Tatsuya Fujimiya

Summary

Affiliation: Yamaguchi University
Country: Japan

Publications

  1. ncbi request reprint Michaelis-Menten elimination kinetics of acetaldehyde during ethanol oxidation
    Tatsuya Fujimiya
    Department of Legal Medicine, Yamaguchi University of Medicine, Minamikogushi, Ube, Japan
    Alcohol Clin Exp Res 26:49S-54S. 2002
  2. doi request reprint QT interval dispersion and cardiac sympathovagal balance shift in rats with acute ethanol withdrawal
    Seiko Shirafuji
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Alcohol Clin Exp Res 34:223-30. 2010
  3. ncbi request reprint Pharmacokinetic study of ethanol and its metabolites during ethanol infusion
    Tatsuya Fujimiya
    Department of Legal Medicine, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    Leg Med (Tokyo) 5:S126-8. 2003
  4. doi request reprint Carvedilol attenuates the progression of alcohol fatty liver disease in rats
    Jinyao Liu
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Alcohol Clin Exp Res 36:1587-99. 2012
  5. doi request reprint Abrupt termination of an ethanol regimen provokes ventricular arrhythmia and enhances susceptibility to the arrhythmogenic effects of epinephrine in rats
    Jinyao Liu
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Alcohol Clin Exp Res 34:S45-53. 2010
  6. ncbi request reprint [The effects of chronic alcohol exposure on progression of liver injury in spontaneously hypertensive rats; preliminary study]
    Ayako Hakucho
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8501, Japan
    Nihon Arukoru Yakubutsu Igakkai Zasshi 48:216-22. 2013
  7. doi request reprint SIAM-Like phenomenon caused by low doses of alcohol
    Akiko Shimamoto
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Alcohol Clin Exp Res 34:S2-6. 2010
  8. doi request reprint Rats in acute withdrawal from ethanol exhibit left ventricular systolic dysfunction and cardiac sympathovagal balance shift
    Jinyao Liu
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, Minami Kogushi, Ube, Yamaguchi, Japan
    Alcohol 43:207-16. 2009
  9. ncbi request reprint Pharmacokinetic study of ethanol and its metabolites in culture cells
    Tatsuya Fujimiya
    Department of Legal Medicine, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    Leg Med (Tokyo) 5:S123-5. 2003
  10. doi request reprint Legal medicine and the death inquiry system in Japan: a comparative study
    Tatsuya Fujimiya
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1 1 1, Ube Yamaguchi 755 8505, Japan
    Leg Med (Tokyo) 11:S6-8. 2009

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Michaelis-Menten elimination kinetics of acetaldehyde during ethanol oxidation
    Tatsuya Fujimiya
    Department of Legal Medicine, Yamaguchi University of Medicine, Minamikogushi, Ube, Japan
    Alcohol Clin Exp Res 26:49S-54S. 2002
    ..Acetaldehyde (AcH) is a toxic metabolite of ethanol (EtOH). The pharmacokinetics of blood AcH during EtOH oxidation was studied with or without the administration of aldehyde dehydrogenase 2 inhibitor (cyanamide) in rabbits...
  2. doi request reprint QT interval dispersion and cardiac sympathovagal balance shift in rats with acute ethanol withdrawal
    Seiko Shirafuji
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Alcohol Clin Exp Res 34:223-30. 2010
    ..However, the homogeneity of myocardial repolarization and its relation with the cardiac sympathovagal balance are unknown, especially in alcoholic subjects. The aim of the present study was to clarify these points...
  3. ncbi request reprint Pharmacokinetic study of ethanol and its metabolites during ethanol infusion
    Tatsuya Fujimiya
    Department of Legal Medicine, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    Leg Med (Tokyo) 5:S126-8. 2003
    ..Approximately one third of ethanol enters the blood as acetate during ethanol infusion. Our results indicate that the kinetic nature of acetaldehyde is different to that of acetate...
  4. doi request reprint Carvedilol attenuates the progression of alcohol fatty liver disease in rats
    Jinyao Liu
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Alcohol Clin Exp Res 36:1587-99. 2012
    ..Medicines that inhibit this pathway may be a relevant treatment for the hepatosteatosis, and then reduce the liver injury that progresses through the stage of steatosis to fibrosis...
  5. doi request reprint Abrupt termination of an ethanol regimen provokes ventricular arrhythmia and enhances susceptibility to the arrhythmogenic effects of epinephrine in rats
    Jinyao Liu
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Alcohol Clin Exp Res 34:S45-53. 2010
    ....
  6. ncbi request reprint [The effects of chronic alcohol exposure on progression of liver injury in spontaneously hypertensive rats; preliminary study]
    Ayako Hakucho
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8501, Japan
    Nihon Arukoru Yakubutsu Igakkai Zasshi 48:216-22. 2013
    ..In conclusion, chronic alcohol intake in rats with hypertension could deteriorate the ethanol-induced liver injury via the sympathetic overactivity...
  7. doi request reprint SIAM-Like phenomenon caused by low doses of alcohol
    Akiko Shimamoto
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Alcohol Clin Exp Res 34:S2-6. 2010
    ..SIAM was induced by low doses of ethanol and evaluated by pharmacokinetic analyses of ethanol and its metabolites...
  8. doi request reprint Rats in acute withdrawal from ethanol exhibit left ventricular systolic dysfunction and cardiac sympathovagal balance shift
    Jinyao Liu
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, Minami Kogushi, Ube, Yamaguchi, Japan
    Alcohol 43:207-16. 2009
    ..Those providing medical care for alcoholics should be aware of this enhanced susceptibility to LV systolic dysfunction with abrupt termination of a continuous ethanol regimen...
  9. ncbi request reprint Pharmacokinetic study of ethanol and its metabolites in culture cells
    Tatsuya Fujimiya
    Department of Legal Medicine, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    Leg Med (Tokyo) 5:S123-5. 2003
    ..These findings suggest that ethanol in culture cells behaves in a kinetic fashion in vivo...
  10. doi request reprint Legal medicine and the death inquiry system in Japan: a comparative study
    Tatsuya Fujimiya
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1 1 1, Ube Yamaguchi 755 8505, Japan
    Leg Med (Tokyo) 11:S6-8. 2009
    ..One aim of a death inquiry is to prevent future loss of life in similar circumstances, which the Japanese system does not consider. The systematic reform of the Japanese death inquiry system is thought to be necessary...
  11. ncbi request reprint Phosphoinositide 3-kinase accelerates calpain-dependent proteolysis of fodrin during hypoxic cell death
    Toshihiko Aki
    Department of Legal Medicine, Yamaguchi University School of Medicine, Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    J Biochem 132:921-6. 2002
    ..These results indicate that PI 3-kinase might accelerate hypoxic cell death by enhancing the calpain-dependent proteolysis of fodrin...
  12. ncbi request reprint Carvedilol improves ethanol-induced liver injury via modifying the interaction between oxidative stress and sympathetic hyperactivity in rats
    Ayako Hakucho
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Hepatol Res . 2013
    ..Additionally, oxidative stress may be responsible for the activation of HSC during the early stage of alcoholic liver disease...
  13. ncbi request reprint Chronic effects of ethanol on pharmacokinetics and left ventricular systolic function in rats
    Jinyao Liu
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Alcohol Clin Exp Res 31:493-9. 2007
    ..The present study has assessed the cause of the U-shaped relationship between the ethanol consumption and left ventricular (LV) systolic dysfunction in a pharmacokinetic way...
  14. ncbi request reprint Determination of endogenous testosterone in rat tissues following fetal alcohol exposure using HPLC with UV detection
    Akiko Shimamoto
    Department of Legal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 8505, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 836:69-73. 2006
    ..These results support the usefulness of this method as a means of quantitating neurosteroids, and illustrate its applicability to fetal alcohol exposure...
  15. doi request reprint Pathological roles of bone marrow-derived stellate cells in a mouse model of alcohol-induced fatty liver
    Tatsuya Fujimiya
    Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Am J Physiol Gastrointest Liver Physiol 297:G451-60. 2009
    ..These results indicate that excess alcohol consumption stimulates both the homing of HSCs from the bone marrow and their profibrogenic cytokine production in a mouse model of alcohol-induced fatty liver disease...
  16. ncbi request reprint Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2
    Toshihiko Aki
    Center for Gene Research, Yamaguchi University, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Oncogene 22:8529-35. 2003
    ....
  17. ncbi request reprint Effect of chronic ethanol administration on disposition of ethanol and its metabolites in rat
    Shuji Kozawa
    Division of Legal Medicine, Department of Social Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
    Alcohol 41:87-93. 2007
    ..Thus, with general alcohol consumption, interindividual differences and intra-individual changes in alcohol metabolism may not take into account increased or accelerated metabolism due to alcohol tolerance...
  18. ncbi request reprint Angiotensin II dependent testicular fibrosis and effects on spermatogenesis after vasectomy in the rat
    Koji Shiraishi
    Department of Urology and Forensic Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan
    J Urol 170:2104-8. 2003
    ..Vasectomy induces testicular interstitial fibrosis in time dependent fashion and inhibits spermatogenesis. We investigated the contribution of angiotensin II (Ang II) to the development of interstitial fibrosis after vasectomy...
  19. ncbi request reprint Activation of mitogen activated protein kinases and apoptosis of germ cells after vasectomy in the rat
    Koji Shiraishi
    Departments of Urology and Legal Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan
    J Urol 168:1273-8. 2002
    ..Vasectomy induces a large amount of germ cell apoptosis. We examined the activation of mitogen activated protein kinases (MAPKs) in association with the apoptosis and proliferation of germ cells after vasectomy in the rat...