M Yamano

Summary

Affiliation: Yamanouchi Pharmaceutical Co
Country: Japan

Publications

  1. ncbi request reprint Corticotropin-releasing hormone receptors mediate consensus interferon-alpha YM643-induced depression-like behavior in mice
    M Yamano
    Applied Pharmacology Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co Ltd, Tsukuba, Japan
    J Pharmacol Exp Ther 292:181-7. 2000
  2. ncbi request reprint Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo
    A Nishida
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co Ltd, Ibaraki, Japan
    J Pharmacol Exp Ther 269:725-31. 1994
  3. ncbi request reprint Comparison of the effects of trimebutine and YM114 (KAE-393), a novel 5-HT3 receptor antagonist, on stress-induced defecation
    K Miyata
    Neuroscience and Gastrointestinal Research Laboratories, Yamanouchi Pharmaceutical Co Ltd, Ibaraki, Japan
    Eur J Pharmacol 250:303-10. 1993
  4. ncbi request reprint YM022 [(R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl- 1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea], a potent and selective gastrin/cholecystokinin-B receptor antagonist, prevents gastric and duodenal lesions in rats
    A Nishida
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba, Japan
    J Pharmacol Exp Ther 270:1256-61. 1994
  5. doi request reprint Influence of gastric acid on gastric emptying and gastric distension-induced pain response in rats--effects of famotidine and mosapride
    Y Keto
    Applied Pharmacology Research Laboratories, Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki, Japan
    Neurogastroenterol Motil 24:147-53, e88. 2012
  6. ncbi request reprint Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro
    H Ito
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Eur J Pharmacol 409:195-201. 2000

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Corticotropin-releasing hormone receptors mediate consensus interferon-alpha YM643-induced depression-like behavior in mice
    M Yamano
    Applied Pharmacology Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co Ltd, Tsukuba, Japan
    J Pharmacol Exp Ther 292:181-7. 2000
    ..The results also suggest that activation of corticotropin-releasing hormone receptors is involved in IFN-alpha-induced depression-like behavior, but the prostaglandin and opioid systems do not participate in this process...
  2. ncbi request reprint Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo
    A Nishida
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co Ltd, Ibaraki, Japan
    J Pharmacol Exp Ther 269:725-31. 1994
    ..v. L-365,260 (1-10 mumol/kg i.v.) and Cl-988 (0.3-3 mumol/kg i.v.) also antagonized acid secretion induced by pentagastrin, with ED50 values of 4.23 and 1.01 mumol/kg, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)..
  3. ncbi request reprint Comparison of the effects of trimebutine and YM114 (KAE-393), a novel 5-HT3 receptor antagonist, on stress-induced defecation
    K Miyata
    Neuroscience and Gastrointestinal Research Laboratories, Yamanouchi Pharmaceutical Co Ltd, Ibaraki, Japan
    Eur J Pharmacol 250:303-10. 1993
    ..Thus, YM114 is a potent and stereoselective 5-HT3 receptor antagonist with much greater protective effects against stress-induced defecation than trimebutine...
  4. ncbi request reprint YM022 [(R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl- 1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea], a potent and selective gastrin/cholecystokinin-B receptor antagonist, prevents gastric and duodenal lesions in rats
    A Nishida
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba, Japan
    J Pharmacol Exp Ther 270:1256-61. 1994
    ..These results suggest that YM022 possesses antisecretory and antiulcer activities that are as potent as those of famotidine in rats and that YM022 represents a useful therapeutic agent in the treatment of peptic ulcer disease...
  5. doi request reprint Influence of gastric acid on gastric emptying and gastric distension-induced pain response in rats--effects of famotidine and mosapride
    Y Keto
    Applied Pharmacology Research Laboratories, Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki, Japan
    Neurogastroenterol Motil 24:147-53, e88. 2012
    ..Delayed gastric emptying and hypersensitivity to gastric distension (GD) contribute importantly to the pathophysiology of FD...
  6. ncbi request reprint Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro
    H Ito
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Eur J Pharmacol 409:195-201. 2000
    ..These results suggest that YM-31636 is a potent and selective 5-HT3 receptor agonist, preferentially acting on the contraction of the colon...