Research Topics
Genomes and GenesSpecies | Naoki YanagawaSummaryAffiliation: Yamagata University Country: Japan Publications
|
Detail Information
Publications
Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma: relation with smoking statusNaoki Yanagawa
Department of Pathology, Yamagata University, Yamagata 990 9585, Japan
Anticancer Res 31:1211-4. 2011..Epidemiological studies have demonstrated a causal link between tobacco smoking and lung cancer. However, lung adenocarcinoma (AC) is also frequently found in non-smokers compared with other non-small cell lung carcinoma (NSCLC) subtypes...
MAGE expressions mediated by demethylation of MAGE promoters induce progression of non-small cell lung cancerNaoki Yanagawa
Department of Pathology, Yamagata University Faculty of Medicine, Yamagata, Japan
Anticancer Res 31:171-5. 2011..These genes are expressed in various tumor cells, but not in healthy tissues except for the testis and placenta. MAGE expression is known to be activated by promoter demethylation...
Pulmonary localized AA type amyloidosis with cyst-like structures and marginal zone B-cell lymphoma of the MALT type coexisting independently in the left upper lungNaoki Yanagawa
Department of Pathology, Yamagata University Faculty of Medicine
Intern Med 47:1529-33. 2008..The tumor in S3 was composed of eosinophilic amorphous deposits. The diagnosis of amyloidosis was confirmed by polarized light examination. After oxidation with permanganate solution, the Congo red staining disappeared...
Detection of HPV-DNA, p53 alterations, and methylation in penile squamous cell carcinoma in Japanese menNaoki Yanagawa
Department of Pathology, Yamagata University School of Medicine, Tamagata, Japan
Pathol Int 58:477-82. 2008..The present results suggest that the majority of penile squamous cell carcinomas in Japanese men are unrelated to HPV, and gene alterations accumulate more frequently in HPV-unrelated penile carcinomas...
Frequent epigenetic silencing of the FHIT gene in penile squamous cell carcinomasNaoki Yanagawa
Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
Virchows Arch 452:377-82. 2008..Methylation of FHIT gene was frequently found than HPV infection, therefore methylation of the FHIT gene is suggested to play an important role in the pathogenesis of penile squamous cell carcinoma...
Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancersNaoki Yanagawa
Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
Lung Cancer 58:131-8. 2007..004) and pleural involvement (P=0.037). In conclusion, the hypermethylation of RASSF1A or RUNX3 gene is therefore a useful biomarker to predict the prognosis in NSCLC, particularly RASSF1A due to SCCs and RUNX3 due to ACs...
Promoter hypermethylation of tumor suppressor and tumor-related genes in non-small cell lung cancersNaoki Yanagawa
Department of Pathology, Yamagata University School of Medicine, Yamagata 990-9585, Japan
Cancer Sci 94:589-92. 2003..In addition, methylation of p16, RASSF1A and RUNX3 was mostly cancer-specific (P < 0.05), and may be utilized as a molecular diagnostic marker of NSCLCs...
Frequent epigenetic silencing of the p16 gene in non-small cell lung cancers of tobacco smokersNaoki Yanagawa
Department of Pathology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan
Jpn J Cancer Res 93:1107-13. 2002..05). These findings suggest that tobacco smoking leads to inactivation of the p16 gene mainly through the epigenetic mechanism, ultimately increasing the risk of NSCLC, especially the squamous cell histological type...
Demethylation of the synuclein gamma gene CpG island in primary gastric cancers and gastric cancer cell linesNaoki Yanagawa
Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
Clin Cancer Res 10:2447-51. 2004....
Comparison of HER2 immunohistochemical results using a monoclonal antibody (SV2-61γ) and a polyclonal antibody (for Dako HercepTest) in advanced gastric cancerGen Tamura
Department of Pathology and Laboratory Medicine, Yamagata Prefectural Central Hospital, Yamagata, Japan
Pathol Int 62:513-7. 2012..1% (11/73) using SV2-61γ and 23.3% (17/73) using Dako HercepTest. Thus, therapeutic decisions might be markedly influenced by the selection of antibody used in the HER2 test...
Parathyroid carcinoma with anaplastic feature: association of a p53 gene mutation with anaplastic transformationGen Tamura
Departments of Pathology and Laboratory Medicine, Yamagata Prefectural Central Hospital, Aoyagi, Yamagata, Japan
Pathol Int 59:107-10. 2009..These findings suggest that the p53 gene mutation is associated with anaplastic transformation of parathyroid carcinoma...
Synchronous Double Malignant Tumors Consisting of Stomach and Hodgkin's Lymphoma with Collision between Gastric Adenocarcinoma and Hodgkin's Lymphoma in the StomachNaoki Yanagawa
Department of Pathology and Laboratory Medicine, Yamagata Prefectural Central Hospital, Yamagata, Japan
Case Rep Gastroenterol 6:797-802. 2012..As a result, gastric adenocarcinoma and metastasis of Hodgkin's lymphoma were collided in the stomach. In conclusion, this case might be helpful in exploring the occurrence mechanism of tumor collision between lymphoma and carcinoma...
New IASLC/ATS/ERS Classification and Invasive Tumor Size are Predictive of Disease Recurrence in Stage I Lung AdenocarcinomaNaoki Yanagawa
Departments of Pathology and Laboratory Medicine and Thoracic Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan
J Thorac Oncol 8:612-8. 2013....
Loss of phosphatase and tensin homolog protein expression is an independent poor prognostic marker in lung adenocarcinomaNaoki Yanagawa
Department of Pathology and Laboratory Medicine, Yamagata Prefectural Central Hospital, Yamagata, Yamagata, Japan
J Thorac Oncol 7:1513-21. 2012..The prognostic role of PTEN in non-small-cell lung carcinoma has not been evaluated completely in the context of other molecular information...
Peripheral T-cell lymphoma arising from an intraglandular lymph node in the parotid gland: a case report and literature reviewNaoki Yanagawa
Department of Pathology and Laboratory Medicine, Yamagata Prefectural Central Hospital, Yamagata, Japan
Pathol Int 62:60-4. 2012..In conclusion, Only 17 cases of primary T/NK-cell lymphoma of the salivary glands have been recorded until now, and the characteristics of these are not clear yet. Additional study is needed...
