Mitsuyuki Matsumoto

Summary

Affiliation: Yamanouchi Pharmaceutical Co
Country: Japan

Publications

  1. ncbi Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species
    M Matsumoto
    Neuroscience and Gastrointestinal Research Laboratory, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki, 305, Japan
    J Biol Chem 271:27217-20. 1996
  2. ncbi Low stringency hybridization study of the dopamine D4 receptor revealed D4-like mRNA distribution of the orphan seven-transmembrane receptor, APJ, in human brain
    M Matsumoto
    Molecular Medicine Laboratories, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki, Japan
    Neurosci Lett 219:119-22. 1996
  3. ncbi The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors
    M Matsumoto
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki, Japan
    Gene 248:183-9. 2000
  4. ncbi An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system
    M Matsumoto
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 272:576-82. 2000
  5. ncbi Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia
    Mitsuyuki Matsumoto
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA
    Neuropsychopharmacology 28:1521-30. 2003
  6. ncbi A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain
    Mitsuyuki Matsumoto
    Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 138:58-69. 2005
  7. ncbi Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides
    Masazumi Kamohara
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba, Ibaraki 305 8585, Japan
    Biochem Biophys Res Commun 330:1146-52. 2005
  8. ncbi Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Mol Genet 15:1245-58. 2006
  9. ncbi Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain
    Cynthia Shannon Weickert
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 61:544-55. 2004
  10. pmc The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia
    Mitsuyuki Matsumoto
    Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki 305 8585, Japan
    Proc Natl Acad Sci U S A 105:6133-8. 2008

Collaborators

Detail Information

Publications19

  1. ncbi Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species
    M Matsumoto
    Neuroscience and Gastrointestinal Research Laboratory, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki, 305, Japan
    J Biol Chem 271:27217-20. 1996
    ..Interestingly, despite its inactivation in humans, the transcripts were abundantly detected in the heart and skeletal muscle, suggesting a novel function of the human gene...
  2. ncbi Low stringency hybridization study of the dopamine D4 receptor revealed D4-like mRNA distribution of the orphan seven-transmembrane receptor, APJ, in human brain
    M Matsumoto
    Molecular Medicine Laboratories, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki, Japan
    Neurosci Lett 219:119-22. 1996
    ..These data suggest that a group of seven-transmembrane receptors, including the D4 and APJ receptor, is preferentially expressed in the white-matter area probably in non-neuronal glial cells...
  3. ncbi The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors
    M Matsumoto
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki, Japan
    Gene 248:183-9. 2000
    ..1-5p14. Transient expression of SALPR in COS-1 cells did not produce any binding sites for somatostatin or angiotensin II, indicating the necessity for further study to discover its ligand and physiological significance...
  4. ncbi An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system
    M Matsumoto
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 272:576-82. 2000
    ..The high sequence conservation and abundant expression in the central nervous system suggest the existence of undiscovered fundamental neuronal systems consisting of SREB family members and their endogenous ligand(s)...
  5. ncbi Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia
    Mitsuyuki Matsumoto
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA
    Neuropsychopharmacology 28:1521-30. 2003
    ..The disease-related laminar difference of COMT expression may be involved in dysregulation of dopamine signaling circuits in the DLPFC of patients with schizophrenia...
  6. ncbi A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain
    Mitsuyuki Matsumoto
    Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 138:58-69. 2005
    ..Together, these data suggest a possible link between SREB family and neural plasticity, which may explain its extremely high conservation throughout vertebrate evolution...
  7. ncbi Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides
    Masazumi Kamohara
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba, Ibaraki 305 8585, Japan
    Biochem Biophys Res Commun 330:1146-52. 2005
    ..The present discovery will eventually lead to a better understanding of the pathophysiological role of proadrenomedullin peptides...
  8. ncbi Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Mol Genet 15:1245-58. 2006
    ..Although, many other DISC1 binding partners still need to be investigated, these data implicate genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia...
  9. ncbi Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain
    Cynthia Shannon Weickert
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 61:544-55. 2004
    ..3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex. Little is known about dysbindin expression in normal or schizophrenic brain...
  10. pmc The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia
    Mitsuyuki Matsumoto
    Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki 305 8585, Japan
    Proc Natl Acad Sci U S A 105:6133-8. 2008
    ..Our data implicate SREB2 as a potential risk factor for psychiatric disorders and its pathway as a target for psychiatric therapy...
  11. pmc Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain
    Jingshan Chen
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 75:807-21. 2004
    ....
  12. pmc Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2
    Shun ichiro Matsumoto
    Molecular Medicine Research Laboratories, Drug Discovery Research, Astellas Pharma, Inc, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Proc Natl Acad Sci U S A 103:4140-5. 2006
    ..Our current findings demonstrated that physiological activation of PKR2 is essential for normal development of the OB and sexual maturation...
  13. ncbi Molecular cloning of monkey histamine H4 receptor
    Tamaki Oda
    Molecular Medicine Laboratories, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki, Japan
    J Pharmacol Sci 98:319-22. 2005
    ..Monkey H(4) receptor was characterized to have comparable similarity with its human counterpart. Discovery of monkey H(4) receptor will contribute to a better interpretation of effective drug discovery...
  14. pmc Effect of schizophrenia risk-associated alleles in SREB2 (GPR85) on functional MRI phenotypes in healthy volunteers
    Eugenia Radulescu
    Clinical Brain Disorders Branch, GCAP, IRP, NIMH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 38:341-9. 2013
    ..The findings in females and during the emotional memory paradigm are consistent with modulation by SREB2 of brain circuitries implicated in mood regulation and may be relevant to neuropsychiatric conditions other than schizophrenia...
  15. doi Identification and relative quantitation of an orphan G-protein coupled receptor SREB2 (GPR85) protein in tissue using a linear ion trap mass spectrometer
    Masatoshi Yuri
    Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    J Proteome Res 10:2658-63. 2011
    ..SREB2 protein expression level in the transgenic mouse was estimated to be 3-fold higher than that in the wild type littermate...
  16. ncbi Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor
    Takatoshi Soga
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Biochem Biophys Res Commun 326:744-51. 2005
    ..Our findings suggest that GPR119, which is a novel endogenous receptor for LPC, is involved in insulin secretion from beta-cells, and is a potential target for anti-diabetic drug development...
  17. ncbi Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system
    Ayako Matsuo
    Department of Anatomy and Neurobiology, Kinki University School of Medicine, Osaka Sayama, Osaka 589 8511, Japan
    Biochem Biophys Res Commun 331:363-9. 2005
    ..These findings suggest that GPRg1 is a candidate receptor for novel physiologically bioactive substrates and that it plays important roles in the central nervous system...
  18. ncbi Gene expression of metabolic enzymes and a protease inhibitor in the prefrontal cortex are decreased in schizophrenia
    Marquis P Vawter
    Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, California 92697 1675, USA
    Neurochem Res 29:1245-55. 2004
    ..These results confirm earlier reports and suggest abnormalities of specific genes related to metabolic and protease activities in the DLPFC might be considered as part of a molecular pathway in male patients with schizophrenia...
  19. ncbi cDNA cloning and characterization of porcine histamine H4 receptor
    Tamaki Oda
    Helix Research Institute, Inc, 1532 3 Yana, Kisarazu, Chiba, 292 0812, Japan
    Biochim Biophys Acta 1575:135-8. 2002
    ..Isolation of the porcine H4 receptor, which is important for understanding of the pharmacology, will aid in better interpretation of physiological role of this subtype of histamine receptor...