Takashi Kanda

Summary

Affiliation: Yamaguchi University
Country: Japan

Publications

  1. doi request reprint Blood-brain barrier destruction determines Fisher/Bickerstaff clinical phenotypes: an in vitro study
    Kazuyuki Saito
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1, Minamikogushi, Ube, Yamaguchi 7558505, Japan
    J Neurol Neurosurg Psychiatry 84:756-65. 2013
  2. doi request reprint Biology of the blood-nerve barrier and its alteration in immune mediated neuropathies
    Takashi Kanda
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 7558505, Japan
    J Neurol Neurosurg Psychiatry 84:208-12. 2013
  3. doi request reprint Usefulness of sural nerve biopsy in the genomic era
    Takashi Kanda
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Neuropathology 29:502-8. 2009
  4. doi request reprint Peripheral nerve pericytes modify the blood-nerve barrier function and tight junctional molecules through the secretion of various soluble factors
    Fumitaka Shimizu
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    J Cell Physiol 226:255-66. 2011
  5. ncbi request reprint Establishment and characterization of human peripheral nerve microvascular endothelial cell lines: a new in vitro blood-nerve barrier (BNB) model
    Masaaki Abe
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Cell Struct Funct 37:89-100. 2012
  6. doi request reprint Peripheral nerve pericytes originating from the blood-nerve barrier expresses tight junctional molecules and transporters as barrier-forming cells
    Fumitaka Shimizu
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Japan
    J Cell Physiol 217:388-99. 2008
  7. doi request reprint Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood-brain barrier function
    Yasuteru Sano
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    J Cell Physiol 225:519-28. 2010
  8. doi request reprint Sera from neuromyelitis optica patients disrupt the blood-brain barrier
    Fumitaka Shimizu
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Japan
    J Neurol Neurosurg Psychiatry 83:288-97. 2012
  9. doi request reprint Hydrocortisone enhances the function of the blood-nerve barrier through the up-regulation of claudin-5
    Yoko Kashiwamura
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 7558505, Japan
    Neurochem Res 36:849-55. 2011
  10. doi request reprint Pericyte-derived glial cell line-derived neurotrophic factor increase the expression of claudin-5 in the blood-brain barrier and the blood-nerve barrier
    Fumitaka Shimizu
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1, Minamikogushi, Ube, Yamaguchi, 7558505, Japan
    Neurochem Res 37:401-9. 2012

Collaborators

Detail Information

Publications34

  1. doi request reprint Blood-brain barrier destruction determines Fisher/Bickerstaff clinical phenotypes: an in vitro study
    Kazuyuki Saito
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1, Minamikogushi, Ube, Yamaguchi 7558505, Japan
    J Neurol Neurosurg Psychiatry 84:756-65. 2013
    ....
  2. doi request reprint Biology of the blood-nerve barrier and its alteration in immune mediated neuropathies
    Takashi Kanda
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 7558505, Japan
    J Neurol Neurosurg Psychiatry 84:208-12. 2013
    ..Potential therapeutic strategies for immune mediated neuropathies manipulating the BNB are also discussed...
  3. doi request reprint Usefulness of sural nerve biopsy in the genomic era
    Takashi Kanda
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Neuropathology 29:502-8. 2009
    ....
  4. doi request reprint Peripheral nerve pericytes modify the blood-nerve barrier function and tight junctional molecules through the secretion of various soluble factors
    Fumitaka Shimizu
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    J Cell Physiol 226:255-66. 2011
    ..Investigation of the characteristics of peripheral nerve pericytes may provide novel strategies for modifying BNB functions and promoting peripheral nerve regeneration...
  5. ncbi request reprint Establishment and characterization of human peripheral nerve microvascular endothelial cell lines: a new in vitro blood-nerve barrier (BNB) model
    Masaaki Abe
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Cell Struct Funct 37:89-100. 2012
    ..These results indicated that FH-BNBs had highly specialized barrier properties and they might therefore be a useful tool to analyze the pathophysiology of various neuropathies...
  6. doi request reprint Peripheral nerve pericytes originating from the blood-nerve barrier expresses tight junctional molecules and transporters as barrier-forming cells
    Fumitaka Shimizu
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Japan
    J Cell Physiol 217:388-99. 2008
    ....
  7. doi request reprint Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood-brain barrier function
    Yasuteru Sano
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    J Cell Physiol 225:519-28. 2010
    ..Thus, conditionally immortalized TY08 cells retaining the in vivo BBB functions should facilitate analyses for determining the pathophysiology of various neurological diseases...
  8. doi request reprint Sera from neuromyelitis optica patients disrupt the blood-brain barrier
    Fumitaka Shimizu
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Japan
    J Neurol Neurosurg Psychiatry 83:288-97. 2012
    ..It is unclear whether sera from patients with NMO can open the BBB, and which component of patient sera is most important for this disruption...
  9. doi request reprint Hydrocortisone enhances the function of the blood-nerve barrier through the up-regulation of claudin-5
    Yoko Kashiwamura
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 7558505, Japan
    Neurochem Res 36:849-55. 2011
    ..We herein report that GCs up-regulate the expression of claudin-5 and increase the barrier properties of the BNB. This is the first report which indicates how GCs affect the blood-nerve barrier...
  10. doi request reprint Pericyte-derived glial cell line-derived neurotrophic factor increase the expression of claudin-5 in the blood-brain barrier and the blood-nerve barrier
    Fumitaka Shimizu
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1, Minamikogushi, Ube, Yamaguchi, 7558505, Japan
    Neurochem Res 37:401-9. 2012
    ..These results indicate that the regulation of GDNF secreted from pericytes may therefore be a novel therapeutic strategy to modify the BBB or BNB functions and promote brain or peripheral nerve regeneration...
  11. ncbi request reprint [A 61-year-old female who suffered from herpes simplex encephalitis with expanded cerebral lesions on MRI and prolonged clinical course--the diagnostic usefulness of PCR using biopsied brain tissue specimens]
    Fumitaka Shimizu
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi 755 8505, Japan
    Brain Nerve 60:1475-80. 2008
    ..We therefore concluded that real-time PCR using biopsied brain tissue specimens is a novel, sensitive method for detecting causative agents in patient with prolonged and undiagnosed encephalitis...
  12. ncbi request reprint [Peripheral neuropathy and blood-nerve barrier]
    Takashi Kanda
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
    Rinsho Shinkeigaku 49:959-62. 2009
    ..Future accumulation of the knowledge concerning the cellular properties of BNB-forming cells will open the door to novel therapeutic strategies for intractable peripheral neuropathies...
  13. ncbi request reprint p.Arg332Cys mutation of NOTCH3 gene in two unrelated Japanese families with CADASIL
    Yasuteru Sano
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Japan
    Intern Med 50:2833-8. 2011
    ..The subject from family B showed recurrent ischemic attacks, followed by a large intracranial hemorrhage. This is the first report to describe the detailed phenotypes of patients with a rare p.Arg332Cys mutation in Japan...
  14. ncbi request reprint [A case of POEMS syndrome with enlarged pancreas due to IgG4-related autoimmune pancreatitis]
    Hideaki Nishihara
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
    Rinsho Shinkeigaku 51:417-21. 2011
    ..Co-existence of monoclonal and polyclonal plasma proliferative changes in the present patient may provide keys to clarify common mechanisms shared by these two rare disorders, POEMS syndrome and IgG4-related autoimmune disease...
  15. ncbi request reprint [Case of painful muscle spasm induced by thoracic vertebral fracture: successful treatment with lumbar sympathetic ganglia block]
    Fumitaka Shimizu
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
    Rinsho Shinkeigaku 48:733-6. 2008
    ..Lumbar sympathetic ganglia block should be recommended to a therapeutic option for the refractory painful muscle spasm of the leg...
  16. doi request reprint A serological analysis of viral and bacterial infections associated with neuromyelitis optica
    Michiaki Koga
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    J Neurol Sci 300:19-22. 2011
    ..These findings indicate that, not single, but various viral infections, can be associated with the development of NMO during the early stages of the illness, although the exact pathogenesis of NMO has yet to be clarified...
  17. ncbi request reprint [Therapeutic strategy for peripheral nerve regeneration; molecular permeability control at the blood-nerve barrier]
    Takashi Kanda
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
    Rinsho Shinkeigaku 48:1028-30. 2008
    ..We also obtained immortal endothelial and pericyte cell lines originating from human BNB. Analyses of physiological characteristics and protein profiles in these BNB-forming cells are underway in our laboratory...
  18. ncbi request reprint [Novel nutritional management regimen for very long-chain acyl-CoA dehydrogenase deficiency]
    Hiroyo Haruki
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
    Rinsho Shinkeigaku 50:172-4. 2010
    ....
  19. doi request reprint Advanced glycation end-products disrupt the blood-brain barrier by stimulating the release of transforming growth factor-β by pericytes and vascular endothelial growth factor and matrix metalloproteinase-2 by endothelial cells in vitro
    Fumitaka Shimizu
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Neurobiol Aging 34:1902-12. 2013
    ....
  20. ncbi request reprint [Blood-nerve barrier: structure and function]
    Takashi Kanda
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Brain Nerve 63:557-69. 2011
    ..In this review article, we discuss the macroscopic and microscopic anatomy of the human BNB as well as the molecular mechanisms of mononuclear cell infiltration across the BNB...
  21. ncbi request reprint [A case of diffuse idiopathic skeletal hyperostosis presenting dysphagia and restrictive ventilatory impairment]
    Masaaki Abe
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Brain Nerve 60:171-4. 2008
    ....
  22. ncbi request reprint Vaccine-associated paralytic poliomyelitis showing biphasic motor paresis
    Mariko Oishi
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
    Rinsho Shinkeigaku 52:744-9. 2012
    ....
  23. doi request reprint GQ1b-seronegative Fisher syndrome: clinical features and new serological markers
    Michiaki Koga
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    J Neurol 259:1366-74. 2012
    ..jejuni strains expressing GD1c-, GalNAc-GM1b-, or GalNAc-GD1c-like LOS. These findings suggest that IgG antibodies against GM1b, GD1c, GalNAc-GM1b, and ganglioside complexes are serological markers for GQ1b-seronegative Fisher syndrome...
  24. doi request reprint Nationwide survey of patients in Japan with Bickerstaff brainstem encephalitis: epidemiological and clinical characteristics
    Michiaki Koga
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    J Neurol Neurosurg Psychiatry 83:1210-5. 2012
    ..Information regarding the epidemiological background of Bickerstaff brainstem encephalitis (BBE) is limited...
  25. ncbi request reprint Neuromyelitis optica with HTLV-1 infection: different from acute progressive HAM?
    Michiaki Koga
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube
    Intern Med 48:1157-9. 2009
    ..Careful testing of anti-AQP4 antibody is necessary to establish whether or not acute HAM is a clinical variant of HAM...
  26. ncbi request reprint Endothelial cells constituting blood-nerve barrier have highly specialized characteristics as barrier-forming cells
    Yasuteru Sano
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
    Cell Struct Funct 32:139-47. 2007
    ..These results suggest that PnMECs constituting the bulk of BNB have a highly specialized characteristic resembling the endothelial cells forming BBB...
  27. ncbi request reprint [Hyperalgesia with loss of temperature sensation in one side of the body due to pinpoint infarction of contralateral spinothalamic tract]
    Yoko Kashiwamura
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
    Rinsho Shinkeigaku 49:262-6. 2009
    ..Oral carbamazepine was partially effective to ameliorate the intractable central poststroke pain...
  28. doi request reprint Isolation and properties of endothelial cells forming the blood-nerve barrier
    Yasuteru Sano
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Methods Mol Biol 686:417-25. 2011
    ..This chapter describes a standard protocol for isolating the endothelial cells forming the BNB. In addition, methods for confirming some of the barrier properties of isolated endothelial cells are also described...
  29. ncbi request reprint [A forty-five-years-old woman suffered from Sjögren syndrome with progressive tetraparesis]
    Fumitaka Shimizu
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
    Rinsho Shinkeigaku 47:502-6. 2007
    ..We consider the immune-mediated impairment of the motor nerve associated with Sjögren syndrome to be the cardinal pathogenesis of the present patient, even though treatment with oral corticosteroids did not ameliorate her symptoms...
  30. ncbi request reprint [Pathology of Crow-Fukase syndrome]
    Takashi Kanda
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamiogushi, Ube, Yamaguchi 755 8505, Japan
    Brain Nerve 60:603-10. 2008
    ....
  31. ncbi request reprint [Artificial control of blood-nerve barrier: a novel therapeutic approach to peripheral neuropathies]
    Takashi Kanda
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
    Rinsho Shinkeigaku 51:1020-2. 2011
    ..For hereditary, metabolic and ischemic neuropathies, the promotion of the entrance of growth factors into PNS parenchyma and of the excretion of toxic substances should powerfully encourage the regeneration of axons...
  32. ncbi request reprint [Disruption of the blood-brain barrier in inflammatory neurological diseases]
    Fumitaka Shimizu
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Japan
    Brain Nerve 65:165-76. 2013
    ....
  33. ncbi request reprint [Polyneuropathy: diagnosis and treatment]
    Takashi Kanda
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
    Rinsho Shinkeigaku 47:769-73. 2007
    ..Hence, we should keep in mind that the exact lesion site does not necessarily present at sural nerve, especially in inflammatory neuropathies and vasculitic neuropathies...
  34. ncbi request reprint [Blood-brain barrier and blood-nerve barrier in neuroinflammatory diseases]
    Toshihiko Maeda
    Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
    Nihon Rinsho 71:789-94. 2013
    ..The control of inflammatory cells and humoral factors such as cytokines at the level of BBB/BNB can develop a novel therapeutic strategy toward the inflammatory/autoimmune nervous system disorders...