Kazuhiro Sako

Summary

Affiliation: Yamanouchi Pharmaceutical Co
Country: Japan

Publications

  1. ncbi request reprint Influence of water soluble fillers in hydroxypropylmethylcellulose matrices on in vitro and in vivo drug release
    Kazuhiro Sako
    Novel Pharmaceutical Laboratories, Yamanouchi Pharmaceutical Co, Ltd, 180 Ozumi, Yaizu shi, 425 0072, Shizuoka, Japan
    J Control Release 81:165-72. 2002
  2. ncbi request reprint Time-release compression-coated core tablet containing nifedipine for chronopharmacotherapy
    Toyohiro Sawada
    DDS Research, Novel Pharmaceutical Research Laboratories, Institute for Technology Development, Yamanouchi Pharmaceutical Co, Ltd, 180 Ozumi, Yaizu shi, Shizuoka 425 0072, Japan
    Int J Pharm 280:103-11. 2004
  3. doi request reprint Mechanism of controlled drug release from a salting-out taste-masking system
    Takayuki Yoshida
    Drug Delivery, Pharmaceutical Research and Development Labs, Astellas Pharma Inc, 180 Ozumi, Yaizu, Shizuoka 425 0072, Japan
    J Control Release 131:47-53. 2008
  4. ncbi request reprint Influence of manufacturing factors on physical stability and solubility of solid dispersions containing a low glass transition temperature drug
    Atsushi Sakurai
    Pharmaceutical Research and Technology Labs, Astellas Pharma Inc, 180 Ozumi, Yaizu, Shizuoka 425 0072, Japan
    Chem Pharm Bull (Tokyo) 60:1366-71. 2012
  5. doi request reprint Extended release of a large amount of highly water-soluble diltiazem hydrochloride by utilizing counter polymer in polyethylene oxides (PEO)/polyethylene glycol (PEG) matrix tablets
    Hiroyuki Kojima
    Pharmaceutical Research and Technology Labs, Astellas Pharma Inc, Shizuoka, Japan
    Eur J Pharm Biopharm 70:556-62. 2008
  6. ncbi request reprint Factors affecting the absorption of nilvadipine from disintegration-controlled matrix tablet in dogs
    Toshiro Sakai
    Pharmaceutical Research and Technology Laboratories, Astellas Pharma Inc, 180 Ozumi, Yaizu, Shizuoka, Japan
    Biol Pharm Bull 34:1731-6. 2011
  7. ncbi request reprint Polymer combination increased both physical stability and oral absorption of solid dispersions containing a low glass transition temperature drug: physicochemical characterization and in vivo study
    Atsushi Sakurai
    Pharmaceutical Research and Technology Labs, Astellas Pharma Inc, 180 Ozumi, Yaizu, Shizuoka, Japan
    Chem Pharm Bull (Tokyo) 60:459-64. 2012
  8. doi request reprint Aminoalkyl methacrylate copolymers for improving the solubility of tacrolimus. I: Evaluation of solid dispersion formulations
    Takatsune Yoshida
    Pharmaceutical Research and Technology Labs, Astellas Pharma Inc, 180 Ozumi, Yaizu, Shizuoka 425 0072, Japan
    Int J Pharm 428:18-24. 2012
  9. ncbi request reprint Timed-release formulation to avoid drug-drug interaction between diltiazem and midazolam
    Toyohiro Sawada
    DDS Research, Novel Pharmaceutical Research Laboratories, Yamanouchi Pharmaceutical Company, Ltd, 180 Ozumi, Yaizu, Shizuoka 425 0072, Japan
    J Pharm Sci 92:790-7. 2003
  10. doi request reprint Effects of physicochemical properties of salting-out layer components on drug release
    Hiroaki Tasaki
    Drug Delivery, Pharmaceutical Research and Technology Labs, Astellas Pharma Inc, Yaizu, Shizuoka, Japan
    Int J Pharm 376:13-21. 2009

Detail Information

Publications13

  1. ncbi request reprint Influence of water soluble fillers in hydroxypropylmethylcellulose matrices on in vitro and in vivo drug release
    Kazuhiro Sako
    Novel Pharmaceutical Laboratories, Yamanouchi Pharmaceutical Co, Ltd, 180 Ozumi, Yaizu shi, 425 0072, Shizuoka, Japan
    J Control Release 81:165-72. 2002
    ..It was found that dissolution of gel-forming HPMC matrices under mechanical stress by glass beads well correlated with the in vivo performance of the matrix, with little correlation by the conventional paddle method...
  2. ncbi request reprint Time-release compression-coated core tablet containing nifedipine for chronopharmacotherapy
    Toyohiro Sawada
    DDS Research, Novel Pharmaceutical Research Laboratories, Institute for Technology Development, Yamanouchi Pharmaceutical Co, Ltd, 180 Ozumi, Yaizu shi, Shizuoka 425 0072, Japan
    Int J Pharm 280:103-11. 2004
    ....
  3. doi request reprint Mechanism of controlled drug release from a salting-out taste-masking system
    Takayuki Yoshida
    Drug Delivery, Pharmaceutical Research and Development Labs, Astellas Pharma Inc, 180 Ozumi, Yaizu, Shizuoka 425 0072, Japan
    J Control Release 131:47-53. 2008
    ..These findings will allow for smarter formulation design...
  4. ncbi request reprint Influence of manufacturing factors on physical stability and solubility of solid dispersions containing a low glass transition temperature drug
    Atsushi Sakurai
    Pharmaceutical Research and Technology Labs, Astellas Pharma Inc, 180 Ozumi, Yaizu, Shizuoka 425 0072, Japan
    Chem Pharm Bull (Tokyo) 60:1366-71. 2012
    ..Further, hot melt extrusion, which can reduce water content, is a suitable manufacturing method for solid dispersions of low-T(g) drugs...
  5. doi request reprint Extended release of a large amount of highly water-soluble diltiazem hydrochloride by utilizing counter polymer in polyethylene oxides (PEO)/polyethylene glycol (PEG) matrix tablets
    Hiroyuki Kojima
    Pharmaceutical Research and Technology Labs, Astellas Pharma Inc, Shizuoka, Japan
    Eur J Pharm Biopharm 70:556-62. 2008
    ..These results suggested that including counter polymer in the PEO/PEG matrix tablet is a useful tool for achieving the sustained release of a large amount of highly water-soluble drug...
  6. ncbi request reprint Factors affecting the absorption of nilvadipine from disintegration-controlled matrix tablet in dogs
    Toshiro Sakai
    Pharmaceutical Research and Technology Laboratories, Astellas Pharma Inc, 180 Ozumi, Yaizu, Shizuoka, Japan
    Biol Pharm Bull 34:1731-6. 2011
    ..Therefore, limited GI transit time is the primary factor that affects the drug release from DCMT and subsequent NiD absorption...
  7. ncbi request reprint Polymer combination increased both physical stability and oral absorption of solid dispersions containing a low glass transition temperature drug: physicochemical characterization and in vivo study
    Atsushi Sakurai
    Pharmaceutical Research and Technology Labs, Astellas Pharma Inc, 180 Ozumi, Yaizu, Shizuoka, Japan
    Chem Pharm Bull (Tokyo) 60:459-64. 2012
    ..These findings suggested that both oral absorption and physicochemical stability of low-T(g) drug will be improved using less amount of solid dispersion of combined two polymers than polymer alone...
  8. doi request reprint Aminoalkyl methacrylate copolymers for improving the solubility of tacrolimus. I: Evaluation of solid dispersion formulations
    Takatsune Yoshida
    Pharmaceutical Research and Technology Labs, Astellas Pharma Inc, 180 Ozumi, Yaizu, Shizuoka 425 0072, Japan
    Int J Pharm 428:18-24. 2012
    ..Thus, it may be inferred that a definite drug/carrier ratio exists to increase drug solubility. Further, by mixing E-SD the solid dispersion prepared with HPMC showed enhanced drug solubility...
  9. ncbi request reprint Timed-release formulation to avoid drug-drug interaction between diltiazem and midazolam
    Toyohiro Sawada
    DDS Research, Novel Pharmaceutical Research Laboratories, Yamanouchi Pharmaceutical Company, Ltd, 180 Ozumi, Yaizu, Shizuoka 425 0072, Japan
    J Pharm Sci 92:790-7. 2003
    ....
  10. doi request reprint Effects of physicochemical properties of salting-out layer components on drug release
    Hiroaki Tasaki
    Drug Delivery, Pharmaceutical Research and Technology Labs, Astellas Pharma Inc, Yaizu, Shizuoka, Japan
    Int J Pharm 376:13-21. 2009
    ..Results further suggest the use of CST(1) to evaluate suitable combinations of salting-out agents and water-soluble polymers in this system...
  11. ncbi request reprint The effect of food on the oral bioavailability of drugs: a review of current developments and pharmaceutical technologies for pharmacokinetic control
    Takehiko Yasuji
    Pharmaceutical Research and Technology Labs Astellas Pharma Inc, 180 Ozumi, Yaizu Shizuoka 425 0072, Japan
    Ther Deliv 3:81-90. 2012
    ..As the structure of drug candidates becomes more complex, different methods of investigation, such as in vitro and in vivo correlation and in silico simulation will be required to predict drug characteristics and food effects...
  12. ncbi request reprint Scintigraphic evaluation of a novel colon-targeted delivery system (CODES) in healthy volunteers
    Masataka Katsuma
    DDS Research, Novel Pharmaceutical Laboratories, Yamanouchi Pharmaceutical Co, Ltd, 180 Ozumi, Yaizu shi, Shizuoka ken 425 0072, Japan
    J Pharm Sci 93:1287-99. 2004
    ..Gamma scintigraphic studies clearly showed that CODES provides for rapid target site release in the colon regardless of the ingestion of food...
  13. ncbi request reprint Effects of absorption promoters on insulin absorption through colon-targeted delivery
    Masataka Katsuma
    Pharmaceutical Technology Administration, Astellas Pharma Inc, Yaizu, Shizuoka 425 0072, Japan
    Int J Pharm 307:156-62. 2006
    ....