Shoichi Hazama

Summary

Affiliation: Yamaguchi University
Country: Japan

Publications

  1. ncbi request reprint Efficacy of orally administered superfine dispersed lentinan (beta-1,3-glucan) for the treatment of advanced colorectal cancer
    Shoichi Hazama
    Department of Surgery II, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Anticancer Res 29:2611-7. 2009
  2. ncbi request reprint UDP-glucuronosyltransferase (UGT) 1A1*28 polymorphism-directed phase II study of irinotecan with 5'-deoxy-5-fluorouridine (5'-DFUR) for metastatic colorectal cancer
    Shinsuke Kanekiyo
    Department of Digestive Surgery and Surgical Oncology Surgery II, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Anticancer Res 33:3423-30. 2013
  3. doi request reprint UGT1A1*6, 1A7*3, and 1A9*22 genotypes predict severe neutropenia in FOLFIRI-treated metastatic colorectal cancer in two prospective studies in Japan
    Shoichi Hazama
    Department of Digestive Surgery and Surgical Oncology Surgery II, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Cancer Sci 104:1662-9. 2013
  4. pmc Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer
    Yoshitaro Shindo
    Department of Digestive Surgery and Surgical Oncology Department of Surgery II, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    J Transl Med 12:175. 2014
  5. ncbi request reprint Combination phase II study of weekly paclitaxel and 5'-DFUR for unresectable or recurrent gastric cancer
    Shigefumi Yoshino
    Department of Digestive Surgery and Surgical Oncology, Graduate School of Medicine, Yamaguchi University, Ube, Japan
    Anticancer Res 33:2629-33. 2013
  6. pmc A phase I clinical trial of vaccination with KIF20A-derived peptide in combination with gemcitabine for patients with advanced pancreatic cancer
    Nobuaki Suzuki
    Departments of Digestive Surgery and Surgical Oncology Surgery II, Yamaguchi University Graduate School of Medicine, Yamaguchi Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunother 37:36-42. 2014
  7. doi request reprint Possible involvement of Wnt11 in colorectal cancer progression
    Mitsuaki Nishioka
    Department of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Mol Carcinog 52:207-17. 2013
  8. ncbi request reprint Improvement of QOL and prognosis by treatment of superfine dispersed lentinan in patients with advanced gastric cancer
    Shigefumi Yoshino
    Department of Surgery II, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Hepatogastroenterology 57:172-7. 2010
  9. pmc A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome
    Shoichi Hazama
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi, Japan
    J Transl Med 12:63. 2014
  10. ncbi request reprint Suppressive effects of cyclophosphamide and gemcitabine on regulatory T-cell induction in vitro
    Shin Kan
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube City, Yamaguchi Prefecture, 755 8505, Japan
    Anticancer Res 32:5363-9. 2012

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Efficacy of orally administered superfine dispersed lentinan (beta-1,3-glucan) for the treatment of advanced colorectal cancer
    Shoichi Hazama
    Department of Surgery II, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Anticancer Res 29:2611-7. 2009
    ..To investigate the safety and effectiveness of SDL, a multi center clinical study in patients with advanced colorectal cancer was conducted...
  2. ncbi request reprint UDP-glucuronosyltransferase (UGT) 1A1*28 polymorphism-directed phase II study of irinotecan with 5'-deoxy-5-fluorouridine (5'-DFUR) for metastatic colorectal cancer
    Shinsuke Kanekiyo
    Department of Digestive Surgery and Surgical Oncology Surgery II, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Anticancer Res 33:3423-30. 2013
    ..We performed a phase II study of irinotecan with 5'-deoxy-5-fluorouridine (5'-DFUR) for metastatic colorectal cancer based on UDP-glucuronosyltransferase (UGT) 1A1 polymorphism...
  3. doi request reprint UGT1A1*6, 1A7*3, and 1A9*22 genotypes predict severe neutropenia in FOLFIRI-treated metastatic colorectal cancer in two prospective studies in Japan
    Shoichi Hazama
    Department of Digestive Surgery and Surgical Oncology Surgery II, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Cancer Sci 104:1662-9. 2013
    ..In this regard, haplotype analyses should substantially impact the prediction of severe hematological toxicities of FOLFIRI. (Clinical Trial Registration: UMIN000002388 and UMIN000002476). ..
  4. pmc Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer
    Yoshitaro Shindo
    Department of Digestive Surgery and Surgical Oncology Department of Surgery II, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    J Transl Med 12:175. 2014
    ..Therefore, in the present study, we performed combination therapy with AIT and GEM for patients with unresectable or recurrent pancreatic cancer...
  5. ncbi request reprint Combination phase II study of weekly paclitaxel and 5'-DFUR for unresectable or recurrent gastric cancer
    Shigefumi Yoshino
    Department of Digestive Surgery and Surgical Oncology, Graduate School of Medicine, Yamaguchi University, Ube, Japan
    Anticancer Res 33:2629-33. 2013
    ..To evaluate the efficacy and safety of their combination, we conducted a combination phase II study of paclitaxel and 5'-DFUR in patients with unresectable or recurrent gastric cancer who had received up to one prior chemotherapy...
  6. pmc A phase I clinical trial of vaccination with KIF20A-derived peptide in combination with gemcitabine for patients with advanced pancreatic cancer
    Nobuaki Suzuki
    Departments of Digestive Surgery and Surgical Oncology Surgery II, Yamaguchi University Graduate School of Medicine, Yamaguchi Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunother 37:36-42. 2014
    ..These results suggest that this combination therapy will be feasible and promising for the treatment of advanced pancreatic cancer...
  7. doi request reprint Possible involvement of Wnt11 in colorectal cancer progression
    Mitsuaki Nishioka
    Department of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Mol Carcinog 52:207-17. 2013
    ..0005). The expression levels of Wnt11 mRNA were correlated with those of FZD7 mRNA (P < 0.0001). These data suggest that Wnt11 may play an important role in CRC progression...
  8. ncbi request reprint Improvement of QOL and prognosis by treatment of superfine dispersed lentinan in patients with advanced gastric cancer
    Shigefumi Yoshino
    Department of Surgery II, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Hepatogastroenterology 57:172-7. 2010
    ..Recently, superfine dispersed lentinan--an oral formulation--has become clinically available. In order to evaluate the efficacy of superfine dispersed lentinan, was conducted multicenter clinical study...
  9. pmc A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome
    Shoichi Hazama
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi, Japan
    J Transl Med 12:63. 2014
    ....
  10. ncbi request reprint Suppressive effects of cyclophosphamide and gemcitabine on regulatory T-cell induction in vitro
    Shin Kan
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube City, Yamaguchi Prefecture, 755 8505, Japan
    Anticancer Res 32:5363-9. 2012
    ..Inhibition of CD4(+)FOXP3(+) regulatory T-cell (Treg) activity may be important for successful cancer immunotherapy. We investigated the suppressive effects of several chemotherapeutic agents on Treg induction in vitro...
  11. pmc Relationship between cytokine gene polymorphisms and risk of postoperative pneumonia with esophageal cancer
    Kazuhiko Sakamoto
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi, 755 8505, Japan
    J Gastrointest Surg 18:1247-53. 2014
    ..We retrospectively evaluated the relationship between cytokine gene polymorphisms and development of postoperative pneumonia after esophagectomy...
  12. pmc A phase ΙI study of five peptides combination with oxaliplatin-based chemotherapy as a first-line therapy for advanced colorectal cancer (FXV study)
    Shoichi Hazama
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Ube, Japan
    J Transl Med 12:108. 2014
    ..To evaluate clinical benefits of cancer vaccination treatment, we conducted a phase II trial using the same peptides in combination with oxaliplatin-based chemotherapy as a first-line therapy...
  13. ncbi request reprint [A patient with intestinal gastrointestinal stromal tumor refractory to molecular targeted but whose quality of life improved after palliative surgery]
    Chiyo Nakasuga
    Dept of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Japan
    Gan To Kagaku Ryoho 39:1902-4. 2012
    ..After the operation, the general condition of the patient improved, and his ECOG PS was maintained as 1 for at least 4 months. Palliative resection may improve QOL...
  14. ncbi request reprint Impact of chemotherapy for colorectal cancer on regulatory T-cells and tumor immunity
    Kazunari Maeda
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube City, Yamaguchi Prefecture 755 8505, Japan
    Anticancer Res 31:4569-74. 2011
    ..The purpose of the present study was to determine how oxaliplatin plus infusional 5-fluorouracil and leucovorin (FOLFOX) and irinotecan plus infusional 5-fluorouracil and leucovorin (FOLFIRI) affect Tregs and other immune effectors...
  15. doi request reprint Phase I study of irinotecan and doxifluridine for metastatic colorectal cancer focusing on the UGT1A1*28 polymorphism
    Shoichi Hazama
    Department of Digestive Surgery and Surgical Oncology Surgery II, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Cancer Sci 101:722-7. 2010
    ..The gene polymorphism should be considered when determining the precise recommended doses to be administered in phase I studies...
  16. doi request reprint The importance of evaluation of DNA amplificability in KRAS mutation testing with dideoxy sequencing using formalin-fixed and paraffin-embedded colorectal cancer tissues
    Naoko Okayama
    Division of Laboratory, Yamaguchi University Hospital, Ube, Yamaguchi, Japan
    Jpn J Clin Oncol 41:165-71. 2011
    ..We evaluated DNA amplificability to achieve a 100% success rate in KRAS mutation testing with dideoxy sequencing using formalin-fixed and paraffin-embedded colorectal cancer tissue samples obtained from a recent clinical trial...