Nobuhito Hirawa

Summary

Affiliation: Yokohama City University
Country: Japan

Publications

  1. doi request reprint ATP2B1 and blood pressure: from associations to pathophysiology
    Nobuhito Hirawa
    Division of Nephrology and Hypertension, Yokohama City University Medical Center, Yokohama, Japan
    Curr Opin Nephrol Hypertens 22:177-84. 2013
  2. doi request reprint Urinary oxidative stress markers closely reflect the efficacy of candesartan treatment for diabetic nephropathy
    Shin ichiro Yoshida
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine and School of Medicine, Yokohama, Japan
    Nephron Exp Nephrol 111:e20-30. 2009
  3. ncbi request reprint A possible relationship of nocturnal blood pressure variability with coronary artery disease in diabetic nephropathy
    Kouichi Tamura
    Department of Medicine II, Yokohama City University School of Medicine, Yokohama, Japan
    Clin Exp Hypertens 29:31-42. 2007
  4. doi request reprint Silent brain infarction and rapid decline of kidney function in patients with CKD: a prospective cohort study
    Mayumi Kobayashi
    Division of Nephrology and Hypertension, Yokohama City University Medical Center, Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine and School of Medicine, Yokohama, Japan
    Am J Kidney Dis 56:468-76. 2010
  5. doi request reprint Mice lacking hypertension candidate gene ATP2B1 in vascular smooth muscle cells show significant blood pressure elevation
    Yusuke Kobayashi
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School ofMedicine, Yokohama, Japan
    Hypertension 59:854-60. 2012
  6. ncbi request reprint Impaired nitric oxide production and increased blood pressure in systemic heterozygous ATP2B1 null mice
    Akira Fujiwara
    aDepartment of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine bDepartment of Nephrology and Hypertension, Yokohama City University Medical Center cMolecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama dCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto eDepartment of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon fDepartment of Health Science, Shiga University of Medical Science, Otsu gCardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Hypertens 32:1415-23. 2014
  7. doi request reprint Effects of carvedilol as third-line add-on therapy on blood pressure and glucose metabolism in type 2 diabetic patients with chronic renal disease stage 3 and above
    Gen Yasuda
    Division of Nephrology and Hypertension, Center Hospital, Yokohama City University School of Medicine, Yokohama, Japan
    Kidney Blood Press Res 36:131-8. 2012
  8. doi request reprint Effect of renin-angiotensin system inhibitor on residual glomerular filtration rate in hemodialysis patients
    Yoko Itoh
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Ther Apher Dial 16:554-9. 2012
  9. pmc Angiotensin receptor-binding protein ATRAP/Agtrap inhibits metabolic dysfunction with visceral obesity
    Akinobu Maeda
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Am Heart Assoc 2:e000312. 2013
  10. pmc Relationship between silent brain infarction and chronic kidney disease
    Mayumi Kobayashi
    Department of Medical Science, Division of Nephrology and Hypertension, Yokohama City University Medical Center, Yokohama City University Graduate School of Medicine and School of Medicine, Yokohama, Japan
    Nephrol Dial Transplant 24:201-7. 2009

Collaborators

Detail Information

Publications16

  1. doi request reprint ATP2B1 and blood pressure: from associations to pathophysiology
    Nobuhito Hirawa
    Division of Nephrology and Hypertension, Yokohama City University Medical Center, Yokohama, Japan
    Curr Opin Nephrol Hypertens 22:177-84. 2013
    ..We also review the findings of studies involving spontaneously hypertensive rats and tissue-specific ATP2B1 knockout mice examining the effects of ATP2B1 on hypertension...
  2. doi request reprint Urinary oxidative stress markers closely reflect the efficacy of candesartan treatment for diabetic nephropathy
    Shin ichiro Yoshida
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine and School of Medicine, Yokohama, Japan
    Nephron Exp Nephrol 111:e20-30. 2009
    ....
  3. ncbi request reprint A possible relationship of nocturnal blood pressure variability with coronary artery disease in diabetic nephropathy
    Kouichi Tamura
    Department of Medicine II, Yokohama City University School of Medicine, Yokohama, Japan
    Clin Exp Hypertens 29:31-42. 2007
    ..Elevated short-term BP variability combined with relative sympathetic prevalence during the night might represent an important risk factor for cardiovascular events in the diabetic population...
  4. doi request reprint Silent brain infarction and rapid decline of kidney function in patients with CKD: a prospective cohort study
    Mayumi Kobayashi
    Division of Nephrology and Hypertension, Yokohama City University Medical Center, Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine and School of Medicine, Yokohama, Japan
    Am J Kidney Dis 56:468-76. 2010
    ....
  5. doi request reprint Mice lacking hypertension candidate gene ATP2B1 in vascular smooth muscle cells show significant blood pressure elevation
    Yusuke Kobayashi
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School ofMedicine, Yokohama, Japan
    Hypertension 59:854-60. 2012
    ..These results suggest that ATP2B1 plays important roles in the regulation of blood pressure through alteration of calcium handling and vasoconstriction in vascular smooth muscle cells...
  6. ncbi request reprint Impaired nitric oxide production and increased blood pressure in systemic heterozygous ATP2B1 null mice
    Akira Fujiwara
    aDepartment of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine bDepartment of Nephrology and Hypertension, Yokohama City University Medical Center cMolecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama dCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto eDepartment of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon fDepartment of Health Science, Shiga University of Medical Science, Otsu gCardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Hypertens 32:1415-23. 2014
    ..The ATP2B1 gene encodes the plasma membrane calcium ATPase isoform 1, which contributes to the maintenance of intracellular calcium homeostasis by removing calcium ions...
  7. doi request reprint Effects of carvedilol as third-line add-on therapy on blood pressure and glucose metabolism in type 2 diabetic patients with chronic renal disease stage 3 and above
    Gen Yasuda
    Division of Nephrology and Hypertension, Center Hospital, Yokohama City University School of Medicine, Yokohama, Japan
    Kidney Blood Press Res 36:131-8. 2012
    ..We evaluated the effect of coadministration of β-blocker (carvedilol) as the third agent with angiotensin II receptor blockers (ARB) and calcium channel blockers (CCB) on blood pressure (BP) regulation and glucose metabolism...
  8. doi request reprint Effect of renin-angiotensin system inhibitor on residual glomerular filtration rate in hemodialysis patients
    Yoko Itoh
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Ther Apher Dial 16:554-9. 2012
    ..A further intervention study is required to investigate whether treatment with renin-angiotensin system inhibitors and suppression of body weight gain preserves residual renal function for a longer time in hemodialysis patients...
  9. pmc Angiotensin receptor-binding protein ATRAP/Agtrap inhibits metabolic dysfunction with visceral obesity
    Akinobu Maeda
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Am Heart Assoc 2:e000312. 2013
    ..Adipose tissue dysfunction has been proposed as the cause of visceral obesity-related metabolic disorders, moving the tissue toward a proinflammatory phenotype...
  10. pmc Relationship between silent brain infarction and chronic kidney disease
    Mayumi Kobayashi
    Department of Medical Science, Division of Nephrology and Hypertension, Yokohama City University Medical Center, Yokohama City University Graduate School of Medicine and School of Medicine, Yokohama, Japan
    Nephrol Dial Transplant 24:201-7. 2009
    ..The association between SBI and chronic kidney disease (CKD) has not been clarified. Moreover, little is known about what factors are related to SBI in CKD patients and whether the prevalence of SBI differs in CKD stage or cause of CKD...
  11. doi request reprint Localization and extent of peritoneal calcification in three uremic patients on continuous ambulatory peritoneal dialysis
    Kyoko Dejima
    Division of Nephrology, Yokohama City University School of Medicine, Yokohama, Japan
    Ther Apher Dial 12:413-6. 2008
    ....
  12. pmc Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis
    Tatsuo Hashimoto
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine and School of Medicine, Kanazawa Ku, Yokohama, Japan
    Am J Pathol 171:1705-12. 2007
    ..APJ deficiency is preventative against oxidative stress-linked atherosclerosis...
  13. ncbi request reprint Effects of atorvastatin versus probucol on low-density lipoprotein subtype distribution and renal function in hyperlipidemic patients with nondiabetic nephropathy
    Gen Yasuda
    Division of Nephrology, Center Hospital, School of Medicine, Yokohama City University, Yokohama, Japan
    Ren Fail 32:680-6. 2010
    ..However, few studies have evaluated the effects of antilipidemic agents on the LDL particle size and renal function in hyperlipidemic patients with nondiabetic nephropathy...
  14. ncbi request reprint High-resolution mapping for essential hypertension using microsatellite markers
    Keisuke Yatsu
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Yokohama, Japan
    Hypertension 49:446-52. 2007
    ..We identified 19 allelic loci that were significantly different between the cases of essential hypertension and the controls...
  15. ncbi request reprint Analysis of factors that affect short-term blood pressure variability in patients with chronic renal failure
    Masashi Sakai
    Department of Medicine II, Yokohama City University School of Medicine, Yokohama, Japan
    Clin Exp Hypertens 27:139-47. 2005
    ..Furthermore, sympathetic nerve overactivity may be involved in cardiovascular complications in CRF patients through the increase in nighttime systolic BP variability...
  16. doi request reprint Long-term efficacy and safety of the small-sized β2-microglobulin adsorption column for dialysis-related amyloidosis
    Yuichiro Yamamoto
    Division of Nephrology, Dialysis and Apheresis, Yokohama City University Medical Center, 45 7, Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Ther Apher Dial 15:466-74. 2011
    ..Improvement of chronic inflammation may be one of the mechanisms through which the beneficial effects of the column is effected...