Naoyuki Morishige

Summary

Affiliation: Yamaguchi University
Country: Japan

Publications

  1. ncbi Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 53:4998-5003. 2012
  2. ncbi Effect of preoperative duration of stromal edema in bullous keratopathy on early visual acuity after endothelial keratoplasty
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    J Cataract Refract Surg 38:303-8. 2012
  3. ncbi Three-dimensional analysis of collagen lamellae in the anterior stroma of the human cornea visualized by second harmonic generation imaging microscopy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 52:911-5. 2011
  4. ncbi Immunohistofluorescence analysis of myofibroblast transdifferentiation in human corneas with bullous keratopathy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Cornea 30:1129-34. 2011
  5. ncbi Quantitative evaluation of corneal epithelial oedema by confocal microscopy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Clin Experiment Ophthalmol 37:249-53. 2009
  6. ncbi Detection of ICP0 protein in tear fluid of individuals with active herpetic epithelial keratitis
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Jpn J Ophthalmol 55:591-4. 2011
  7. ncbi Detection of subepithelial fibrosis associated with corneal stromal edema by second harmonic generation imaging microscopy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 50:3145-50. 2009
  8. ncbi Unusual phenotype of an individual with the R124C mutation in the TGFBI gene
    Naoyuki Morishige
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube, Japan
    Arch Ophthalmol 122:1224-7. 2004
  9. ncbi [Structural analysis of normal corneas and diseased corneas by applying second harmonic generation]
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Japan
    Nihon Ganka Gakkai Zasshi 115:1025-35. 2011
  10. ncbi Localization of semaphorin 3A in the rat cornea
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Exp Eye Res 86:669-74. 2008

Detail Information

Publications35

  1. ncbi Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 53:4998-5003. 2012
    ....
  2. ncbi Effect of preoperative duration of stromal edema in bullous keratopathy on early visual acuity after endothelial keratoplasty
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    J Cataract Refract Surg 38:303-8. 2012
    ..To clarify the relationship between visual acuity after Descemet-stripping automated endothelial keratoplasty (DSAEK) and the preoperative duration of stromal edema...
  3. ncbi Three-dimensional analysis of collagen lamellae in the anterior stroma of the human cornea visualized by second harmonic generation imaging microscopy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 52:911-5. 2011
    ..The structure of collagen lamellae in the anterior stroma of the human cornea is thought to be an important determinant of corneal rigidity. The three-dimensional structure of such collagen lamellae in normal human corneas was examined...
  4. ncbi Immunohistofluorescence analysis of myofibroblast transdifferentiation in human corneas with bullous keratopathy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Cornea 30:1129-34. 2011
    ..To detect the transdifferentiation of keratocytes into myofibroblasts in human corneas with bullous keratopathy and to examine the relation of such transdifferentiation to the clinical course of the disease...
  5. ncbi Quantitative evaluation of corneal epithelial oedema by confocal microscopy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Clin Experiment Ophthalmol 37:249-53. 2009
    ....
  6. ncbi Detection of ICP0 protein in tear fluid of individuals with active herpetic epithelial keratitis
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Jpn J Ophthalmol 55:591-4. 2011
    ..Here, we investigated whether ICP0 of herpes simplex virus 1 is detectable in the tear fluid of patients with herpetic epithelial keratitis...
  7. ncbi Detection of subepithelial fibrosis associated with corneal stromal edema by second harmonic generation imaging microscopy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 50:3145-50. 2009
    ..Human corneas with or without stromal edema were examined by second harmonic generation (SHG) imaging microscopy to characterize stromal collagen organization...
  8. ncbi Unusual phenotype of an individual with the R124C mutation in the TGFBI gene
    Naoyuki Morishige
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube, Japan
    Arch Ophthalmol 122:1224-7. 2004
  9. ncbi [Structural analysis of normal corneas and diseased corneas by applying second harmonic generation]
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Japan
    Nihon Ganka Gakkai Zasshi 115:1025-35. 2011
    ....
  10. ncbi Localization of semaphorin 3A in the rat cornea
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Exp Eye Res 86:669-74. 2008
    ..These observations show that Sema3A is expressed in all cells of the rat cornea with the exception of superficial epithelial cells...
  11. ncbi Upregulation of ZO-1 in cultured human corneal epithelial cells by a peptide (PHSRN) corresponding to the second cell-binding site of fibronectin
    Ryoji Yanai
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 50:2757-64. 2009
    ..To investigate the effect of a peptide (PHSRN) corresponding to the second cell-binding site of fibronectin on the expression of ZO-1 in cultured human corneal epithelial (HCE) cells...
  12. ncbi Open clinical study of eye drops containing the fibronectin-derived peptide PHSRN for treatment of persistent corneal epithelial defects
    Naoyuki Yamada
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Cornea 31:1408-13. 2012
    ..We have now examined the clinical efficacy of eye drops containing the PHSRN peptide for treatment of persistent epithelial defects (PEDs) of the cornea...
  13. ncbi Upregulation of connexin43 expression in corneal fibroblasts by corneal epithelial cells
    Ji Ae Ko
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 50:2054-60. 2009
    ..They have now examined the effect of corneal epithelial cells on the expression of the gap-junction protein connexin43 in corneal fibroblasts...
  14. ncbi New mode of treatment for lattice corneal dystrophy type I: corneal epithelial debridement and fibronectin eye drops
    Yukiko Morita
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Jpn J Ophthalmol 56:26-30. 2012
    ..We investigated the efficacy of corneal epithelial debridement followed by application of autologous fibronectin eye drops in the treatment of patients with this mutation...
  15. ncbi Expression of semaphorin 3A in the rat corneal epithelium during wound healing
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Biochem Biophys Res Commun 395:451-7. 2010
    ..They further suggest that Sema3A might play a role in the regulation of corneal epithelial wound healing...
  16. ncbi Disruption of zonula occludens-1 localization in the rabbit corneal epithelium by contact lens-induced hypoxia
    Ryoji Yanai
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 50:4605-10. 2009
    ..This function depends on tight junctions, of which zonula occludens (ZO)-1 is a major component. The authors have investigated the effects of hypoxia on ZO-1 localization and expression in the rabbit corneal epithelium in vivo...
  17. ncbi Delayed corneal epithelial wound healing after penetrating keratoplasty in individuals with lattice corneal dystrophy
    Koji Kawamoto
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube City, Yamaguchi, Japan
    Am J Ophthalmol 142:173-4. 2006
    ..To investigate whether corneal epithelial cells of individuals with lattice corneal dystrophy (LCD) possess an intrinsic defect...
  18. ncbi Persistent epithelial defects due to neurotrophic keratopathy treated with a substance p-derived peptide and insulin-like growth factor 1
    Teruo Nishida
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Jpn J Ophthalmol 51:442-7. 2007
    ..The clinical efficacy of eye drops containing FGLM-amide and IGF-1 for the treatment of persistent epithelial defects in individuals with neurotrophic keratopathy was examined in a prospective open study...
  19. ncbi Delayed wound closure and phenotypic changes in corneal epithelium of the spontaneously diabetic Goto-Kakizaki rat
    Makiko Wakuta
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube City, Yamaguchi 755 8505, Japan
    Invest Ophthalmol Vis Sci 48:590-6. 2007
    ..To characterize wound closure and phenotypic changes in the corneal epithelium of the Goto-Kakizaki (GK) rat, a spontaneous model of type 2 diabetes...
  20. ncbi Double mutation (R124H, N544S) of TGFBI in two sisters with combined expression of Avellino and lattice corneal dystrophies
    Naoyuki Yamada
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
    Mol Vis 15:974-9. 2009
    ..We now report two cases with both R124H and N544S mutations of TGFBI...
  21. ncbi Development of an instrument for measurement of light scattering at the corneal epithelial basement membrane in diabetic patients
    Norihisa Takahashi
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Jpn J Ophthalmol 51:185-90. 2007
    ....
  22. ncbi Up-regulation of semaphorin 3A in human corneal fibroblasts by epidermal growth factor released from cocultured human corneal epithelial cells
    Ji Ae Ko
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
    Biochem Biophys Res Commun 377:104-8. 2008
    ..This effect of EGF may play an important role in maintenance of corneal structure and repair of corneal damage...
  23. ncbi In vivo biopsy by laser confocal microscopy for evaluation of traumatic recurrent corneal erosion
    Tai ichiro Chikama
    Department of Ocular Pathophysiology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Mol Vis 14:2333-9. 2008
    ..Laser in vivo confocal microscopy noninvasively provides images that are equivalent to high quality histology. We have now applied this technique to identify pathological characteristics of traumatic recurrent corneal erosion (RCE)...
  24. ncbi Up-regulation of HSP70 by the fibronectin-derived peptide PHSRN in human corneal epithelial cells
    Ji Ae Ko
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube City, Yamaguchi 755 8505, Japan
    Biochem Biophys Res Commun 370:424-8. 2008
    ..Our results suggest that induction of HSP70 expression may contribute to the promotion of corneal epithelial migration by PHSRN and hence to corneal epithelial wound healing...
  25. ncbi Comparison of confocal biomicroscopy and noncontact specular microscopy for evaluation of the corneal endothelium
    Makiko Hara
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube City, Yamaguchi, Japan
    Cornea 22:512-5. 2003
    ..To compare the clinical efficacy of confocal biomicroscopy with that of noncontact specular microscopy for the evaluation of the corneal endothelium...
  26. ncbi Two cases of methicillin-resistant Staphylococcus aureus keratitis after Epi-LASIK
    Norimasa Nomi
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Jpn J Ophthalmol 52:440-3. 2008
    ..We describe two severe cases of methicillin-resistant Staphylococcus aureus (MRSA) keratitis following Epi-LASIK surgery...
  27. ncbi Differential regulation of focal adhesion kinase and paxillin phosphorylation by the small GTP-binding protein Rho in human corneal epithelial cells
    Jun Saito
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube, Japan
    Jpn J Ophthalmol 48:199-207. 2004
    ..The signaling pathway responsible for this effect of LPA was examined in this study with a human corneal epithelial (HCE) cell line...
  28. ncbi Correlation of corneal sensation, but not of basal or reflex tear secretion, with the stage of diabetic retinopathy
    Jun Saito
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube City, Yamaguchi, Japan
    Cornea 22:15-8. 2003
    ..To examine the possible relation between corneal sensation or tear secretion and the stage of diabetic retinopathy in diabetic patients...
  29. ncbi [Correlation of the presence of meibomian gland dysfunction with the incidence of superficial punctate keratopathy after penetrating keratoplasty]
    Kei Shiozawa
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube 755-8505, Japan
    Nippon Ganka Gakkai Zasshi 107:84-7. 2003
    ..There was no interaction between the presence of MGD and hypolacrimation and the incidence of SPK. CONCLUSION: This study suggested that the active treatment of MGD is important in the post-surgery management of SPK...
  30. ncbi Modification of a soft contact lens for use during irrigation and aspiration in the penetrating keratoplasty triple procedure
    Koji Kawamoto
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube, Japan
    Arch Ophthalmol 124:550-1. 2006
    ..The newly designed soft contact lens thus improves management of the lens cortex during the penetrating keratoplasty triple procedure...
  31. ncbi Herpes simplex virus type 1 ICP0 localizes in the stromal layer of infected rabbit corneas and resides predominantly in the cytoplasm and/or perinuclear region of rabbit keratocytes
    Naoyuki Morishige
    The Eye Institute, University of California at Irvine, School of Medicine, Irvine, CA 92697, USA
    J Gen Virol 87:2817-25. 2006
    ..These findings provide new data demonstrating that anterior corneal keratocytes become infected and express ICP0 during acute HSV-1 infection...
  32. ncbi Second-harmonic imaging microscopy of normal human and keratoconus cornea
    Naoyuki Morishige
    The Eye Institute, School of Medicine, University of California Irvine Medical Center, Orange, California
    Invest Ophthalmol Vis Sci 48:1087-94. 2007
    ..The purpose of this study was to evaluate the ability of second-harmonic imaging to identify differences in corneal stromal collagen organization between normal human and keratoconus corneas...
  33. ncbi The corneas of naive mice contain both CD4+ and CD8+ T cells
    Kevin R Mott
    Center for Neurobiology and Vaccine Development, Ophthalmology Research Laboratories, Cedars Sinai Medical Center Burns and Allen Research Institute, Los Angeles, CA 90272, USA
    Mol Vis 13:1802-12. 2007
    ..To determine if the corneas of naive mice contain resident CD4+ and CD8+ T cells...
  34. ncbi Corneal response to femtosecond laser photodisruption in the rabbit
    Naoyuki Morishige
    The Eye Institute, University of California at Irvine, Medical Center, Orange, CA 92868, USA
    Exp Eye Res 86:835-43. 2008
    ..However, a thicker stromal interface was seen with the higher energy suggesting greater stromal damage...
  35. ncbi Detection of corneal fibrosis by imaging second harmonic-generated signals in rabbit corneas treated with mitomycin C after excimer laser surface ablation
    Marjan Farid
    Gavin S Herbert Eye Institute, University of California, Irvine Medical Center, Orange, California 92868, USA
    Invest Ophthalmol Vis Sci 49:4377-83. 2008
    ..The purpose of this study was to assess whether SHG signals can detect differences in corneal fibrosis after excimer laser surface ablation (photorefractive keratectomy [PRK])...