Genomes and Genes


Kengo Azushima


Affiliation: Yokohama City University
Country: Japan


  1. Ohsawa M, Tamura K, Wakui H, Kanaoka T, Azushima K, Uneda K, et al. Effects of pitavastatin add-on therapy on chronic kidney disease with albuminuria and dyslipidemia. Lipids Health Dis. 2015;14:161 pubmed publisher
  2. Haruhara K, Wakui H, Azushima K, Kurotaki D, Kawase W, Uneda K, et al. Angiotensin receptor-binding molecule in leukocytes in association with the systemic and leukocyte inflammatory profile. Atherosclerosis. 2018;269:236-244 pubmed publisher
    ..These results suggest that leukocyte ATRAP is an emerging marker capable of reflecting the systemic and leukocyte inflammatory profile, and plays a role as an anti-inflammatory factor in the pathophysiology of NCDs. ..
  3. Ohki K, Wakui H, Kishio N, Azushima K, Uneda K, Haku S, et al. Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue. Sci Rep. 2018;8:2846 pubmed publisher
    ..Hyperactivity of AT1 receptor could be related to formation of insulin resistance related to metabolic syndrome. ..
  4. Ohki K, Wakui H, Azushima K, Uneda K, Haku S, Kobayashi R, et al. ATRAP Expression in Brown Adipose Tissue Does Not Influence the Development of Diet-Induced Metabolic Disorders in Mice. Int J Mol Sci. 2017;18: pubmed publisher
    ..Future studies that modulate ATRAP in WAT are necessary to assess its in vivo functions in the development of obesity-related metabolic disorders. ..
  5. Kino T, Ishigami T, Murata T, Doi H, Nakashima Sasaki R, Chen L, et al. Eplerenone-Resistant Salt-Sensitive Hypertension in Nedd4-2 C2 KO Mice. Int J Mol Sci. 2017;18: pubmed publisher
    ..Our results from Nedd4-2 C2 KO mice suggest that enhanced ENaC gene expression is critically involved in salt-sensitive hypertension under certain conditions of specific enzyme isoforms for their ubiquitination. ..
  6. Minegishi S, Ishigami T, Kawamura H, Kino T, Chen L, Nakashima Sasaki R, et al. An Isoform of Nedd4-2 Plays a Pivotal Role in Electrophysiological Cardiac Abnormalities. Int J Mol Sci. 2017;18: pubmed publisher