Masaru Okuda

Summary

Affiliation: Yamaguchi University
Country: Japan

Publications

  1. ncbi request reprint The role of nucleophosmin in centrosome duplication
    Masaru Okuda
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yoshida 1677 1, Yamaguchi, Japan, 753 8515
    Oncogene 21:6170-4. 2002
  2. ncbi request reprint Detection of Borrelia garinii, Borrelia tanukii and Borrelia sp. closely related to Borrelia valaisiana in Ixodes ticks removed from dogs and cats in Japan
    Hiroko Hiraoka
    Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    Vet Parasitol 144:188-92. 2007
  3. ncbi request reprint Detection of DNA of 'Candidatus Mycoplasma haemominutum' and Spiroplasma sp. in unfed ticks collected from vegetation in Japan
    Shoko Taroura
    Faculty of Agriculture, Yamaguchi University, Japan
    J Vet Med Sci 67:1277-9. 2005
  4. ncbi request reprint Experimental inoculation of beagle dogs with Ehrlichia species detected from Ixodes ovatus
    Malaika Watanabe
    Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    Vet Parasitol 136:147-54. 2006
  5. ncbi request reprint Detection of rickettsial DNA in ixodid ticks recovered from dogs and cats in Japan
    Hiroko Hiraoka
    Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    J Vet Med Sci 67:1217-22. 2005
  6. ncbi request reprint Overexpression of BUBR1 is associated with chromosomal instability in bladder cancer
    Yoshiaki Yamamoto
    Department of Urology, Yamaguchi University School of Medicine, Ube 755 8505, Yamaguchi, Japan
    Cancer Genet Cytogenet 174:42-7. 2007
  7. ncbi request reprint Cloning of the feline GADD45 cDNA and analysis of its mutation in feline lymphoma cell lines
    Tatsuo Oikawa
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    J Vet Med Sci 68:297-301. 2006
  8. ncbi request reprint Application of polymerase chain reaction to analysis of antigen receptor rearrangements to support endoscopic diagnosis of canine alimentary lymphoma
    Naoki Kaneko
    Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    J Vet Med Sci 71:555-9. 2009
  9. ncbi request reprint Clinical usefulness of antibodies against Babesia gibsoni detected by ELISA with recombinant P50
    Takako Miyama
    Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    J Vet Med Sci 68:1371-3. 2006
  10. ncbi request reprint Use of formalin-fixed paraffin-embedded tissue and single-strand conformation polymorphism analysis for polymerase chain reaction of antigen receptor rearrangements in dogs
    Naoki Kaneko
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Japan
    J Vet Med Sci 71:535-8. 2009

Collaborators

Detail Information

Publications66

  1. ncbi request reprint The role of nucleophosmin in centrosome duplication
    Masaru Okuda
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yoshida 1677 1, Yamaguchi, Japan, 753 8515
    Oncogene 21:6170-4. 2002
    ..Thus, NPM/B23 would constitute one of the licensing systems for centrosome duplication, ensuring the coordination of centrosome and DNA duplication, which limiting duplication once per cell cycle...
  2. ncbi request reprint Detection of Borrelia garinii, Borrelia tanukii and Borrelia sp. closely related to Borrelia valaisiana in Ixodes ticks removed from dogs and cats in Japan
    Hiroko Hiraoka
    Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    Vet Parasitol 144:188-92. 2007
    ..closely related to B. valaisiana. The data was confirmed by analysis of the flagellin gene sequence. Infected ticks carried by companion animals can be introduced into the human environment...
  3. ncbi request reprint Detection of DNA of 'Candidatus Mycoplasma haemominutum' and Spiroplasma sp. in unfed ticks collected from vegetation in Japan
    Shoko Taroura
    Faculty of Agriculture, Yamaguchi University, Japan
    J Vet Med Sci 67:1277-9. 2005
    ..Mycoplasma haemominutum'. Spiroplasma DNA was also detected from unfed I. ovatus in Hokkaido, Fukushima and Yamaguchi Prefectures. The analysis of nucleotides sequence suggested that this Spiroplasma was distinct from registered species...
  4. ncbi request reprint Experimental inoculation of beagle dogs with Ehrlichia species detected from Ixodes ovatus
    Malaika Watanabe
    Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    Vet Parasitol 136:147-54. 2006
    ..i. These data suggest that infection of dogs with EIO is possible, though is probably of low pathogenic importance. Cross-reactivity of EIO infected dog serum with E. canis raises the likelihood of false E. canis seropositive dogs...
  5. ncbi request reprint Detection of rickettsial DNA in ixodid ticks recovered from dogs and cats in Japan
    Hiroko Hiraoka
    Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    J Vet Med Sci 67:1217-22. 2005
    ..Rickettsia canada-like DNA was detected from Haemaphysalis sp. removed from a dog in Fukuoka, and ;Candidatus Rickettsia tarasevichiae'-like DNA was from Ixodes sp. removed from a dog in Hokkaido...
  6. ncbi request reprint Overexpression of BUBR1 is associated with chromosomal instability in bladder cancer
    Yoshiaki Yamamoto
    Department of Urology, Yamaguchi University School of Medicine, Ube 755 8505, Yamaguchi, Japan
    Cancer Genet Cytogenet 174:42-7. 2007
    ..Overexpression of BUBR1 predicted tumor recurrence and disease progression. These data suggest that overexpression of BUBR1 is potentially a new tumor marker for estimating biological characteristics of bladder cancer...
  7. ncbi request reprint Cloning of the feline GADD45 cDNA and analysis of its mutation in feline lymphoma cell lines
    Tatsuo Oikawa
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    J Vet Med Sci 68:297-301. 2006
    ..However, no mutations were detected by sequence analysis of feline GADD45 in several feline lymphoma cell lines, indicating that the GADD45 mutation might be uncommon in feline oncogenesis...
  8. ncbi request reprint Application of polymerase chain reaction to analysis of antigen receptor rearrangements to support endoscopic diagnosis of canine alimentary lymphoma
    Naoki Kaneko
    Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    J Vet Med Sci 71:555-9. 2009
    ..Furthermore, a TCRgamma-positive result in PARR may imply a poor prognosis...
  9. ncbi request reprint Clinical usefulness of antibodies against Babesia gibsoni detected by ELISA with recombinant P50
    Takako Miyama
    Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    J Vet Med Sci 68:1371-3. 2006
    ..However, 14 other anemic dogs with a confirmed history of B. gibsoni infection were all positive, thus confirming the higher sensitivity of ELISA in detecting a history of infection...
  10. ncbi request reprint Use of formalin-fixed paraffin-embedded tissue and single-strand conformation polymorphism analysis for polymerase chain reaction of antigen receptor rearrangements in dogs
    Naoki Kaneko
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Japan
    J Vet Med Sci 71:535-8. 2009
    ..These results show that PARR-FFPE is viable for tissues with an appropriate formalin fixation time and that application of FFPE and SSCP for PARR are useful for diagnosis and retrospective study of canine lymphoid neoplasia...
  11. ncbi request reprint Nationwide survey of leptospira antibodies in dogs in Japan: results from microscopic agglutination test and enzyme-linked immunosorbent assay
    Emiko Iwamoto
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yoshida, Yamaguchi, Japan
    J Vet Med Sci 71:1191-9. 2009
    ..To the best of our knowledge, the present study is the first nationwide survey of Leptospira infection in dogs, and the findings are relevant not only for clinical veterinary medicine but also for public health...
  12. ncbi request reprint Molecular cloning of the canine fragile histidine triad (FHIT) gene and Fhit protein expression in canine peripheral blood mononuclear cells
    Hiroko Hiraoka
    Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    J Vet Med Sci 71:645-9. 2009
    ..The deduced amino acid sequence was well conserved between species, and anti-human Fhit antibody could be used to detect the canine Fhit protein. These findings will be useful for future research...
  13. ncbi request reprint Enzyme-linked immunosorbent assay for the detection of canine Leptospira antibodies using recombinant OmpL1 protein
    Masaru Okuda
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    J Vet Med Sci 67:249-54. 2005
    ..109 +/- 0.046 and 0.089 +/- 0.046, respectively). These data suggest that the detection of anti-Leptospira antibodies by ELISA using the GST-rOmpL1 protein can be applied for diagnosis of canine leptospirosis...
  14. ncbi request reprint Neutropenia associated with osteomyelitis due to Hepatozoon canis infection in a dog
    Takako Shimokawa Miyama
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, Yoshida, Yamaguchi, Japan
    J Vet Med Sci 73:1389-93. 2011
    ..canis infection. This is the first report of neutropenia associated with H. canis infection. H. canis infection can be included in the differential diagnosis in canine cases of neutropenia in areas where the disease is endemic...
  15. ncbi request reprint Ehrlichia canis infection in two dogs that emigrated from endemic areas
    Kenji Baba
    Laboratory of Veterinary Parasitology, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    J Vet Med Sci 74:775-8. 2012
    ..Thus, even in non-endemic areas, E. canis infection should be included in the differential diagnosis of clinically ill dogs that emigrated from endemic areas...
  16. ncbi request reprint A dog with myelodysplastic syndrome: chronic myelomonocytic leukemia
    Hiroko Hiraoka
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yoshida, Yamaguchi, Japan
    J Vet Med Sci 69:665-8. 2007
    ..Based on the features of the bone marrow and the peripheral blood, this case was confirmed to be myelodysplastic syndrome--Chronic myelomonocytic leukaemia (MDS-CMML)...
  17. ncbi request reprint Nafamostat mesilate is not appropriate as an anticoagulant during continuous renal replacement therapy in dogs
    Takako Shimokawa Miyama
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    J Vet Med Sci 72:363-7. 2010
    ..Further, all the dogs suffered vomiting during CRRT with NM infusion. We therefore recommend that NM is not used as an anticoagulant during CRRT in dogs...
  18. ncbi request reprint Evaluation of the hemodynamic impact of continuous renal replacement therapy in healthy dogs
    Takako Shimokawa Miyama
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
    J Vet Med Sci 72:493-7. 2010
    ..These observations suggest that the CRRT protocol used in the present study can be safely applied to clinical cases with acute renal failure...
  19. doi request reprint Characterization of monoclonal antibodies against canine P-selectin glycoprotein ligand-1 (PSGL-1)
    Saori Umeki
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    Vet Immunol Immunopathol 142:119-25. 2011
    ..These anti-cPSGL-1 monoclonal antibodies will be useful for analysis of the canine P-selectin and PSGL-1 system...
  20. ncbi request reprint Development of high-grade B-cell lymphoma concurrent with T-cell chronic lymphocytic leukemia in a dog
    Takumi Okawa
    Laboratories of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    J Vet Med Sci 74:677-80. 2012
    ..Chemotherapy using the L-VCA short protocol was effective for 155 days, but the dog died on day 194 after diagnosis, despite rescue therapies...
  21. ncbi request reprint Aberrations of the FHIT gene and Fhit protein in canine lymphoma cell lines
    Hiroko Hiraoka
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    J Vet Med Sci 71:769-77. 2009
    ..In the present study, we detected aberrations in the FHIT gene and Fhit protein expression in all 5 canine lymphoma cell lines, and this phenomenon might be an important factor in promoting canine lymphoma...
  22. pmc Detection of Babesia canis rossi, B. canis vogeli, and Hepatozoon canis in dogs in a village of eastern Sudan by using a screening PCR and sequencing methodologies
    Maremichi Oyamada
    Faculty of Agriculture, Yamaguchi University, Japan
    Clin Diagn Lab Immunol 12:1343-6. 2005
    ..Among 78 dogs, 5 were infected with Babesia canis rossi and 2 others were infected with B. canis vogeli. Thirty-three dogs were positive for Hepatozoon. Hepatozoon canis was detected by sequence analysis...
  23. ncbi request reprint Expression of the MDR1 gene and P-glycoprotein in canine mast cell tumor cell lines
    Munekazu Nakaichi
    Department of Veterinary Surgery, Yamaguchi University, Yoshida, Japan
    J Vet Med Sci 69:111-5. 2007
    ..These findings suggest that the expressions of MDR1 gene and P-gp probably contribute to cellular drug resistance in canine mast cell tumors...
  24. ncbi request reprint Establishment of five canine lymphoma cell lines and tumor formation in a xenotransplantation model
    Saori Umeki
    Laboratory of Veterinary Internal Medicine, The United Graduate School of Veterinary Science, Yamaguchi University, Yoshida, Yamaguchi, Japan
    J Vet Med Sci 75:467-74. 2013
    ..Establishment of novel canine lymphoma cell lines with different characteristics is critical for elucidating the pathophysiology of canine lymphoma and improving current therapies...
  25. doi request reprint Calreticulin expression in neoplastic versus normal dog mammary glands: a cDNA subtraction-based study
    Takumi Okawa
    Department of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan
    Res Vet Sci 92:80-91. 2012
    ..Furthermore, cCRT was molecularly cloned, and the amino acid sequence of cCRT was found to be very similar to those of other species. Further studies are required to elucidate additional roles of cCRT in canine MGT...
  26. ncbi request reprint Activity of matrix metalloproteinase-2 (MMP-2) in canine oronasal tumors
    Munekazu Nakaichi
    Department of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University, 1677 1 Ooaza Yoshida, Yamaguchi 753 8515, Japan
    Res Vet Sci 82:271-9. 2007
    ..The MMP-2/TIMP-2 ratio was also positively correlated with MMP-2 activity in gelatin zymography. These results indicate that the MMP-2/TIMP-2 ratio may be of value in evaluating the prognosis in canine oronasal cavity tumors...
  27. ncbi request reprint Magnetic resonance imaging and clinical findings in a miniature Schnauzer with hypodipsic hypernatremia
    Takako Shimokawa Miyama
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    J Vet Med Sci 71:1387-91. 2009
    ..Magnetic resonance imaging revealed dysgenesis of the corpus callosum and other forebrain structures. On the basis of these findings, congenital brain malformation associated with failure of the osmoreceptor system was suspected...
  28. doi request reprint Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats
    Yutaka Terada
    Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    J Gen Virol 93:1930-4. 2012
    ..These results indicate that the 5'-terminal region of the S gene is not essential for the development of FIP...
  29. doi request reprint Superficial necrolytic dermatitis associated with extrapancreatic glucagonoma in a dog
    Takuya Mizuno
    Laboratory of Veterinary Internal Medicine, Yamaguci University, Yamaguchi, Japan
    Vet Dermatol 20:72-9. 2009
    ..Immunohistochemical analysis of the neoplastic cells revealed that the tumour was a glucagonoma, consistent with earlier findings of persistent glucagonaemia and hypoaminoacidaemia...
  30. pmc Transcriptional control of BubR1 by p53 and suppression of centrosome amplification by BubR1
    Tatsuo Oikawa
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    Mol Cell Biol 25:4046-61. 2005
    ..Our studies demonstrate the molecular aspect of genomic convergence in cultured cells, providing critical information for understanding the stepwise progression of tumors...
  31. ncbi request reprint Prekallikrein deficiency in a dog
    Takumi Okawa
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    J Vet Med Sci 73:107-11. 2011
    ..The comparison revealed that the dog had a point mutation in exon 8 that leads to an amino acid substitution in the fourth apple domain of PK. This is the first report showing a point mutation of PK in a dog with PK deficiency...
  32. pmc Molecular detection of a new Anaplasma species closely related to Anaplasma phagocytophilum in canine blood from South Africa
    Hisashi Inokuma
    Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    J Clin Microbiol 43:2934-7. 2005
    ..This suggests that a new Anaplasma species closely related to A. phagocytophilum occurs in Africa...
  33. pmc Determination of the nucleotide sequences of heat shock operon groESL and the citrate synthase gene (gltA) of Anaplasma (Ehrlichia) platys for phylogenetic and diagnostic studies
    Hisashi Inokuma
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 753 8515 Yamaguchi, Japan
    Clin Diagn Lab Immunol 9:1132-6. 2002
    ..The topology of the groEL- and gltA-based phylogenetic tree was similar to that derived from 16S rRNA gene analyses with distances. Both groESL- and gltA-based PCRs specific to A. platys were also developed based upon the alignment data...
  34. doi request reprint Anti-adhesive property of P-selectin glycoprotein ligand-1 (PSGL-1) due to steric hindrance effect
    Saori Umeki
    The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi, Japan
    J Cell Biochem 114:1271-85. 2013
    ..This study implies that PSGL-1 has Janus-faced functions, being both adhesive and anti-adhesive...
  35. ncbi request reprint Epidemiological survey of Babesia gibsoni infection in dogs in eastern Japan
    Takako Miyama
    Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    J Vet Med Sci 67:467-71. 2005
    ..Twenty-two of 35 B. gibsoni-positive dogs were infected with hemoplasma, and the rate of infection was significantly higher than that of B. gibsoni-negative dogs...
  36. ncbi request reprint Molecular survey of Mycoplasma haemofelis and 'Candidatus mycoplasma haemominutum' infection in cats in Yamaguchi and surrounding areas
    Hisashi Inokuma
    Faculty of Agriculture, Yamaguchi University, Japan
    J Vet Med Sci 66:1017-20. 2004
    ..Hemoplasma infections were more frequently detected in free-roaming cats than inside cats. Also, the status of FeLV infection was another significant risk factor for hemoplasma infection...
  37. pmc Dogs as sentinels for human infection with Japanese encephalitis virus
    Hiroshi Shimoda
    Yamaguchi University, Yoshida, Yamaguchi 753 8515, Japan
    Emerg Infect Dis 16:1137-9. 2010
    ..We found that JEV-infected mosquitoes have spread throughout Japan and that dogs, but not cats, might be good sentinels for monitoring JEV infection in urban/residential areas...
  38. ncbi request reprint Tick paralysis by Ixodes holocyclus in a Japanese traveler returning from Australia associated with Rickettsia helvetica infection
    Hisashi Inokuma
    Faculty of Agriculture, Yamaguchi University, Japan
    J Travel Med 10:61-3. 2003
  39. doi request reprint Molecular cloning of canine interleukin-31 and its expression in various tissues
    Takuya Mizuno
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    Vet Immunol Immunopathol 131:140-3. 2009
    ..Furthermore, we detected low levels of canine IL-31 in the thymus, testis, spleen, and kidneys, but not in the skin of atopic dogs...
  40. ncbi request reprint Tick paralysis by Ixodes holocyclus in a Japanese traveler returning from Australia
    Hisashi Inokuma
    Faculty of Agriculture, Yamaguchi University, 753 8515 Yamaguchi, Japan
    Ann N Y Acad Sci 990:357-8. 2003
  41. pmc Epidemiological survey of Babesia species in Japan performed with specimens from ticks collected from dogs and detection of new Babesia DNA closely related to Babesia odocoilei and Babesia divergens DNA
    Hisashi Inokuma
    Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    J Clin Microbiol 41:3494-8. 2003
    ..The sequences were similar to those of Babesia odocoilei (97.7%) and Babesia divergens (97.6%). This is the first report of the detection of DNA belonging to this group in Japan...
  42. ncbi request reprint Epidemiological survey of Anaplasma platys and Ehrlichia canis using ticks collected from dogs in Japan
    Hisashi Inokuma
    Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    Vet Parasitol 115:343-8. 2003
    ..platys has already been spread widely in Japan. No positive reactions were observed in any ticks examined for E. canis...
  43. ncbi request reprint Demonstration of Anaplasma (Ehrlichia) platys inclusions in peripheral blood platelets of a dog in Japan
    Hisashi Inokuma
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    Vet Parasitol 110:145-52. 2002
    ..The sequence analysis of the 16S rRNA, citrate synthase and heat shock protein genes of DNA from the infected platelets confirmed that the inclusions were A. platys. This is the first detection of A. platys inclusions in dogs in Japan...
  44. pmc Detection of ehrlichial DNA in Haemaphysalis ticks recovered from dogs in Japan that is closely related to a novel Ehrlichia sp. found in cattle ticks from Tibet, Thailand, and Africa
    Hisashi Inokuma
    Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    J Clin Microbiol 42:1353-5. 2004
    ..Three positive samples were detected from Haemaphysalis ticks, and higher levels of similarity (98.46 to 99.06%) were found to recently detected Ehrlichia spp. from cattle ticks in Tibet, Thailand, and Africa...
  45. ncbi request reprint Analysis of the 18S rRNA gene sequence of a Hepatozoon detected in two Japanese dogs
    Hisashi Inokuma
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    Vet Parasitol 106:265-71. 2002
    ..americanum and H. catasbianae. These results suggest that the Hepatozoon detected in the Japanese dogs might be a strain variant of H. canis, but is apparently a different species than H. americanum...
  46. ncbi request reprint Phylogenetic analysis of Theileria sp. from sika deer, Cervus nippon, in Japan
    Hisashi Inokuma
    Laboratory of Veterinary Internal Medicine, Yamaguchi University, Yamaguchi, Japan
    Vet Parasitol 120:339-45. 2004
    ..Phylogenetic analysis of the gene sequences also revealed that Theileria sp. detected from sika deer comprise a clade that is clearly distinct from the clade comprised of Theileria from cattle...
  47. ncbi request reprint Molecular survey of Babesia infection in dogs in Okinawa, Japan
    Hisashi Inokuma
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    Vet Parasitol 121:341-6. 2004
    ..canis and B. gibsoni, respectively. Sequence analysis of the PCR products revealed that the 18S rRNA gene sequence of B. canis detected from dogs in Okinawa was very close to B. canis vogeli with sequence similarity of 99.94%...
  48. ncbi request reprint Seroepidemiological study of canine ehrlichial infections in Yamaguchi prefecture and surrounding areas of Japan
    Malaika Watanabe
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    Vet Parasitol 124:101-7. 2004
    ..The remaining ten dogs had similar high titers to two or more of the antigens. This is the first serological evidence obtained of canine infection with the domestic Ehrlichia of Japan...
  49. ncbi request reprint Malignant transformation of T-cell large granular lymphocyte leukemia in a dog
    Tomoko Takahashi
    Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Yamaguchi, Japan
    J Vet Med Sci 69:677-81. 2007
    ..This was regarded as malignant transformation from LGL chronic leukemia to the acute type. Sequential chemotherapy was started, but the dog died on day 190. Necropsy revealed tumor cell infiltration into the heart, skin, and brain...
  50. ncbi request reprint Crossreactivity of antibodies to canine CD25 and Foxp3 and identification of canine CD4+CD25 +Foxp3+ cells in canine peripheral blood
    Takuya Mizuno
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677 1Yoshida, Yamaguchi 753 8515, Japan
    J Vet Med Sci 71:1561-8. 2009
    ..ConA stimulation of canine PBMCs induced Foxp3 and CD25 expression in CD4(+) and CD4(-) cells. These data indicate that the activation of canine lymphocytes might induce the production of adaptive Treg cells, as observed in humans...
  51. ncbi request reprint Expression of a tumor-associated antigen, RCAS1, in canine mammary tumors
    Yasuhiko Okamura
    Department of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University, Japan
    J Vet Med Sci 66:651-8. 2004
    ..These observations suggest that RCAS1 probably plays an important role in tumor progression and escape from immune surveillance in canine mammary tumors...
  52. ncbi request reprint Tick infestation of sika deer (Cervus nippon) in the western part of Yamaguchi Prefecture, Japan
    Hisashi Inokuma
    Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    J Vet Med Sci 64:615-7. 2002
    ..flava and H. megaspinosa were dominant in October, November and March. This is the first report of H. yeni in the mainland of Japan. Small numbers of H. kitaokai, Amblyomma testudinarium and Ixodes ovatus were also recorded...
  53. ncbi request reprint Molecular cloning of canine RCAS1 cDNA
    Yasuhiko Okamura
    Faculty of Agriculture, Yamaguchi University, Yoshida, Yamaguchi, Japan
    J Vet Med Sci 65:913-5. 2003
    ..2% and 96.7% homologies with those of human and mouse RCAS1 respectively. Canine RCAS1 has an N-terminal transmembrane segment and a coiled-coil structure in the C-terminal protein, which are highly conserved in mouse and human RCAS1...
  54. ncbi request reprint Autoantibodies against T-Cell costimulatory molecules are produced in canine autoimmune diseases
    Tanvir S Khatlani
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    J Immunother 26:12-20. 2003
    ..The autoantibodies against CTLA-4, demonstrated here for the first time in canine autoimmune diseases, may modulate the immune response in dogs with autoimmune diseases...
  55. ncbi request reprint Detection of the anti-P53 antibodies in dogs with tumors
    Noriko Kanaya
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yoshida, Japan
    J Vet Med Sci 64:973-9. 2002
    ..These results suggest that the anti-P53 antibodies are also produced in tumor dogs with p53 gene mutations...
  56. ncbi request reprint Centrosome amplification and chromosomal instability in feline lymphoma cell lines
    Ryuta Miki
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Japan
    J Vet Med Sci 66:797-805. 2004
    ..Furthermore, this study suggests the presence of unknown mechanism that leads to the centrosome amplification in feline lymphomas...
  57. ncbi request reprint Centrosome hyperamplification predicts progression and tumor recurrence in bladder cancer
    Yoshiaki Yamamoto
    Department of Urology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Clin Cancer Res 10:6449-55. 2004
    ..In this study, we investigated whether CH could be used as a prognostic biomarker for patients with bladder cancer...
  58. ncbi request reprint Effects of salivary gland extract from Rhipicephalus sanguineus on IgG subclass production and cytokine mRNA expression in mononuclear cells of canine peripheral blood
    Koutaro Matsumoto
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Japan
    J Vet Med Sci 65:137-40. 2003
    ..SGE had no effect on the mRNA expression of IL-4. These results suggest that the suppression of IgG2 production by SGE from R. sanguineus was caused by the suppression of IFN-gamma production...
  59. ncbi request reprint A mammalian in vitro centriole duplication system: evidence for involvement of CDK2/cyclin E and nucleophosmin/B23 in centrosome duplication
    Pheruza Tarapore
    Department of Cell Biology, University of Cincinnati College of Medicine, P O Box 670521, Ohio 45267 0521, USA
    Cell Cycle 1:75-81. 2002
    ....
  60. ncbi request reprint Serological evidence of infection of Anaplasma and Ehrlichia in domestic animals in Xinjiang Uygur Autonomous Region area, China
    Bayin Chahan
    Veterinary College, Xingjiang Agricultural University, Urumqui, China
    Vet Parasitol 134:273-8. 2005
    ..Antibody titers up to 1:320 were recorded. These results indicate that ruminants kept in these areas may be infected with some species of Anaplasma and Ehrlichia...
  61. ncbi request reprint Survey of ixodid tick species on domestic cats in Japan
    Yojiro Shimada
    Merial Japan Ltd, Tokyo, Japan
    Vet Parasitol 111:231-9. 2003
    ..5%) male recovered from 62 cats in autumn, only 32 (15.6%) were identified. Most of the larvae were fully- or partly-engorged Haemaphysalis spp., and it was difficult to identify them further by morphological characterization...
  62. ncbi request reprint Divergence of p33/34 gene of Theileria found in Cervus nippon in Japan
    Hisashi Inokuma
    Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
    J Vet Med Sci 70:401-5. 2008
    ..7% to 70.1% and 64.1% to 70.0% respectively. These findings suggest that there are at least two genetically distinct strains of Theileria of sika deer in Japan...
  63. ncbi request reprint A case of atypical canine lymphoma with oral mass and multiple osteolysis
    Tetsuro Ito
    Veterinary Teaching Hospital, School of Veterinary Medicine, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    J Vet Med Sci 69:977-80. 2007
    ..The case was diagnosed as atypical lymphoma and treated by multi-drug chemotherapy. On the 142nd day after the first admission, the case had remission and the oral mass and multiple osteolysis were improved...
  64. ncbi request reprint Epidemiological survey of Ehrlichia canis and related species infection in dogs in eastern Sudan
    Hisashi Inokuma
    Obihiro University of Agriculture and Veterinary Medicine, 080 8555 Obihiro, Japan
    Ann N Y Acad Sci 1078:461-3. 2006
    ..Among these, 30 dogs were single-positive: 25 for E. canis, 2 for A. platys, 1 for M. hemocanis, and 2 for "C. M. haemoparvum." The rest of the dogs (48.7%) were positive for two or more pathogens...
  65. doi request reprint Isolation of Aspergillus udagawae from a fatal case of feline orbital aspergillosis
    Rui Kano
    Mycoses 51:360-1. 2008
    ..Antifungal susceptibility testing results revealed that this isolate had high in vitro MIC to amphotericin B (AMB) that correlated with in vivo failure of therapy with AMB...
  66. ncbi request reprint Molecular cloning of the canine telomerase reverse transcriptase gene and its expression in neoplastic and non-neoplastic cells
    Mitsuhiro Yazawa
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113 8657, Japan
    Am J Vet Res 64:1395-400. 2003
    ..To perform molecular cloning of the canine telomerase reverse transcriptase (TERT) gene and determine its expression in neoplastic and non-neoplastic cells...