Shin Ichi Ozaki
Affiliation: Yamaguchi University
- Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutationsShin Ichi Ozaki
Department of Biological Sciences, Yamaguchi University, Yamaguchi, Japan
Biosci Biotechnol Biochem 72:2318-23. 2008..The results indicate that structural changes in the heme vicinity are transmitted to PLP existing 20 A away from heme. A possible explanation of our results is discussed on the basis of CBS structure...
- Mutagenesis studies of human cystathionine beta-synthase: residues important for heme binding and substrate interactionsShin Ichi Ozaki
Department of Biological Sciences, Yamaguchi University, 1677 1 Yoshida, Yamaguchi, 753 8515, Japan
Protein Pept Lett 17:351-5. 2010..Our mutagenesis studies suggest that Arg-266 is important to sense structural changes in heme-binding site, and that Gln-222 as well as Tyr-223 are involved in interactions with substrates...