G Tamura

Summary

Affiliation: Yamagata University
Country: Japan

Publications

  1. ncbi request reprint The common 18-base pair deletion at codons 418-423 of the E-cadherin gene in differentiated-type adenocarcinomas and intramucosal precancerous lesions of the stomach with the features of gastric foveolar epithelium
    Y Endoh
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    J Pathol 189:201-6. 1999
  2. pmc Promoter methylation status of E-cadherin, hMLH1, and p16 genes in nonneoplastic gastric epithelia
    Takayoshi Waki
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Am J Pathol 161:399-403. 2002
  3. ncbi request reprint Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines
    Teiichiro Honda
    Department of Pathology, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Jpn J Cancer Res 93:857-60. 2002
  4. pmc Promoter hypermethylation of the Chfr gene in neoplastic and non-neoplastic gastric epithelia
    T Honda
    Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Br J Cancer 90:2013-6. 2004
  5. ncbi request reprint Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients
    Tomohiro Tozawa
    Department of Pathology, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Cancer Sci 95:736-40. 2004
  6. pmc Demethylation of MAGE promoters during gastric cancer progression
    T Honda
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Br J Cancer 90:838-43. 2004
  7. pmc Hypermethylation of the hMLH1 gene promoter in solitary and multiple gastric cancers with microsatellite instability
    K Sakata
    Department of Pathology, Yamagata University School of Medicine, Iida nishi 2 2 2, Yamagata 990 9585, Japan
    Br J Cancer 86:564-7. 2002
  8. ncbi request reprint Mutations in mitochondrial control region DNA in gastric tumours of Japanese patients
    G Tamura
    Department of Pathology, Yamagata University School of Medicine, Japan
    Eur J Cancer 35:316-9. 1999
  9. ncbi request reprint Promoter methylation status of tumor suppressor and tumor-related genes in neoplastic and non-neoplastic gastric epithelia
    G Tamura
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Histol Histopathol 19:221-8. 2004
  10. ncbi request reprint Genetic and epigenetic alterations of tumor suppressor and tumor-related genes in gastric cancer
    G Tamura
    Department of Pathology, Yamagata University School of Medicine, Japan
    Histol Histopathol 17:323-9. 2002

Collaborators

Detail Information

Publications67

  1. ncbi request reprint The common 18-base pair deletion at codons 418-423 of the E-cadherin gene in differentiated-type adenocarcinomas and intramucosal precancerous lesions of the stomach with the features of gastric foveolar epithelium
    Y Endoh
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    J Pathol 189:201-6. 1999
    ..This mutation was previously reported in an advanced carcinoma of undifferentiated type. The results suggest that these tumours progress to undifferentiated-type carcinomas through loss of E-cadherin function...
  2. pmc Promoter methylation status of E-cadherin, hMLH1, and p16 genes in nonneoplastic gastric epithelia
    Takayoshi Waki
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Am J Pathol 161:399-403. 2002
    ..Therefore, detection of hMLH1 methylation in nonneoplastic gastric epithelia may be useful for screening patients who may be at risk of developing gastric cancer...
  3. ncbi request reprint Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines
    Teiichiro Honda
    Department of Pathology, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Jpn J Cancer Res 93:857-60. 2002
    ..2. These data indicate that bi-allelic hypermethylation of the TSLC1 promoter and resulting gene silencing occur in a subset of primary gastric cancers...
  4. pmc Promoter hypermethylation of the Chfr gene in neoplastic and non-neoplastic gastric epithelia
    T Honda
    Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Br J Cancer 90:2013-6. 2004
    ..Thus, Chfr promoter hypermethylation is mostly cancer specific and frequently leads to chromosome instability in gastric cancer...
  5. ncbi request reprint Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients
    Tomohiro Tozawa
    Department of Pathology, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Cancer Sci 95:736-40. 2004
    ..Hypermethylation of DAP-kinase appears to be a significant prognostic factor in primary biliary tract carcinomas...
  6. pmc Demethylation of MAGE promoters during gastric cancer progression
    T Honda
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Br J Cancer 90:838-43. 2004
    ..183). Demethylation of MAGE-A1 and -A3 occurs during progressive stages of gastric cancer, and may be associated with aggressive biological behaviour of gastric cancer...
  7. pmc Hypermethylation of the hMLH1 gene promoter in solitary and multiple gastric cancers with microsatellite instability
    K Sakata
    Department of Pathology, Yamagata University School of Medicine, Iida nishi 2 2 2, Yamagata 990 9585, Japan
    Br J Cancer 86:564-7. 2002
    ..Hypermethylation of the hMLH1 promoter occurs in non-cancerous gastric mucosa of microsatellite instability-H tumours and may increase the risk of subsequent neoplasia...
  8. ncbi request reprint Mutations in mitochondrial control region DNA in gastric tumours of Japanese patients
    G Tamura
    Department of Pathology, Yamagata University School of Medicine, Japan
    Eur J Cancer 35:316-9. 1999
    ..In summary, mtDNA is mutated in a subset of benign and malignant gastric tumours, but, disruption of the mtDNA repair system appears not to be significantly involved in gastric tumours of Japanese patients...
  9. ncbi request reprint Promoter methylation status of tumor suppressor and tumor-related genes in neoplastic and non-neoplastic gastric epithelia
    G Tamura
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Histol Histopathol 19:221-8. 2004
    ..In clinical applications RUNX3 and TSLC1 methylation may be utilized as molecular diagnostic markers, and hMLH1 and p16 methylation as predictors of malignancy in the stomach...
  10. ncbi request reprint Genetic and epigenetic alterations of tumor suppressor and tumor-related genes in gastric cancer
    G Tamura
    Department of Pathology, Yamagata University School of Medicine, Japan
    Histol Histopathol 17:323-9. 2002
    ..The molecular pathways of gastric carcinogenesis depend on the histological background, and gastric carcinomas show distinct biological behaviors as a result of discernible cellular genetic and epigenetic alterations...
  11. ncbi request reprint Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer
    Gen Tamura
    Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    World J Gastroenterol 12:192-8. 2006
    ..Thus, while the molecular pathways of gastric carcinogenesis are dependent on histological background, specific genetic alterations can still be used for risk assessment, diagnosis, and prognosis...
  12. ncbi request reprint Molecular characterization of undifferentiated-type gastric carcinoma
    G Tamura
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Lab Invest 81:593-8. 2001
    ....
  13. pmc Frequent hypermethylation of the hMLH1 gene promoter in differentiated-type tumors of the stomach with the gastric foveolar phenotype
    Y Endoh
    Department of Pathology, Yamagata University School of Medicine, Yamagata Niigata University School of Medicine, Niigata, Japan
    Am J Pathol 157:717-22. 2000
    ..Hypermethylation of hMLH1 promoter is an initial, vital event in the development of foveolar-type tumors of the stomach...
  14. ncbi request reprint Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways
    Y Endoh
    Department of Pathology, Yamagata University School of Medicine, Japan
    J Pathol 191:257-63. 2000
    ..The 'suppressor pathway', represented by p53 alteration, could participate in the tumourigenesis of the CIM-type, but is rare in foveolar-type tumours...
  15. ncbi request reprint Microsatellite instability in esophageal squamous cell carcinoma is not associated with hMLH1 promoter hypermethylation
    Masahiro Hayashi
    Department of Pathology, Yamagata University School of Medicine, Japan
    Pathol Int 53:270-6. 2003
    ..e. the suppressor pathway), and that MSI in esophageal SCC probably represent random replication errors rather than being associated with DNA mismatch repair deficiency...
  16. pmc Frequent loss of expression without sequence mutations of the DCC gene in primary gastric cancer
    K Sato
    Departments of Pathology, Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, 990 9585, Japan
    Br J Cancer 85:199-203. 2001
    ..01). These results indicate that DCC is frequently silenced, probably by epigenetic mechanisms instead of sequence mutations in gastric cancer...
  17. ncbi request reprint Loss of heterozygosity during the development and progression of differentiated adenocarcinoma of the stomach
    S Nishizuka
    Department of Pathology, School of Medicine, Iwate Medical University, Morioka, Japan
    J Pathol 185:38-43. 1998
    ..05). These results suggest that LOH on 4p, 7q, 14q, 17p, and 21q is a relatively early event, while LOH on 2q, 5q, 6p, 11q, and 18q typically accumulates during the progression of gastric carcinogenesis...
  18. pmc Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers
    Z Jin
    Department of Pathology, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Br J Cancer 85:69-73. 2001
    ..These results indicate that APC promoter CpG island hypermethylation is a cancer-specific change and may be a more common mechanism of inactivation of this tumour suppressor gene in primary breast cancers than previously suspected...
  19. ncbi request reprint Microsatellite alterations and target gene mutations in the early stages of multiple gastric cancer
    S Ogata
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    J Pathol 194:334-40. 2001
    ..Mutations of E2F-4 are early events in multiple gastric cancer development, occurring even in the intestinal metaplastic mucosa, with mutations of other target genes to follow during cancer progression...
  20. ncbi request reprint Molecular and cellular phenotypic profiles of gastric noninvasive neoplasia
    Zhe Jin
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Lab Invest 82:1637-45. 2002
    ..01). In summary, the Padova international classification correlated with both the molecular and cellular phenotypic profiles. In practice, p53 and hMLH1 immunohistochemistry discriminated Ca-NIN from L-NIN and H-NIN tumors...
  21. pmc RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer
    M Endoh
    Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Br J Cancer 93:1395-9. 2005
    ....
  22. ncbi request reprint The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma
    C Maesawa
    Department of Pathology, Iwate Medical University School of Medicine, Morioka, Japan
    J Pathol 176:249-58. 1995
    ..The considerable differences in the incidences of genetic alterations between gastric adenoma and carcinoma indicate that the sequential development of gastric carcinoma from adenoma is uncommon in gastric carcinogenesis...
  23. ncbi request reprint Absence of BAT-26 instability in gastric intestinal metaplasia
    Z Jin
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Pathol Int 51:473-5. 2001
    ..Although all MSI-H gastric cancer samples showed BAT-26 instability, as assessed using 12 dinucleotide microsatellite markers, BAT-26 instability was not found in the adjacent intestinal metaplastic mucosa in any of the samples...
  24. ncbi request reprint Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer
    Kiyoshi Sato
    Department of Pathology, Yamagata University School of Medicine, Japan
    Virchows Arch 440:160-5. 2002
    ..Therefore, we conclude that PTEN does not participate in gastric carcinogenesis as a tumor suppressor gene...
  25. pmc Commonly deleted region on the long arm of chromosome 7 in differentiated adenocarcinoma of the stomach
    S Nishizuka
    Department of Pathology, Iwate Medical University School of Medicine, Morioka, Japan
    Br J Cancer 76:1567-71. 1997
    ..1). This is identical to the region identified for other human malignancies. These observations indicate that a putative tumour suppressor gene at 7q31.1 may be involved in the pathogenesis of differentiated adenocarcinoma of the stomach...
  26. ncbi request reprint Hypermethylation of Chfr and hMLH1 in gastric noninvasive and early invasive neoplasias
    Naoyuki Homma
    Department of Pathology, Yamagata University School of Medicine, 990 9585, Yamagata, 2 2 2 Iida nishi, Japan
    Virchows Arch 446:120-6. 2005
    ..Thus, some gastric tumors with the foveolar or ordinary phenotype may develop as a result of age-related methylation of Chfr and hMLH1, although Chfr methylation was not associated with CIN...
  27. ncbi request reprint Genetic analysis of cutaneous squamous cell carcinomas arising from different areas
    Masahiro Hayashi
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Pathol Int 53:602-7. 2003
    ..Our findings suggest that sun-exposed SCC in Japan may be relatively less involved with p53 mutation, and that non-sun-exposed SCC acquire more genetic alterations than sun-exposed SCC...
  28. ncbi request reprint Promoter hypermethylation of tumor suppressor and tumor-related genes in non-small cell lung cancers
    Naoki Yanagawa
    Department of Pathology, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Cancer Sci 94:589-92. 2003
    ..In addition, methylation of p16, RASSF1A and RUNX3 was mostly cancer-specific (P < 0.05), and may be utilized as a molecular diagnostic marker of NSCLCs...
  29. ncbi request reprint Demethylation of the synuclein gamma gene CpG island in primary gastric cancers and gastric cancer cell lines
    Naoki Yanagawa
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Clin Cancer Res 10:2447-51. 2004
    ....
  30. ncbi request reprint Analysis of genetic alterations in renal cell carcinoma using the polymerase chain reaction
    Y Suzuki
    Department of Pathology, Iwate Medical University School of Medicine, Morioka, Japan
    Virchows Arch 424:453-7. 1994
    ..The results suggest that the genetic pathway in the genesis of RCC differs considerably from that of other common human carcinomas...
  31. ncbi request reprint Carcinosarcomas (malignant mullerian mixed tumors) of the uterus and ovary: a genetic study with special reference to histogenesis
    Zhe Jin
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Int J Gynecol Pathol 22:368-73. 2003
    ..Ten tumors were monoclonal, one was biclonal (collision tumor), and another was probably biclonal; the other three were of indeterminate histogenesis. These data indicate that most uterine and ovarian carcinosarcomas are monoclonal...
  32. ncbi request reprint Tissue-specific involvement of multiple mitochondrial DNA deletions in familial mitochondrial myopathy
    S Nishizuka
    Department of Pathology, School of Medicine, Iwate Medical University, Japan
    Biochem Biophys Res Commun 247:24-7. 1998
    ..A similar deletion pattern was found in the skeletal muscle but not in the leukocytes of the other patient. The results suggest the complex mechanism to generate, expand and eliminate the deleted mtDNA in humans...
  33. ncbi request reprint Esophageal adenocarcinoma that probably originated in the esophageal gland duct: a case report
    Y Endoh
    Department of Pathology, Yamagata University School of Medicine, Japan
    Pathol Int 49:156-9. 1999
    ..Barrett's metaplastic epithelium or ectopic gastric mucosa was not found around the tumor. It is strongly suggested that this unique carcinoma is derived from the esophageal gland ducts...
  34. ncbi request reprint Multiple tumor suppressor genes are increasingly methylated with age in non-neoplastic gastric epithelia
    Kanji So
    Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Cancer Sci 97:1155-8. 2006
    ..Quantitative analysis of DNA methylation using DNA microarrays is a promising method for risk assessment in the development of gastric cancer...
  35. ncbi request reprint Promoter methylation status of DAP-kinase and RUNX3 genes in neoplastic and non-neoplastic gastric epithelia
    Takayoshi Waki
    Department of Pathology, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Cancer Sci 94:360-4. 2003
    ..01), although those in gastric cancers were almost the same. RUNX3 methylation is mostly cancer-specific, except for very old individuals, and therefore may be a possible molecular diagnostic marker and malignancy predictor...
  36. ncbi request reprint Histogenesis of hepatoid adenocarcinoma of the stomach: molecular evidence of identical origin with coexistent tubular adenocarcinoma
    Sunao Akiyama
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Int J Cancer 106:510-5. 2003
    ..Microsatellite analysis indicated more than 3 common patterns of loss of heterozygosity in 8 cases. These observations strongly suggested that hepatoid adenocarcinomas were of identical origin to coexistent tubular adenocarcinomas...
  37. ncbi request reprint Quantitative assessment of RUNX3 methylation in neoplastic and non-neoplastic gastric epithelia using a DNA microarray
    Kanji So
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Pathol Int 56:571-5. 2006
    ..This microarray-based methylation assay is a promising method for the quantitative assessment of gene methylation...
  38. ncbi request reprint Methylation status of EXT1 and EXT2 promoters and two mutations of EXT2 in chondrosarcoma
    Takashi Tsuchiya
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, Yamagata, Japan
    Cancer Genet Cytogenet 158:148-55. 2005
    ..When considering tumor development in primary chondrosarcoma, we should include mutations in EXT2, along with the status of other members of the EXT gene family...
  39. ncbi request reprint Expression of tumor suppressor and tumor-related proteins in differentiated carcinoma, undifferentiated carcinoma with tubular component and pure undifferentiated carcinoma of the stomach
    Teiichiro Honda
    Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Jpn J Clin Oncol 35:580-6. 2005
    ..We attempted to clarify the derivation of undifferentiated-type gastric carcinoma with tubular component by using TMA...
  40. ncbi request reprint MAGE expressions mediated by demethylation of MAGE promoters induce progression of non-small cell lung cancer
    Naoki Yanagawa
    Department of Pathology, Yamagata University Faculty of Medicine, Yamagata, Japan
    Anticancer Res 31:171-5. 2011
    ..These genes are expressed in various tumor cells, but not in healthy tissues except for the testis and placenta. MAGE expression is known to be activated by promoter demethylation...
  41. ncbi request reprint Involvement of adenomatous polyposis coli (APC) gene in testicular yolk sac tumor of infants
    Noriko Kato
    Department of Pathology, Yamagata University School of Medicine, 990 9585, Japan
    Hum Pathol 37:48-53. 2006
    ..These data indicate that inactivation of the APC gene, by allelic loss and/or promoter methylation, is related to the occurrence of infantile YSTs...
  42. ncbi request reprint Spreading of methylation within RUNX3 CpG island in gastric cancer
    Naoyuki Homma
    Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Cancer Sci 97:51-6. 2006
    ..The detection of hypermethylation at multiple regions within the RUNX3 CpG island may be useful in the diagnosis and risk assessment of gastric cancer...
  43. ncbi request reprint Detection of HPV-DNA, p53 alterations, and methylation in penile squamous cell carcinoma in Japanese men
    Naoki Yanagawa
    Department of Pathology, Yamagata University School of Medicine, Tamagata, Japan
    Pathol Int 58:477-82. 2008
    ..The present results suggest that the majority of penile squamous cell carcinomas in Japanese men are unrelated to HPV, and gene alterations accumulate more frequently in HPV-unrelated penile carcinomas...
  44. ncbi request reprint Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma: relation with smoking status
    Naoki Yanagawa
    Department of Pathology, Yamagata University, Yamagata 990 9585, Japan
    Anticancer Res 31:1211-4. 2011
    ..Epidemiological studies have demonstrated a causal link between tobacco smoking and lung cancer. However, lung adenocarcinoma (AC) is also frequently found in non-smokers compared with other non-small cell lung carcinoma (NSCLC) subtypes...
  45. doi request reprint Frequent epigenetic silencing of the FHIT gene in penile squamous cell carcinomas
    Naoki Yanagawa
    Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Virchows Arch 452:377-82. 2008
    ..Methylation of FHIT gene was frequently found than HPV infection, therefore methylation of the FHIT gene is suggested to play an important role in the pathogenesis of penile squamous cell carcinoma...
  46. doi request reprint Parathyroid carcinoma with anaplastic feature: association of a p53 gene mutation with anaplastic transformation
    Gen Tamura
    Departments of Pathology and Laboratory Medicine, Yamagata Prefectural Central Hospital, Aoyagi, Yamagata, Japan
    Pathol Int 59:107-10. 2009
    ..These findings suggest that the p53 gene mutation is associated with anaplastic transformation of parathyroid carcinoma...
  47. ncbi request reprint Hypomethylation of hepatocyte nuclear factor-1beta (HNF-1beta) CpG island in clear cell carcinoma of the ovary
    Noriko Kato
    Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, Japan
    Virchows Arch 452:175-80. 2008
    ..These results strongly suggest that hypomethylation of the HNF-1beta CpG island participates in the HNF-1beta up-regulation in ovarian CCC...
  48. ncbi request reprint Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers
    Naoki Yanagawa
    Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Lung Cancer 58:131-8. 2007
    ..004) and pleural involvement (P=0.037). In conclusion, the hypermethylation of RASSF1A or RUNX3 gene is therefore a useful biomarker to predict the prognosis in NSCLC, particularly RASSF1A due to SCCs and RUNX3 due to ACs...
  49. ncbi request reprint Frequent epigenetic silencing of the p16 gene in non-small cell lung cancers of tobacco smokers
    Naoki Yanagawa
    Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Jpn J Cancer Res 93:1107-13. 2002
    ..05). These findings suggest that tobacco smoking leads to inactivation of the p16 gene mainly through the epigenetic mechanism, ultimately increasing the risk of NSCLC, especially the squamous cell histological type...
  50. ncbi request reprint E-cadherin expression in follicular carcinoma of the thyroid
    Noriko Kato
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Pathol Int 52:13-8. 2002
    ..Analysis of methylation of the E-CD gene promoter using the methylation-specific polymerase chain reaction (MSP) method revealed no methylated alleles in the DNA from FC...
  51. pmc Hypermethylation of the RUNX3 gene promoter in testicular yolk sac tumor of infants
    Noriko Kato
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Am J Pathol 163:387-91. 2003
    ..001). In normal testes of the young group, RUNX3 methylation was not detected. These results strongly suggest that RUNX3 is one of the tumor suppressors involved in the pathogenesis of testicular YSTs in infants...
  52. ncbi request reprint Ameloblastoma with basal cell carcinoma-like feature emerging as a nasal polyp
    N Kato
    Department of Pathology, Yamagata University School of Medicine, Japan
    Pathol Int 49:747-51. 1999
    ..It is emphasized that immunohistochemical examination using anticytokeratin antibody KL-1 and antiepithelial antibody Ber-EP4 is a good tool for distinguishing ameloblastoma with BCC-like features from adamantinoid BCC...
  53. ncbi request reprint Apocrine adenosis of the breast: clonal evidence of neoplasia
    Y Endoh
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Histopathology 38:221-4. 2001
    ..We report here a case of apocrine adenosis of the breast in a 66-year-old woman. To clarify the nature of this lesion, we examined it by clonal analysis...
  54. ncbi request reprint Rare case of biphasic tumor of the breast with prominent CD34-positive spindle cells
    M Hayashi
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Pathol Int 51:713-7. 2001
    ..Immunohistochemistry revealed the spindle-shaped tumor cells to be myofibroblastic, but not myoepithelial in nature, ultimately categorizing this tumor as a malignant phyllodes tumor with prominent myofibroblastic differentiation...
  55. ncbi request reprint Age-related methylation of tumor suppressor and tumor-related genes: an analysis of autopsy samples
    Takayoshi Waki
    Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, 990 9585, Japan
    Oncogene 22:4128-33. 2003
    ..Thus, age-related methylation of a different set of genes is thought to constitute a field defect in different organs...
  56. doi request reprint Quantitative assessment of gene methylation in neoplastic and non-neoplastic gastric epithelia using methylation-specific DNA microarray
    Gen Tamura
    Department of Pathology and Laboratory Medicine, Yamagata Prefectural Central Hospital, Yamagata, Japan
    Pathol Int 59:895-9. 2009
    ..Quantitative analysis of gene methylation using methylation-specific DNA microarray is a promising method for cancer diagnosis...
  57. ncbi request reprint Esophageal extraskeletal Ewing's sarcoma
    Chihaya Maesawa
    Department of Pathology, Iwate Medical University School of Medicine, Morioka, Japan
    Hum Pathol 33:130-2. 2002
    ..A reverse transcriptase-polymerase chain reaction followed by sequencing revealed an EWSR1/ERG chimeric transcript, which combined EWSR1 exon 10 with ERG exon 6. The present report added a new entity of esophageal small round cell tumor...
  58. ncbi request reprint [Sarcomatoid carcinoma of the thymus which caused acute epicarditis]
    S Takahara
    Department of Cardiovascular Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan
    Kyobu Geka 63:375-8. 2010
    ..He died 33 months after surgery. The possibility of diseases like this tumor must be kept in mind for a patient with chest symptoms. Paclitaxel monotherapy is likely to be effective in treating sarcomatoid carcinoma of the thymus...
  59. doi request reprint Malignant solitary fibrous tumor with superior vena cava syndrome
    Satoshi Shiono
    Department of Thoracic Surgery, Yamagata Prefectural Central Hospital, 1800 Oazaaoyagi, Yamagata, 990 2292, Japan
    Gen Thorac Cardiovasc Surg 57:321-3. 2009
    ..Postoperative radiotherapy was performed due to incomplete resection, but the tumor relapsed within 4 months. Gemcitabine-based chemotherapy was ineffective...
  60. ncbi request reprint Primitive neuroectodermal tumor of the breast: immunohistochemistry and fluorescence in situ hybridization
    Gen Tamura
    Department of Pathology and Laboratory Medicine, Yamagata Prefectural Central Hospital, Yamagata, Japan
    Pathol Int 57:509-12. 2007
    ..The patient has been disease free for 6 months after surgery followed by chemoradiation therapy. FISH is extremely useful for accurate diagnosis of EFT, especially in cases of unusual locations...
  61. ncbi request reprint High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk
    Takao Maekita
    Carcinogenesis Division, National Cancer Center Research Institute, Tsukiji, Tokyo, Japan
    Clin Cancer Res 12:989-95. 2006
    ..Here, we analyzed the effect of H. pylori infection on the quantity of methylated DNA molecules in noncancerous gastric mucosae and examined its association with gastric cancer risk...
  62. ncbi request reprint B cells capturing antigen conjugated with CpG oligodeoxynucleotides induce Th1 cells by elaborating IL-12
    Hidekazu Shirota
    Department of Respiratory and Infectious Diseases, Graduate School of Medicine, Tohoku University, Sendai, Japan
    J Immunol 169:787-94. 2002
    ....
  63. ncbi request reprint Oligodeoxynucleotides without CpG motifs work as adjuvant for the induction of Th2 differentiation in a sequence-independent manner
    Kunio Sano
    Department of Respiratory and Infectious Diseases, Graduate School of Medicine, Tohoku University, Sendai, Japan
    J Immunol 170:2367-73. 2003
    ..This is the first study suggesting that ODNs, independent of the sequences, enhance immune responses through the promoted capture of ODN-conjugated Ag by APCs...
  64. ncbi request reprint Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers
    Yuriko Mori
    Department of Medicine, University of Maryland School of Medicine, Baltimore Veterans Affairs Hospital, Baltimore, Maryland 21201, USA
    Cancer Res 62:3641-5. 2002
    ..2%), and an endoplasmic reticulum chaperone protein gene SEC63 (37.5%). The mutational spectra for genes with high mutation frequencies were also significantly different between MSI-H gastric and colorectal cancers...
  65. ncbi request reprint Peritumoral CpG oligodeoxynucleotide treatment inhibits tumor growth and metastasis of B16F10 melanoma cells
    Nagisa Kunikata
    Department of Dermatology, Tohoku University, Graduate School of Medicine, Sendai, Japan
    J Invest Dermatol 123:395-402. 2004
    ..These results suggest that CpG ODN are promising as a preventive and therapeutic anti-metastatic measure against melanoma...
  66. ncbi request reprint Linkage and association of childhood asthma with the chromosome 12 genes
    Chenchen Shao
    Department of Medical Genetics, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Hum Genet 49:115-22. 2004
    ..Our results suggest that NOS1 and STAT6 are asthma-susceptibility genes and that chromosome region 12q24.23-q24.33 contains other susceptibility gene(s)...
  67. ncbi request reprint [Gastric cancer: histological type, histogenesis, and gene abnormalities]
    Gen Tamura
    Dept of Pathology and Laboratory Medicine, Yamagata Prefectural Central Hospital
    Gan To Kagaku Ryoho 35:343-9. 2008
    ..Thus, the molecular pathways of gastric carcinogenesis are dependent on histological background, and specific genetic abnormalities can be used for risk assessment, diagnosis, and prognosis...