F Okada

Summary

Affiliation: Yamagata University
Country: Japan

Publications

  1. pmc Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system
    Junichi Fujii
    Department of Biomolecular Function, Yamagata University Graduate School of Medicine, 2 2 2 Iidanishi, Yamagata 990 9585, Japan
    Reprod Biol Endocrinol 3:43. 2005
  2. pmc Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase
    F Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, 2 2 2, Iidanishi, Yamagata 990 9585, Japan
    Br J Cancer 94:854-62. 2006
  3. ncbi request reprint Involvement of reactive nitrogen oxides for acquisition of metastatic properties of benign tumors in a model of inflammation-based tumor progression
    Futoshi Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Yamagata 990 9585, Japan
    Nitric Oxide 14:122-9. 2006
  4. ncbi request reprint Deterioration of ischemia/reperfusion-induced acute renal failure in SOD1-deficient mice
    Takuya Yamanobe
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, 2 2 2 Iidanishi, Yamagata, 990 9585, Japan
    Free Radic Res 41:200-7. 2007
  5. pmc Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production
    Yoshihito Iuchi
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Yamagata, Japan
    Biochem J 402:219-27. 2007
  6. pmc Thymosin-beta4 regulates motility and metastasis of malignant mouse fibrosarcoma cells
    Tokushige Kobayashi
    Division of Cancer Pathobiology, Research Section of Pathophysiology, Hokkaido University, Sapporo, Japan
    Am J Pathol 160:869-82. 2002
  7. ncbi request reprint Beyond foreign-body-induced carcinogenesis: impact of reactive oxygen species derived from inflammatory cells in tumorigenic conversion and tumor progression
    Futoshi Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Yamagata, Japan
    Int J Cancer 121:2364-72. 2007
  8. ncbi request reprint Proteomic profiling for cancer progression: Differential display analysis for the expression of intracellular proteins between regressive and progressive cancer cell lines
    Eiko Hayashi
    Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine, Ube, Japan
    Proteomics 5:1024-32. 2005
  9. ncbi request reprint Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1
    Makoto Hiromura
    Division of Cancer Biology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    J Biol Chem 279:53407-18. 2004
  10. pmc Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: implication of inflammation-associated carcinogenesis and tumor progression
    Hiroshi Tazawa
    Divisions of Cancer Pathobiology and Cancer Related Genes Research, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Am J Pathol 163:2221-32. 2003

Collaborators

  • Junichi Fujii
  • Mary Dinauer
  • Takashige Abe
  • Hiroshi Tazawa
  • Yoshihito Iuchi
  • Masanobu Kobayashi
  • Wenli Zhao
  • Mitsuteru Natsuizaka
  • Kunishige Onuma
  • Takuya Yamanobe
  • Koji Nakagawa
  • Yoshihiko Tomita
  • Stephanie Darmanin
  • Takeshi Kondo
  • Hiroki Tanaka
  • Masahiro Asaka
  • Jun ichi Hamada
  • Yuki Nagaoka
  • Eiko Hayashi
  • Tatsuya Ishii
  • Hisakazu Fujita
  • Makoto Hiromura
  • Jingxin Wang
  • Masuo Hosokawa
  • Tokushige Kobayashi
  • Satoshi Kondo
  • Masanobu Shindoh
  • Hideyuki Koide
  • Masaki Miyamoto
  • Hironobu Asao
  • Wakako Suhara
  • Mariko Ozasa
  • Tadashi Onoda
  • Fumihiro Higashino
  • Suguru Kamada
  • Kiyoshi Aita
  • Reza Shirkoohi
  • Masato Takimoto
  • Noboru Kuzumaki
  • Hongjiang Qiao
  • Satoshi Kuzumaki
  • Kazuaki Sato
  • Qiang Fu
  • Jian Chen
  • Hongyan Cui
  • Masanori Fujimoto
  • Kazuyuki Nakamura
  • Yoshihiro Ohba
  • Shinjiro Toyosaki
  • Yoshitaka Ikeda
  • Xiulian Zhang
  • Shingo Matsuki
  • Junji Hamuro
  • Yuu ichi Hattori
  • Naoki Kotani
  • Norio Iizuka
  • Kaoru Otsu
  • Yoshiya Ueyama
  • Yasuhiro Kuramitsu
  • Toshiyuki Obata
  • Daniel Auguin
  • Masayuki Noguchi
  • Takeshi Shibata
  • Christian Roumestand
  • Nobuyuki Fujii
  • Tetsuya Aoyama
  • Toshiyuki Shibata
  • Lan Yuan
  • Santoso Cornain
  • Masonobu Kobayashi
  • Naoko Tomita
  • Wei Ding
  • Satoru Ito
  • Sung Ki Choi
  • Prem Seth

Detail Information

Publications19

  1. pmc Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system
    Junichi Fujii
    Department of Biomolecular Function, Yamagata University Graduate School of Medicine, 2 2 2 Iidanishi, Yamagata 990 9585, Japan
    Reprod Biol Endocrinol 3:43. 2005
    ..Thus, many antioxidative and redox enzyme genes are expressed and aggressively protect gametes and embryos in reproductive systems...
  2. pmc Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase
    F Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, 2 2 2, Iidanishi, Yamagata 990 9585, Japan
    Br J Cancer 94:854-62. 2006
    ..These results suggested that the orally active SOD derivative prevented tumour progression promoted by inflammation, which is thought to be through scavenging inflammatory cell-derived superoxide anion...
  3. ncbi request reprint Involvement of reactive nitrogen oxides for acquisition of metastatic properties of benign tumors in a model of inflammation-based tumor progression
    Futoshi Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Yamagata 990 9585, Japan
    Nitric Oxide 14:122-9. 2006
    ..These results showed that nitric oxide and its reactive nitrogen oxide species cooperatively play a pivotal role in the progression of benign tumor cells in inflamed lesions...
  4. ncbi request reprint Deterioration of ischemia/reperfusion-induced acute renal failure in SOD1-deficient mice
    Takuya Yamanobe
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, 2 2 2 Iidanishi, Yamagata, 990 9585, Japan
    Free Radic Res 41:200-7. 2007
    ..Thus, the increased ARF in SOD1-/- mice appears to be mainly attributable to a deficiency in CuZnSOD. These data support the view that ROS are exacerbating factors in ischemia/reperfusion-induced ARF...
  5. pmc Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production
    Yoshihito Iuchi
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Yamagata, Japan
    Biochem J 402:219-27. 2007
    ....
  6. pmc Thymosin-beta4 regulates motility and metastasis of malignant mouse fibrosarcoma cells
    Tokushige Kobayashi
    Division of Cancer Pathobiology, Research Section of Pathophysiology, Hokkaido University, Sapporo, Japan
    Am J Pathol 160:869-82. 2002
    ..These findings indicate that thymosin-beta4 molecule regulates fibrosarcoma cell tumorigenicity and metastasis through actin-based cytoskeletal organization...
  7. ncbi request reprint Beyond foreign-body-induced carcinogenesis: impact of reactive oxygen species derived from inflammatory cells in tumorigenic conversion and tumor progression
    Futoshi Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Yamagata, Japan
    Int J Cancer 121:2364-72. 2007
    ....
  8. ncbi request reprint Proteomic profiling for cancer progression: Differential display analysis for the expression of intracellular proteins between regressive and progressive cancer cell lines
    Eiko Hayashi
    Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine, Ube, Japan
    Proteomics 5:1024-32. 2005
    ..The results suggest an important complementary role for proteomics in identification of molecular abnormalities in tumor progression...
  9. ncbi request reprint Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1
    Makoto Hiromura
    Division of Cancer Biology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    J Biol Chem 279:53407-18. 2004
    ..This observation will facilitate the design of specific inhibitors for Akt, a core intracellular survival factor underlying various human neoplastic diseases...
  10. pmc Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: implication of inflammation-associated carcinogenesis and tumor progression
    Hiroshi Tazawa
    Divisions of Cancer Pathobiology and Cancer Related Genes Research, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Am J Pathol 163:2221-32. 2003
    ..These results suggested that inflammation, especially when neutrophils infiltrate into tumor tissue, is primarily important for benign tumor cells to acquire metastatic phenotype...
  11. ncbi request reprint Synergistic up-regulation of Hexokinase-2, glucose transporters and angiogenic factors in pancreatic cancer cells by glucose deprivation and hypoxia
    Mitsuteru Natsuizaka
    Department of Pathological Oncology, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, Japan
    Exp Cell Res 313:3337-48. 2007
    ..Our results thus suggest that the enhanced expressions of those genes mediated by the activation of AMPK and HIF-1 therefore play a pivotal role in the tumor formation of pancreatic cancers...
  12. ncbi request reprint Suppression of in vivo tumorigenicity of rat hepatoma cell line KDH-8 cells by soluble TGF-beta receptor type II
    Wenli Zhao
    Division of Cancer Pathobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo, Hokkaido 060 0815, Japan
    Cancer Immunol Immunother 51:381-8. 2002
    ....
  13. ncbi request reprint Inflammation and free radicals in tumor development and progression
    Futoshi Okada
    Division of Cancer Pathobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Redox Rep 7:357-68. 2002
    ..This article reviews the current findings linking inflammation and cancer, and shed light on inflammatory cell-derived free radicals as major endogenous reactive substances for tumor development and progression...
  14. pmc The role of nicotinamide adenine dinucleotide phosphate oxidase-derived reactive oxygen species in the acquisition of metastatic ability of tumor cells
    Futoshi Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, 2 2 2, Iidanishi, Yamagata 990 9585 Japan
    Am J Pathol 169:294-302. 2006
    ....
  15. ncbi request reprint Establishment and characterization of human urothelial cancer xenografts in severe combined immunodeficient mice
    Takashige Abe
    Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Urol 13:47-57. 2006
    ..To establish and characterize a murine xenograft model of human urothelial cancer in severe combined immunodeficient (SCID) mice for therapeutic simulation...
  16. ncbi request reprint Hypoxia suppresses the production of matrix metalloproteinases and the migration of human monocyte-derived dendritic cells
    Wenli Zhao
    Department of Pathological Oncology, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Eur J Immunol 35:3468-77. 2005
    ..Our results suggest that the hypoxic microenvironment in solid tumor tissues may suppress the function of DC...
  17. ncbi request reprint siRNA gelsolin knockdown induces epithelial-mesenchymal transition with a cadherin switch in human mammary epithelial cells
    Hiroki Tanaka
    Division of Cancer Gene Regulation, Research Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Int J Cancer 118:1680-91. 2006
    ....
  18. ncbi request reprint Accelerated impairment of spermatogenic cells in SOD1-knockout mice under heat stress
    Tatsuya Ishii
    Department of Urology, Yamagata University School of Medicine, 2 2 2 Iidanishi, Yamagata, 990 9585, Japan
    Free Radic Res 39:697-705. 2005
    ..Alternatively, since even a short exposure triggers harmful damage to spermatogenic cells, generated ROS may function as a type of signal for cell death rather than directly causing oxidative damage to cells...
  19. ncbi request reprint Specific inactivation of cysteine protease-type cathepsin by singlet oxygen generated from naphthalene endoperoxides
    Yuki Nagaoka
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Japan
    Biochem Biophys Res Commun 331:215-23. 2005
    ..These data suggest that singlet oxygen oxidatively modifies an amino acid residue essential for catalysis and consequently results in the irreversible inactivation of cysteine protease-type cathepsin...