Y Aratani

Summary

Affiliation: Yokohama City University
Country: Japan

Publications

  1. ncbi request reprint Contribution of the myeloperoxidase-dependent oxidative system to host defence against Cryptococcus neoformans
    Yasuaki Aratani
    Kihara Institute for Biological Research, Yokohama City University, Maioka cho 641 12, Totsuka, Yokohama 244 0813, Japan
    J Med Microbiol 55:1291-9. 2006
  2. ncbi request reprint In vivo role of myeloperoxidase for the host defense
    Yasuaki Aratani
    Kihara Institute for Biological Research, Yokohama City University, Yokohama, Japan
    Jpn J Infect Dis 57:S15. 2004
  3. pmc Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase
    Y Aratani
    Kihara Institute for Biological Research and Graduate School of Integrated Science, Yokohama City University, Totsuka ku, Yokohama 244 0813, Japan
    Infect Immun 67:1828-36. 1999
  4. ncbi request reprint Relative contributions of myeloperoxidase and NADPH-oxidase to the early host defense against pulmonary infections with Candida albicans and Aspergillus fumigatus
    Y Aratani
    Kihara Institute for Biological Research, Yokohama City University, Maioka cho 641 12, Totsuka, Yokohama 244 0813, Japan
    Med Mycol 40:557-63. 2002
  5. ncbi request reprint Differential host susceptibility to pulmonary infections with bacteria and fungi in mice deficient in myeloperoxidase
    Y Aratani
    Kihara Institute for Biological Research, Yokohama City University, Totsuka, Yokohama 244 0813, Japan
    J Infect Dis 182:1276-9. 2000
  6. ncbi request reprint Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans
    Yasuaki Aratani
    Kihara Institute for Biological Research, Yokohama City University, Maioka cho 641 12, Totsuka, Yokohama 244 0813, Japan
    J Infect Dis 185:1833-7. 2002
  7. ncbi request reprint Genetic interaction between DNA polymerase beta and DNA-PKcs in embryogenesis and neurogenesis
    N Niimi
    Kihara Institute for Biological Research and Graduate School of Integrated Science, Yokohama City University, 641 12 Maioka cho, Totsuka ku, Yokohama 244 0813, Japan
    Cell Death Differ 12:184-91. 2005
  8. ncbi request reprint Earlier onset of neutrophil-mediated inflammation in the ultraviolet-exposed skin of mice deficient in myeloperoxidase and NADPH oxidase
    J Komatsu
    Kihara Institute for Biological Research, Yokohama City University, Maioka cho 641 12, Totsuka, Yokohama, 244 0813, Japan
    Inflamm Res 55:200-6. 2006
  9. doi request reprint Myeloperoxidase deficiency induces MIP-2 production via ERK activation in zymosan-stimulated mouse neutrophils
    N Tateno
    Graduate School of Nanobioscience, Yokohama City University, Kanazawa, Yokohama, Japan
    Free Radic Res 47:376-85. 2013
  10. ncbi request reprint Retardation of early-onset PMA-induced apoptosis in mouse neutrophils deficient in myeloperoxidase
    T Tsurubuchi
    Kihara Institute for Biological Research, Yokohama City University, Totsuka, Yokohama 244-0813, Japan
    J Leukoc Biol 70:52-8. 2001

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Contribution of the myeloperoxidase-dependent oxidative system to host defence against Cryptococcus neoformans
    Yasuaki Aratani
    Kihara Institute for Biological Research, Yokohama City University, Maioka cho 641 12, Totsuka, Yokohama 244 0813, Japan
    J Med Microbiol 55:1291-9. 2006
    ..neoformans not only in the lungs but also in the spleen in the absence of MPO. Taken together, these data suggest a major role of MPO in the response to cryptococcal infection...
  2. ncbi request reprint In vivo role of myeloperoxidase for the host defense
    Yasuaki Aratani
    Kihara Institute for Biological Research, Yokohama City University, Yokohama, Japan
    Jpn J Infect Dis 57:S15. 2004
    ..These results suggest that MPO and NADPH-oxidase are equally important for early host defense against a large inocula of Candida...
  3. pmc Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase
    Y Aratani
    Kihara Institute for Biological Research and Graduate School of Integrated Science, Yokohama City University, Totsuka ku, Yokohama 244 0813, Japan
    Infect Immun 67:1828-36. 1999
    ..The mutant mice serve as a model for studying pulmonary and systemic candidiasis...
  4. ncbi request reprint Relative contributions of myeloperoxidase and NADPH-oxidase to the early host defense against pulmonary infections with Candida albicans and Aspergillus fumigatus
    Y Aratani
    Kihara Institute for Biological Research, Yokohama City University, Maioka cho 641 12, Totsuka, Yokohama 244 0813, Japan
    Med Mycol 40:557-63. 2002
    ..funigatus, indicating that MPO is unable to play a role in host defense in the absence of NADPH-oxidase. This strongly suggests that hydrogen peroxide, the precursor of HOCl, is solely derived from O2- produced by NADPH-oxidase...
  5. ncbi request reprint Differential host susceptibility to pulmonary infections with bacteria and fungi in mice deficient in myeloperoxidase
    Y Aratani
    Kihara Institute for Biological Research, Yokohama City University, Totsuka, Yokohama 244 0813, Japan
    J Infect Dis 182:1276-9. 2000
    ..These results suggest that the MPO-dependent oxidative system is important for host defense against fungi and bacteria, although the effect varies by pathogen species...
  6. ncbi request reprint Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans
    Yasuaki Aratani
    Kihara Institute for Biological Research, Yokohama City University, Maioka cho 641 12, Totsuka, Yokohama 244 0813, Japan
    J Infect Dis 185:1833-7. 2002
    ..These results suggest that MPO and NADPH-oxidase are equally important for early host defense against a large inoculum of Candida...
  7. ncbi request reprint Genetic interaction between DNA polymerase beta and DNA-PKcs in embryogenesis and neurogenesis
    N Niimi
    Kihara Institute for Biological Research and Graduate School of Integrated Science, Yokohama City University, 641 12 Maioka cho, Totsuka ku, Yokohama 244 0813, Japan
    Cell Death Differ 12:184-91. 2005
    ..The mutants did not exhibit apoptosis but were lethal with defective neurulation at midgestation. These results suggest a genetic interaction between Polbeta and DNA-PKcs in embryogenesis and neurogenesis...
  8. ncbi request reprint Earlier onset of neutrophil-mediated inflammation in the ultraviolet-exposed skin of mice deficient in myeloperoxidase and NADPH oxidase
    J Komatsu
    Kihara Institute for Biological Research, Yokohama City University, Maioka cho 641 12, Totsuka, Yokohama, 244 0813, Japan
    Inflamm Res 55:200-6. 2006
    ..This study examined the role of neutrophil-derived reactive oxygen species (ROS) in neutrophil recruitment into ultraviolet B (UVB)-exposed skin of mice...
  9. doi request reprint Myeloperoxidase deficiency induces MIP-2 production via ERK activation in zymosan-stimulated mouse neutrophils
    N Tateno
    Graduate School of Nanobioscience, Yokohama City University, Kanazawa, Yokohama, Japan
    Free Radic Res 47:376-85. 2013
    ..Collectively, these results strongly suggest that both lack of HOCl and accumulation of H2O2 due to MPO deficiency contribute to the up-regulation of MIP-2 production in mouse neutrophils stimulated with zymosan...
  10. ncbi request reprint Retardation of early-onset PMA-induced apoptosis in mouse neutrophils deficient in myeloperoxidase
    T Tsurubuchi
    Kihara Institute for Biological Research, Yokohama City University, Totsuka, Yokohama 244-0813, Japan
    J Leukoc Biol 70:52-8. 2001
    ..This retardation was almost completely reversed when MPO or HOCl was exogenously added. These results suggest that coexistence of HOCl and superoxide accelerates the early onset of neutrophil apoptosis...
  11. ncbi request reprint Decreased topoisomerase IIalpha expression confers increased resistance to ICRF-193 as well as VP-16 in mouse embryonic stem cells
    M Kobayashi
    Kihara Institute for Biological Research and Graduate School of Integrated Science, Yokohama City University, Maioka-cho 641-12, Totsuka-ku, 244-0813, Yokohama, Japan
    Cancer Lett 166:71-7. 2001
    ..Importantly, the heterozygous cells exhibited an increased resistance to ICRF-193 as well as VP-16, suggesting that ICRF-193, like VP-16, exerts its cytotoxicity through converting topo II to a poison...
  12. pmc Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta
    N Sugo
    Kihara Institute for Biological Research, Graduate School of Integrated Science, Yokohama City University, Totsuka ku, Yokohama 244 0813, USA
    EMBO J 19:1397-404. 2000
    ..These findings indicate that Polbeta plays an essential role in neural development...
  13. ncbi request reprint Contribution of myeloperoxidase to coronary artery vasculitis associated with MPO-ANCA production
    A Ishida-Okawara
    Department of Bioactive Molecules, National Institute of Infectious Diseases, Tokyo, Japan
    Inflammation 25:381-7. 2001
    ..Vasculitis did develop in a few MPO-deficient mice, though the incidence of vasculitis was much lower in MPO-deficient mice than in C57BL/6 mice...
  14. ncbi request reprint DNA polymerase beta is not essential for the formation of palindromic (P) region of T cell receptor gene
    H Gonda
    Center for Molecular Biology and Genetics, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Immunol Lett 78:45-9. 2001
    ..This result unequivocally indicates that pol-beta, which is one of the repair-type DNA polymerases most abundantly expressed in thymus and spleen, is not essential for the formation of P region...
  15. ncbi request reprint Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis
    P M Sullivan
    Department of Pathology and Laboratory of Medicine, The University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
    J Biol Chem 272:17972-80. 1997
    ..Thus the structural differences between human APOE3 and mouse ApoE proteins are sufficient to cause an increased susceptibility to dietary-induced hypercholesterolemia and atherosclerosis in the 3/3 mice...
  16. pmc Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia
    M Watanabe
    Department of Pathology, University of North Carolina, Chapel Hill 27599 7525
    Proc Natl Acad Sci U S A 92:1585-9. 1995
    ..Thus, the heterozygous mutants are promising for studying the in vivo role of elevated levels of homocyst(e)ine in the etiology of cardiovascular diseases...