Naoyuki Morishige

Summary

Affiliation: Yamaguchi University
Country: Japan

Publications

  1. doi request reprint Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 53:4998-5003. 2012
  2. doi request reprint Effect of preoperative duration of stromal edema in bullous keratopathy on early visual acuity after endothelial keratoplasty
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    J Cataract Refract Surg 38:303-8. 2012
  3. ncbi request reprint Detection of subepithelial fibrosis associated with corneal stromal edema by second harmonic generation imaging microscopy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 50:3145-50. 2009
  4. doi request reprint Immunohistofluorescence analysis of myofibroblast transdifferentiation in human corneas with bullous keratopathy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Cornea 30:1129-34. 2011
  5. ncbi request reprint Quantitative evaluation of corneal epithelial oedema by confocal microscopy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Clin Experiment Ophthalmol 37:249-53. 2009
  6. doi request reprint Three-dimensional analysis of collagen lamellae in the anterior stroma of the human cornea visualized by second harmonic generation imaging microscopy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 52:911-5. 2011
  7. doi request reprint Localization of semaphorin 3A in the rat cornea
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Exp Eye Res 86:669-74. 2008
  8. ncbi request reprint [Structural analysis of normal corneas and diseased corneas by applying second harmonic generation]
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Japan
    Nihon Ganka Gakkai Zasshi 115:1025-35. 2011
  9. doi request reprint Detection of ICP0 protein in tear fluid of individuals with active herpetic epithelial keratitis
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Jpn J Ophthalmol 55:591-4. 2011
  10. ncbi request reprint Unusual phenotype of an individual with the R124C mutation in the TGFBI gene
    Naoyuki Morishige
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube, Japan
    Arch Ophthalmol 122:1224-7. 2004

Detail Information

Publications40

  1. doi request reprint Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 53:4998-5003. 2012
    ....
  2. doi request reprint Effect of preoperative duration of stromal edema in bullous keratopathy on early visual acuity after endothelial keratoplasty
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    J Cataract Refract Surg 38:303-8. 2012
    ..To clarify the relationship between visual acuity after Descemet-stripping automated endothelial keratoplasty (DSAEK) and the preoperative duration of stromal edema...
  3. ncbi request reprint Detection of subepithelial fibrosis associated with corneal stromal edema by second harmonic generation imaging microscopy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 50:3145-50. 2009
    ..Human corneas with or without stromal edema were examined by second harmonic generation (SHG) imaging microscopy to characterize stromal collagen organization...
  4. doi request reprint Immunohistofluorescence analysis of myofibroblast transdifferentiation in human corneas with bullous keratopathy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Cornea 30:1129-34. 2011
    ..To detect the transdifferentiation of keratocytes into myofibroblasts in human corneas with bullous keratopathy and to examine the relation of such transdifferentiation to the clinical course of the disease...
  5. ncbi request reprint Quantitative evaluation of corneal epithelial oedema by confocal microscopy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Clin Experiment Ophthalmol 37:249-53. 2009
    ....
  6. doi request reprint Three-dimensional analysis of collagen lamellae in the anterior stroma of the human cornea visualized by second harmonic generation imaging microscopy
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 52:911-5. 2011
    ..The structure of collagen lamellae in the anterior stroma of the human cornea is thought to be an important determinant of corneal rigidity. The three-dimensional structure of such collagen lamellae in normal human corneas was examined...
  7. doi request reprint Localization of semaphorin 3A in the rat cornea
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Exp Eye Res 86:669-74. 2008
    ..These observations show that Sema3A is expressed in all cells of the rat cornea with the exception of superficial epithelial cells...
  8. ncbi request reprint [Structural analysis of normal corneas and diseased corneas by applying second harmonic generation]
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Japan
    Nihon Ganka Gakkai Zasshi 115:1025-35. 2011
    ....
  9. doi request reprint Detection of ICP0 protein in tear fluid of individuals with active herpetic epithelial keratitis
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Jpn J Ophthalmol 55:591-4. 2011
    ..Here, we investigated whether ICP0 of herpes simplex virus 1 is detectable in the tear fluid of patients with herpetic epithelial keratitis...
  10. ncbi request reprint Unusual phenotype of an individual with the R124C mutation in the TGFBI gene
    Naoyuki Morishige
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube, Japan
    Arch Ophthalmol 122:1224-7. 2004
  11. doi request reprint Upregulation of ZO-1 in cultured human corneal epithelial cells by a peptide (PHSRN) corresponding to the second cell-binding site of fibronectin
    Ryoji Yanai
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 50:2757-64. 2009
    ..To investigate the effect of a peptide (PHSRN) corresponding to the second cell-binding site of fibronectin on the expression of ZO-1 in cultured human corneal epithelial (HCE) cells...
  12. doi request reprint Open clinical study of eye drops containing the fibronectin-derived peptide PHSRN for treatment of persistent corneal epithelial defects
    Naoyuki Yamada
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Cornea 31:1408-13. 2012
    ..We have now examined the clinical efficacy of eye drops containing the PHSRN peptide for treatment of persistent epithelial defects (PEDs) of the cornea...
  13. doi request reprint Upregulation of connexin43 expression in corneal fibroblasts by corneal epithelial cells
    Ji Ae Ko
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 50:2054-60. 2009
    ..They have now examined the effect of corneal epithelial cells on the expression of the gap-junction protein connexin43 in corneal fibroblasts...
  14. doi request reprint New mode of treatment for lattice corneal dystrophy type I: corneal epithelial debridement and fibronectin eye drops
    Yukiko Morita
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Jpn J Ophthalmol 56:26-30. 2012
    ..We investigated the efficacy of corneal epithelial debridement followed by application of autologous fibronectin eye drops in the treatment of patients with this mutation...
  15. doi request reprint Expression of semaphorin 3A in the rat corneal epithelium during wound healing
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Biochem Biophys Res Commun 395:451-7. 2010
    ..They further suggest that Sema3A might play a role in the regulation of corneal epithelial wound healing...
  16. doi request reprint Disruption of zonula occludens-1 localization in the rabbit corneal epithelium by contact lens-induced hypoxia
    Ryoji Yanai
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 50:4605-10. 2009
    ..This function depends on tight junctions, of which zonula occludens (ZO)-1 is a major component. The authors have investigated the effects of hypoxia on ZO-1 localization and expression in the rabbit corneal epithelium in vivo...
  17. ncbi request reprint Delayed corneal epithelial wound healing after penetrating keratoplasty in individuals with lattice corneal dystrophy
    Koji Kawamoto
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube City, Yamaguchi, Japan
    Am J Ophthalmol 142:173-4. 2006
    ..To investigate whether corneal epithelial cells of individuals with lattice corneal dystrophy (LCD) possess an intrinsic defect...
  18. doi request reprint Role of the JNK signaling pathway in downregulation of connexin43 by TNF-α in human corneal fibroblasts
    Kazuhiro Kimura
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
    Curr Eye Res 38:926-32. 2013
    ..We have now examined the role of mitogen-activated protein kinase (MAPK) signaling pathways in TNF-α-induced downregulation of the gap junction protein connexin43 (Cx43) in human corneal fibroblasts...
  19. ncbi request reprint Persistent epithelial defects due to neurotrophic keratopathy treated with a substance p-derived peptide and insulin-like growth factor 1
    Teruo Nishida
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Jpn J Ophthalmol 51:442-7. 2007
    ..The clinical efficacy of eye drops containing FGLM-amide and IGF-1 for the treatment of persistent epithelial defects in individuals with neurotrophic keratopathy was examined in a prospective open study...
  20. ncbi request reprint Delayed wound closure and phenotypic changes in corneal epithelium of the spontaneously diabetic Goto-Kakizaki rat
    Makiko Wakuta
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube City, Yamaguchi 755 8505, Japan
    Invest Ophthalmol Vis Sci 48:590-6. 2007
    ..To characterize wound closure and phenotypic changes in the corneal epithelium of the Goto-Kakizaki (GK) rat, a spontaneous model of type 2 diabetes...
  21. doi request reprint Up-regulation of semaphorin 3A in human corneal fibroblasts by epidermal growth factor released from cocultured human corneal epithelial cells
    Ji Ae Ko
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
    Biochem Biophys Res Commun 377:104-8. 2008
    ..This effect of EGF may play an important role in maintenance of corneal structure and repair of corneal damage...
  22. pmc Double mutation (R124H, N544S) of TGFBI in two sisters with combined expression of Avellino and lattice corneal dystrophies
    Naoyuki Yamada
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
    Mol Vis 15:974-9. 2009
    ..We now report two cases with both R124H and N544S mutations of TGFBI...
  23. ncbi request reprint Development of an instrument for measurement of light scattering at the corneal epithelial basement membrane in diabetic patients
    Norihisa Takahashi
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Jpn J Ophthalmol 51:185-90. 2007
    ....
  24. pmc In vivo biopsy by laser confocal microscopy for evaluation of traumatic recurrent corneal erosion
    Tai ichiro Chikama
    Department of Ocular Pathophysiology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Mol Vis 14:2333-9. 2008
    ..Laser in vivo confocal microscopy noninvasively provides images that are equivalent to high quality histology. We have now applied this technique to identify pathological characteristics of traumatic recurrent corneal erosion (RCE)...
  25. pmc Persistence of structural changes at the anterior cornea in bullous keratopathy patients after endothelial keratoplasty
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    PLoS ONE 8:e74279. 2013
    ..SEF and ASS persisted for more than 6 months in a substantial proportion of individuals with a preoperative duration of stromal edema of at least 12 months. ..
  26. ncbi request reprint Two cases of methicillin-resistant Staphylococcus aureus keratitis after Epi-LASIK
    Norimasa Nomi
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Jpn J Ophthalmol 52:440-3. 2008
    ..We describe two severe cases of methicillin-resistant Staphylococcus aureus (MRSA) keratitis following Epi-LASIK surgery...
  27. doi request reprint Bullous keratopathy as a progressive disease: evidence from clinical and laboratory imaging studies
    Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Cornea 32:S77-83. 2013
    ....
  28. ncbi request reprint Inhibition by female sex hormones of collagen gel contraction mediated by retinal pigment epithelial cells
    Kazuhiro Kimura
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 55:2621-30. 2014
    ..Collagen contraction mediated by retinal pigment epithelial (RPE) cells contributes to the pathogenesis of proliferative vitreoretinopathy (PVR). We examined the effects of sex hormones on this process...
  29. ncbi request reprint Comparison of confocal biomicroscopy and noncontact specular microscopy for evaluation of the corneal endothelium
    Makiko Hara
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube City, Yamaguchi, Japan
    Cornea 22:512-5. 2003
    ..To compare the clinical efficacy of confocal biomicroscopy with that of noncontact specular microscopy for the evaluation of the corneal endothelium...
  30. doi request reprint Up-regulation of HSP70 by the fibronectin-derived peptide PHSRN in human corneal epithelial cells
    Ji Ae Ko
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube City, Yamaguchi 755 8505, Japan
    Biochem Biophys Res Commun 370:424-8. 2008
    ..Our results suggest that induction of HSP70 expression may contribute to the promotion of corneal epithelial migration by PHSRN and hence to corneal epithelial wound healing...
  31. ncbi request reprint Differential regulation of focal adhesion kinase and paxillin phosphorylation by the small GTP-binding protein Rho in human corneal epithelial cells
    Jun Saito
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube, Japan
    Jpn J Ophthalmol 48:199-207. 2004
    ..The signaling pathway responsible for this effect of LPA was examined in this study with a human corneal epithelial (HCE) cell line...
  32. ncbi request reprint Correlation of corneal sensation, but not of basal or reflex tear secretion, with the stage of diabetic retinopathy
    Jun Saito
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube City, Yamaguchi, Japan
    Cornea 22:15-8. 2003
    ..To examine the possible relation between corneal sensation or tear secretion and the stage of diabetic retinopathy in diabetic patients...
  33. ncbi request reprint [Correlation of the presence of meibomian gland dysfunction with the incidence of superficial punctate keratopathy after penetrating keratoplasty]
    Kei Shiozawa
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube 755 8505, Japan
    Nihon Ganka Gakkai Zasshi 107:84-7. 2003
    ..To examine the correlation of the presence of meibomian gland dysfunction(MGD) with the incidence of superficial punctate keratopathy (SPK) after penetrating keratoplasty...
  34. ncbi request reprint Modification of a soft contact lens for use during irrigation and aspiration in the penetrating keratoplasty triple procedure
    Koji Kawamoto
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube, Japan
    Arch Ophthalmol 124:550-1. 2006
    ..The newly designed soft contact lens thus improves management of the lens cortex during the penetrating keratoplasty triple procedure...
  35. pmc Second-harmonic imaging microscopy of normal human and keratoconus cornea
    Naoyuki Morishige
    The Eye Institute, School of Medicine, University of California Irvine Medical Center, Orange, California
    Invest Ophthalmol Vis Sci 48:1087-94. 2007
    ..The purpose of this study was to evaluate the ability of second-harmonic imaging to identify differences in corneal stromal collagen organization between normal human and keratoconus corneas...
  36. ncbi request reprint The corneas of naive mice contain both CD4+ and CD8+ T cells
    Kevin R Mott
    Center for Neurobiology and Vaccine Development, Ophthalmology Research Laboratories, Cedars Sinai Medical Center Burns and Allen Research Institute, Los Angeles, CA 90272, USA
    Mol Vis 13:1802-12. 2007
    ..To determine if the corneas of naive mice contain resident CD4+ and CD8+ T cells...
  37. pmc Corneal response to femtosecond laser photodisruption in the rabbit
    Naoyuki Morishige
    The Eye Institute, University of California at Irvine, Medical Center, Orange, CA 92868, USA
    Exp Eye Res 86:835-43. 2008
    ..However, a thicker stromal interface was seen with the higher energy suggesting greater stromal damage...
  38. doi request reprint Detection of corneal fibrosis by imaging second harmonic-generated signals in rabbit corneas treated with mitomycin C after excimer laser surface ablation
    Marjan Farid
    Gavin S Herbert Eye Institute, University of California, Irvine Medical Center, Orange, California 92868, USA
    Invest Ophthalmol Vis Sci 49:4377-83. 2008
    ..The purpose of this study was to assess whether SHG signals can detect differences in corneal fibrosis after excimer laser surface ablation (photorefractive keratectomy [PRK])...
  39. ncbi request reprint Herpes simplex virus type 1 ICP0 localizes in the stromal layer of infected rabbit corneas and resides predominantly in the cytoplasm and/or perinuclear region of rabbit keratocytes
    Naoyuki Morishige
    The Eye Institute, University of California at Irvine, School of Medicine, Irvine, CA 92697, USA
    J Gen Virol 87:2817-25. 2006
    ..These findings provide new data demonstrating that anterior corneal keratocytes become infected and express ICP0 during acute HSV-1 infection...