Isao Sakaida

Summary

Affiliation: Yamaguchi University
Country: Japan

Publications

  1. pmc Iron regulation by hepatocytes and free radicals
    Taro Takami
    Division of Laboratory, Yamaguchi University Hospital, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    J Clin Biochem Nutr 48:103-6. 2011
  2. doi request reprint Efficacy and safety of a 14-day administration of tolvaptan in the treatment of patients with ascites in hepatic oedema
    Isao Sakaida
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    J Int Med Res 41:835-47. 2013
  3. ncbi request reprint The pharmacokinetics and pharmacodynamics of tolvaptan in patients with liver cirrhosis with insufficient response to conventional diuretics: a multicentre, double-blind, parallel-group, phase III study
    I Sakaida
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    J Int Med Res 40:2381-93. 2012
  4. ncbi request reprint [Autologous bone marrow cell infusion therapy for liver cirrhosis--now and future]
    Isao Sakaida
    Department of Gastroenterology and Hepatology, Yamaguchi University, Graduate School of Medicine, Ube 755 8505, Japan
    Rinsho Byori 59:1092-8. 2011
  5. ncbi request reprint Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice
    Isao Sakaida
    Department of Gastroenterology and Hepatology, School of Medicine, Yamaguchi University, Yamaguchi, Japan
    Hepatology 40:1304-11. 2004
  6. doi request reprint Autologous bone marrow cell infusion therapy for liver cirrhosis
    Isao Sakaida
    Department of Gastroenterology and Hepatology, Yamaguchi University, Graduate School of Medicine, Ube, Yamaguchi Prefecture, Japan
    J Gastroenterol Hepatol 23:1349-53. 2008
  7. ncbi request reprint Development of cell therapy using autologous bone marrow cells for liver cirrhosis
    Isao Sakaida
    Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube, 755 8505, Japan
    Med Mol Morphol 38:197-202. 2005
  8. doi request reprint Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver
    Yoshio Marumoto
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    Biochem Biophys Res Commun 367:546-52. 2008
  9. ncbi request reprint A subpopulation of bone marrow cells depleted by a novel antibody, anti-Liv8, is useful for cell therapy to repair damaged liver
    Naoki Yamamoto
    Department of Molecular Science and Applied Medicine Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    Biochem Biophys Res Commun 313:1110-8. 2004
  10. ncbi request reprint Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes
    Tsuyoshi Ishikawa
    Department of Molecular Science and Applied Medicine Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube, 755 8505 Yamaguchi, Japan
    Cell Tissue Res 323:221-31. 2006

Detail Information

Publications111 found, 100 shown here

  1. pmc Iron regulation by hepatocytes and free radicals
    Taro Takami
    Division of Laboratory, Yamaguchi University Hospital, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    J Clin Biochem Nutr 48:103-6. 2011
    ..Several detoxification system and anti-oxidant defense mechanisms exist to prevent cellular damage by free radicals. Excessive free radicals can lead to hepatocellular damage, liver fibrosis, and hepatocarcinogenesis...
  2. doi request reprint Efficacy and safety of a 14-day administration of tolvaptan in the treatment of patients with ascites in hepatic oedema
    Isao Sakaida
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    J Int Med Res 41:835-47. 2013
    ....
  3. ncbi request reprint The pharmacokinetics and pharmacodynamics of tolvaptan in patients with liver cirrhosis with insufficient response to conventional diuretics: a multicentre, double-blind, parallel-group, phase III study
    I Sakaida
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    J Int Med Res 40:2381-93. 2012
    ..This study investigated the pharmacokinetic and pharmacodynamic profile of tolvaptan, and verified its efficacy and safety in patients with liver cirrhosis-associated ascites, with insufficient response to conventional diuretic treatment...
  4. ncbi request reprint [Autologous bone marrow cell infusion therapy for liver cirrhosis--now and future]
    Isao Sakaida
    Department of Gastroenterology and Hepatology, Yamaguchi University, Graduate School of Medicine, Ube 755 8505, Japan
    Rinsho Byori 59:1092-8. 2011
    ..05). No major adverse effects were noted. In conclusion, autologous BMC infusion might be considered as a novel treatment for advanced LC patients...
  5. ncbi request reprint Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice
    Isao Sakaida
    Department of Gastroenterology and Hepatology, School of Medicine, Yamaguchi University, Yamaguchi, Japan
    Hepatology 40:1304-11. 2004
    ..This finding introduces a new concept for the therapy of liver fibrosis...
  6. doi request reprint Autologous bone marrow cell infusion therapy for liver cirrhosis
    Isao Sakaida
    Department of Gastroenterology and Hepatology, Yamaguchi University, Graduate School of Medicine, Ube, Yamaguchi Prefecture, Japan
    J Gastroenterol Hepatol 23:1349-53. 2008
    ..This review summarizes previous findings plus these recent experimental results, as well as recent clinical trials of BMC transfusion into patients with end-stage chronic liver disease...
  7. ncbi request reprint Development of cell therapy using autologous bone marrow cells for liver cirrhosis
    Isao Sakaida
    Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube, 755 8505, Japan
    Med Mol Morphol 38:197-202. 2005
    ..Results from the GFP/CCl4 model showed that cell therapy using autologous bone marrow cells has the potential to become an effective treatment for patients with liver failure. A summary of findings from the GFP/CCl4 model is described...
  8. doi request reprint Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver
    Yoshio Marumoto
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    Biochem Biophys Res Commun 367:546-52. 2008
    ..XBP1 and GRP78 are associated with ER stress. Thus, continuous high XBP1 and GRP78 expression might be essential for the survival and proliferation of BMC in a CCl(4)-induced persistent liver damage environment...
  9. ncbi request reprint A subpopulation of bone marrow cells depleted by a novel antibody, anti-Liv8, is useful for cell therapy to repair damaged liver
    Naoki Yamamoto
    Department of Molecular Science and Applied Medicine Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    Biochem Biophys Res Commun 313:1110-8. 2004
    ..These findings suggest that the subpopulation of Liv8-negative cells includes useful cells to perform cell therapy on repair damaged liver...
  10. ncbi request reprint Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes
    Tsuyoshi Ishikawa
    Department of Molecular Science and Applied Medicine Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube, 755 8505 Yamaguchi, Japan
    Cell Tissue Res 323:221-31. 2006
    ..Administration of FGF2 in combination with BMT improves the liver function and prognosis of mice with CCl(4)-induced liver damage...
  11. ncbi request reprint Heat-shock protein 27 is phosphorylated in gemcitabine-resistant pancreatic cancer cells
    Kumiko Taba
    Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Anticancer Res 30:2539-43. 2010
    ..Materials and Methods and..
  12. ncbi request reprint Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon-tetrachloride-induced liver fibrosis in mice
    Tsuyoshi Ishikawa
    Department of Molecular Science and Applied Medicine, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    Cell Tissue Res 327:463-70. 2007
    ..Thus, the administration of FGF2 in combination with BMT synergistically improves CCl(4)-induced liver fibrosis in mice. This treatment has the potential of being an effective therapy for patients with liver cirrhosis...
  13. ncbi request reprint Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet
    Kotaro Kawaguchi
    Department of Gastroenterology and Hepatology, School of Medicine, Yamaguchi University, Minami Kogushi 1 1 1 Ube, Yamaguchi 755 8505, Japan
    Biochem Biophys Res Commun 315:187-95. 2004
    ..These results indicate that pioglitazone may be one of the candidates for the benefit drugs for the liver disease of patients with NASH...
  14. doi request reprint Identification of genes specifically methylated in Epstein-Barr virus-associated gastric carcinomas
    Toshiyuki Okada
    Department of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Cancer Sci 104:1309-14. 2013
    ..Inactivation of these genes may suppress their function as tumor suppressor genes or tumor-associated antigens and help to develop and maintain EBVaGC. ..
  15. ncbi request reprint Stronger Neo-Minophagen C, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein
    Isao Hidaka
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Liver Int 27:845-53. 2007
    ..The aim of this study was to investigate if SNMC had an anti-oxidative effect, as oxidative stress has been proposed to be one of the mechanisms of liver injury in hepatitis C virus (HCV)-associated chronic liver diseases...
  16. ncbi request reprint Proteomic analysis of serum marker proteins in recipient mice with liver cirrhosis after bone marrow cell transplantation
    Yuichiro Yokoyama
    Department of Molecular Science and Applied Medicine Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Minami Kogushi, Ube, Yamaguchi, Japan
    Proteomics 6:2564-70. 2006
    ..ApoA1 increased at early stage (48 h and 1 wk) after BMC transplantation in this mouse model of liver cirrhosis. The early elevation of apoA1 might be useful to predict liver regeneration in cirrhotic mice after BMC transplantation...
  17. doi request reprint Effect of transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma
    Takahiro Yamasaki
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi, 755 8505, Japan
    J Gastroenterol 47:715-22. 2012
    ..In the study reported here, we investigated the predictors influencing response and survival in HCC patients receiving TAI using lipiodol and DSMs...
  18. ncbi request reprint Molecular signature associated with plasticity of bone marrow cell under persistent liver damage by self-organizing-map-based gene expression
    Kaoru Omori
    Department of Molecular Science and Applied Medicine Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    FEBS Lett 578:10-20. 2004
    ..On the basis of gene expression with self-organizing map using specific equation, genes were classified into 153 clusters. The information is useful to understand the dramatic gene activation during the process of the plasticity of BMC...
  19. ncbi request reprint Identification of up- and down-regulated proteins in gemcitabine-resistant pancreatic cancer cells using two-dimensional gel electrophoresis and mass spectrometry
    Yasuhiro Kuramitsu
    Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Anticancer Res 30:3367-72. 2010
    ..These results suggest an important complementary role for proteomics in the identification of proteins which may play a role in the poor response of pancreatic cancer to GEM...
  20. doi request reprint TWIST1 hypermethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer
    Toshiyuki Okada
    Department of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Genes Chromosomes Cancer 49:452-62. 2010
    ..In addition, TWIST1 mRNA expression is a possible molecular marker for predicting the outcome in patients with CRC. Confirmatory studies using independent data sets are needed to confirm our findings...
  21. doi request reprint Efficient detection of hepatocellular carcinoma by a hybrid blood test of epigenetic and classical protein markers
    Norio Iizuka
    Departments of Surgery II Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Clin Chim Acta 412:152-8. 2011
    ..There are few blood tests for an efficient detection of hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV) infection...
  22. ncbi request reprint Therapeutic potential of canine bone marrow stromal cells (BMSCs) in the carbon tetrachloride (CCl4) induced chronic liver dysfunction mouse model
    Tomoya Haraguchi
    Department of Veterinary Surgery Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    J Vet Med Sci 74:607-11. 2012
    ..These results suggest that canine BMSCs are an effective cell source for liver regeneration...
  23. doi request reprint Timeline for development of autologous bone marrow infusion (ABMi) therapy and perspective for future stem cell therapy
    Shuji Terai
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi, 755 8505, Japan
    J Gastroenterol 47:491-7. 2012
    ..However, ABMi therapy may not be possible in patients who are unable to undergo general anesthesia; therefore, we have started to develop a next-generation stem cell therapy using cultured mesenchymal stem cells...
  24. doi request reprint Usefulness of magnifying endoscopy with narrow-band imaging for determining gastric tumor margin
    Shu Kiyotoki
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    J Gastroenterol Hepatol 25:1636-41. 2010
    ..We evaluated the usefulness of ME-NBI for determining the tumor margin compared with indigocarmine chromoendoscopy (ICC)...
  25. ncbi request reprint Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy
    Shuji Terai
    Department of Molecular Science and Applied Medicine Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    Stem Cells 24:2292-8. 2006
    ..05). No major adverse effects were noted. In conclusion, ABMI therapy should be considered as a novel treatment for patients with decompensated LC...
  26. ncbi request reprint Proteomic differential display analysis for TS-1-resistant and -sensitive pancreatic cancer cells using two-dimensional gel electrophoresis and mass spectrometry
    Kanako Yoshida
    Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Anticancer Res 31:2103-8. 2011
    ..These findings could be useful to overcome the TS-1-resistance of pancreatic cancer cells...
  27. doi request reprint Granulocyte colony-stimulating factor and interleukin-1β are important cytokines in repair of the cirrhotic liver after bone marrow cell infusion: comparison of humans and model mice
    Yuko Mizunaga
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Cell Transplant 21:2363-75. 2012
    ..The infused BMCs induced an early decrease of both G-CSF and IL-1β in serum and an increase in the model mice with LC. These dynamic cytokine changes might be important to repair liver cirrhosis after BMC infusion...
  28. doi request reprint Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription
    Sohji Nishina
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Gastroenterology 134:226-38. 2008
    ..The aim of this study was to investigate how hepatic iron overload develops in the presence of HCV proteins...
  29. ncbi request reprint Relation between serum levels of cell-free DNA and inflammation status in hepatitis C virus-related hepatocellular carcinoma
    Michihisa Iida
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Oncol Rep 20:761-5. 2008
    ....
  30. doi request reprint New method for detection of gastric cancer by hyperspectral imaging: a pilot study
    Shu Kiyotoki
    Yamaguchi University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Yamaguchi, Japan
    J Biomed Opt 18:26010. 2013
    ..3%) cases were well enhanced by image processing Differences in spectral reflectance between tumors and normal mucosa suggested that tumors can be clearly distinguished from background mucosa with HSI technology...
  31. doi request reprint Bone-marrow-derived cells cultured in serum-free medium reduce liver fibrosis and improve liver function in carbon-tetrachloride-treated cirrhotic mice
    Takuya Iwamoto
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi, 755 8505, Japan
    Cell Tissue Res 351:487-95. 2013
    ..01). Moreover, matrix metalloproteinase-9 expression was increased in the liver (P<0.01). Thus, infusion of bone-marrow-derived cultured cells improved liver function and liver fibrosis in mice with CCl4-induced cirrhosis...
  32. ncbi request reprint Risk factors for delayed bleeding from endoscopic submucosal dissection of gastric neoplasms
    Munetaka Nakamura
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Scand J Gastroenterol 47:1108-14. 2012
    ..Delayed bleeding is a major complication of endoscopic submucosal dissection (ESD) of gastric neoplasms. We aimed to clarify risk factors for delayed bleeding from ESD...
  33. doi request reprint Splenectomy enhances the anti-fibrotic effect of bone marrow cell infusion and improves liver function in cirrhotic mice and patients
    Takuya Iwamoto
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    J Gastroenterol 47:300-12. 2012
    ..To analyze how splenectomy may potentiate the effects of bone marrow cell infusion on cirrhosis, we performed a mouse study and a clinical trial on patients with cirrhosis...
  34. pmc Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation
    Shinya Kuwashiro
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi, 755 8505, Japan
    Cell Tissue Res 344:125-34. 2011
    ..Medaka NAS was improved by Tel administration but fatty acid content was not affected. Tel reduced the infiltration of macrophages into the liver and ameliorated NASH pathology...
  35. ncbi request reprint Up-regulation of 42 kDa tubulin alpha-6 chain fragment in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus
    Yasuhiro Kuramitsu
    Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Anticancer Res 31:3331-6. 2011
    ..These results suggest that tubulin alpha-6 chain is one of the candidates for biomarkers for well-differentiated HCV-associated HCC...
  36. doi request reprint Pilot study of combination therapy with transcatheter arterial infusion chemotherapy using iodized oil and percutaneous radiofrequency ablation during occlusion of hepatic blood flow for hepatocellular carcinoma
    Ryu Shiraishi
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Am J Clin Oncol 31:311-6. 2008
    ..In this study, we evaluated the efficacy and safety of combination therapy with transcatheter arterial infusion chemotherapy (TAI) using iodized oil and balloon-occluded RF ablation in patients with hepatocellular carcinoma...
  37. ncbi request reprint Outcomes of endoscopic submucosal dissection for early gastric cancer and factors associated with incomplete resection
    Atsushi Goto
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Hepatogastroenterology 60:46-53. 2013
    ..The objective of this study was to summarize the outcomes of endoscopic submucosal dissection performed on patients with early gastric cancer and to identify factors associated with incomplete resection and non-curative resection...
  38. doi request reprint Hepatic arterial infusion chemotherapy in combination with pegylated interferon-α-2b for advanced hepatocellular carcinoma
    Kohsuke Okita
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Hepatogastroenterology 59:533-7. 2012
    ..In this study, we investigated the efficacy of combination therapy comprising HAIC and pegylated interferon (PEG-IFN)-α-2b in advanced HCC patients by comparing our results with previous data...
  39. doi request reprint Fine-tuning the criteria for strip biopsy and endoscopic submucosal dissection improves the outcome of early gastric carcinoma treatment
    Jun Nishikawa
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan
    J Gastroenterol Hepatol 25:1514-7. 2010
    ..Strip biopsy and endoscopic submucosal dissection (ESD) have been developed as a local treatment for early gastric cancer (EGC). However, the lesion criteria for the use of ESD, rather than strip biopsy, remain to be elucidated...
  40. pmc TNFR1-mediated signaling is important to induce the improvement of liver fibrosis by bone marrow cell infusion
    Takuro Hisanaga
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Cell Tissue Res 346:79-88. 2011
    ..TNFR1-mediated signaling might be important to induce the improvement of liver fibrosis by bone marrow cell infusion...
  41. ncbi request reprint Proteomic analysis of autoantibodies in patients with hepatocellular carcinoma
    Motonari Takashima
    Department of Surgery II, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Proteomics 6:3894-900. 2006
    ..The three antibodies were considered patient-specific antibodies in HCC and may be candidate diagnostic biomarkers for HCC...
  42. ncbi request reprint An in vivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes
    Shuji Terai
    Department of Molecular Science and Applied Medicine Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505
    J Biochem 134:551-8. 2003
    ..These results reveal that recipient conditions and microenvironments represent key factors for successful cell therapy using BMCs...
  43. ncbi request reprint Proteomic profiling of proteins decreased in hepatocellular carcinoma from patients infected with hepatitis C virus
    Yuichiro Yokoyama
    Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8605, Japan
    Proteomics 4:2111-6. 2004
    ..05). The decrease of 8 proteins was characteristic in HCC. We will discuss the implication of these proteins for the loss of function of hepatocytes and for the possibility of carcinogenesis of HCV-related HCC...
  44. ncbi request reprint Herbal medicine Rhei rhizome prevents liver fibrosis in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet
    Haiyan Jin
    Department of Gastroenterology and Hepatology, School of Medicine, Yamaguchi University, Minami Kogushi 1 1 1 Ube, Yamaguchi 755 8505, Japan
    Life Sci 76:2805-16. 2005
    ..These results indicate that Rhei rhizome significantly reduces liver fibrosis by the direct inhibition of stellate cell activation without reducing hepatocyte cell death...
  45. ncbi request reprint Human homologue of maid is a useful marker protein in hepatocarcinogenesis
    Taro Takami
    Department of Molecular Science and Applied Medicine Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Ube, Japan
    Gastroenterology 128:1369-80. 2005
    ..Human homologue of maid (HHM) is a helix-loop-helix (HLH) transcriptional regulatory protein that is involved in the hepatic stem cell development and differentiation. We analyzed the potential involvement of HHM in hepatocarcinogenesis...
  46. ncbi request reprint Percutaneous radiofrequency ablation with cooled electrodes combined with hepatic arterial balloon occlusion in hepatocellular carcinoma
    Takahiro Yamasaki
    Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, 755 8505, Japan
    J Gastroenterol 40:171-8. 2005
    ..In this study, we investigated the efficacy of balloon-occluded RFA and balloon-microcatheter-occluded RFA, using a cool RF single electrode...
  47. doi request reprint Bortezomib induces tumor-specific cell death and growth inhibition in hepatocellular carcinoma and improves liver fibrosis
    Issei Saeki
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi, 755 8505, Japan
    J Gastroenterol 48:738-50. 2013
    ..The ubiquitination is important to the generatation of HCC. The antitumor and antifibrosis effects of an ubiquitin-proteasome system inhibitor, bortezomib, on HCC with liver cirrhosis (LC) were analyzed in vitro and in vivo...
  48. doi request reprint Role of DNA methylation in the development of Epstein-Barr virus-associated gastric carcinoma
    Mari Saito
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    J Med Virol 85:121-7. 2013
    ..Aberrant DNA methylation might lead to the development and progression of EBV-associated gastric carcinoma...
  49. doi request reprint A novel transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma: a prospective randomized trial
    Takahiro Yamasaki
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    J Gastroenterol 46:359-66. 2011
    ..In this study, we investigated the efficacy of TAI using lipiodol and DSM in a prospective randomized trial...
  50. doi request reprint Epstein-Barr virus upregulates phosphorylated heat shock protein 27 kDa in carcinoma cells using the phosphoinositide 3-kinase/Akt pathway
    Yuki Fukagawa
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Electrophoresis 29:3192-200. 2008
    ..Thus, activation of the PI3K/Akt pathway may contribute to the establishment of a malignant phenotype in EBV-infected gastric carcinomas...
  51. doi request reprint Medaka as a model for human nonalcoholic steatohepatitis
    Toshihiko Matsumoto
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi, Japan
    Dis Model Mech 3:431-40. 2010
    ..Our model should prove helpful for the dissection of the causes of human NASH and for the design of new and effective therapies...
  52. ncbi request reprint Protein level of apolipoprotein E increased in human hepatocellular carcinoma
    Yuichiro Yokoyama
    Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Int J Oncol 28:625-31. 2006
    ..ApoE level in tumorous tissues is frequently elevated and may be a good histological marker for HCC...
  53. ncbi request reprint Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein
    Takakazu Furutani
    Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Ube, Japan
    Gastroenterology 130:2087-98. 2006
    ..The aim of this study was to determine whether iron overload contributes to development of hepatocellular carcinoma (HCC) in transgenic mice expressing the hepatitis C virus (HCV) polyprotein...
  54. ncbi request reprint Prognostic factors in patients with advanced hepatocellular carcinoma receiving hepatic arterial infusion chemotherapy
    Takahiro Yamasaki
    Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube 755 8505, Japan
    J Gastroenterol 40:70-8. 2005
    ..The prognosis of patients with advanced hepatocellular carcinoma (HCC) is poor. We aimed to clarify the prognostic factors in patients with advanced HCC receiving hepatic arterial infusion chemotherapy (HAIC)...
  55. ncbi request reprint Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine
    Sayaka Mori-Iwamoto
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Int J Oncol 31:1345-50. 2007
    ..HSP27 may play an important role in the resistibility to gemcitabine, and it could also be a possible biomarker for predicting the response of pancreatic cancer patients to treatment with gemcitabine...
  56. ncbi request reprint Preoperative evaluation of early colorectal cancer using an ultrasound mini probe
    Ryo Tanabe
    Department of Gastroenterology and Hepatology, Yamaguchi University, Graduate School of Medicine, Yamaguchi, Japan
    Hepatogastroenterology 59:1794-9. 2012
    ..We investigated whether endoscopic ultrasonography (EUS) can assess the depth of invasion of early colorectal cancer exhibiting the V pit pattern on magnifying endoscopy with submucosal invasion of 1,000 μm or deeper...
  57. doi request reprint Ezetimibe reduces fatty acid quantity in liver and decreased inflammatory cell infiltration and improved NASH in medaka model
    Toshiyuki Oishi
    Department of Gastroenterology and Hepatology, Yamaguchi University, Graduated School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    Biochem Biophys Res Commun 422:22-7. 2012
    ..In this study we analyzed the effect of ezetimibe, a small intestine cholesterol transporter inhibitor, on NASH...
  58. doi request reprint Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication
    Mie Ando
    Department of Basic Laboratory Sciences, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Liver Int 28:1158-66. 2008
    ..The aim of this study was to investigate whether inhibiting HCV replication could restore the mitochondrial redox state and electron transport activity...
  59. ncbi request reprint Herbal medicine Inchin-ko-to (TJ-135) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet
    Isao Sakaida
    Department of Gastroenterology and Hepatology, School of Medicine, Yamaguchi University, Minami Kogushi 1 1 1 Ube, Yamaguchi 755 8505, Japan
    J Hepatol 38:762-9. 2003
    ..The aim of this study was to investigate whether TJ-135 has any influence on the development of preneoplastic lesions as well as liver fibrosis...
  60. doi request reprint Double balloon endoscope facilitates endoscopic retrograde cholangiopancreatography in roux-en-y anastomosis patients
    Sayaka Iwamoto
    Department of Gastroenterology and Hepatology, Hikari Municipal Yamato General Hospital, Yamaguchi, Japan
    Dig Endosc 22:64-8. 2010
    ..None of the patients suffered from any complications. A double balloon endoscope is therefore considered to be useful for carrying out ERCP and associated procedures in patients with a Roux-en-Y anastomosis...
  61. ncbi request reprint Herbal medicine Sho-saiko-to (TJ-9) increases expression matrix metalloproteinases (MMPs) with reduced expression of tissue inhibitor of metalloproteinases (TIMPs) in rat stellate cell
    Isao Sakaida
    Department of Gastroenterology and Hepatology, Yamaguchi University, School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    Life Sci 74:2251-63. 2004
    ..These results show that TJ-9 increased MMP-2, 13 activity with reduced TIMP-1, 2 activities on HSCs possibly via P38 pathway...
  62. ncbi request reprint Lesson from the GFP/CCl4 model--translational research project: the development of cell therapy using autologous bone marrow cells in patients with liver cirrhosis
    Shuji Terai
    Department of Molecular Science and Applied Medicine Gastroenterology and Hepatology, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi, 755 8505, Japan
    J Hepatobiliary Pancreat Surg 12:203-7. 2005
    ..Here we describe the findings from the GFP/CCl(4) model and the scope of the translational research project...
  63. doi request reprint Continuos intravenous infusion of atrial natriuretic peptide (ANP) prevented liver fibrosis in rat
    Noriko Ishigaki
    Department of Gastroenterology and Hepatology, Yamaguchi University, Graduated School of Medicine, Minami Kogushi 1 1 1 Ube, Yamaguchi 755 8505, Japan
    Biochem Biophys Res Commun 378:354-9. 2009
    ..Our results showed that continuous ANP infusion has the specific capacity of inhibiting HSC activation and protecting hepatocytes and the useful capacity to suppress the liver fibrosis...
  64. doi request reprint KNK437 downregulates heat shock protein 27 of pancreatic cancer cells and enhances the cytotoxic effect of gemcitabine
    Kumiko Taba
    Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Chemotherapy 57:12-6. 2011
    ..This report describes the benefits of a treatment strategy combining the HSP inhibitor KNK437 with GEM for GEM-resistant pancreatic cancer cells...
  65. ncbi request reprint Heat-shock protein 27 plays the key role in gemcitabine-resistance of pancreatic cancer cells
    Yasuhiro Kuramitsu
    Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Anticancer Res 32:2295-9. 2012
    ..In this review, we summarize the current understanding of HSP27 and its role in gemcitabine resistance...
  66. ncbi request reprint Identification of four isoforms of aldolase B down-regulated in hepatocellular carcinoma tissues by means of two-dimensional Western blotting
    Yufeng Wang
    Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    In Vivo 25:881-6. 2011
    ..In the present study, two-dimensional (2-D) Western blot analysis demonstrated a significantly lower expression of four isoforms of aldolase B in cancerous than in non-cancerous tissues...
  67. ncbi request reprint A reduced COX-2 expression and a reduced number of pericryptal myofibroblasts are associated with depressed adenoma of the colon
    Katsunori Harada
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi 755 8505, Japan
    Oncol Rep 17:1353-8. 2007
    ..The histogenesis of depressed adenomas differs from that of elevated adenomas. Our results suggest that a low number of pericryptal myofibroblasts and a low COX-2 expression are associated with depressed adenomas...
  68. ncbi request reprint Relationship between molecular markers and endoscopic findings in laterally spreading tumors
    Shinichi Hashimoto
    Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Japan
    J Gastroenterol Hepatol 22:30-6. 2007
    ..The aim of this study was to estimate the biological features of each type of endoscopic finding of LST using two molecular markers, matrix metalloproteinase-7 (MMP-7) and beta-catenin...
  69. doi request reprint Usefulness of computed tomography enteroclysis in the intestinal tract
    Hideko Onoda
    Department of Radiology, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Jpn J Radiol 28:193-8. 2010
    ..The aim of this study was to evaluate computed tomography enteroclysis (CTE) of the small intestinal tract...
  70. ncbi request reprint Novel findings for the development of drug therapy for various liver diseases: Current state and future prospects for our liver regeneration therapy using autologous bone marrow cells for decompensated liver cirrhosis patients
    Taro Takami
    Division of Laboratory, Yamaguchi University Hospital, Ube, Yamaguchi, Japan
    J Pharmacol Sci 115:274-8. 2011
    ..Herein, we present results for the GFP/CCl(4) model and ABMi therapy and future prospects for a new liver regeneration therapy...
  71. ncbi request reprint [A case of enteric muco-submucosal elongated polyp]
    Junichi Nishimura
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 109:1940-5. 2012
    ..The histologic findings of resected specimen were compatible with colonic muco-submucosal elongated polyp. The polyp was considered to be classified as enteric muco-submucosal elongated polyp...
  72. ncbi request reprint Increased expression of heat shock protein-binding protein 1 and heat shock protein 70 in human hepatocellular carcinoma tissues
    Yuichiro Yokoyama
    Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, Yamaguchi 755 8505, Japan
    Mol Med Report 1:197-201. 2008
    ..The ratio of HspBP1 to Hsp70 in HCC may provide novel information concerning the characterization of tumors, tumor progression and resistance to treatment...
  73. ncbi request reprint Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry
    Kuniko Mikuriya
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Int J Oncol 30:849-55. 2007
    ..These glycolytic proteins and transgelin, were confirmed by Western blotting and immunohistochemistry...
  74. ncbi request reprint Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells
    Jinhua Shen
    Department of Gastroenterology and Hepatology, School of Medicine, Yamaguchi University, Minami Kogushi 1 1 1, Ube, Yamaguchi Pref 755 8505, Japan
    Life Sci 77:1502-15. 2005
    ..These findings indicate that P38 and JNK pathways are involved in the signal transduction of leptin enhancement of LPS-induced TNF-alpha production...
  75. ncbi request reprint Increased expression and phosphorylation of liver glutamine synthetase in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus
    Yasuhiro Kuramitsu
    Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Electrophoresis 27:1651-8. 2006
    ..5-Da peptide, from serine 320 to arginine 327 in GS. PMF followed by PSD analysis is thought to be useful for the determination of phosphorylation sites of proteins showing molecular heterogeneity...
  76. doi request reprint Methylated cyclin D2 gene circulating in the blood as a prognosis predictor of hepatocellular carcinoma
    Masahito Tsutsui
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Clin Chim Acta 411:516-20. 2010
    ..We examined preoperatively the methylated CCND2 gene levels present in the serum following release from HCC cells as a prognosis predictor in patients undergoing curative hepatectomy...
  77. ncbi request reprint A new cell therapy using bone marrow cells to repair damaged liver
    Shuji Terai
    Department of Molecular Science and Applied Medicine Gastroenterology and Hepatology, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube 755 8505, Japan
    J Gastroenterol 37:162-3. 2002
    ..Cell therapy using autologous bone marrow cells has few ethical problems and many applications for treating severe liver disease. Further in vitro and in vivo analysis is crucial to develop the therapy for clinical use...
  78. ncbi request reprint Hepatocellular carcinoma with nonalcoholic steatohepatitis
    Sayaka Mori
    Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube 755 8505, Japan
    J Gastroenterol 39:391-6. 2004
    ..Patients with NASH and cirrhosis may progress to HCC, and regular screening, based on tumor markers and imaging modalities, is needed to detect HCC in patients with NASH and cirrhosis...
  79. ncbi request reprint A proteomic profiling of gemcitabine resistance in pancreatic cancer cell lines
    Sayaka Mori-Iwamoto
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi 755 8505, Japan
    Mol Med Report 1:429-34. 2008
    ..These results suggest that HSP27 and NPM may play a role in the poor response of pancreatic cancer to gemcitabine...
  80. ncbi request reprint Telmisartan prevents hepatic fibrosis and enzyme-altered lesions in liver cirrhosis rat induced by a choline-deficient L-amino acid-defined diet
    Haiyan Jin
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1 1 1 Ube, Yamaguchi 755 8505, Japan
    Biochem Biophys Res Commun 364:801-7. 2007
    ..Tel inhibited HSCs activation and proliferation. These results suggested that Tel could be a promising drug for NASH related liver fibrosis...
  81. ncbi request reprint A new hepatic encephalopathy model to monitor the change of neural amino acids and astrocytes with behaviour disorder
    Yumiko Isobe-Harima
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Liver Int 28:117-25. 2008
    ..To elucidate the pathogenesis of hepatic encephalopathy (HE), we developed a new HE model with behaviour disorder...
  82. doi request reprint A novel colonoscope with high color-rendering white light-emitting diodes
    Jun Nishikawa
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Gastrointest Endosc 73:598-602. 2011
    ..Light-emitting diodes (LEDs) are being used for a variety of new uses because of their cost-effectiveness and durability. We therefore considered using white LEDs as a light source for GI endoscopes to simplify the endoscopic system...
  83. ncbi request reprint Leptin receptor-deficient Zucker (fa/fa) rat retards the development of pig serum-induced liver fibrosis with Kupffer cell dysfunction
    Isao Sakaida
    Department of Gastroenterology and Hepatology, School of Medicine, Yamaguchi University, Minami Kogushi 1 1 1, Yamaguchi Ube 755 8505, Japan
    Life Sci 73:2491-501. 2003
    ..These results suggest that leptin receptor deficiency retards the development of liver fibrosis due to the dysfunction of Kuppfer cells...
  84. ncbi request reprint Study on the colonoscopic features of GVHD enteritis that developed after hematopoietic stem cell transplantation
    Katsunori Harada
    Department of Gastroenterology and Hepatology, Yamaguchi, Japan
    Hepatogastroenterology 54:2221-7. 2007
    ..Our aim was to develop a colonoscopic protocol for detection of GVHD enteritis...
  85. doi request reprint Computed tomography enteroclysis for recurrent severe gastrointestinal bleeding in a patient with vascular malformation of the small bowel
    Kensaku Shimizu
    Department of Radiology, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Japan
    Jpn J Radiol 28:58-61. 2010
    ..After embolization, the repeated tarry stool disappeared and the severe anemia dramatically improved. CTE may be a safe and useful method for determining the cause of small intestinal bleeding and for subsequent therapy...
  86. doi request reprint Senescence marker protein 30 (SMP30)/regucalcin (RGN) expression decreases with aging, acute liver injuries and tumors in zebrafish
    Koichi Fujisawa
    Center for Reparative Medicine, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube Yamaguchi 755 8505, Japan
    Biochem Biophys Res Commun 414:331-6. 2011
    ..Decreased expression was observed in foci, hepatocellular carcinomas, cholangiocellular carcinomas and mixed tumors as compared to the surrounding area. We thus showed the importance of SMP30/RGN in liver proliferation and tumorigenesis...
  87. ncbi request reprint Current strategies for chemoprevention of hepatocellular carcinoma
    Kiwamu Okita
    First Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Japan
    Oncology 62:24-8. 2002
    ..Accordingly, antifibrotic agents are promising candidates for chemoprevention of HCC. The results of our study are discussed within the scope of the current state of the art as regards chemopreventing HCC...
  88. ncbi request reprint [Candidate drugs for non-alcoholic steatohepatitis (NASH)]
    Shuji Terai
    Nihon Yakurigaku Zasshi 129:271-5. 2007
  89. doi request reprint Autologous bone marrow cell infusion therapy for liver cirrhosis patients
    Shuji Terai
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    J Hepatobiliary Pancreat Sci 18:23-5. 2011
    ..Multicenter trials in Japan and Korea have also shown the effectiveness of ABMi therapy. In this review, we report the current status of ABMi therapy for liver cirrhosis patients...
  90. ncbi request reprint Gadolinium chloride reverses dimethylnitrosamine (DMN)-induced rat liver fibrosis with increased matrix metalloproteinases (MMPs) of Kupffer cells
    Isao Sakaida
    Department of Gastroenterology and Hepatology School of Medicine, Yamaguchi University, Yamaguchi Pref 755 8505, Ube, Japan
    Life Sci 72:943-59. 2003
    ..SB203580, inhibitor of P38 pathway diminished these activation and prevented apoptosis. These results suggest that Kuppfer cells can reverse liver fibrosis via the expression of MMPs mainly through P38 pathway...
  91. doi request reprint Successful retrieval of an impacted mechanical lithotripsy basket: a case report
    Shomei Ryozawa
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Dig Endosc 22:S111-3. 2010
    ..The present report describes the safe and effective use of rat-tooth forceps in the management of an impacted lithotripter basket...
  92. ncbi request reprint Ubiquitin is a possible new predictive marker for the recurrence of human hepatocellular carcinoma
    Hitoshi Shirahashi
    First Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Japan
    Liver 22:413-8. 2002
    ..In this study, we evaluated the meaning of ubiquitination in chronic liver diseases, especially human hepatocellular carcinoma, with regard to recurrence...
  93. doi request reprint Ulceration after arterial microcoil embolization
    Toshiyuki Ooishi
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Gastrointest Endosc 67:723; discussion 724. 2008
  94. doi request reprint ERCP using double-balloon endoscopes in patients with Roux-en-Y anastomosis
    Shomei Ryozawa
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1 1 1, Minamikogushi, Ube, Yamaguchi, Japan
    J Hepatobiliary Pancreat Surg 16:613-7. 2009
    ..Therefore, at present, at many institutions, ERCP is not generally performed for those with a Roux-en-Y anastomosis...
  95. ncbi request reprint Cytochrome c is a possible new marker for fulminant hepatitis in humans
    Isao Sakaida
    Department of Gastroenterology and Hepatology, School of Medicine, Yamaguchi University, 1 1 1 Minami kogushi, Ube, 755 8505, Japan
    J Gastroenterol 40:179-85. 2005
    ..Cytochrome c is known as a substance related to apoptosis. We investigated serum cytochrome c levels in patients with fulminant hepatitis (FH) compared with these levels in patients with acute or chronic liver diseases...
  96. ncbi request reprint [Bone marrow cell as a source of hepatic stem cell]
    Isao Sakaida
    Department of Hepatology and Gastroenterology, Graduate School of Medicine, Yamaguchi University
    Nihon Shokakibyo Gakkai Zasshi 103:607-14. 2006
  97. doi request reprint Usefulness of Sonazoid contrast-enhanced ultrasonography for hepatocellular carcinoma: comparison with pathological diagnosis and superparamagnetic iron oxide magnetic resonance images
    Keiko Korenaga
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Yamaguchi University, 1 1 1 Minami kogushi, Ube, Yamaguchi, 755 8505, Japan
    J Gastroenterol 44:733-41. 2009
    ..The examination was performed by comparing the images during the Kupffer phase of Sonazoid-CEUS with superparamagnetic iron oxide magnetic resonance (SPIO-MRI)...
  98. ncbi request reprint D-Penicillamine improved laparoscopic and histological findings of the liver in a patient with Wilson's disease: 3-year follow-up after diagnosis of Coombs-negative hemolytic anemia of Wilson's disease
    Isao Sakaida
    Department of Gastroenterology and Hepatology, School of Medicine, Yamaguchi University, 1 1 1 Minami kogushi, Ube, 755 8505, Japan
    J Gastroenterol 40:646-51. 2005
    ..After 3 years, she again underwent laparoscopic examination, and the laparoscopic and histological findings of her liver were obviously improved. Management of the copper level can reverse severe liver fibrosis in Wilson's disease...
  99. ncbi request reprint Proteomic profiling of heat shock protein 70 family members as biomarkers for hepatitis C virus-related hepatocellular carcinoma
    Motonari Takashima
    Department of Surgery II, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Abe, Yamaguchi 755 8505, Japan
    Proteomics 3:2487-93. 2003
    ..Our results suggest that these four proteins play important roles in the pathogenesis of HCV-related HCC and could be molecular targets for diagnosis and treatment of this disease...
  100. ncbi request reprint The iron chelator deferoxamine causes activated hepatic stellate cells to become quiescent and to undergo apoptosis
    Haiyan Jin
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Japan
    J Gastroenterol 42:475-84. 2007
    ..Hepatic stellate cells (HSCs) play a pivotal role in liver fibrogenesis. Here, we studied whether the iron chelator deferoxamine (DFO) affected cultured HSC activation and apoptosis...
  101. ncbi request reprint L-cysteine administration prevents liver fibrosis by suppressing hepatic stellate cell proliferation and activation
    Takashi Horie
    Pharmaceuticals Research Laboratories, Ajinomoto Co, Inc, 1 1, Suzuki cho, Kawasaki ku, Kawasaki 210 8681, Japan
    Biochem Biophys Res Commun 305:94-100. 2003
    ..These findings suggest that L-cysteine is effective against liver fibrosis. The mechanism of inhibition of fibrosis in the liver is surmized to be direct inhibition of activated HSC proliferation and HSC transformation by L-cysteine...