Yasuchika Takeishi

Summary

Affiliation: Yamagata University
Country: Japan

Publications

  1. ncbi request reprint Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy
    Yasuchika Takeishi
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106 5029, USA
    Cardiovasc Res 53:131-7. 2002
  2. ncbi request reprint Hyperuricemia associated with high cardiac event rates in the elderly with chronic heart failure
    Takeshi Niizeki
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata
    J Cardiol 47:219-28. 2006
  3. ncbi request reprint Azelnidipine inhibits H2O2-induced cell death in neonatal rat cardiomyocytes
    Yo Koyama
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, 990 9585, Japan
    Cardiovasc Drugs Ther 21:69-72. 2007
  4. ncbi request reprint Serum resistin is associated with high risk in patients with congestive heart failure--a novel link between metabolic signals and heart failure
    Yasuchika Takeishi
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
    Circ J 71:460-4. 2007
  5. ncbi request reprint Role of diacylglycerol kinase in cellular regulatory processes: a new regulator for cardiomyocyte hypertrophy
    Yasuchika Takeishi
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, Japan
    Pharmacol Ther 115:352-9. 2007
  6. ncbi request reprint Dynamic 123I-BMIPP single-photon emission computed tomography in patients with congestive heart failure: effect of angiotensin II type-1 receptor blockade
    Yasuchika Takeishi
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Clin Cardiol 27:204-10. 2004
  7. ncbi request reprint Fatty acid metabolism assessed by 125I-iodophenyl 9-methylpentadecanoic acid (9MPA) and expression of fatty acid utilization enzymes in volume-overloaded hearts
    T Miyamoto
    Yamagata University School of Medicine, Yamagata, Japan
    Eur J Clin Invest 34:176-81. 2004
  8. ncbi request reprint Linkage disequilibrium analyses of natriuretic peptide precursor B locus reveal risk haplotype conferring high plasma BNP levels
    Yasuchika Takeishi
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, Japan
    Biochem Biophys Res Commun 362:480-4. 2007
  9. ncbi request reprint Serum heart-type fatty acid binding protein predicts cardiac events in elderly patients with chronic heart failure
    Takeshi Niizeki
    The First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata
    J Cardiol 46:9-15. 2005
  10. ncbi request reprint Angiotensin-converting enzyme inhibition improves cardiac fatty acid metabolism in patients with congestive heart failure
    S Yamauchi
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Nucl Med Commun 24:901-6. 2003

Collaborators

Detail Information

Publications88

  1. ncbi request reprint Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy
    Yasuchika Takeishi
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106 5029, USA
    Cardiovasc Res 53:131-7. 2002
    ..However, the abundance and activity of these kinases in human hearts are unknown...
  2. ncbi request reprint Hyperuricemia associated with high cardiac event rates in the elderly with chronic heart failure
    Takeshi Niizeki
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata
    J Cardiol 47:219-28. 2006
    ..Therefore, this study tried to identify the clinical characteristics of elderly CHF patients (+/-70 years) in our institution and to evaluate whether uric acid levels can effectively estimate the prognosis for elderly CHF patients...
  3. ncbi request reprint Azelnidipine inhibits H2O2-induced cell death in neonatal rat cardiomyocytes
    Yo Koyama
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, 990 9585, Japan
    Cardiovasc Drugs Ther 21:69-72. 2007
    ..We evaluated the antioxidant effects of azelnidipine compared to another dihyropyridine calcium channel blocker, nifedipine, in neonatal rat cardiomyocytes...
  4. ncbi request reprint Serum resistin is associated with high risk in patients with congestive heart failure--a novel link between metabolic signals and heart failure
    Yasuchika Takeishi
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
    Circ J 71:460-4. 2007
    ..Therefore, the purpose of this study was to examine whether: (1) resistin is correlated with the severity of heart failure; and (2) resistin can predict clinical outcomes of patients with heart failure...
  5. ncbi request reprint Role of diacylglycerol kinase in cellular regulatory processes: a new regulator for cardiomyocyte hypertrophy
    Yasuchika Takeishi
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, Japan
    Pharmacol Ther 115:352-9. 2007
    ..These data provide a novel insight for subcellular mechanisms of cardiac hypertrophy and heart failure, and DGKzeta may be a new therapeutic target to prevent cardiac hypertrophy and progression to heart failure...
  6. ncbi request reprint Dynamic 123I-BMIPP single-photon emission computed tomography in patients with congestive heart failure: effect of angiotensin II type-1 receptor blockade
    Yasuchika Takeishi
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Clin Cardiol 27:204-10. 2004
    ..Although recent studies have demonstrated that a variety of metabolic and/or neurohumoral factors are involved in the progression of this syndrome, the precise mechanisms responsible for this complex condition are poorly understood...
  7. ncbi request reprint Fatty acid metabolism assessed by 125I-iodophenyl 9-methylpentadecanoic acid (9MPA) and expression of fatty acid utilization enzymes in volume-overloaded hearts
    T Miyamoto
    Yamagata University School of Medicine, Yamagata, Japan
    Eur J Clin Invest 34:176-81. 2004
    ..The aim of the present study was to examine fatty acid metabolism and protein expressions of PPARalpha and fatty acid oxidation enzymes in volume-overloaded rabbit hearts...
  8. ncbi request reprint Linkage disequilibrium analyses of natriuretic peptide precursor B locus reveal risk haplotype conferring high plasma BNP levels
    Yasuchika Takeishi
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, Japan
    Biochem Biophys Res Commun 362:480-4. 2007
    ..In the present study, we performed association study of single nucleotide polymorphisms (SNPs) surrounding the natriuretic peptide precursor B (NPPB) gene with plasma BNP levels in 2970 adult Japanese...
  9. ncbi request reprint Serum heart-type fatty acid binding protein predicts cardiac events in elderly patients with chronic heart failure
    Takeshi Niizeki
    The First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata
    J Cardiol 46:9-15. 2005
    ..However, there are no data for the prognostic value of H-FABP in the elderly population. This study investigated whether H-FABP can effectively predict the prognosis in elderly patients (> or = 70 years) with chronic heart failure...
  10. ncbi request reprint Angiotensin-converting enzyme inhibition improves cardiac fatty acid metabolism in patients with congestive heart failure
    S Yamauchi
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Nucl Med Commun 24:901-6. 2003
    ....
  11. doi request reprint Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade
    Takeshi Niizeki
    Dept of Cardiology, Pulmonology, and Nephrology, Yamagata Univ School of Medicine, Yamagata, Japan
    Am J Physiol Heart Circ Physiol 295:H245-55. 2008
    ..DGKepsilon may be a novel therapeutic target to prevent cardiac hypertrophy and progression to heart failure...
  12. ncbi request reprint Cardiac-specific overexpression of diacylglycerol kinase zeta attenuates left ventricular remodeling and improves survival after myocardial infarction
    Takeshi Niizeki
    Department of Cardiology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, Japan 990 9585
    Am J Physiol Heart Circ Physiol 292:H1105-12. 2007
    ..DGKzeta may be a potential novel therapeutic target to prevent LV remodeling after MI...
  13. ncbi request reprint Pitavastatin inhibits cardiac hypertrophy in a rat model of progressive renal injury
    Hiroki Takahashi
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    J Cardiovasc Pharmacol 46:487-93. 2005
    ..These results suggest that pitavastatin has a beneficial effect on cardiac hypertrophy in renal failure through preventing the activation of ERK...
  14. ncbi request reprint High serum level of pentosidine, an advanced glycation end product (AGE), is a risk factor of patients with heart failure
    Yo Koyama
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    J Card Fail 13:199-206. 2007
    ..We investigated whether serum pentosidine is a risk factor for heart failure...
  15. doi request reprint Genetic polymorphisms of paraoxonase-1 are associated with chronic kidney disease in Japanese women
    Kazunobu Ichikawa
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Kidney Int 76:183-9. 2009
    ..Our study shows that this PON1 G-to-A substitution may be a key player in a common pathway to chronic kidney and cardiovascular diseases in women...
  16. ncbi request reprint Central role of endogenous Toll-like receptor-2 activation in regulating inflammation, reactive oxygen species production, and subsequent neointimal formation after vascular injury
    Tetsuro Shishido
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan
    Biochem Biophys Res Commun 345:1446-53. 2006
    ..Here, we report that vascular injury-mediated cytokine expression, reactive oxygen species (ROS) production, as well as subsequent neointimal formation requires Toll-like receptor-2 (TLR-2) mediated signaling pathway in vivo...
  17. doi request reprint High-mobility group box 1 restores cardiac function after myocardial infarction in transgenic mice
    Tatsuro Kitahara
    Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Cardiovasc Res 80:40-6. 2008
    ....
  18. doi request reprint Serum YKL-40 predicts adverse clinical outcomes in patients with chronic heart failure
    Olga Bilim
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    J Card Fail 16:873-9. 2010
    ..Circulating levels of YKL-40 are related to the degree of inflammation, tissue remodeling, fibrosis, and cancer progression...
  19. doi request reprint Relation of serum heat shock protein 60 level to severity and prognosis in chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    Takeshi Niizeki
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Am J Cardiol 102:606-10. 2008
    ..In conclusion, serum HSP 60 level was related to the severity of CHF and associated with a high risk for adverse cardiac events in patients CHF...
  20. doi request reprint Serum midkine as a predictor of cardiac events in patients with chronic heart failure
    Tatsuro Kitahara
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    J Card Fail 16:308-13. 2010
    ..However, the relationship between midkine and HF has not been previously examined. Therefore, we examined clinical significance of serum midkine levels to determine the prognosis of HF patients...
  21. ncbi request reprint Heart-type fatty acid-binding protein is more sensitive than troponin T to detect the ongoing myocardial damage in chronic heart failure patients
    Takeshi Niizeki
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    J Card Fail 13:120-7. 2007
    ..We hypothesized that a cytosolic marker (H-FABP) is more sensitive than a myofibrillar component (TnT) in the detection of OMD in CHF...
  22. ncbi request reprint Cardiac sympathetic denervation and ongoing myocardial damage for prognosis in early stages of heart failure
    Takanori Arimoto
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    J Card Fail 13:34-41. 2007
    ..Heart-type fatty acid binding protein (H-FABP) has been used as a marker of ongoing myocardial damage. The prognostic value of combination (123)I-MIBG imaging and H-FABP in heart failure is unknown...
  23. ncbi request reprint Risk stratification of chronic heart failure patients by multiple biomarkers: implications of BNP, H-FABP, and PTX3
    Mitsunori Ishino
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Circ J 72:1800-5. 2008
    ..For prognostic evaluation from different aspects, the utility of combined measurement of the 3 biomarkers in patients with CHF was examined in the present study...
  24. doi request reprint Role of LOX-1 in monocyte adhesion-triggered redox, Akt/eNOS and Ca2+ signaling pathways in endothelial cells
    Nobuo Sakamoto
    First Department of Internal Medicine, Fukushima Medical University, Fukushima 960 1295, Japan
    J Cell Physiol 220:706-15. 2009
    ..We provide evidence that LOX-1 plays a role in redox-sensitive, Akt/eNOS and Ca2+ signaling pathways in monocyte adhesion to ECs independent of the ox-LDL-LOX-1 axis...
  25. ncbi request reprint Cystatin C, a novel measure of renal function, is an independent predictor of cardiac events in patients with heart failure
    Takanori Arimoto
    From the First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    J Card Fail 11:595-601. 2005
    ..The purpose of the present study was to examine the clinical significance of serum cystatin C level in patients with mild to moderate heart failure...
  26. ncbi request reprint Midkine exacerbates pressure overload-induced cardiac remodeling
    Shunsuke Netsu
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Biochem Biophys Res Commun 443:205-10. 2014
    ..MK-Tg mice showed more severe cardiac hypertrophy and dysfunction, and showed lower survival rate after TAC than WT mice. We conclude that midkine plays a critical role in cardiac hypertrophy and remodelling. ..
  27. ncbi request reprint Cardiac-specific overexpression of diacylglycerol kinase zeta prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice
    Takanori Arimoto
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Circulation 113:60-6. 2006
    ..We hypothesized that DGK might prevent GPCR agonist-induced activation of diacylglycerol downstream signaling cascades and subsequent cardiac hypertrophy...
  28. doi request reprint Ongoing myocardial damage in patients with heart failure and preserved ejection fraction
    Daisuke Kutsuzawa
    The Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    J Cardiol 60:454-61. 2012
    ..To investigate this relationship, we measured the cardiac-specific cytosolic marker, heart-type fatty acid binding protein (H-FABP), and a myofibrillar component (troponin T), and analyzed clinical outcomes...
  29. doi request reprint Suppressive effects of valsartan on microalbuminuria and CRP in patients with metabolic syndrome (Val-Mets)
    Tetsuro Shishido
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Clin Exp Hypertens 33:117-23. 2011
    ..These results indicate that the anti-inflammatory properties of valsartan might also have beneficial effects in Mets patients without DM...
  30. ncbi request reprint Dynamic 123I-MIBG SPECT reflects sympathetic nervous integrity and predicts clinical outcome in patients with chronic heart failure
    Takanori Arimoto
    First Department of Internal Medicine, Yamagata University School of Medicine, Iida Nishi, Japan
    Ann Nucl Med 18:145-50. 2004
    ..The present results indicate a potential role of dynamic SPECT in shortening the 123I-MIBG imaging protocol...
  31. ncbi request reprint Circulating levels of heart-type fatty acid-binding protein in a general Japanese population: effects of age, gender, and physiologic characteristics
    Takeshi Niizeki
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Circ J 71:1452-7. 2007
    ..This study was carried out to examine the relationships of H-FABP levels with age, gender, and other physiologic characteristics in a large population of community-dwelling residents...
  32. ncbi request reprint Diacylglycerol kinase zeta attenuates pressure overload-induced cardiac hypertrophy
    Mutsuo Harada
    Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, Japan
    Circ J 71:276-82. 2007
    ....
  33. doi request reprint Factors correlated with plasma renin activity in general Japanese population
    Hiroshi Abiko
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2 2 2, Iida Nishi, Yamagata, 990 9585, Japan
    Clin Exp Nephrol 13:130-7. 2009
    ..However, the factors correlated with plasma renin activity (PRA) are unclarified in general Japanese population. To examine this point, we conducted a community-based cross-sectional study...
  34. pmc Diacylglycerol kinase zeta inhibits myocardial atrophy and restores cardiac dysfunction in streptozotocin-induced diabetes mellitus
    Olga Bilim
    Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Cardiovasc Diabetol 7:2. 2008
    ..Diacylglycerol kinase (DGK) converts DAG to phosphatidic acid and acts as an endogenous regulator of PKC activity. Akt/PKB is associated with a downstream insulin signaling, and PKCbeta attenuates insulin-stimulated Akt phosphorylation...
  35. ncbi request reprint An angiotensin II type-I receptor blocker, olmesartan medoxomil, attenuates lipid peroxidation in renal injury induced by subtotal nephrectomy
    Toshiyuki Takahashi
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, 990 9585, Japan
    Clin Exp Nephrol 11:202-8. 2007
    ..In this study, we examined the involvement of oxidative lipids and the effect of olmesartan on lipid peroxidation in the progressive renal injury induced by renal mass reduction in rats...
  36. doi request reprint A novel polymorphism in CDC6 is associated with the decline in lung function of ex-smokers in COPD
    Noriaki Takabatake
    Department of Pulmonary Medicine, Tohoku Central Hospital, Wagocho, Yamagata, Japan
    Biochem Biophys Res Commun 381:554-9. 2009
    ..These results suggest that CDC6 may be one of the susceptibility genes that contribute to rapid decline in lung function despite smoking cessation in these patients with COPD...
  37. ncbi request reprint Dynamic assessment of myocardial involvement in patients with end-stage renal disease by ultrasonic tissue characterization and serum markers of collagen metabolism
    Kaniz Fatema
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Clin Cardiol 27:228-34. 2004
    ..Congestive heart failure is the most common cause of mortality in patients with end-stage renal disease (ESRD). However, noninvasive assessment for cardiac involvement in ESRD has not been established...
  38. doi request reprint In a non-diabetic Japanese population, the combination of macroalbuminuria and increased urine beta 2-microglobulin predicts a decline of renal function: the Takahata study
    Ami Ikeda
    Department of Cardiology, Yamagata University School of Medicine, Yamagata, Japan
    Nephrol Dial Transplant 24:841-7. 2009
    ....
  39. ncbi request reprint Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice
    Takeshi Niizeki
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Circ J 72:309-17. 2008
    ....
  40. ncbi request reprint Ongoing myocardial damage relates to cardiac sympathetic nervous disintegrity in patients with heart failure
    Takanori Arimoto
    First Department of Internal Medicine, Division of Radiology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Ann Nucl Med 19:535-40. 2005
    ..Heart-type fatty acid binding protein (H-FABP) is released into the circulation when the myocardium is injured, and H-FABP has been recently used as a novel marker for the diagnosis of ongoing myocardial damage...
  41. ncbi request reprint Prognostic value of elevated circulating heart-type fatty acid binding protein in patients with congestive heart failure
    Takanori Arimoto
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    J Card Fail 11:56-60. 2005
    ..The purpose of the present study was to examine the clinical significance of increased serum H-FABP levels in patients with congestive heart failure...
  42. doi request reprint Usefulness of intensity variation in the left atrial appendage with contrast echocardiography to predict ischemic stroke recurrence in patients with atrial fibrillation
    Hidenobu Okuyama
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Am J Cardiol 101:1630-7. 2008
    ..244, p <0.01). In conclusion, LAA intensity variation on contrast transesophageal echocardiography is a new sensitive index for LAA flow stagnation and recurrent cerebrovascular events in patients with AF with stroke...
  43. ncbi request reprint Pentraxin 3, a new marker for vascular inflammation, predicts adverse clinical outcomes in patients with heart failure
    Satoshi Suzuki
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Am Heart J 155:75-81. 2008
    ..The purpose of the present study was to examine the clinical significance of plasma PTX3 levels in patients with heart failure...
  44. doi request reprint Relationship between antinuclear antibody and microalbuminuria in the general population: the Takahata study
    Mizue Ishikawa
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, 990 9585, Japan
    Clin Exp Nephrol 12:200-6. 2008
    ..However, the relationship between antinuclear antibody (ANA) and microalbuminuria in the general population is unknown. Thus, we conducted a cross-sectional study to examine the relationship between ANA and microalbuminuria...
  45. ncbi request reprint Adenovirus-mediated overexpression of diacylglycerol kinase-zeta inhibits endothelin-1-induced cardiomyocyte hypertrophy
    Hiroki Takahashi
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Circulation 111:1510-6. 2005
    ..Because DGK inactivates DAG, a strong activator of protein kinase C (PKC), we hypothesized that DGK inhibited ET-1-induced activation of a DAG-PKC signaling cascade and subsequent cardiomyocyte hypertrophy...
  46. ncbi request reprint A single nucleotide polymorphism in the CCL1 gene predicts acute exacerbations in chronic obstructive pulmonary disease
    Noriaki Takabatake
    First Department of Internal Medicine, Yamagata University School of Medicine 2 2 2, Iida Nishi, Yamagata 990 9585, Japan
    Am J Respir Crit Care Med 174:875-85. 2006
    ..Acute exacerbations (AEs) in chronic obstructive pulmonary disease (COPD) are a major cause of morbidity and mortality in COPD...
  47. ncbi request reprint Serum carboxy-terminal telopeptide of type I collagen (ICTP) predicts cardiac events in chronic heart failure patients with preserved left ventricular systolic function
    Tatsuro Kitahara
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Circ J 71:929-35. 2007
    ..The present study was designed to examine whether carboxy-terminal telopeptide of type I collagen (ICTP), a marker of collagen degradation, is useful for determining the prognosis of such patients...
  48. doi request reprint Overexpression of diacylglycerol kinase zeta inhibits endothelin-1-induced decreases in Ca2+ transients and cell shortening in mouse ventricular myocytes
    Kazuhide Nishimaru
    Department of Cardiovascular Pharmacology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, 990 9585 Japan
    J Mol Cell Cardiol 44:520-6. 2008
    ....
  49. ncbi request reprint Combination of heart-type fatty acid binding protein and brain natriuretic peptide can reliably risk stratify patients hospitalized for chronic heart failure
    Takeshi Niizeki
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Circ J 69:922-7. 2005
    ..The aim of the present study was to prospectively study whether a combination of markers for myocardial cell injury and left ventricular overload at admission can reliably risk stratify patients hospitalized for chronic heart failure (CHF)...
  50. pmc Long pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction
    Satoshi Suzuki
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    PLoS ONE 8:e53133. 2013
    ..This study aimed to examine the influence of PTX3 on cardiac hypertrophy and left ventricular dysfunction with respect to pressure overload...
  51. doi request reprint Usefulness of albuminuria as a prognostic indicator in patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    Takeshi Niizeki
    Department of Cardiology, Okitama Public General Hospital, Yamagata, Japan
    Am J Cardiol 111:1180-6. 2013
    ..In conclusion, albuminuria is a powerful and independent predictor of adverse prognosis in patients with CHF and could be useful for risk stratification of patients with CHF...
  52. ncbi request reprint Diminution of angiotensin II-induced contraction of the abdominal aorta isolated from Watanabe heritable hyperlipidemic rabbits
    Katsunari Tasaki
    Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, Japan
    J Smooth Muscle Res 41:87-97. 2005
    ..These results suggest that the WHHL rabbit abdominal aorta displays attenuated angiotensin II-induced contraction, mainly due to an abnormality in the angiotensin II-specific contractile pathway of the medial smooth muscle...
  53. ncbi request reprint Impact of aortic arch stiffness on recurrence of stroke in patients with acute ischemic stroke
    Hidenobu Okuyama
    Department of Cardiology, Yamagata University School of Medicine, Yamagata, Japan
    Circ J 72:1296-302. 2008
    ..The atherosclerotic process also affects aortic stiffness. The purpose of the present study was to evaluate aortic arch stiffness by transesophageal echocardiography (TEE) and its effect on recurrence of stroke...
  54. ncbi request reprint Persistently increased serum concentration of heart-type fatty acid-binding protein predicts adverse clinical outcomes in patients with chronic heart failure
    Takeshi Niizeki
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Circ J 72:109-14. 2008
    ..This study examined whether serial measurement of the H-FABP level provides additional prognostic information...
  55. ncbi request reprint Modulation of doxorubicin-induced cardiac dysfunction in toll-like receptor-2-knockout mice
    Naoki Nozaki
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Circulation 110:2869-74. 2004
    ..Oxidative stress is one of the major factors in doxorubicin (Dox)-induced cardiac dysfunction. Thus, we hypothesized that TLRs contribute to the pathogenesis of Dox-induced cardiac dysfunction...
  56. ncbi request reprint A nonfunctioning single nucleotide polymorphism in olfactory receptor gene family is associated with the forced expiratory volume in the first second/the forced vital capacity values of pulmonary function test in a Japanese population
    Noriaki Takabatake
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2 2 2, Iida Nishi, Yamagata 990 9585, Japan
    Biochem Biophys Res Commun 364:662-7. 2007
    ..0/FVC values (global P = 0.005). These results suggest that OR4X1 may be one of the genes that contribute to the individual variability of FEV1.0/FVC value in pulmonary function test...
  57. doi request reprint Combination of conventional biomarkers for risk stratification in chronic heart failure
    Takeshi Niizeki
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    J Cardiol 53:179-87. 2009
    ..Combination of several biomarkers simultaneously could enhance risk stratification in CHF...
  58. ncbi request reprint Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction
    Tetsuro Shishido
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Circulation 108:2905-10. 2003
    ..In this study, we determined whether TLR-2 was involved in cardiac remodeling after myocardial infarction...
  59. doi request reprint Soluble Receptor for advanced glycation end products (RAGE) is a prognostic factor for heart failure
    Yo Koyama
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    J Card Fail 14:133-9. 2008
    ..In the present study, we measured serum soluble RAGE levels in patients and examined whether serum soluble RAGE predicts prognosis in patients with heart failure...
  60. ncbi request reprint Long-term treatment with angiotensin II type 1 receptor antagonist, CV-11974, restores beta-catenin mRNA expression in volume-overloaded rabbit hearts
    Makoto Itoh
    First Department of Internal Medicine, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Heart Vessels 17:36-41. 2002
    ..05). These data suggest that volume overload may downregulate beta-catenin expression by an AT1 receptor-mediated pathway...
  61. doi request reprint Altered expression of antimicrobial molecules in cigarette smoke-exposed emphysematous mice lungs
    Yoko Shibata
    Department of Cardiology, Yamagata University School of Medicine, Yamagata, Japan
    Respirology 13:1061-5. 2008
    ..This study evaluated the expression of antimicrobial molecules in mice lungs with cigarette smoke-induced emphysematous changes...
  62. doi request reprint 8-Hydroxy-2'-deoxyguanosine is a prognostic mediator for cardiac event
    Satoshi Suzuki
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Eur J Clin Invest 41:759-66. 2011
    ..8-Hydroxy-2'-deoxyguanosine (8-OHdG) is produced from deoxyguanosine in DNA by ROS. The purpose of this present study was to examine the clinical significance of serum 8-OHdG levels in patients with heart failure...
  63. ncbi request reprint C-reactive protein elevation predicts the occurrence of atrial structural remodeling in patients with paroxysmal atrial fibrillation
    Tetsu Watanabe
    First Department of Internal Medicine, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Heart Vessels 20:45-9. 2005
    ..Thus, it remains unclear whether CRP and the inflammatory state are contributory to LA remodeling or whether LA remodeling or AF induces elevation in CRP and inflammation...
  64. pmc Differential regulation of diacylglycerol kinase isoform in human failing hearts
    Olga Bilim
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    J Cardiothorac Surg 6:65. 2011
    ..This is the first report that describes the differential regulation of DGK isoforms in normal and failing human hearts...
  65. doi request reprint Association of CC chemokine ligand 5 genotype with urinary albumin excretion in the non-diabetic Japanese general population: the Takahata study
    Tsuneo Konta
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, Japan
    J Hum Genet 53:267-74. 2008
    ..6 +/- 1.6 mg/g, n = 1,530) (P = 0.001). In conclusion, these results suggested that genetic variation of CCL5 might be an important risk factor for albuminuria in the non-diabetic Japanese general population...
  66. ncbi request reprint Involvement of pulmonary endothelial cell injury in the pathogenesis of pulmonary fibrosis: clinical assessment by 123I-MIBG lung scintigraphy
    Noriaki Takabatake
    First Department of Internal Medicine, Yamagata University School of Medicine, 2 2 2, Iida Nishi, Yamagata, 990 9585, Japan
    Eur J Nucl Med Mol Imaging 32:221-8. 2005
    ..The aim of this study was to evaluate the pulmonary vascular status in patients with PF by lung scintigraphic assessment of 123I-metaiodobenzylguanidine (123I-MIBG), which reflects latent endothelial cell lesions...
  67. ncbi request reprint Role of nitric oxide in the progression of cardiovascular remodeling induced by carotid arterio-venous shunt in rabbits
    Takuya Miyamoto
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Jpn Heart J 44:127-37. 2003
    ..In this model with chronic volume-overload, NO plays a pivotal role in the progression of cardiovascular remodeling by regulating the loading conditions of the heart...
  68. ncbi request reprint Elevated serum fibrin-monomer levels are associated with high long-term cerebrovascular event rates in acute ischemic stroke patients
    Harutoshi Tamura
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Circ J 71:1573-9. 2007
    ..It has been reported that, in patients with acute ischemic stroke, higher levels of serum FM reflect intracardiac thrombus formation...
  69. ncbi request reprint Ratio of peak early to late diastolic filling velocity of the left ventricular inflow is associated with left atrial appendage thrombus formation in elderly patients with acute ischemic stroke and sinus rhythm
    Liu Ling
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
    J Cardiol 48:75-84. 2006
    ..To investigate the useful parameters of transthoracic echocardiography (TTE) for the diagnosis of stroke subtypes in patients with acute cerebral infarction...
  70. ncbi request reprint High serum level of neopterin is a risk factor of patients with heart failure
    Toshiki Sasaki
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Int J Cardiol 145:318. 2010
    ..0001). In the multivariate Cox analysis, serum neopterin concentration was an independent risk factor for cardiac events (hazard ratio 1.70, 95%CI 1.16-2.50, P=0.0068). Serum neopterin concentration is a novel prognostic marker for CHF...
  71. ncbi request reprint In vivo evidence of endothelial injury in chronic obstructive pulmonary disease by lung scintigraphic assessment of (123)I-metaiodobenzylguanidine
    Tsuyoshi Arao
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    J Nucl Med 44:1747-54. 2003
    ..The aim of this study was to clarify the involvement of the pulmonary microvascular injury in the pathogenesis of chronic obstructive pulmonary disease (COPD)...
  72. ncbi request reprint [201Tl, 123I-BMIPP dual SPECT]
    Yasuchika Takeishi
    First Department of Internal Medicine, Yamagata University School of Medicine
    Nihon Rinsho 61:353-6. 2003
  73. ncbi request reprint Chronic hypertriglyceridemia in young watanabe heritable hyperlipidemic rabbits impairs endothelial and medial smooth muscle function
    Tetsuro Shishido
    First Department of Internal Medicine, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Life Sci 74:1487-501. 2004
    ..These results suggest that hypertriglyceridemia aggravates functional impairment induced by hypercholesterolemia in endothelial and smooth muscle cells...
  74. ncbi request reprint Reactive oxygen species regulate FLICE inhibitory protein (FLIP) and susceptibility to Fas-mediated apoptosis in cardiac myocytes
    Joji Nitobe
    First Department of Internal Medicine, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Cardiovasc Res 57:119-28. 2003
    ..FLICE inhibitory protein (FLIP) is a key molecule for blocking Fas-induced apoptosis by functioning as a caspase-8 dominant negative...
  75. ncbi request reprint Presence of intermittent J waves in multiple leads in relation to episode of atrial and ventricular fibrillation
    Yuichi Tsunoda
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata 990 9985, Japan
    J Electrocardiol 37:311-4. 2004
    ..He suffered spontaneous ventricular fibrillation and resuscitated by direct current. He has no structural heart disease...
  76. ncbi request reprint Comparison of nitric oxide production in response to carbachol between macrovascular and microvascular cardiac endothelial cells
    Takehiko Miyashita
    First Department of Internal Medicine, Yamagata University School of Medicine, Japan
    Circ J 66:511-5. 2002
    ..The present data suggest that the upregulation of the M3 receptor by the ACE inhibitor and AT1 receptor antagonist is a new beneficial effect of these drugs on microvascular endothelial function...
  77. ncbi request reprint A novel polymorphism in secretory phospholipase A2-IID is associated with body weight loss in chronic obstructive pulmonary disease
    Noriaki Takabatake
    First Department of Internal Medicine, Yamagata University School of Medicine, 2 2 2, Iida Nishi, Yamagata 990 9585, Japan
    Am J Respir Crit Care Med 172:1097-104. 2005
    ....
  78. ncbi request reprint Mast cells contribute to flow restoration by bone marrow cell transplantation in rats with ischemic limbs
    Hiroko Tajima
    First Department of Internal Medicine, Fukushima Medical University, Fukushima, Japan
    Int Heart J 50:247-57. 2009
    ..Mast cells may not be involved in ischemia-induced natural angiogenesis and a partial recovery of CBF, however, they appear to be involved in the therapeutic angiogenesis by BMCT...
  79. doi request reprint LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells
    Koichi Sugimoto
    First Department of Internal Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Cardiovasc Res 84:127-36. 2009
    ..Membrane type 1 matrix metalloproteinase (MT1-MMP) has been shown to be involved in atherogenesis. This study was conducted to investigate the role of the LOX-1-MT1-MMP axis in RhoA and Rac1 activation in response to ox-LDL in ECs...
  80. ncbi request reprint Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium
    Seigo Itoh
    Cardiovascular Research Institute, University of Rochester, Rochester, NY, USA
    Circulation 113:1787-98. 2006
    ....
  81. ncbi request reprint Rotigaptide (ZP123) improves atrial conduction slowing in chronic volume overload-induced dilated atria
    Ketil Haugan
    Zealand Pharma A S, Smedeland 26B, DK 2600 Glostrup, Denmark
    Basic Clin Pharmacol Toxicol 99:71-9. 2006
    ..Whether rotigaptide may possess antiarrhythmic efficacy in other models of atrial fibrillation remains to be determined...
  82. ncbi request reprint Mechanism for atrial tachyarrhythmia in chronic volume overload-induced dilated atria
    Masamichi Hirose
    Department of Molecular Pharmacology, Shinshu University School of Medicine, Nagano, Japan
    J Cardiovasc Electrophysiol 16:760-9. 2005
    ..Mechanism of chronic volume overload-induced AT...
  83. ncbi request reprint Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation
    Seigo Itoh
    Cardiovascular Research Institute, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 280:24135-42. 2005
    ..LY333,531, a specific PKCbeta inhibitor, inhibited both p90RSK and cTnI (Ser(23/24)) phosphorylation by H2O2. Taken together, our data support a new redox-sensitive mechanism regulating cTnI phosphorylation in cardiomyocytes...
  84. ncbi request reprint Remodeling of the left atrium in pacing-induced atrial cardiomyopathy
    Brian D Hoit
    University Hospitals of Cleveland and Case Western Reserve University, OH, USA
    Mol Cell Biochem 238:145-50. 2002
    ..Thus, rapid pacing-induced atrial failure is associated with differential changes in MMP activity, an unchanged number of calcium pumps, and compensatory changes in the level of phospholamban...
  85. ncbi request reprint Short cardiac iodine-123-metaiodobenzylguanidine imaging protocol in heart failure
    Takanori Arimoto
    Division of Cardiology, Ishinomaki Red Cross Hospital, Ishinomaki, Japan
    Circ J 72:1106-11. 2008
    ..For assessment of cardiac sympathetic nervous activity, the conventional protocol for iodine-123-metaiodobenzylguanidine ((123)I-MIBG) imaging requires several hours...
  86. doi request reprint Male-specific cardiac pathologies in mice lacking either the A or B subunit of factor XIII
    Masayoshi Souri
    Department of Molecular Patho Biochemistry and Patho Biology, Yamagata University, School of Medicine, Iida nishi 2 2 2, Yamagata 990 9585, Japan
    Thromb Haemost 99:401-8. 2008
    ..It is important therefore to examine possible cardiac involvement in human patients with congenital FXIII deficiency...
  87. ncbi request reprint Comparative effects of amlodipine monotherapy and combination therapy with betaxolol on cardiac autonomic nervous activity and health-related quality of life in patients with poorly controlled hypertension
    Bonpei Takase
    National Defense Medical College, Tokorozawa, Japan
    Circ J 72:764-9. 2008
    ..The aim of the study was to evaluate whether the combined treatment of calcium channel blocker, amlodipine and beta-blocker, betaxolol, favorably affects cardiac autonomic nervous activity (CANA) and health-related quality of life (HRQL)...
  88. ncbi request reprint Enhanced regional washout of technetium-99m-sestamibi in patients with coronary spastic angina
    Souichi Ono
    Department of Radiology and Cardiology, Yamagata Prefectural Shinjo Hospital, Japan
    Ann Nucl Med 17:393-8. 2003
    ..Thus, we investigated whether reverse redistribution and washout of 99mTc-sestamibi could be used in the diagnosis and follow-up of patients with coronary spastic angina...