ..This potential for apatite formation may play an important role in osteoblastic differentiation...
  73. ncbi request reprint Surgical outcomes in patients with T4 gastric carcinoma
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Am Coll Surg 202:223-30. 2006
    ..There is controversy about the best therapeutic surgical approach for treatment of patients with T4 gastric cancer...
  74. ncbi request reprint Second-line docetaxel plus cisplatin for advanced gastric cancer showing resistance to S-1
    R Takagawa
    Yokohama City University Medical Center, Gastroenterological, 4 57 Urafunecho, Minami Ku, Yokohama 232 0024, Japan
    J Chemother 23:44-8. 2011
    ..Non-hematological toxicities were generally mild to moderate and controllable. this study showed satisfactory therapeutic outcomes for patients with gastric cancer refractory to S- 1 chemotherapy...
  75. ncbi request reprint Appropriate lymph node dissection for early gastric cancer based on lymph node metastases
    C Kunisaki
    Second Department of Surgery, Yokohama City University School of Medicine, Yokohama, Japan
    Surgery 129:153-7. 2001
    ..In submucosal cancer, gastrectomy with dissection of group 1 and some group 2 lymph nodes should be sufficient to remove all nodal metastases...
  76. ncbi request reprint Correlation of immunohistochemical p53 labeling index with inhibition rate in chemosensitivity test in gastric and colon cancer
    N Hosaka
    Second Department of Surgery and Department of Pathology, Yokohama City University, School of Medicine, 3-9 Fukuura Kanazawa-ku, Yokohama, Japan
    Anticancer Res 21:229-35. 2001
    ..We therefore concluded that immunohistochemical studies for p53 and p21 were useful for predicting the chemosensitivities of colon and gastric cancer to MMC and 5-FU...
  77. ncbi request reprint Prognostic factors in adenocarcinoma of the gastric cardia: pathologic stage analysis and multivariate regression analysis
    Y Kajiyama
    Department of Surgery, Toranomon Hospital, Tokyo, Japan
    J Clin Oncol 15:2015-21. 1997
    ....
  78. ncbi request reprint Correlating purity by microdissection with gene expression in gastric cancer tissue
    Y Otsuka
    Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan
    Scand J Clin Lab Invest 67:367-79. 2007
    ..Tissues of 70% purity for cancer cells, acquired by microdissection, were therefore deemed to be of sufficient quality to distinguish between gene expression profiles from microdissected and non-microdissected specimens...
  79. ncbi request reprint Effects of apatite and wollastonite containing glass-ceramic powder and two types of alumina powder in composites on osteoblastic differentiation of bone marrow cells
    K Nishio
    Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Kawahara cho 54, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Biomed Mater Res 55:164-76. 2001
    ..The delta-crystal phase of alumina powder in a composite promotes greater osteoblastic differentiation than the alpha-crystal phase of alumina powder...
  80. doi request reprint Perioperative use of a neutrophil elastase inhibitor in video-assisted thoracoscopic oesophagectomy for cancer
    H Makino
    Department of Surgery, Gastroenterological Centre, Yokohama City University, Minami Ku, Yokohama, Japan
    Br J Surg 98:975-82. 2011
    ..This study was undertaken to assess the value of administering perioperative sivelestat sodium hydrate (SSH), a selective neutrophil elastase inhibitor, after video-assisted thoracoscopic oesophagectomy for cancer...
  81. ncbi request reprint Marked increase of trypsin(ogen) in serum of linitis plastica (gastric cancer, borrmann 4) patients
    Y Ichikawa
    Second Department of Surgery, Yokohoma City University School of Medicine, Yokohama, Japan
    Clin Cancer Res 6:1385-8. 2000
    ..Therefore, serum concentration of trypsin(ogen) might be a good marker of gastric cancer of linitis plastica...
  82. ncbi request reprint Surgical treatment of esophageal cancer: Tokyo experience of the three-field technique
    H Udagawa
    Department of Gastroenterological Surgery, Toranomon Hospital, Tokyo, Japan
    Dis Esophagus 14:110-4. 2001
    ..Further trials are now under way with the aim of improving the results of the technique and also extending the applications of limited surgery and non-surgical therapy...
  83. ncbi request reprint Efficacy of chemoradiotherapy with low-dose cisplatin and continuous infusion of 5-fluorouracil for unresectable squamous cell carcinoma of the esophagus
    Ryo Takagawa
    Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, Yokohama 236 0004, Japan
    Dis Esophagus 22:482-9. 2009
    ..These findings confirmed that the chemoradiotherapy regimen had curative potential for unresectable esophageal cancer...
  84. ncbi request reprint Positive and negative regulation of chondrogenesis by splice variants of PEBP2alphaA/CBFalpha1 in clonal mouse EC cells, ATDC5
    H Akiyama
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Cell Physiol 181:169-78. 1999
    ..Therefore, we conclude that PEBP2alphaA acts as a positive regulator of chondrogenesis, and that this positive effect may be finely tuned by the opposing effect of the til-1 G2 isoform...
  85. ncbi request reprint Surgical outcomes for early gastric cancer in the upper third of the stomach
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University, Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0024, Japan
    J Am Coll Surg 200:15-9. 2005
    ..The aim of this study is to analyze and establish a therapeutic strategy for early tumors in the upper third of the stomach...
  86. ncbi request reprint High expression of atypical protein kinase C lambda/iota in gastric cancer as a prognostic factor for recurrence
    Ryo Takagawa
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Ann Surg Oncol 17:81-8. 2010
    ..This study aimed to clarify the relationship between aPKClambda/iota expression and the clinicopathological features of gastric cancer...
  87. ncbi request reprint Clinical evaluation of granisetron as an inhibitor of nausea and vomiting induced by oral anticancer drugs
    Shinji Togo
    Department of Surgery II, Yokohama City University, Kanazawa Ku, Yokohama 236 0004, Japan
    Oncol Rep 9:277-82. 2002
    ..2% on the 5th day of treatment. iv) There was no adverse reaction or abnormality of laboratory test values attributable to granisetron. Granisetron was safe and effective against nausea and vomiting induced by oral anticancer drugs...
  88. ncbi request reprint Modified POSSUM to predict postoperative morbidity following gastrectomy
    Yuichi Otsuka
    Gastroenterological Surgery, Yokohama City University, Japan
    Hepatogastroenterology 54:1142-5. 2007
    ..In order to predict morbidity after gastrectomy for gastric cancer in aged patients, the Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity (POSSUM) scoring system was applied...
  89. doi request reprint Clinical characteristics of rectal cancer involving the anal canal
    Mitsuyoshi Ota
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    J Gastrointest Surg 15:460-5. 2011
    ..This study evaluates the clinical characteristics of rectal cancer involving the anal canal...
  90. ncbi request reprint Developing an appropriate staging system for esophageal carcinoma
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Am Coll Surg 201:884-90. 2005
    ..In this study, we evaluated the surgical outcomes of esophageal cancer according to five existing staging systems and assessed their prognostic significance...
  91. ncbi request reprint Surgical outcome in patients with gastric adenocarcinoma in the upper third of the stomach
    Chikara Kunisaki
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Surgery 137:165-71. 2005
    ..Here we attempt to clarify the debate by retrospectively evaluating surgical outcome...
  92. ncbi request reprint Surgical outcome of para-aortic lymph node dissection preserving neural tissue based on anatomical evaluations
    Masato Nomura
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Kanazawa Ku, Yokohama, Japan
    J Gastrointest Surg 9:781-8. 2005
    ..7 and 9.7 months, respectively (P < 0.02). We conclude that para-aortic lymph node dissection preserving neural tissue is useful in patients with three or fewer para-aortic metastatic lymph nodes that are in front of the neural tissue...
  93. ncbi request reprint Lack of efficacy of prophylactic continuous hyperthermic peritoneal perfusion on subsequent peritoneal recurrence and survival in patients with advanced gastric cancer
    Chikara Kunisaki
    Second Department of Surgery, Yokohama City University, School of Medicine, Yokohama, Japan
    Surgery 131:521-8. 2002
    ..Few studies have assessed the clinical significance of continuous hyperthermic peritoneal perfusion in peritoneal recurrence...
  94. ncbi request reprint Indication for hepatic resection in the treatment of liver metastasis from gastric cancer
    Hirochika Makino
    Department of Surgery, Gastroenterological Center, Yokohama City University, 4 57, Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    Anticancer Res 30:2367-76. 2010
    ..The significance of hepatic resection for liver metastasis after gastric cancer is not well established. This study aimed to evaluate the effect of hepatic resection in such patients...
  95. ncbi request reprint Phase II study of weekly paclitaxel as a second-line treatment for S-1-refractory advanced gastric cancer
    Goro Matsuda
    Department of Surgery, Gastroenterological Center, Graduate School of Medicine, Yokohama City University, Japan
    Anticancer Res 29:2863-7. 2009
    ..We retrospectively evaluated the efficacy of weekly paclitaxel therapy as second-line treatment for patients with advanced gastric cancer that was refractory to S-1...
  96. ncbi request reprint Basaloid cell carcinoma of the esophagus with a metastatic neck tumor of unknown origin: report of a case
    Masakazu Kawamoto
    Second Department of Surgery, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Surg Today 33:529-32. 2003
    ..Postoperative recombinant chemotherapy with cisplatin and 5-fluorouracil was given for the unknown primary site, which we still have not identified. No recurrence of the esophageal cancer has been detected...
  97. ncbi request reprint [Effectiveness of continuous hyperthermic peritoneal perfusion for the peritoneal dissemination of gastric cancer]
    Hirotoshi Akiyama
    Second Dept of Surgery, Yokohama City University School of Medicine
    Gan To Kagaku Ryoho 29:2168-73. 2002
    ..In the patients with CHPP, the incidences of respiratory failure and renal failure were each statistically greater than in the patients undergoing CHPP...
  98. ncbi request reprint [A case of gastric cancer with multiple liver metastases responding to combined hepatic arterial and aortic infusion chemotherapy with cisplatinum, 5-fluorouracil, and levofolinate calcium]
    Mitsutaka Sugita
    2nd Dept of Surgery, Yokohama City University School of Medicine
    Gan To Kagaku Ryoho 29:1835-9. 2002
    ..Combined hepatic arterial and aortic infusion chemotherapy with CDDP, 5-FU, and l-LV is thought to be an effective regimen for advanced gastric cancer with multiple liver metastases...