Research Topics
Genomes and Genes | Michiko AiharaSummaryAffiliation: Yokohama City University Country: Japan Publications
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Detail Information
Publications
Food-dependent exercise-induced anaphylaxis: influence of concurrent aspirin administration on skin testing and provocationM Aihara
Department of Dermatology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
Br J Dermatol 146:466-72. 2002..Provocation tests in patients with food-dependent exercise-induced anaphylaxis (FDEIA) are often negative, even after a sufficient quantity of the implicated food and exercise have been taken...
Pharmacogenetics of cutaneous adverse drug reactionsMichiko Aihara
Department of Dermatology, Yokohama City University School of Medicine, Yokohama, Japan
J Dermatol 38:246-54. 2011..Pharmacogenetic screening based on associations between adverse reactions and specific HLA alleles helps to avoid serious conditions associated with drug hypersensitivity...
Association of serum interleukin-18 and other biomarkers with disease severity in adults with atopic dermatitisKenzen Kou
Department of Environmental Immuno Dermatology, Yokohama City University Graduate School of Medicine, Kanazawa Ku, Yokohama City, Japan
Arch Dermatol Res 304:305-12. 2012..A panel of biomarkers (IL-18, TARC, total IgE, and LDH) may be more useful to accurately assess clinical severity in adult AD patients...
Oral administration of collagen tripeptide improves dryness and pruritus in the acetone-induced dry skin modelTomoko Okawa
Department of Environmental Immuno Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
J Dermatol Sci 66:136-43. 2012..However, more effective, simpler therapies are desired. Collagen tripeptide (CTP) is a highly purified, non-antigenic, low-allergenic collagen fraction that is known to have various biological effects...
Semaphorin3A alleviates skin lesions and scratching behavior in NC/Nga mice, an atopic dermatitis modelJunko Yamaguchi
Department of Environmental Immuno Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
J Invest Dermatol 128:2842-9. 2008..Because the interruption of the itch-scratch cycle likely contributes to the improvement of the AD-like skin lesions, Sema3A is promising in the treatment of patients with refractory AD, as well as overall itching dermatosis...
Effects of TNCB sensitization in DS-Nh mice, serving as a model of atopic dermatitis, in comparison with NC/Nga miceSetsuko Matsukura
Department of Environmental Immuno Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Int Arch Allergy Immunol 136:173-80. 2005..It has been predicted that a type-1 and type-2 helper T cell (Th1/Th2) imbalance exists in atopic dermatitis (AD). In DS-Nh mice, an AD mouse model, Staphylococcus aureus increases on the skin surface...
Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice: implications for human diseaseMio Kirino
Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
J Allergy Clin Immunol 122:290-7, 297.e1-8. 2008..Oxidative stress has been implicated in the exacerbation of atopic dermatitis (AD)...
[A case of cashew nut allergy followed by almond allergy]Natsue Kakemizu
Department of Dermatology of Yokohama City University Medical Center
Arerugi 52:1022-6. 2003
Effects of photocatalytic agent on DS-Nh mice, developing atopic dermatitis-like eruption with an increase of Staphylococcus aureusTakeshi Kambara
Department of Environmental Immuno Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Int Arch Allergy Immunol 141:151-7. 2006..We investigated the bactericidal effect of TiO2 with UV irradiation on DS-Nh mice to prevent the aggravation of the dermatitis...
Neuropeptides concentrations in the skin of a murine (NC/Nga mice) model of atopic dermatitisMasako Katsuno
Department of Environmental Immuno Dermatology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa, Yokohama, Japan
J Dermatol Sci 33:55-65. 2003..It has been reported that the expression of neuropeptides (NPs), and the density and structure of peripheral nerves in atopic dermatitis (AD) are different from those in normal skin...
Hyperproduction of IFN-gamma by CpG oligodeoxynucleotide-induced exacerbation of atopic dermatitis-like skin lesion in some NC/Nga miceMomoko Takakura
Department of Environmental Immuno Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
J Invest Dermatol 125:1156-62. 2005..These results suggest that the suppression of Th2 cytokines may not completely prevent dermatitis and that IFN-gamma may play a role in developing dermatitis in some NC/Nga mice...
Quantitative analysis of nerve growth factor (NGF) in the atopic dermatitis and psoriasis horny layer and effect of treatment on NGF in atopic dermatitisJunko Yamaguchi
Department of Environmental Immuno Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
J Dermatol Sci 53:48-54. 2009..In the present study, we measured skin NGF levels in AD patients and determined whether they correlate to AD severity as well as treatment effects...
Toxic epidermal necrolysis in a child successfully treated with cyclosporin A and methylprednisoloneYukoh Aihara
Department of Pediatrics, Yokohama City University Medical Center, Yokohama, Japan
Pediatr Int 49:659-62. 2007
Drug-induced hypersensitivity syndrome due to cyanamide associated with multiple reactivation of human herpesvirusesNaoko Mitani
Department of Dermatology, Yokohama City University Medical Center, Yokohama, Japan
J Med Virol 75:430-4. 2005..Disturbance of the immune system was suggested by the persistent low level of IgG, and consecutive viral reactivation may have participated in the prolonged course in this case...
Effects of tributyltin on the development of atopic dermatitis-like eruptions in DS-Nh miceChiaki Iwamura
Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Int Arch Allergy Immunol 141:337-45. 2006..These findings suggest that the increase in S. aureus and the enhancement of Th2 response induced by TBT exacerbate the AD-like lesions in mice treated with TNCB...
New horny layer marker proteins for evaluating skin condition in atopic dermatitisYumiko Yamane
Department of Environmental Immuno Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Int Arch Allergy Immunol 150:89-101. 2009..Atopic dermatitis (AD) has a complicated pathogenesis and its clinical features vary greatly among patients. Although many clinical parameters have been reported, it remains difficult to evaluate AD skin conditions adequately...
A Role of Staphyococcus aureus, Interleukin-18, Nerve Growth Factor and Semaphorin 3A, an Axon Guidance Molecule, in Pathogenesis and Treatment of Atopic DermatitisZenro Ikezawa
Department of Environmental Immuno Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Allergy Asthma Immunol Res 2:235-46. 2010..Because the interruption of the itch-scratch cycle likely contributes to the improvement of the AD-like lesions, Sema3A is expected to become a promising treatment of patients with refractory AD...
[Analysis of 76 patients with urticaria and angioedema induced by non-steroidal anti-inflammatory drugs (NSAIDs) in Japan]Maki Moriya
Department of Dermatology, Yokohama City University School of Medicine, Yokohama, Japan
Arerugi 60:699-707. 2011..We analyzed the clinical characteristics of patients with NSAIDs-induced urticaria and angioedema without asthma in Japan...
Different patterns of cytokines, ECP and immunoglobulin profiles at two adverse drug reactions in a patientYukoh Aihara
Department of Pediatrics, Yokohama City University Medical Center, Yokohama, Japan
Pediatr Int 47:616-21. 2005..We experienced carbamazepine-induced HS in a 14-year-old boy, who had cefaclor-induced cutaneous eruptions 15 months later. To clarify the mechanisms of HS and the differences between two diseases we studied this case in detail...
Severe obliterative bronchitis associated with Stevens-Johnson syndromeTetsukan Woo
Department of Respiratory Medicine, Yokohama City University School of Medicine, Japan
Intern Med 50:2823-7. 2011..Therefore, early awareness of this condition is needed and lung transplantation must be considered at an early stage of this disease...
[Stevens-Johnson syndrome]Michiko Aihara
Department of Dermatology, Yokohama City University School of Medicine
Nippon Rinsho 60:322-7. 2002
