Syu ichi Hirai

Summary

Affiliation: Yokohama City University
Country: Japan

Publications

  1. ncbi The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex
    Syu ichi Hirai
    Department of Molecular Biology, Graduate School of Medical Science, Yokohama City University, Yokohama 236 0004, Japan
    J Neurosci 26:11992-2002. 2006
  2. ncbi MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase
    S I Hirai
    Department of Molecular Biology, Yokohama City University School of Medicine, 3 9, Fukuura, Kanazawa Ku, Yokohama 236, Japan
    J Biol Chem 272:15167-73. 1997
  3. ncbi Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2
    S Hirai
    Department of Molecular Biology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236, Japan
    J Biol Chem 273:7406-12. 1998
  4. doi Axon formation in neocortical neurons depends on stage-specific regulation of microtubule stability by the dual leucine zipper kinase-c-Jun N-terminal kinase pathway
    Syu ichi Hirai
    Department of Molecular Biology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Neurosci 31:6468-80. 2011
  5. ncbi MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo
    Syu ichi Hirai
    Department of Molecular Biology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Development 129:4483-95. 2002
  6. ncbi Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo
    Syu ichi Hirai
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9, Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Gene Expr Patterns 5:517-23. 2005
  7. ncbi Developmental changes in the expression pattern of the JNK activator kinase MUK/DLK/ZPK and active JNK in the mouse cerebellum
    Jun Suenaga
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Cell Tissue Res 325:189-95. 2006
  8. ncbi Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex
    Fumiyasu Imai
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Development 133:1735-44. 2006
  9. ncbi Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells
    Naoyuki Manabe
    Department of Molecular Biology, Yokohama City University School of Medicine, Kanazawa Ku, Yokohama, Japan
    Dev Dyn 225:61-9. 2002
  10. ncbi Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration
    Naoya Yamashita
    Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Neurosci 26:13357-62. 2006

Collaborators

Detail Information

Publications17

  1. ncbi The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex
    Syu ichi Hirai
    Department of Molecular Biology, Graduate School of Medical Science, Yokohama City University, Yokohama 236 0004, Japan
    J Neurosci 26:11992-2002. 2006
    ..These data suggest that DLK plays a significant role in the coordinated regulation of radial migration and axon projection by modulating JNK activity...
  2. ncbi MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase
    S I Hirai
    Department of Molecular Biology, Yokohama City University School of Medicine, 3 9, Fukuura, Kanazawa Ku, Yokohama 236, Japan
    J Biol Chem 272:15167-73. 1997
    ..Taken together, these results suggest that MLK family members are MAPK kinase kinases preferentially acting on the JNK/SAPK pathway...
  3. ncbi Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2
    S Hirai
    Department of Molecular Biology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236, Japan
    J Biol Chem 273:7406-12. 1998
    ..These results provide a molecular aspect to the differential regulation of the two JNK activators by a variety of cellular stimuli...
  4. doi Axon formation in neocortical neurons depends on stage-specific regulation of microtubule stability by the dual leucine zipper kinase-c-Jun N-terminal kinase pathway
    Syu ichi Hirai
    Department of Molecular Biology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Neurosci 31:6468-80. 2011
    ..Together, these in vivo and in vitro observations indicate that the DLK-JNK pathway facilitates axon formation in neocortical neurons via stage-specific regulation of microtubule stability...
  5. ncbi MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo
    Syu ichi Hirai
    Department of Molecular Biology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Development 129:4483-95. 2002
    ..In COS-1 cells, MUK/DLK/ZPK overexpression impairs the radial organization of microtubules without massive depolymerization. These results suggest that MUK/DLK/ZPK and JNK regulate radial cell migration via microtubule-based events...
  6. ncbi Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo
    Syu ichi Hirai
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9, Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Gene Expr Patterns 5:517-23. 2005
    ..The intensely overlapping localization of betaIII-tubulin and MUK/DLK/ZPK indicated that this protein kinase is tightly associated with the microtubules of neurons...
  7. ncbi Developmental changes in the expression pattern of the JNK activator kinase MUK/DLK/ZPK and active JNK in the mouse cerebellum
    Jun Suenaga
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Cell Tissue Res 325:189-95. 2006
    ....
  8. ncbi Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex
    Fumiyasu Imai
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Development 133:1735-44. 2006
    ..Therefore, we concluded that, at least in the later stages of neurogenesis, regulation of cell cycle exit is independent of adherens junctions...
  9. ncbi Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells
    Naoyuki Manabe
    Department of Molecular Biology, Yokohama City University School of Medicine, Kanazawa Ku, Yokohama, Japan
    Dev Dyn 225:61-9. 2002
    ....
  10. ncbi Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration
    Naoya Yamashita
    Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Neurosci 26:13357-62. 2006
    ..Loss of crmp1 in a dab1 heterozygous background led to the disruption of hippocampal lamination, a Reeler-like phenotype. In addition to axon guidance, CRMP1 regulates neuronal migration by mediating Reln signaling...
  11. pmc The interaction of Kinesin-1 with its adaptor protein JIP1 can be regulated via proteins binding to the JIP1-PTB domain
    Tomoko Satake
    Department of Molecular Biology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    BMC Cell Biol 14:12. 2013
    ..The kinesin-1-binding protein, JIP1, can function as an adaptor protein that links kinesin-1 and other JIP1-binding "cargo" proteins. However, it is unknown whether these "cargo" proteins influence the JIP1-kinesin-1 binding...
  12. ncbi Neonatal pancreatic cells redifferentiate into both neural and pancreatic lineages
    Wenping Zhao
    Department of Regenerative Medicine, Graduate School of Medical Science, Yokohama City University, Yokohama 236 0004, Japan
    Biochem Biophys Res Commun 352:84-90. 2007
    ..The neuronal differentiation of pancreatic cells, however, occurs prior to endocrine differentiation and gradually becomes dominant, thus implying a default neuronal lineage specification for cultured pancreatic cells...
  13. doi Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth
    Kenji Hayashi
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, Kanazawa Ku, Yokohama 236 0004, Japan
    J Neurosci 31:12094-103. 2011
    ..In conclusion, the present results suggested a novel function for PAR1b in the maintenance of mature dendritic spine morphology by regulating microtubule growth and the accumulation of p140Cap in dendritic spines...
  14. doi De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy
    Hirotomo Saitsu
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Nat Genet 40:782-8. 2008
    ..Furthermore, binding of the mutant protein to syntaxin was impaired. These findings suggest that haploinsufficiency of STXBP1 causes EIEE...
  15. pmc Dominant-negative mutations in alpha-II spectrin cause West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay
    Hirotomo Saitsu
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Am J Hum Genet 86:881-91. 2010
    ..These findings suggest that pathological aggregation of alpha/beta spectrin heterodimers and abnormal AIS integrity resulting from SPTAN1 mutations were involved in pathogenesis of infantile epilepsy...
  16. ncbi A DNA vaccine containing inverted terminal repeats from adeno-associated virus increases immunity to HIV
    Ke Qin Xin
    Department of Bacteriology, Yokohama City University School of Medicine, Japan
    J Gene Med 5:438-45. 2003
    ..This study explores whether DNA vaccine immunogenicity can be improved by introducing inverted terminal repeats (ITRs) from adeno-associated virus (AAV) into the regulatory region of the DNA plasmid...
  17. ncbi Renal cell carcinoma- and pheochromocytoma-specific altered gene expression profiles in VHL mutant clones
    Mutsumi I Tsuchiya
    Department of Urology, Kochi Medical School, Nankoku City, Kochi 783 8505, Japan
    Oncol Rep 13:1033-41. 2005
    ..Moreover, a mutation in the elongin-binding domain may induce type 2B tumors through different molecular pathways compared to those induced by type 1- or 2A-associated mutations in the HIF-alpha -binding region...