Yuya Takakubo

Summary

Affiliation: Yamagata University
Country: Japan

Publications

  1. doi request reprint Inflammatory immune cell responses and Toll-like receptor expression in synovial tissues in rheumatoid arthritis patients treated with biologics or DMARDs
    Yuya Takakubo
    Department of Orthopedic Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Clin Rheumatol 32:853-61. 2013
  2. doi request reprint Midterm clinico-radiologic findings of an open label observation study of add-on tacrolimus with biologics or non-biologic DMARDs
    Yuya Takakubo
    Department of Orthopedic Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Rheumatol Int 32:3487-94. 2012
  3. pmc Immune-regulatory mechanisms in systemic autoimmune and rheumatic diseases
    Yuya Takakubo
    Department of Medicine, Biomedicum Helsinki, University of Helsinki, PO Box 700, Haartmaninkatu 8, 00029 HUS, Finland
    Clin Dev Immunol 2012:941346. 2012
  4. ncbi request reprint CASE REPORTS: intraarticular fibroma of the tendon sheath in the knee
    Yuya Takakubo
    Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, Japan
    Clin Orthop Relat Res 439:280-5. 2005
  5. doi request reprint Mid-term results of joint-preserving procedures by a modified Mann method for big toe deformities in rheumatoid patients undergoing forefoot surgeries
    Yuya Takakubo
    Department of Orthopedic Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, 990 9585, Japan
    Mod Rheumatol 20:147-53. 2010
  6. ncbi request reprint Distribution of myeloid dendritic cells and plasmacytoid dendritic cells in the synovial tissues of rheumatoid arthritis
    Yuya Takakubo
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, and Yamagata Saisei Hospital, Yamagata, Japan
    J Rheumatol 35:1919-31. 2008
  7. doi request reprint Toll-like receptors and their adaptors are regulated in macrophages after phagocytosis of lipopolysaccharide-coated titanium particles
    Tomoyuki Hirayama
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    J Orthop Res 29:984-92. 2011
  8. ncbi request reprint Enhanced osteolytic potential of monocytes/macrophages derived from bone marrow after particle stimulation
    Yasunobu Tamaki
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    J Biomed Mater Res B Appl Biomater 84:191-204. 2008
  9. doi request reprint Expression of Toll-like receptors and their signaling pathways in rheumatoid synovitis
    Yasunobu Tamaki
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, Japan
    J Rheumatol 38:810-20. 2011
  10. doi request reprint Increased expression of toll-like receptors in aseptic loose periprosthetic tissues and septic synovial membranes around total hip implants
    Yasunobu Tamaki
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    J Rheumatol 36:598-608. 2009

Collaborators

  • Michiaki Takagi
  • Tomoyuki Hirayama
  • Stuart B Goodman
  • Reijo Lappalainen
  • Georg Fuellen
  • Zygmunt Mackiewicz
  • Susanna Sihvonen
  • Riitta Koivuniemi
  • Yi Liu
  • Yrjo T Konttinen
  • Yasunobu Tamaki
  • Kan Sasaki
  • Pauliina Porola
  • Juji Ito
  • Emilia Kaivosoja
  • Suran Yang
  • Vasily Stegaev
  • Liisa M Virkki
  • Shinji Kobayashi
  • Akiko Sasaki
  • Katsuyuki Dairaku
  • Junya Sasaki
  • Kazuya Owashi
  • Sami Myllymaa
  • Hannu Korhonen
  • Katja Myllymaa
  • Steffi S I Falk
  • Peter Szodoray
  • Hiroharu Ohki
  • Nina Trokovic
  • Yan Bing
  • Tamon Asano
  • Heikki Valleala
  • Jorma Vuotila
  • Eero Jukka
  • Mikael Laine
  • Mari Ainola
  • Urpo Yli-Kerttula
  • Dan C Nordström
  • Maija Liisa Krogerus
  • Riitta Komulainen
  • Heikki Relas
  • Markku Mali
  • Satu Nyrhinen
  • Mitsunori Yamakawa
  • Gonçalo Baretto
  • Masaji Ishii
  • Hiroyuki Kawaji
  • Kaoru Goto
  • Hiroshi Hasegawa
  • Toshihiko Ogino
  • Jari Salo

Detail Information

Publications20

  1. doi request reprint Inflammatory immune cell responses and Toll-like receptor expression in synovial tissues in rheumatoid arthritis patients treated with biologics or DMARDs
    Yuya Takakubo
    Department of Orthopedic Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Clin Rheumatol 32:853-61. 2013
    ..Patients clinically responding to biologics might still have the potential of moderate/severe local joint inflammation, composed in particular of and possibly driven by the autoinflammatory TLR(+) cells...
  2. doi request reprint Midterm clinico-radiologic findings of an open label observation study of add-on tacrolimus with biologics or non-biologic DMARDs
    Yuya Takakubo
    Department of Orthopedic Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Rheumatol Int 32:3487-94. 2012
    ..The combination therapy of TAC with BIO or non-BIO DMARDs represents an effective and relatively safe mode of therapy in treatment-resistant RA...
  3. pmc Immune-regulatory mechanisms in systemic autoimmune and rheumatic diseases
    Yuya Takakubo
    Department of Medicine, Biomedicum Helsinki, University of Helsinki, PO Box 700, Haartmaninkatu 8, 00029 HUS, Finland
    Clin Dev Immunol 2012:941346. 2012
    ..Re-establishment of autoimmune regulation and tolerance in SAIRDs by the end of the current decade should be the final and realistic target...
  4. ncbi request reprint CASE REPORTS: intraarticular fibroma of the tendon sheath in the knee
    Yuya Takakubo
    Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, Japan
    Clin Orthop Relat Res 439:280-5. 2005
    ..Magnetic resonance imaging therefore was valid for detection of this intraarticular lesion. The lesion, which was located between the posterior capsule of the left knee and the posterior cruciate ligament, was excised arthroscopically...
  5. doi request reprint Mid-term results of joint-preserving procedures by a modified Mann method for big toe deformities in rheumatoid patients undergoing forefoot surgeries
    Yuya Takakubo
    Department of Orthopedic Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, 990 9585, Japan
    Mod Rheumatol 20:147-53. 2010
    ....
  6. ncbi request reprint Distribution of myeloid dendritic cells and plasmacytoid dendritic cells in the synovial tissues of rheumatoid arthritis
    Yuya Takakubo
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, and Yamagata Saisei Hospital, Yamagata, Japan
    J Rheumatol 35:1919-31. 2008
    ..To examine the precise tissue distribution of dendritic cells (DC) and indoleamine 2,3-dioxygenase (IDO)-expressing cells in synovial tissue and synovial fluid (SF) from patients with rheumatoid arthritis (RA) and osteoarthritis (OA)...
  7. doi request reprint Toll-like receptors and their adaptors are regulated in macrophages after phagocytosis of lipopolysaccharide-coated titanium particles
    Tomoyuki Hirayama
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    J Orthop Res 29:984-92. 2011
    ..This down- and/or up-regulation of the potential TLR-mediated responses to LPS-coated particles reflects the proactive behavior of effector cells...
  8. ncbi request reprint Enhanced osteolytic potential of monocytes/macrophages derived from bone marrow after particle stimulation
    Yasunobu Tamaki
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    J Biomed Mater Res B Appl Biomater 84:191-204. 2008
    ..This study was designed to evaluate the osteolytic potential in vitro of monocytes/macrophages derived from bone marrow...
  9. doi request reprint Expression of Toll-like receptors and their signaling pathways in rheumatoid synovitis
    Yasunobu Tamaki
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, Japan
    J Rheumatol 38:810-20. 2011
    ..Toll-like receptors (TLR) recognizing endogenous and exogenous danger signals could play a role in rheumatoid arthritis (RA). Our aim was to describe the presence, localization, and extent of expression of TLR and their adapters...
  10. doi request reprint Increased expression of toll-like receptors in aseptic loose periprosthetic tissues and septic synovial membranes around total hip implants
    Yasunobu Tamaki
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    J Rheumatol 36:598-608. 2009
    ..Our objective was to elucidate tissue localization and functional roles of TLR in periprosthetic tissues in 2 different pathologic conditions, aseptic and septic implant loosening...
  11. pmc Minocycline-induced periarticular black bones in inflamed joints which underwent arthroplastic reconstruction
    Suran Yang
    Department of Orthopedic Surgery, Yamagata University School of Medicine, Yamagata, Japan
    Clin Orthop Surg 4:181-7. 2012
    ..On a retrospective basis, we investigated the short-term clinico-radiological results of total joint arthroplasties in which the patient developed minocycline-induced periarticular black bone...
  12. doi request reprint Cement removal and bone bed preparation of the femoral medullary canal assisted by flexible endoscope in total hip revision arthroplasty
    Michiaki Takagi
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    J Orthop Sci 14:719-26. 2009
    ..The flexible endoscope was applied to cemented femoral medullary canal to obtain better visual field and assist surgical procedures in total hip revision arthroplasty...
  13. doi request reprint Osteogenesis of human mesenchymal stem cells on micro-patterned surfaces
    Emilia Kaivosoja
    Department of Medicine, Institute of Clinical Medicine, Helsinki University Central Hospital, Haartmaninkatu 8, FI 00029 HUS, Finland
    J Biomater Appl 27:862-71. 2013
    ..Results suggest that the osseocompatibility/integration of implants could be improved by changing the monotonous and featureless implant-host interface into micro-patterned interface to provide physical differentiation cues...
  14. doi request reprint Sex steroids in Sjögren's syndrome
    Yrjo T Konttinen
    Department of Medicine, Helsinki University Central Hospital, PO Box 700, 00029 HUS, Helsinki, Finland
    J Autoimmun 39:49-56. 2012
    ....
  15. pmc Initial evaluation on subsidence of cemented collarless polished tapered stem applied to the patients with narrow femoral medullar canal
    Katsuyuki Dairaku
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Open Orthop J 4:147-51. 2010
    ..We have been applied cemented collarless polished tapered (CPT) stem to the patients with small femur. Radiographic evaluation was performed to access the clinical feature of the stem in early stage of the follow-up...
  16. ncbi request reprint Toll-like receptors in the interface membrane around loosening total hip replacement implants
    Michiaki Takagi
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    J Biomed Mater Res A 81:1017-26. 2007
    ..This suppression after particle phagocytosis might prevent excessive and harmful host responses, and injury to innocent bystander cells/tissues...
  17. ncbi request reprint Laminin isoform profiles in salivary glands in Sjögren's syndrome
    Pauliina Porola
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Adv Clin Chem 55:35-59. 2011
    ..It seems that LM alterations precede the lymphocyte infiltration, suggesting that acinar BM-Int pathology, perhaps related to endo- and intracrine sex steroid metabolism, represents an early pathogenic phases in SS...
  18. ncbi request reprint Role of innate immune sensors, TLRs, and NALP3 in rheumatoid arthritis and osteoarthritis
    Yuya Takakubo
    Department of Orthopaedic Surgery, Yamagata University Faculty of Medicine, Yamagata, Japan
    J Long Term Eff Med Implants 24:243-51. 2014
    ..Precise and intensive analyses of both receptors, signal pathways, and cross talk mechanisms may provide a new therapeutic approach as molecular targets. ..
  19. doi request reprint Prevention of excessive postoperative sliding of the short femoral nail in femoral trochanteric fractures
    Juji Ito
    Department of Orthopaedic Surgery, Nihonkai General Hospital, 30 Akihocho, Sakata, Yamagata, 998 8501, Japan
    Arch Orthop Trauma Surg 135:651-7. 2015
    ..However, precise analyses of excessive sliding and lag screw cut-out were limited. The purpose of this study was to investigate the factors that induce this unfavorable event...
  20. doi request reprint Outcomes of switching anti-TNF drugs in rheumatoid arthritis--a study based on observational data from the Finnish Register of Biological Treatment (ROB-FIN)
    Liisa M Virkki
    University of Helsinki, Haartmaninkatu 8, Helsinki, Finland
    Clin Rheumatol 30:1447-54. 2011
    ..The results suggest that a second TNF blocker can restore the response in cases of secondary LOE and maintain it after switching due to an AE...