Takashi Ishikawa

Summary

Affiliation: Yokohama City University
Country: Japan

Publications

  1. ncbi request reprint Impacts and predictors of cytotoxic anticancer agents in different breast cancer subtypes
    Takashi Ishikawa
    Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama, Japan
    Oncol Res 20:71-9. 2012
  2. ncbi request reprint Transcription-reverse transcription concerted reaction and minimal residual disease in axillary sentinel nodes of breast cancer
    T Ishikawa
    Department of General Surgery, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Eur J Surg Oncol 33:430-4. 2007
  3. ncbi request reprint False-positive and false-negative cases of fine-needle aspiration cytology for palpable breast lesions
    Takashi Ishikawa
    Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama, 232 0024, Japan
    Breast Cancer 14:388-92. 2007
  4. ncbi request reprint A multicenter phase II study of docetaxel 60 mg/m2 as first-line chemotherapy in patients with advanced or recurrent breast cancer
    Takashi Ishikawa
    Department of General Surgery, Yokohama City University Medical Center, Minami Ku, Yokohama 232 0024, Japan
    Breast Cancer 11:374-9. 2004
  5. doi request reprint Pathological examination with two-millimetre serial sectioning for sentinel lymph node biopsies in breast cancer
    T Ishikawa
    Department of General Surgery, Yokohama City University Medical Center, Yokohama, Japan
    Eur J Surg Oncol 35:895-6. 2009
  6. ncbi request reprint Blue-dye technique complements four-node sampling for early breast cancer
    T Ishikawa
    Department of General Surgery, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Eur J Surg Oncol 31:1119-24. 2005
  7. doi request reprint A human epidermal growth factor receptor 2 expression-based approach to neoadjuvant chemotherapy for operable breast cancer
    Takashi Ishikawa
    Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan
    Jpn J Clin Oncol 40:620-6. 2010
  8. ncbi request reprint Feasibility of AC/EC followed by weekly paclitaxel in node-positive breast cancer in Japan
    Takashi Ishikawa
    Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, 4 57, Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Anticancer Res 29:1515-20. 2009
  9. ncbi request reprint Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response
    Ryusei Matsuyama
    Department of Gastroenterological Surgery, Yokohama City University, Graduate School of Medicine, Fukuura, Kanazawa Ku, Yokohama, Kanagawa, Japan
    Int J Cancer 119:406-13. 2006
  10. ncbi request reprint Real-time PCR (TaqMan PCR) quantification of carcinoembryonic antigen (CEA) mRNA in the peripheral blood of colorectal cancer patients
    Masaru Miura
    Department of Surgery II, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Japan, 236 0004
    Anticancer Res 23:1271-6. 2003

Collaborators

Detail Information

Publications86

  1. ncbi request reprint Impacts and predictors of cytotoxic anticancer agents in different breast cancer subtypes
    Takashi Ishikawa
    Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama, Japan
    Oncol Res 20:71-9. 2012
    ..049). Cytotoxic anticancer agents were associated with different responses in different breast cancer subtypes. Identifying basal-type cancer and further subdivision of nonbasal types is important for treating TN patients...
  2. ncbi request reprint Transcription-reverse transcription concerted reaction and minimal residual disease in axillary sentinel nodes of breast cancer
    T Ishikawa
    Department of General Surgery, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Eur J Surg Oncol 33:430-4. 2007
    ..To investigate the use of transcription-reverse transcription concerted reaction (TRC) to detect axillary lymph node metastases...
  3. ncbi request reprint False-positive and false-negative cases of fine-needle aspiration cytology for palpable breast lesions
    Takashi Ishikawa
    Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama, 232 0024, Japan
    Breast Cancer 14:388-92. 2007
    ..Fine-needle aspiration cytology (FNA) is less traumatic and technically easy to apply to small breast tumors...
  4. ncbi request reprint A multicenter phase II study of docetaxel 60 mg/m2 as first-line chemotherapy in patients with advanced or recurrent breast cancer
    Takashi Ishikawa
    Department of General Surgery, Yokohama City University Medical Center, Minami Ku, Yokohama 232 0024, Japan
    Breast Cancer 11:374-9. 2004
    ..However, the efficacy of this agent as a first-line drug when used at a lower dosage is unclear. This study was performed to evaluate the clinical efficacy and safety of 60 mg/m2 docetaxel for the treatment of breast cancer...
  5. doi request reprint Pathological examination with two-millimetre serial sectioning for sentinel lymph node biopsies in breast cancer
    T Ishikawa
    Department of General Surgery, Yokohama City University Medical Center, Yokohama, Japan
    Eur J Surg Oncol 35:895-6. 2009
    ..To compare enhanced pathology with serial sectioning and the transcription-reverse transcription concerted reaction (TRC) for detecting sentinel node (SN) metastasis in breast cancer cases...
  6. ncbi request reprint Blue-dye technique complements four-node sampling for early breast cancer
    T Ishikawa
    Department of General Surgery, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Eur J Surg Oncol 31:1119-24. 2005
    ..To examine four-node axillary sampling assisted by a blue dye (4NAS/dye) technique as a sentinel node biopsy (SNB) for breast cancer...
  7. doi request reprint A human epidermal growth factor receptor 2 expression-based approach to neoadjuvant chemotherapy for operable breast cancer
    Takashi Ishikawa
    Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan
    Jpn J Clin Oncol 40:620-6. 2010
    ..We investigated the pathological effects of neoadjuvant chemotherapy based on the human epidermal growth factor receptor 2 in operable breast cancer...
  8. ncbi request reprint Feasibility of AC/EC followed by weekly paclitaxel in node-positive breast cancer in Japan
    Takashi Ishikawa
    Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, 4 57, Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Anticancer Res 29:1515-20. 2009
    ..The feasibility and efficacy of adriamycin or epirubicin in combination with cyclophosphamide followed by weekly paclitaxel (AC/EC-weekly PAC) as adjuvant chemotherapy for breast cancer was investigated...
  9. ncbi request reprint Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response
    Ryusei Matsuyama
    Department of Gastroenterological Surgery, Yokohama City University, Graduate School of Medicine, Fukuura, Kanazawa Ku, Yokohama, Kanagawa, Japan
    Int J Cancer 119:406-13. 2006
    ..Our "Response Index" system, consisting of TNFRSF1B, SLC35F5 and OPRT, has great potential for predicting the efficacy of 5-FU-based chemotherapy against liver metastases from colorectal cancer...
  10. ncbi request reprint Real-time PCR (TaqMan PCR) quantification of carcinoembryonic antigen (CEA) mRNA in the peripheral blood of colorectal cancer patients
    Masaru Miura
    Department of Surgery II, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Japan, 236 0004
    Anticancer Res 23:1271-6. 2003
    ..This indicates that quantification of CEA mRNA is useful for the evaluation of colorectal cancer progress and that the post-operative increase of CEA mRNA can be a predictive marker for micrometastasis...
  11. ncbi request reprint Prediction of chemosensitivity of colorectal cancer to 5-fluorouracil by gene expression profiling with cDNA microarrays
    Daisuke Shimizu
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236 0004, Japan
    Int J Oncol 27:371-6. 2005
    ..The gene set thus identified successfully predicted the sensitivities of 5 other colorectal cancer cell lines and could also separate 5-FU resistant clinical samples from sensitive ones...
  12. doi request reprint Is lymph-node micrometastasis in gallbladder cancer a significant prognostic factor?
    Mikiko Tanabe
    Department of Gastroenterological Surgery, Yokoham City University, Yokohama, Japan
    Hepatogastroenterology 59:31-5. 2012
    ..The purpose of our study was to investigate prognostic significance of lymph-node micrometastasis in gallbladder carcinoma...
  13. doi request reprint The topoisomerase II alpha gene status in primary breast cancer is a predictive marker of the response to anthracycline-based neoadjuvant chemotherapy
    Kae Kawachi
    Division of Anatomic and Surgical Pathology, Yokohama City University Medical Center, Minami Ku, Yokohama, Japan
    Pathol Res Pract 206:156-62. 2010
    ..TOP2A overexpression was not significantly associated with response (p=0.580). Our results thus suggest that the TOP2A/CEP17 ratio may be a useful predictor of the effects of anthracycline-based neoadjuvant chemotherapy in breast cancer...
  14. ncbi request reprint Early-onset brain metastases in a breast cancer patient after pathological complete response to neoadjuvant chemotherapy
    Kazuhiro Shimada
    Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, 4 57 Urafunecho, Minami Ku, Yokohama 232 0024, Japan
    Anticancer Res 33:5119-21. 2013
    ..Physicians should be aware of the possibility of early brain metastases, and consider new treatment strategies to prevent brain metastases in high-risk patients who achieve pCR...
  15. pmc High expression of ATP-binding cassette transporter ABCC11 in breast tumors is associated with aggressive subtypes and low disease-free survival
    Akimitsu Yamada
    Department of Clinical Oncology and Breast Surgery, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa, Japan
    Breast Cancer Res Treat 137:773-82. 2013
    ..017 and P < 0.001, respectively). We have shown, for the first time, that ABCC1, ABCC11, and ABCG2 are highly expressed in aggressive breast cancer subtypes, and that tumor ABCC11 expression is associated with poor prognosis...
  16. ncbi request reprint MUC1 overexpression is the most reliable marker of invasive carcinoma in intraductal papillary-mucinous tumor (IPMT)
    Michio Ueda
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Hepatogastroenterology 52:398-403. 2005
    ..To clarify the development of pancreatic cancer we performed immunohistochemical analysis of the presence of the major apomucin and cell-cycle regulatory proteins using the tissues of IPMT and ductal adenocarcinoma (DC) of the pancreas...
  17. ncbi request reprint Human equilibrative nucleoside transporter 1 is associated with the chemosensitivity of gemcitabine in human pancreatic adenocarcinoma and biliary tract carcinoma cells
    Ryutaro Mori
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Oncol Rep 17:1201-5. 2007
    ..We conclude that increased hENT1 expression is a most important determinant of gemcitabine sensitivity at least in an in vitro study...
  18. ncbi request reprint Locally advanced mucinous carcinoma of the breast with sudden growth acceleration: a case report
    Takashi Ishikawa
    Department of Surgery, Yokohama City University, School of Medicine, Yokohama, Japan
    Jpn J Clin Oncol 32:64-7. 2002
    ..This case showed completely opposite features to all of these typical biological features of pure mucinous carcinomas...
  19. doi request reprint CT assessment of breast cancer for pathological involvement of four or more axillary nodes
    Ichiro Ogino
    Department of Radiation Oncology, Yokohama City University Medical Center, Minami Ku, Japan
    Breast Cancer 19:125-30. 2012
    ..To predict the likelihood of ≥4 pathologically positive axillary nodes in breast cancer patients by computed tomography (CT) before neoadjuvant chemotherapy (NAC)...
  20. ncbi request reprint [Advances in breast cancer chemotherapy]
    Takashi Ishikawa
    Department of General Surgery, Yokohama City University Medical Center
    Nihon Rinsho 64:529-35. 2006
    ..Controversies and future directions are the high cost of treatment and the prediction of response to each drug for individual patients...
  21. ncbi request reprint Current progress in the prediction of chemosensitivity for breast cancer
    Daisuke Shimizu
    Department of General Surgery, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Breast Cancer 11:42-8. 2004
    ..Taken together with recent data, studies for drug sensitivity should provide insights into the mechanisms of drug sensitivity and the optimal design of more effective treatment strategies in breast cancer...
  22. ncbi request reprint Pharmacologic preconditioning effects: prostaglandin E1 induces heat-shock proteins immediately after ischemia/reperfusion of the mouse liver
    Ken ichi Matsuo
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Gastrointest Surg 9:758-68. 2005
    ..Our results suggested that PGE1 induces HSPs immediately after ischemia reperfusion. HSPs might therefore play an important role in the protective effects of PGE1 against ischemia/reperfusion injury of the liver...
  23. pmc Breast cancer manifested by hematologic disorders
    Takashi Ishikawa
    Department of Breast and Thyroid Surgery Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    J Thorac Dis 4:650-4. 2012
    ..Metastatic tumors in the bone marrow, lung, and liver showed different sensitivities to different anti-cancer agents. We report a case of breast cancer manifested by hematologic disorders which was treated by a sequential chemotherapy...
  24. ncbi request reprint Expression of dihydropyrimidine dehydrogenase, thymidylate synthase, p53 and p21 in metastatic liver tumor from colorectal cancer after 5-fluorouracil-based chemotherapy
    Shigeru Yamagishi
    Yokohama City University Graduate School of Medicine, Department of Gastroenterological Surgery, Yokohama, Japan
    Anticancer Res 25:1237-42. 2005
    ..The expression of genes thought to be related to 5-FU chemosensitivity has been extensively investigated. However, little data is available on the expression patterns of these genes after chemotherapy...
  25. ncbi request reprint Telomerase activity and Bcl-2 expression in gallbladders of pancreaticobiliary maljunction patients: a preliminary study
    Yasushi Ichikawa
    Department of Surgery 2, Yokohama City University, School of Medicine, 3 9 Fukuura, Kanazawa Ku, 236 0004, Yokohama, Japan
    J Hepatobiliary Pancreat Surg 11:34-9. 2004
    ..In the present study, telomerase activity and Bcl-2 expression in the gallbladder mucosa of PBM and non-PBM gallbladders were investigated...
  26. ncbi request reprint Biliobiliary fistulas manifested by worsening liver function--a case report
    Takashi Ishikawa
    Department of Gastroenterological Surgery, Yokohama City University, Graduate School of Medicine, Kobayashi Clinic, Yokohama, Japan
    Hepatogastroenterology 52:1092-4. 2005
    ....
  27. doi request reprint Gastrointestinal stromal tumor with two genetic abnormalities on different alleles: report of a case
    Yasushi Ichikawa
    Department of Gastroenterological Surgery, Yokohama City University Postgraduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Surg Today 40:262-6. 2010
    ..Cloning analysis indicated that the point mutation and the deletion were present on different alleles...
  28. ncbi request reprint Association between breast cancer risk and the wild-type allele of human ABC transporter ABCC11
    Ikuko Ota
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama City University Medical Center, Yokohama, Japan
    Anticancer Res 30:5189-94. 2010
    ..The G allele determines the wet type of earwax as a Mendelian trait with a dominant phenotype. The present study examined the association between the frequency rate of breast cancer and the frequency of the G allele of ABCC11...
  29. ncbi request reprint [Molecular factors promoting carcinogenesis and malignant behavior of intraductal papillary mucinous tumors]
    Yasushi Ichikawa
    Department of Surgery II, Yokohama City University, School of Medicine, Yokohama, Japan
    Nihon Geka Gakkai Zasshi 104:443-6. 2003
    ..They will be important molecular targets for the radical treatment of pancreatic cancer...
  30. doi request reprint Sebaceous carcinoma of the breast
    Ayumi Murakami
    Department of Pathology, Yokohama City University Medical Center, Yokohama, Japan
    Pathol Int 59:188-92. 2009
    ..This is the first case of an androgen receptor-positive mammary SC to be reported, and therefore contributes to the understanding of the clinicopathological features of SC of the breast...
  31. doi request reprint Observational study of blue dye-assisted four-node sampling for axillary staging in early breast cancer
    K Narui
    Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Eur J Surg Oncol 36:731-6. 2010
    ..We previously reported blue dye-assisted four-node axillary sampling (4NAS/dye) to be a suitable method for detecting sentinel nodes (SNs) without RIs. Here, we present an interim report on an observational study of this technique...
  32. ncbi request reprint Evaluation of dynamic studies of MR mammography for the diagnosis of intraductal lesions with nipple discharge
    Takashi Ishikawa
    Second Department of Surgery, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama, Japan
    Breast Cancer 11:288-94. 2004
    ..We assessed the utility of dynamic magnetic resonance imaging (MRI) in differentiating benign from malignant lesions of the breast and then applied MRI to diagnose intraductal breast tumors with nipple discharge...
  33. ncbi request reprint Mechanism of liver regeneration after partial hepatectomy using mouse cDNA microarray
    Shinji Togo
    Department of Surgery II, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    J Hepatol 40:464-71. 2004
    ....
  34. doi request reprint Allergic reactions to oxaliplatin in a single institute in Japan
    Yasushi Ichikawa
    Department of Clinical Oncology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Jpn J Clin Oncol 39:616-20. 2009
    ..Our experience indicates that allergy to oxaliplatin may be a significant concern and that methods are required for suppression of this allergy...
  35. ncbi request reprint ST-segment depression in lead aVR predicts predischarge left ventricular dysfunction in patients with reperfused anterior acute myocardial infarction with anterolateral ST-segment elevation
    M Kosuge
    Department of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
    Am Heart J 142:51-7. 2001
    ..CONCLUSIONS: We conclude that in patients with an anterolateral AMI, ST-segment depression in lead aVR on admission ECG is useful for predicting larger infarct and left ventricular dysfunction despite successful reperfusion...
  36. ncbi request reprint Relationship between myocardial damage and C-reactive protein levels immediately after onset of acute myocardial infarction
    K Kimura
    The Department of Cardiology, Yokohama City University Medical Center, Japan
    Jpn Circ J 65:67-70. 2001
    ..0) before discharge. These results suggest that the clinical situation of elevated CRP immediately after onset is associated with less myocardial damage and better left ventricular function in reperfused anterior AMI...
  37. ncbi request reprint Successful left trisegmentectomy for polycystic liver disease accompanied by jaundice
    I Endo
    Second Department of Surgery, Yokohama City University School of Medicine, Yokohama, Japan
    Dig Surg 18:320-2. 2001
    ..We report a case of severe polycystic liver disease (PLD) with jaundice in a 57-year-old woman who underwent successful left trisegmentectomy...
  38. ncbi request reprint Comparison of results of early reperfusion in patients with inferior wall acute myocardial infarction with and without complete atrioventricular block
    K Kimura
    Critical Care and Emergency Medical Center, Yokohama City University School of Medicine, Japan
    Am J Cardiol 84:731-3, A8. 1999
    ..Early reperfusion may promote the restoration of normal sinus rhythm and effectively reduce infarct size in these patients...
  39. ncbi request reprint Genetic instability did not lead to p53 mutations in an extremely early-onset breast cancer in a cancer-prone family
    T Ishikawa
    Department of Surgery, Yokohama City University, School of Medicine, Yokohama, Kanagawa, Japan
    Jpn J Clin Oncol 29:332-5. 1999
    ..A positive family history is a major contributor to risk of development of breast cancer...
  40. ncbi request reprint Matrilysin as a target for chemotherapy for colon cancer: use of antisense oligonucleotides as antimetastatic agents
    K Miyazaki
    Division of Cell Biology, Kihara Institute for Biological Research, Yokohama City University, Yokohama, Japan
    Cancer Chemother Pharmacol 43:S52-5. 1999
    ..These results suggest that matrilysin has an important role in the liver metastasis of human colon cancer and that matrilysin antisense oligonucleotides have therapeutic potential for the prevention of metastasis...
  41. ncbi request reprint Identification of genes regulating colorectal carcinogenesis by using the algorithm for diagnosing malignant state method
    Yasushi Ichikawa
    Second Department of Surgery, School of Medicine, Yokohama City University, Yokohama, Japan
    Biochem Biophys Res Commun 296:497-506. 2002
    ..Included in the 135 genes were tumor suppressor and growth factor-related genes and were consistent with the literature. ADMS is a reliable means for identifying genes useful for the diagnosis of cancer...
  42. ncbi request reprint VEGF receptor antisense therapy inhibits angiogenesis and peritoneal dissemination of human gastric cancer in nude mice
    Masako Kamiyama
    Department of Surgery II, Yokohama City University, School of Medicine, Yokohama, Japan
    Cancer Gene Ther 9:197-201. 2002
    ..Microvessel density was significantly reduced in the KDR/Flk-1-ASO-treated tumor nodules. The KDR/Flk-1 antisense strategy, therefore, decreases tumor dissemination apparently by inhibiting angiogenesis...
  43. ncbi request reprint Differences in inflammatory activity at the onset of acute myocardial infarction according to the clinical presentation of preinfarction angina
    M Kosuge
    The Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
    Jpn Circ J 65:707-10. 2001
    ..In such patients, the pathogenetic mechanisms may differ from those in other subsets of patients with AMI and active inflammation may play a more important role in AMI onset...
  44. ncbi request reprint Matrilysin stimulates DNA synthesis of cultured vascular endothelial cells and induces angiogenesis in vivo
    I Nishizuka
    Department of Surgery 2, Yokohama City University, School of Medicine, 3 9 Fukuura Kanazawa ku, 236 0004, Yokohama, Japan
    Cancer Lett 173:175-82. 2001
    ..In conclusion, matrilysin may be associated with angiogenesis of human colon cancer through the direct proliferative action on endothelial cells...
  45. ncbi request reprint Early peak creatine kinase activity is not always a marker of successful reperfusion with myocardial salvage in patients with reperfused anterior acute myocardial infarction
    M Kosuge
    Department of Cardiology, Yokohama City University Medical Center, Japan
    Am Heart J 141:759-64. 2001
    ..01). CONCLUSIONS: We conclude that compared with early peak CK, late peak CK consistently reflects good myocardial salvage in patients with anterior AMI who had successful reperfusion within 6 hours from symptom onset...
  46. ncbi request reprint Clinical significance of serum CEA protein and CEA mRNA after resection of colorectal liver metastases
    M Kijima
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Anticancer Res 25:1327-32. 2005
    ..It is difficult to predict the recurrence of colorectal liver metastasis after curative hepatectomy. We investigated the relationship between subsequent metastasis and both CEA protein and CEA mRNA (TaqMan PCR) diachronic levels...
  47. pmc Plasma free amino acid profiling of five types of cancer patients and its application for early detection
    Yohei Miyagi
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center, Yokohama, Japan
    PLoS ONE 6:e24143. 2011
    ..Therefore, the purpose of the present study was to determine the characteristics of the PFAA profiles in cancer patients and the possibility of using this information for early detection...
  48. ncbi request reprint Inhibition of osteoclast differentiation and bone resorption by cathepsin K antisense oligonucleotides
    T Ishikawa
    Second Department of Surgery, Yokohama City University, Yokohama, Japan
    Mol Carcinog 32:84-91. 2001
    ..Cathepsin K may play important roles in bone resorption as well as in differentiation of osteoclasts. These findings indicate that the inhibition of this enzyme may prevent the development of bone metastasis from breast cancer...
  49. ncbi request reprint Implications of the absence of ST-segment elevation in lead V4R in patients who have inferior wall acute myocardial infarction with right ventricular involvement
    M Kosuge
    The Department of Cardiology, Yokohama City University Medical Center, Japan
    Clin Cardiol 24:225-30. 2001
    ..In such patients, the incidence of RVI may be underestimated on the basis of ST-segment elevation in lead V4R...
  50. ncbi request reprint Electrocardiographic criteria for predicting total occlusion of the proximal left anterior descending coronary artery in anterior wall acute myocardial infarction
    M Kosuge
    The Department of Cardiology, Yokohama City University Medical Center, Japan
    Clin Cardiol 24:33-8. 2001
    ..001). CONCLUSIONS: We conclude that a greater degree of ST-segment depression in lead III than that of ST-segment elevation in lead aVL is a useful predictor of proximal LAD occlusion in patients with anterior AMI...
  51. ncbi request reprint Correlation of immunohistochemical p53 labeling index with inhibition rate in chemosensitivity test in gastric and colon cancer
    N Hosaka
    Second Department of Surgery and Department of Pathology, Yokohama City University, School of Medicine, 3-9 Fukuura Kanazawa-ku, Yokohama, Japan
    Anticancer Res 21:229-35. 2001
    ..We therefore concluded that immunohistochemical studies for p53 and p21 were useful for predicting the chemosensitivities of colon and gastric cancer to MMC and 5-FU...
  52. ncbi request reprint Doppler index and plasma level of atrial natriuretic hormone are improved by optimizing atrioventricular delay in atrioventricular block patients with implanted DDD pacemakers
    N Toda
    Second Department of Internal Medicine Yokohama City University School of Medicine, Yokohama, Japan
    Pacing Clin Electrophysiol 24:1660-3. 2001
    ..This study shows the importance of the optimal AV delay setting in patients with an implanted DDD pacemaker, the Doppler index and plasma ANP levels are good indicators for optimizing AV delay...
  53. ncbi request reprint Marked increase of trypsin(ogen) in serum of linitis plastica (gastric cancer, borrmann 4) patients
    Y Ichikawa
    Second Department of Surgery, Yokohoma City University School of Medicine, Yokohama, Japan
    Clin Cancer Res 6:1385-8. 2000
    ..Therefore, serum concentration of trypsin(ogen) might be a good marker of gastric cancer of linitis plastica...
  54. ncbi request reprint Investigation of 5-FU disposition after oral administration of capecitabine, a triple-prodrug of 5-FU, using a physiologically based pharmacokinetic model in a human cancer xenograft model: comparison of the simulated 5-FU exposures in the tumour tissue b
    Y Tsukamoto
    Nippon Roche Research Centre, Kamakura, Kanagawa, Japan
    Biopharm Drug Dispos 22:1-14. 2001
    ....
  55. ncbi request reprint The ribs: anatomic and radiologic considerations
    Y Kurihara
    Department of Radiology, St Marianna University School of Medicine, Kawasaki City, Kanagawa, Japan
    Radiographics 19:105-19; quiz 151-2. 1999
    ..It is imperative that the radiologist be familiar with normal rib anatomy, normal rib variants, and the radiologic appearance of the ribs to prevent misdiagnosis...
  56. ncbi request reprint Enhanced ghrelin expression and subsequent acid secretion in mice with genetic H(2)-receptor knockout
    Mamoru Arakawa
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Gastroenterol 42:711-8. 2007
    ..The present study was designed to clarify the dynamics of ghrelin in H(2) receptor (H(2)R)-null mice by genetic H(2)R knockout...
  57. ncbi request reprint Analysis of gene expression involved in brain metastasis from breast cancer using cDNA microarray
    Itaru Nishizuka
    Department of Surgery 2, Yokohama City University, School of Medicine, 3 9 Fukuura Kanazawa ku, Kanagawa 236 0004, Japan
    Breast Cancer 9:26-32. 2002
    ..The patterns of metastases to different organs are determined by the tumor cell phenotype and interactions between the tumor cells and the organ environment...
  58. ncbi request reprint [Function of MMP-7 in colorectal cancer]
    Yasushi Ichikawa
    Department of Surgery II, Yokohama City University School of Medicine
    Nihon Rinsho 61:209-14. 2003
  59. doi request reprint The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors
    Yasuyuki Kojima
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Hum Pathol 39:824-31. 2008
    ..This is also the first evidence to show aPKC lambda/iota overexpression in breast cancer and demonstrates that its localization is associated with the trend of pathologic type of the tumor...
  60. ncbi request reprint Mechanism of postoperative liver failure after excessive hepatectomy investigated using a cDNA microarray
    Tomoyuki Morita
    Second Department of Surgery, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004 Japan
    J Hepatobiliary Pancreat Surg 9:352-9. 2002
    ....
  61. ncbi request reprint [Screening of novel biomarkers for the detection of intraperitoneally disseminated cancer cells using human cDNA microarray]
    Chouhei Sakakura
    Dept of Gastroenterological Surgery, Kyoto Prefectural University of Medicine
    Gan To Kagaku Ryoho 29:2271-4. 2002
    ..The results of this global gene expression analysis of gastric cancer cells with peritoneal dissemination promise to provide new insights into the study of human gastric cancer peritoneal dissemination...
  62. ncbi request reprint Cross-linked collagen C- and N-telopeptides for an early diagnosis of bone metastasis from breast cancer
    Konosuke Kiuchi
    Second Department of Surgery, Yokohama City University, Yokohama 236 0004, Japan
    Oncol Rep 9:595-8. 2002
    ..5 ng/ml of ICTP, had a solitary lesion of bone metastasis. Although ICTP is not sensitive enough to detect an early stage of bone metastasis, it is a better biochemical marker than NTx for detecting bone metastasis from breast cancer...
  63. ncbi request reprint Pregnancy-associated breast cancer with multiple metastases
    Takashi Ishikawa
    Department of Surgery, Yokohama City University School of Medicine, 236 0004 Yokohama, Japan
    Eur J Surg 168:428-30. 2002
  64. ncbi request reprint Evaluation of transcatheter arterial embolization prior to percutaneous tumor ablation in patients with hepatocellular carcinoma: a randomized controlled trial
    Masatoshi Akamatsu
    Department of Gastroenterology, The University of Tokyo Hospital, Tokyo, Japan
    Liver Int 24:625-9. 2004
    ..We continued the study after the introduction of RFA and compared TAE combined with RFA (TAE/RFA) with RFA only...
  65. ncbi request reprint Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa
    Yasushi Fukushima
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur J Pharmacol 502:243-52. 2004
    ..These findings provide evidence that different G-protein coupled-receptors affect differentiation into different cell lineages derived from common stem cells in gastric mucosa...
  66. ncbi request reprint Neither hepatitis C virus genotype nor virus load affects survival of patients with hepatocellular carcinoma
    Masatoshi Akamatsu
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Eur J Gastroenterol Hepatol 16:459-66. 2004
    ..This study was conducted to elucidate whether these two factors are capable of predicting the prognosis of patients with HCC...
  67. ncbi request reprint Hepatocellular carcinoma in elderly patients: beneficial therapeutic efficacy using percutaneous ethanol injection therapy
    Takuma Teratani
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Japan
    Cancer 95:816-23. 2002
    ..The age of patients with hepatocellular carcinoma (HCC) has been increasing worldwide. The objective of this study was to assess the efficacy and safety of percutaneous ethanol injection therapy (PEIT) in elderly patients with HCC...
  68. ncbi request reprint Extremely early onset of ranitidine action on human histamine H2 receptors expressed in HEK293 cells
    Yasushi Fukushima
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Digestion 68:145-52. 2003
    ..This study aims to characterize how rapidly famotidine and ranitidine, the most widely used histamine H2 receptor antagonists, interact with the human histamine H2 receptor...
  69. ncbi request reprint Prognostic value of combination of cardiac troponin T and B-type natriuretic peptide after initiation of treatment in patients with chronic heart failure
    Junnichi Ishii
    Division of Critical Care, Fujita Health University Graduate School of Health Sciences, Toyoake 470 1192, Japan
    Clin Chem 49:2020-6. 2003
    ....
  70. ncbi request reprint 4-Methylumbelliferone induces the expression of membrane type 1-matrix metalloproteinase in cultured human skin fibroblasts
    Toshiya Nakamura
    Department of Medical Technology, Hirosaki University School of Health Sciences, Hirosaki, Japan
    Biochem Biophys Res Commun 298:646-50. 2002
    ..These results suggest that 4-methylumbelliferone induces the expression of membrane type 1-matrix metalloproteinase, resulting in activation of matrix metalloproteinase-2, in cultured human skin fibroblasts...
  71. ncbi request reprint Factors predisposing to poorly differentiated hepatocellular carcinoma and its recurrence
    Masatoshi Akamatsu
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 52:391-7. 2005
    ....
  72. ncbi request reprint Development of well-differentiated hepatocellular carcinoma in large adenomatous hyperplasia after long-term follow-up: a case report
    Yutaka Midorikawa
    Hepato Biliary Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    Hepatogastroenterology 49:1098-101. 2002
    ..One year after surgery, the patient is doing well without signs of recurrence...
  73. pmc Early passenger leukocyte migration and acute immune reactions in the rat recipient spleen during liver engraftment: with particular emphasis on donor major histocompatibility complex class II+ cells
    Toyokazu Okuda
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Transplantation 74:103-11. 2002
    ....
  74. ncbi request reprint A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma
    Shuichiro Shiina
    Department of Gastroenterology, University of Tokyo, Japan
    Gastroenterology 129:122-30. 2005
    ..Percutaneous radiofrequency ablation is a recently introduced treatment for hepatocellular carcinoma, whereas ethanol injection is now a standard therapy. We compared their long-term outcomes...
  75. ncbi request reprint [Safety and efficacy of hypotonic CDDP intraperitoneal administration for gastric cancer with peritoneal dissemination]
    Takeo Bamba
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences
    Gan To Kagaku Ryoho 32:1695-7. 2005
    ..Although intraperitoneal CDDP administration is safe to be carried out intraoperatively, the effect on survival is not better than new anticancer drugs, such as TS-1 and paclitaxel...
  76. ncbi request reprint Matrilysin (MMP-7) degrades VE-cadherin and accelerates accumulation of beta-catenin in the nucleus of human umbilical vein endothelial cells
    Yasushi Ichikawa
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Japan
    Oncol Rep 15:311-5. 2006
    ....
  77. ncbi request reprint MMP-7 (matrilysin) accelerated growth of human umbilical vein endothelial cells
    Nailin Huo
    Department of Surgery 2, Yokohama City University School of Medicine, 3 9 Fukuura Kanazawa ku, Yokohama 236 0004, Japan
    Cancer Lett 177:95-100. 2002
    ..From this study, we conclude that MMP-7 directly induces angiogenesis, and that therefore MMP-7 would be a good target of cancer therapy...
  78. ncbi request reprint Age-related comparison of the profiles of patients with hepatocellular carcinoma
    Tomonori Fujishima
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Japan
    Hepatogastroenterology 53:913-8. 2006
    ..Therefore this study aims to evaluate whether the clinicopathological features in young patients with HCC significantly differ from those of elderly patients...
  79. ncbi request reprint [A case of advanced breast cancer with multiple liver metastases resistant to chemotherapy responding to high-dose toremifene]
    Chizuru Matsumoto
    Dept of General Surgery, Yokohama City University Medical Center
    Gan To Kagaku Ryoho 34:449-51. 2007
    ..Liver dysfunction recovered after administration of TOR, and primary tumor and liver metastases were evaluated as a partial response (PR). The same therapy has been performed for six months with no evidence of deterioration...
  80. ncbi request reprint Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
    Takayuki Shindo
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Nat Med 8:856-63. 2002
    ..KLF5 thus seems to be a key element linking external stress and cardiovascular remodeling...
  81. ncbi request reprint Acyclic retinoid inhibits neointima formation through retinoic acid receptor beta-induced apoptosis
    Nanae Kada
    Department of Cardiovascular Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Arterioscler Thromb Vasc Biol 27:1535-41. 2007
    ..With the objective of addressing the therapeutic potential in the cardiovasculature, namely neointima formation, effects of ACR on neointima formation and the involved mechanisms were investigated...
  82. ncbi request reprint Involvement of chemical mediators in nasal allergic responses of HDC-KO mice
    Md Ashequr Rahman
    Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8530, Japan
    Eur J Pharmacol 567:245-51. 2007
    ..Therefore, it can be concluded that not only histamine, but also substance P and prostaglandin D(2), participated in the nasal allergic responses induced by antigen in mice...
  83. ncbi request reprint Outbreak of hepatitis C virus infection in an outpatient clinic
    Takashi Ishikawa
    Department of Internal Medicine, University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 20:1087-93. 2005
    ..Six were outpatients of the clinic, which is located near the hospital. An extensive survey of clinic outpatients conducted by the local health department revealed six more new acute hepatitis cases during this period...
  84. doi request reprint Secondary mutations in the kinase domain of the KIT gene are predominant in imatinib-resistant gastrointestinal stromal tumor
    Toshirou Nishida
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Osaka, Japan
    Cancer Sci 99:799-804. 2008
    ..Resistant lesions showed monoclonal development of tumor cells. Taken together, additional cis-positioned mutations in the kinase domains are a major cause of secondary resistance to imatinib in Japanese GIST patients...
  85. ncbi request reprint Risk stratification using a combination of cardiac troponin T and brain natriuretic peptide in patients hospitalized for worsening chronic heart failure
    Junnichi Ishii
    Division of Critical Care, Graduate School of Health Sciences, Fujita Health University, Toyoake, Japan
    Am J Cardiol 89:691-5. 2002
    ..Measuring the combination of admission concentrations of cTnT and BNP may be a highly effective means of risk stratification of patients hospitalized for worsening chronic heart failure...
  86. ncbi request reprint [Early prediction of response to primary chemotherapy by sequential FDG -PET in patients with advanced breast cancer]
    Nobuyoshi Momiyama
    Momiyama Clinic
    Nihon Rinsho 65:385-8. 2007