T Ichiyama

Summary

Affiliation: Yamaguchi University
Country: Japan

Publications

  1. ncbi request reprint Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Brain Dev 31:731-8. 2009
  2. ncbi request reprint Dexamethasone decreases cerebrospinal fluid soluble tumor necrosis factor receptor 1 levels in bacterial meningitis
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Brain Dev 30:95-9. 2008
  3. ncbi request reprint Cysteinyl leukotrienes enhance tumour necrosis factor-alpha-induced matrix metalloproteinase-9 in human monocytes/macrophages
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Clin Exp Allergy 37:608-14. 2007
  4. ncbi request reprint Cerebrospinal fluid levels of cytokines in non-herpetic acute limbic encephalitis: comparison with herpes simplex encephalitis
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Cytokine 44:149-53. 2008
  5. ncbi request reprint NF-kappaB activation in cerebrospinal fluid cells from patients with meningitis
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Japan
    Neurol Res 24:709-12. 2002
  6. ncbi request reprint Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in non-herpetic acute limbic encephalitis
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    J Neurol 256:1846-50. 2009
  7. doi request reprint Cysteinyl leukotrienes induce macrophage inflammatory protein-1 in human monocytes/macrophages
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Int Arch Allergy Immunol 148:147-53. 2009
  8. ncbi request reprint Intravenous immunoglobulin inhibits NF-kappaB activation and affects Fcgamma receptor expression in monocytes/macrophages
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, 755 8505 Ube, Yamaguchi, Japan
    Naunyn Schmiedebergs Arch Pharmacol 369:428-33. 2004
  9. ncbi request reprint Cerebrospinal fluid and serum levels of cytokines and soluble tumor necrosis factor receptor in influenza virus-associated encephalopathy
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Scand J Infect Dis 35:59-61. 2003
  10. ncbi request reprint Serum cytokine concentrations of influenza-associated acute necrotizing encephalopathy
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Japan
    Pediatr Int 45:734-6. 2003

Collaborators

Detail Information

Publications98

  1. ncbi request reprint Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Brain Dev 31:731-8. 2009
    ..We suggest that cytokines mediate the pathogenesis of acute encephalopathy associated with HHV-6 infection, and that the elevated levels of serum IL-6, sTNFR1, and CSF IL-6 are important for predicting neurological sequelae...
  2. ncbi request reprint Dexamethasone decreases cerebrospinal fluid soluble tumor necrosis factor receptor 1 levels in bacterial meningitis
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Brain Dev 30:95-9. 2008
    ..0063). Our present study suggests that dexamethasone inhibits increase of CSF sTNFR1 levels after antibiotics therapy in bacterial meningitis...
  3. ncbi request reprint Cysteinyl leukotrienes enhance tumour necrosis factor-alpha-induced matrix metalloproteinase-9 in human monocytes/macrophages
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Clin Exp Allergy 37:608-14. 2007
    ..Matrix metalloproteinase-9 (MMP-9) is an important enzyme responsible for airway remodelling. Monocytes/macrophages have a cysteinyl leukotriene 1 (cysLT1) receptor, but its function is poorly understood...
  4. ncbi request reprint Cerebrospinal fluid levels of cytokines in non-herpetic acute limbic encephalitis: comparison with herpes simplex encephalitis
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Cytokine 44:149-53. 2008
    ..Recently, non-herpetic acute limbic encephalitis (NHALE) was identified as a new subgroup of limbic encephalitis. The immunological pathophysiology of NHALE is still unclear...
  5. ncbi request reprint NF-kappaB activation in cerebrospinal fluid cells from patients with meningitis
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Japan
    Neurol Res 24:709-12. 2002
    ..Our data suggested that CSF cells produce pro-inflammatory cytokines through NF-kappaB activation in meningitis, and that increased NF-kappaB activation in CSF cells indicate infectious meningitis rather than carcinomatous meningitis...
  6. ncbi request reprint Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in non-herpetic acute limbic encephalitis
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    J Neurol 256:1846-50. 2009
    ..001) but did not differ in patients with NHALE in the acute and convalescent stages. Our preliminary study suggests that the prolonged imbalance of MMP-9 and TIMP-1 is associated with the pathogenesis of NHALE...
  7. doi request reprint Cysteinyl leukotrienes induce macrophage inflammatory protein-1 in human monocytes/macrophages
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Int Arch Allergy Immunol 148:147-53. 2009
    ..Macrophage inflammatory protein-1alpha (MIP-1alpha) and MIP-1beta are known for their chemotactic and proinflammatory effects on monocytes/macrophages which have a cysteinyl leukotriene 1 (CysLT(1)) receptor...
  8. ncbi request reprint Intravenous immunoglobulin inhibits NF-kappaB activation and affects Fcgamma receptor expression in monocytes/macrophages
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, 755 8505 Ube, Yamaguchi, Japan
    Naunyn Schmiedebergs Arch Pharmacol 369:428-33. 2004
    ..These findings suggest that IVIG inhibits TNF-alpha-induced NF-kappaB activation in monocytes/macrophages, and blocks FcgammaRIII on the membranes of monocytes/macrophages...
  9. ncbi request reprint Cerebrospinal fluid and serum levels of cytokines and soluble tumor necrosis factor receptor in influenza virus-associated encephalopathy
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Scand J Infect Dis 35:59-61. 2003
    ..The results suggested that cytokines not only in serum but also in CSF play a pivotal role in influenza virus-associated encephalopathy, and that the CSF TNF-alpha and sTNFR1 levels may be important for predicting neurological sequelae...
  10. ncbi request reprint Serum cytokine concentrations of influenza-associated acute necrotizing encephalopathy
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Japan
    Pediatr Int 45:734-6. 2003
  11. ncbi request reprint Cysteinyl leukotrienes induce monocyte chemoattractant protein 1 in human monocytes/macrophages
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Clin Exp Allergy 35:1214-9. 2005
    ..Monocytes/macrophages have a cysteinyl leukotriene 1 (CysLT1) receptor, but its function is poorly understood. Objective To elucidate the biological function of the CysLT1 receptor of human monocytes/macrophages...
  12. ncbi request reprint Serum levels of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in subacute sclerosing panencephalitis
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    J Neurol Sci 252:45-8. 2007
    ..High serum MMP-9 and MMP-9/TIMP-1 levels will promote brain invasion through the BBB by immunocompetent cells in the blood. Our findings suggest that the balance of serum MMP-9 and TIMP-1 levels modulate the inflammatory cascade of SSPE...
  13. ncbi request reprint An immunoglobulin agent (IVIG) inhibits NF-kappaB activation in cultured endothelial cells of coronary arteries in vitro
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Inflamm Res 53:253-6. 2004
    ..We examined whether or not IVIG inhibits TNF-alpha-induced activation of transcription factor NF-kappaB, a factor that is essential for the expression of proinflammatory cytokines, in human coronary artery endothelial cells (CAEC)...
  14. ncbi request reprint Serum and CSF levels of cytokines in acute encephalopathy following prolonged febrile seizures
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Brain Dev 30:47-52. 2008
    ..Our results suggest that serum IL-6, IL-10, TNF-alpha, and CSF IL-6 are part of the regulatory system of cytokines in AEPFS...
  15. ncbi request reprint Analysis of cytokine levels and NF-kappaB activation in peripheral blood mononuclear cells in influenza virus-associated encephalopathy
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Cytokine 27:31-7. 2004
    ..Influenza virus-associated encephalopathy (IE) is suggested to be a proinflammatory cytokine-related disease...
  16. ncbi request reprint Analysis of serum and cerebrospinal fluid cytokine levels in subacute sclerosing panencephalitis in Papua New Guinea
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Cytokine 33:17-20. 2006
    ..Subacute sclerosing panencephalitis (SSPE) is a rare progressive inflammatory disease characterized by the persistent infection of the brain by the measles virus. However, the immunological pathophysiology of SSPE is still unclear...
  17. ncbi request reprint [Low-dose therapy with carbamazepine for convulsions associated with mild gastroenteritis]
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Yamaguchi
    No To Hattatsu 37:493-7. 2005
    ..e. for 2 to 9 days (mean, 6.4 days). Low dose therapy with carbamazepine once per day is thus effective for convulsions associated with mild gastroenteritis...
  18. doi request reprint Mononuclear cell subpopulations in CSF and blood of children with bacterial meningitis
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    J Infect 58:28-31. 2009
    ..To elucidate mononuclear cell subsets of the cerebrospinal fluid (CSF) in order to investigate the pathogenesis of bacterial meningitis (BM)...
  19. ncbi request reprint [Cytokine analysis of acute encephalopathy following prolonged febrile seizures]
    T Ichiyama
    No To Hattatsu 40:141-4. 2008
  20. ncbi request reprint Analysis of serum soluble CD40 ligand in patients with influenza virus-associated encephalopathy
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    J Neurol Sci 239:53-7. 2005
    ..Our findings suggest that the serum sCD40L concentration during acute IE is important for predicting the prognosis at an early stage...
  21. ncbi request reprint [Neurological diseases in childhood and cytokines]
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi
    No To Hattatsu 40:359-62. 2008
    ..It is important for the diagnosis and treatment of diseases to understand their pathogenesis and severity by analyzing cytokines and NF-kappa B activation...
  22. ncbi request reprint Analysis of cytokine levels in cerebrospinal fluid in mumps meningitis: comparison with echovirus type 30 meningitis
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Cytokine 30:243-7. 2005
    ..It is unclear whether or not the CSF cytokine profiles in viral meningitis differ with the kind of causative virus...
  23. ncbi request reprint Matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in influenza-associated encephalopathy
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Pediatr Infect Dis J 26:542-4. 2007
    ..Our results suggest that an imbalance between MMP-9 and TIMP-1 damages the blood-brain barrier and promotes febrile seizure or encephalopathy in influenza virus infection...
  24. ncbi request reprint Cerebrospinal fluid levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in subacute sclerosing panencephalitis
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    J Infect 56:376-80. 2008
    ....
  25. ncbi request reprint Intravenous immunoglobulin does not increase FcgammaRIIB expression on monocytes/macrophages during acute Kawasaki disease
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Rheumatology (Oxford) 44:314-7. 2005
    ..Regarding the mechanism of IVIG during acute KD, we investigated whether or not IVIG increases the expression of FcgammaRIIB in peripheral blood CD14+ monocytes/macrophages...
  26. ncbi request reprint Serum levels of matrix metalloproteinase-9 and its tissue inhibitor (TIMP-1) in acute disseminated encephalomyelitis
    Takashi Ichiyama
    Yamaguchi University School of Medicine, Japan
    J Neuroimmunol 172:182-6. 2006
    ..These findings suggest that MMP-9 and TIMP-1 secondarily play some roles in the inflammatory cascade of ADEM...
  27. ncbi request reprint Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi and ONO Pharmaceutical Co Ltd, Osaka, Japan
    Clin Exp Allergy 33:802-7. 2003
    ..Pranlukast inhibits contraction of the tracheal muscle, and thereby antagonizes the binding of LTC4, LTD4 and LTE4. However, the action of pranlukast on monocytes/macrophages and T cells is unknown...
  28. ncbi request reprint NF-kappaB activation in peripheral blood monocytes/macrophages and T cells during acute Kawasaki disease
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan
    Clin Immunol 99:373-7. 2001
    ..05). The present findings suggest that CD14+ monocytes/macrophages play an important role in cytokine production during acute KD...
  29. pmc Clarithromycin inhibits NF-kappaB activation in human peripheral blood mononuclear cells and pulmonary epithelial cells
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Antimicrob Agents Chemother 45:44-7. 2001
    ..These findings are consistent with the idea that clarithromycin suppresses the production of proinflammatory cytokines via inhibition of NF-kappaB activation...
  30. ncbi request reprint Detection of influenza virus RNA by reverse transcription-PCR and proinflammatory cytokines in influenza-virus-associated encephalopathy
    Y Ito
    Department of Pediatrics, Nagoya University School of Medicine, Japan
    J Med Virol 58:420-5. 1999
    ..Proinflammatory cytokines and soluble cytokine receptors may mediate the disease. The high plasma concentration of IL-6 could be an indicator of the progression to encephalopathy...
  31. ncbi request reprint Theophylline inhibits NF-kappa B activation and I kappa B alpha degradation in human pulmonary epithelial cells
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Japan
    Naunyn Schmiedebergs Arch Pharmacol 364:558-61. 2001
    ..These findings are consistent with the idea that theophylline suppresses the production of proinflammatory cytokines via inhibition of NF-kappaB activation through protection of the IkappaBalpha protein...
  32. ncbi request reprint Anti-inflammatory effect of intravenous immunoglobulin in comparison with dexamethasone in vitro: implication for treatment of Kawasaki disease
    Haruyuki Makata
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube, 755 8505, Yamaguchi, Japan
    Naunyn Schmiedebergs Arch Pharmacol 373:325-32. 2006
    ..These findings suggest that IVIG or dexamethasone therapy should be chosen to match the types of cells that are activated during acute KD...
  33. ncbi request reprint Cerebrospinal fluid concentrations of alpha-melanocyte-stimulating hormone in bacterial and aseptic meningitis
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Japan
    Acta Paediatr 89:803-5. 2000
    ..We speculate that elevated alpha-MSH levels in CSF during acute bacterial meningitis reflect negative feedback in response to severe inflammation associated with neurological sequelae induced by proinflammatory cytokines...
  34. ncbi request reprint Elevated cerebrospinal fluid level of ciliary neurotrophic factor in acute disseminated encephalomyelitis
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, 755 8505, Yamaguchi, Japan
    J Neurol Sci 177:146-9. 2000
    ..Our results suggest that CNTF is part of the regulatory system for oligodendrocyte functions, such as remyelination, in ADEM...
  35. ncbi request reprint Sodium valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Japan
    Brain Res 857:246-51. 2000
    ..Our results suggest that VPA can modulate immune responses in vitro. These findings raise the possibility that such modulation might occur with clinical use of VPA...
  36. pmc Expression of CTLA-4 (CD152) in peripheral blood T cells of children with influenza virus infection including encephalopathy in comparison with respiratory syncytial virus infection
    H Ayukawa
    Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Clin Exp Immunol 137:151-5. 2004
    ..Down-regulation of antigen-activated peripheral blood T cell activation might play an important role in the pathogenesis of influenza virus-associated encephalopathy and host defence against influenza virus infection...
  37. ncbi request reprint Thiopental inhibits NF-kappaB activation in human glioma cells and experimental brain inflammation
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube 755 8505, Japan
    Brain Res 911:56-61. 2001
    ..These findings are consistent with the idea that thiopental exerts antiinflammatory effects in cultured cells and experimental murine brain inflammation, through suppression of TNF-alpha production via inhibition of NF-kappaB activation...
  38. pmc CTLA-4 (CD152) expression in peripheral blood T cells in Kawasaki disease
    T Matsubara
    Department of Paediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Clin Exp Immunol 132:169-73. 2003
    ..Our results suggested that the level of activation of peripheral blood T cells is very low during acute KD...
  39. ncbi request reprint [Proinflammatory cytokine levels in cerebrospinal fluid from children with acute encephalitis]
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine
    No To Hattatsu 29:466-70. 1997
    ....
  40. pmc NF-kappaB activation in peripheral blood mononuclear cells in neonatal asphyxia
    K Hasegawa
    Department of Paediatrics, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Clin Exp Immunol 132:261-4. 2003
    ..008, and versus 1.6 +/- 1.4%, P = 0.014, respectively). Our findings suggest that NF-kappaB activation in peripheral blood CD14+ monocytes/macrophages in neonatal asphyxia is important for predicting the subsequent neurological sequelae...
  41. ncbi request reprint Acute encephalopathy associated with influenza and other viral infections
    M Mizuguchi
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Acta Neurol Scand Suppl 186:45-56. 2007
    ..Theophylline is a risk factor of these syndromes. The pathogenesis is yet to be clarified, but an increasing body of evidence points to excitotoxicity and delayed neuronal death...
  42. pmc Immunological profile of peripheral blood lymphocytes and monocytes/macrophages in Kawasaki disease
    T Matsubara
    Department of Paediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Clin Exp Immunol 141:381-7. 2005
    ..This review focuses on the immune response of peripheral blood lymphocytes and monocytes/macrophages during acute KD...
  43. doi request reprint Anti-inflammatory effect of 1alpha,25-dihydroxyvitamin D(3) in human coronary arterial endothelial cells: Implication for the treatment of Kawasaki disease
    Yasuo Suzuki
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    J Steroid Biochem Mol Biol 113:134-8. 2009
    ..Our results suggest that adjunctive 1alpha,25-(OH)(2)D(3) may modulate the inflammatory response during KD vasculitis...
  44. pmc Intravenous immunoglobulin does not increase FcγRIIB expression levels on monocytes in children with immune thrombocytopenia
    M Shimomura
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Clin Exp Immunol 169:33-7. 2012
    ..We suggest that IVIG does not increase FcγRIIB expression in peripheral blood monocytes in children with ITP...
  45. pmc Cysteine, histidine and glycine exhibit anti-inflammatory effects in human coronary arterial endothelial cells
    S Hasegawa
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Clin Exp Immunol 167:269-74. 2012
    ....
  46. doi request reprint Enhancement of activated beta1-integrin expression by prostaglandin E2 via EP receptors in isolated human coronary arterial endothelial cells: implication for the treatment of Kawasaki disease
    M Kajimoto
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi, 755 8505, Japan
    Inflamm Res 58:224-8. 2009
    ..We evaluated the function of the EP receptors in the expression of activated beta(1)-integrin stimulated by PGE(2) in human coronary arterial endothelial cells (HCAEC)...
  47. doi request reprint CSF neurofilament and soluble TNF receptor 1 levels in subacute sclerosing panencephalitis
    Takeshi Matsushige
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    J Neuroimmunol 205:155-9. 2008
    ..011). We suggest that CSF NF-H levels can be used as a marker of development of neuronal degeneration in SSPE, and that TNF-alpha modifies the neurodestructive pathogenesis in SSPE...
  48. ncbi request reprint Effect of montelukast on nuclear factor kappaB activation and proinflammatory molecules
    Shinji Maeba
    Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Ann Allergy Asthma Immunol 94:670-4. 2005
    ..Montelukast is known as a cysteinyl leukotriene 1 receptor antagonist. However, the action of montelukast in terms of nuclear factor KB (NF-kappaB) activation and the production of proinflammatory molecules is unknown...
  49. ncbi request reprint Clinically mild encephalitis/encephalopathy with a reversible splenial lesion
    H Tada
    Department of Pediatrics, Graduate School of Medicine, Chiba University, Japan
    Neurology 63:1854-8. 2004
    ..To clarify whether patients with clinical diagnoses of encephalitis/encephalopathy with a reversible lesion in the splenium of the corpus callosum (SCC) share common clinical features...
  50. ncbi request reprint Theophylline inhibits NF-kappaB activation in human peripheral blood mononuclear cells
    Masashi Umeda
    Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Int Arch Allergy Immunol 128:130-5. 2002
    ..Theophylline exerts an antiinflammatory effect on allergic inflammation through inhibition of NF-kappaB activation in mast cells. However, the action of theophylline on monocytes/macrophages and T cells is unknown...
  51. ncbi request reprint Roles of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in acute encephalopathy following prolonged febrile seizures
    Naoko Suenaga
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755 8505, Japan
    J Neurol Sci 266:126-30. 2008
    ..Furthermore, an imbalance of serum MMP-9 and TIMP-1 levels in patients with AEPFS may be associated with severe neurological sequelae...
  52. ncbi request reprint Soluble tumor necrosis factor receptor 1 and tissue inhibitor of metalloproteinase-1 in hemolytic uremic syndrome with encephalopathy
    Masahiro Shiraishi
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    J Neuroimmunol 196:147-52. 2008
    ..Our preliminary study suggests that serum IL-6, sTNFR1 and TIMP-1 levels, particularly sTNFR1 and TIMP-1, are important for predicting neurological complications in patients with HUS...
  53. ncbi request reprint Acute encephalopathy with refractory status epilepticus: bilateral mesial temporal and claustral lesions, associated with a peripheral marker of oxidative DNA damage
    Takashi Shiihara
    Department of Pediatrics, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    J Neurol Sci 250:159-61. 2006
    ..Serial measurements of oxidative stress markers in acute encephalitis, encephalopathy, or status epilepticus could clarify the relationships between acute brain damage and free radicals...
  54. ncbi request reprint Fosfomycin inhibits NF-kappaB activation in U-937 and Jurkat cells
    Yasuto Yoneshima
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Yamaguchi 755 8505, Ube, Japan
    Int J Antimicrob Agents 21:589-92. 2003
    ..These findings are consistent with the idea that fosfomycin suppresses the production of proinflammatory cytokines via inhibition of NF-kappaB activation...
  55. ncbi request reprint NF-kappaB activation is inhibited in human pulmonary epithelial cells transfected with alpha-melanocyte-stimulating hormone vector
    T Ichiyama
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9040, USA
    Peptides 21:1473-7. 2000
    ..We showed a possibility of gene therapy for chronic inflammatory lung diseases...
  56. ncbi request reprint [Regulation of proinflammatory cytokine cascade in Kawasaki disease]
    Susumu Furukawa
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine
    Nihon Rinsho 66:258-64. 2008
    ..We focus on the different mechanism of IVIG, corticosteroid and anti-TNF agents with regard to the anti-inflammatory effects...
  57. ncbi request reprint Prostaglandin E2 suppresses beta1-integrin expression via E-prostanoid receptor in human monocytes/macrophages
    Shunji Hasegawa
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Japan
    Cell Immunol 263:161-5. 2010
    ..We suggest that PGE2 has anti-inflammatory effects, leading to the inhibited expression of beta1-integrin in human monocytes/macrophages, and that the EP4 receptor may play an important role in PGE2-mediated inhibition...
  58. doi request reprint Functional expression of cysteinyl leukotriene receptors on human platelets
    Shunji Hasegawa
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Platelets 21:253-9. 2010
    ....
  59. ncbi request reprint [Analysis of 11 patients with profound multiple disabilities who underwent laryngotracheal separation]
    Madoka Kajimoto
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Yamaguchi
    No To Hattatsu 39:366-70. 2007
    ..Laryngotracheal separation surgery can reduce the burden of health care for patients with PMD by improving their respiratory conditions and methods of nutrition intake...
  60. ncbi request reprint Cerebrospinal fluid levels of cytokines and soluble tumour necrosis factor receptor in acute disseminated encephalomyelitis
    Takashi Ichiyama
    Department of Paediatrics, Yamaguchi University School of Medicine, Ube, Japan
    Eur J Pediatr 161:133-7. 2002
    ..We speculated that TNF-alpha is related to demyelination and that IL-10 is induced to modulate TNF-alpha-induced inflammation in ADEM...
  61. ncbi request reprint Low-dose carbamazepine therapy for benign infantile convulsions
    Hironori Matsufuji
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Brain Dev 27:554-7. 2005
    ..Therefore, we recommend the administration of a once-daily dose of 5mg/kg of carbamazepine until up to 2 or 3 years of age as a treatment for BIC...
  62. ncbi request reprint Ketotic hypoglycemia in patients with allergic diseases
    Tomoyo Matsubara
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Pediatr Int 45:653-5. 2003
    ..The present study investigated whether elimination diets are related to the occurrence of ketotic hypoglycemia...
  63. ncbi request reprint A severe case of chronic infantile neurologic, cutaneous, articular syndrome treated with biologic agents
    Tomoyo Matsubara
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Arthritis Rheum 54:2314-20. 2006
    ..Pathologic examination of autopsy specimens was also performed. This case illustrates the continued difficulty in management of patients with CINCA syndrome and the complexity of the inflammatory pathways in this disorder...
  64. doi request reprint Clinical characteristics of benign convulsions with rotavirus gastroenteritis
    Masashi Motoyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    J Child Neurol 24:557-61. 2009
    ..In conclusion, carbamazepine therapy was effective for benign convulsions with rotavirus gastroenteritis...
  65. doi request reprint Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-kappaB pathways
    Kunio Hashimoto
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Int Arch Allergy Immunol 149:275-82. 2009
    ..The intracellular signal transduction pathway of MCP-1 production induced by CysLT in human monocytes/macrophages is unclear...
  66. ncbi request reprint Hemiconvulsion-hemiplegia syndrome and elevated interleukin-6: case report
    Masahiko Kimura
    Department of Pediatrics, Shimane Medical University, Izumo, Japan
    J Child Neurol 17:705-7. 2002
    ..Elevation of cerebrospinal fluid interleukin-6 may be related to the severe neurologic sequelae of our patient despite the relatively short seizure duration...
  67. ncbi request reprint West syndrome associated with mosaic Down syndrome
    Madoka Kajimoto
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Brain Dev 29:447-9. 2007
    ..This report re-emphasize that chromosomal analysis is recommended for epileptic patients with infantile onset when the cause is unclear...
  68. ncbi request reprint [Investigation of swimming classes for school children with epilepsy--a questionnaire survey of school nursing teachers]
    M Nishikawa
    Department of Pediatrics, Yamaguchi University School of Medicine
    No To Hattatsu 30:15-9. 1998
    ..We suggest that the nursing teachers had more than a few misconceptions regarding epilepsy. For the comprehensive management of epilepsy, it is necessary for medical staffs to cooperate with nursing teachers...
  69. ncbi request reprint [Clinical course and findings in and differential diagnosis of subacute sclerosing panencephalitis]
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine
    Nihon Rinsho 65:1481-2. 2007
    ..In the early stage, psychiatric diseases and epilepsy should be ruled out. Neurodegenerative diseases and other encephalitis/encephalopathy should be also excluded...
  70. ncbi request reprint Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in perinatal asphyxia
    Shinpei Sunagawa
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Brain Dev 31:588-93. 2009
    ..Our preliminary study suggests that serum MMP-9 levels on birth day are important for predicting neurological prognosis of neonates with asphyxia...
  71. doi request reprint Time lag between the increase of IL-6 with fever and NF-kappaB activation in the peripheral blood in inflammatory myofibroblastic tumor
    Reiji Fukano
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Cytokine 44:293-7. 2008
    ....
  72. ncbi request reprint [Orbicularis oculi electromyogram in a girl with ocular myasthenia gravis]
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine
    No To Hattatsu 24:380-3. 1992
    ..In our patient, orbicularis oculi EMG was useful in the estimation of the severity of ocular myasthenia gravis and the effect of its treatment...
  73. ncbi request reprint [Perioperative evaluation of cerebral hemodynamics by transcranial Doppler ultrasonography in patient with hemolytic uremic syndrome]
    M Nishikawa
    Department of Pediatrics, Yamaguchi University, School of Medicine, Ube, Yamaguchi
    No To Hattatsu 32:520-3. 2000
    ..Thus TCD may be useful in evaluating intracranial hemodynamics in HUS encephalopathy in the absence of MRI and SPECT abnormalities at the early stage of illness...
  74. doi request reprint Serial cerebrospinal fluid neurofilament concentrations in bacterial meningitis
    Takeshi Matsushige
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    J Neurol Sci 280:59-61. 2009
    ..04 vs. 1.19 ng/mL as median, p=0.024). We suggest that neuronal injury occurs in bacterial meningitis regardless of the presence or absence of neurological sequelae...
  75. ncbi request reprint [Cerebral infarction in a boy with subdural abscess]
    M Fukuda
    Department of Pediatrics, Yamaguchi University School of Medicine
    No To Hattatsu 23:273-7. 1991
    ..Cerebral angiography disclosed a stenosis at the trifurcated portion of the left internal carotid artery near the abscess. These findings suggested the occurrence of infarction due to angiitis of the internal carotid artery...
  76. ncbi request reprint [The relation between one-sided occipital flattening and laterality of rolling-over]
    T Hayashi
    Department of Pediatrics, Yamauchi University School of Medicine, Ube
    No To Hattatsu 23:362-5. 1991
    ..These findings suggest that laterality of rolling-over, one of asymmetrical motor developments is not related to the head positioning in early infancy...
  77. ncbi request reprint Acute encephalopathy associated with influenza and other viral infections
    M Mizuguchi
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Acta Neurol Scand 115:45-56. 2007
    ..Theophylline is a risk factor of these syndromes. The pathogenesis is yet to be clarified, but an increasing body of evidence points to excitotoxicity and delayed neuronal death...
  78. ncbi request reprint Safety from thromboembolism using intravenous immunoglobulin therapy in Kawasaki disease: Study of whole-blood viscosity
    Miki Nishikawa
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube shi, Yamaguchi, Japan
    Pediatr Int 45:156-8. 2003
    ..IVIG therapy might increase the blood viscosity both in vitro and in vivo, which has been reported as a risk factor for cardiovascular or cerebrovascular thromboembolism in adults...
  79. ncbi request reprint Elevated CSF IL-6 in a patient with respiratory syncytial virus encephalopathy
    Yuko Otake
    Department of Pediatrics, Jichi Medical University, 3311 1 Yaksiji, Shimotsuke, Tochigi, Japan
    Brain Dev 29:117-20. 2007
    ....
  80. ncbi request reprint Ultrasonographic evaluation of cervical lymph nodes in Kawasaki disease
    Norimichi Tashiro
    Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Pediatrics 109:E77-7. 2002
    ..The purpose of this study was to compare the ultrasonographic feature of cervical lymph nodes in patients with KD, bacterial lymphadenitis, and infectious mononucleosis...
  81. ncbi request reprint Prognostic factors in influenza-associated encephalopathy
    Takashi Nagao
    Department of Pediatrics, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan
    Pediatr Infect Dis J 27:384-9. 2008
    ..Given the high mortality and morbidity rates attributable to this severe neurologic complication of influenza, we conducted a nationwide study in Japan to identify the prognostic factors...
  82. ncbi request reprint Nuclear factor-kappaB activation in peripheral blood mononuclear cells in children with sepsis
    Noriko Hotta
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Crit Care Med 35:2395-401. 2007
    ..To determine the activation of nuclear factor-[kappa]B in peripheral blood CD14+ monocyte/macrophages and CD3+, CD4+, and CD8+ T cells in children with sepsis...
  83. doi request reprint Cytokine levels in sputum of patients with tracheostomy and profound multiple disabilities
    Kazutoyo Asada
    Department of Pediatrics, National Hospital Organization Sanyo Hospital, Yamaguchi, Japan
    Cytokine 42:71-6. 2008
    ..Airway immunopathogenesis is unclear in patients with profound multiple disabilities (PMD) who undergo tracheostomy...
  84. ncbi request reprint Increased cytokine levels in a cerebral mycotic aneurysm in a child with Down's syndrome
    Hiroshi Ozawa
    Department of Pediatrics, Tokyo Metropolitan Hachioji Children s Hospital, Hachioji, Tokyo, Japan
    Brain Dev 27:434-6. 2005
    ..MR angiography showed an aneurysm of the right middle cerebral artery. We think that cytokines and the formation abnormality of collagen fibers are related to the production of aneurysms...
  85. doi request reprint Clinical characteristics of respiratory syncytial virus infection-associated acute otitis media
    Kiyoko Tomochika
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Pediatr Int 51:484-7. 2009
    ..It is known that children with respiratory syncytial virus (RSV) infection frequently have complications of acute otitis media (AOM)...
  86. ncbi request reprint MMP-9 and TIMP-1 in the cord blood of premature infants developing BPD
    Shinnosuke Fukunaga
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Pediatr Pulmonol 44:267-72. 2009
    ..006). The MMP-9 levels and MMP-9/TIMP-1 ratios in the cord blood may be related to the pathogenesis and severity of BPD and maternal chorioamnionitis...
  87. ncbi request reprint Clinical sepsis in neonates is responsible for the lower prevalence of developing allergy
    Manami Ryozawa
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Pediatr Int 49:15-8. 2007
    ..The purpose of the present study was to perform a prospective epidemiological study of the effect of perinatal infection on the development of allergy...
  88. doi request reprint Inhaled corticosteroid therapy reduces cytokine levels in sputum from very preterm infants with chronic lung disease
    Rie Honda
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi, Japan
    Acta Paediatr 98:118-22. 2009
    ..To evaluate the effects of inhaled corticosteroid therapy and high-frequency oscillatory ventilation (oscillation) on preterm infants with chronic lung disease (CLD)...
  89. ncbi request reprint CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis
    Takaaki Ishizu
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neuroimmunol 175:52-8. 2006
    ..In contrast, IL-17 produced by activated CD4(+) memory T cells was not increased. The results suggested that various cytokines related to activation of macrophages/microglias and Th(1) and Th(2) cells are upregulated in CSF in ADEM...
  90. ncbi request reprint High concentration of serum nitrite/nitrate obtained from patients with influenza-associated encephalopathy
    Hisashi Kawashima
    Department of Paediatrics, Tokyo Medical University, Tokyo, Japan
    Pediatr Int 44:705-7. 2002
  91. ncbi request reprint Non-herpetic acute limbic encephalitis: cerebrospinal fluid cytokines and magnetic resonance imaging findings
    Kyoko Asaoka
    First Department of Internal Medicine, Kurume University School of Medicine, Kurume
    Intern Med 43:42-8. 2004
    ..In the present study, clinical findings and cerebrospinal fluid (CSF) cytokines in patients with non-herpetic ALE were investigated...
  92. ncbi request reprint Longitudinal analysis of cytokines and chemokines in the cerebrospinal fluid of a patient with Neuro-Sweet disease presenting with recurrent encephalomeningitis
    Akio Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan Akio Kimura
    Intern Med 47:135-41. 2008
    ..Neutrophil and other inflammatory cell activities are influenced by many cytokines and chemokines, but to date, no studies have examined the levels of these factors in patients with NSD...
  93. ncbi request reprint Herpes simplex virus type 2 recurrent meningitis (Mollaret's meningitis): a consideration for the recurrent pathogenesis
    Rumi Sato
    First Department of Internal Medicine, Kurume University School of Medicine, Asahi machi 67, Kurume 830 0011, Japan
    J Infect 51:e217-20. 2005
    ..For this patient, long-term suppressive and patient-initiated therapies were conducted to prevent the recurrence of meningitis...
  94. ncbi request reprint Ginkgo nut intoxication in a 2-year-old male
    Shunji Hasegawa
    Department of Allergy, Yamaguchi University, School of Medicine, and Department of Hospital Pharmacy, Niigata City General Hospital, Japan
    Pediatr Neurol 35:275-6. 2006
    ..After the treatment, his symptoms were resolved. The neurotoxicity of ginkgo nuts should be recognized by pediatricians and parents who have infants...
  95. ncbi request reprint Adult meningism and viral meningitis, 1997-2004: clinical data and cerebrospinal fluid cytokines
    Masako Nagafuchi
    The Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume
    Intern Med 45:1209-12. 2006
    ..Clinical findings and cerebrospinal fluid (CSF) cytokines in adult patients with meningism were investigated and compared with those in viral meningitis...
  96. ncbi request reprint Non-herpetic acute limbic encephalitis: a new subgroup of limbic encephalitis?
    Hiroshi Shoji
    Intern Med 43:348. 2004
  97. ncbi request reprint Probable chronic viral encephalitis with microglial nodules in the entire brain: a case report with necropsy
    Toshihiro Imaizumi
    First Department Neurology of Internal Medicine, Kurume University School of Medicine, Japan
    Med Sci Monit 11:CS23-26. 2005
    ..Chronic encephalitis has rarely been seen, probably due to its viral origins, which may produce the disease in healthy or immunocompromised hosts. The etiology and pathophysiology of these types of encephalitis have not yet been clarified...
  98. ncbi request reprint Successful treatment of neonatal herpes simplex-type 1 infection complicated by hemophagocytic lymphohistiocytosis and acute liver failure
    Keitaro Yamada
    Department of Neonatology, Gifu Prefectural General Medical Center, Gifu, Japan
    Tohoku J Exp Med 214:1-5. 2008
    ..Neonatal disseminated HSV infections may be complicated by the development of HLH and hypercyokinemia. If HLH is suspected, not only high-dose acyclovir therapy but also anti-cytokine therapy should be considered...