F Okada

Summary

Affiliation: Yamagata University
Country: Japan

Publications

  1. ncbi Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system
    Junichi Fujii
    Department of Biomolecular Function, Yamagata University Graduate School of Medicine, 2 2 2 Iidanishi, Yamagata 990 9585, Japan
    Reprod Biol Endocrinol 3:43. 2005
  2. ncbi Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase
    F Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, 2 2 2, Iidanishi, Yamagata 990 9585, Japan
    Br J Cancer 94:854-62. 2006
  3. ncbi Involvement of reactive nitrogen oxides for acquisition of metastatic properties of benign tumors in a model of inflammation-based tumor progression
    Futoshi Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Yamagata 990 9585, Japan
    Nitric Oxide 14:122-9. 2006
  4. ncbi Deterioration of ischemia/reperfusion-induced acute renal failure in SOD1-deficient mice
    Takuya Yamanobe
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, 2 2 2 Iidanishi, Yamagata, 990 9585, Japan
    Free Radic Res 41:200-7. 2007
  5. ncbi Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production
    Yoshihito Iuchi
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Yamagata, Japan
    Biochem J 402:219-27. 2007
  6. ncbi Thymosin-beta4 regulates motility and metastasis of malignant mouse fibrosarcoma cells
    Tokushige Kobayashi
    Division of Cancer Pathobiology, Research Section of Pathophysiology, Hokkaido University, Sapporo, Japan
    Am J Pathol 160:869-82. 2002
  7. ncbi Beyond foreign-body-induced carcinogenesis: impact of reactive oxygen species derived from inflammatory cells in tumorigenic conversion and tumor progression
    Futoshi Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Yamagata, Japan
    Int J Cancer 121:2364-72. 2007
  8. ncbi Proteomic profiling for cancer progression: Differential display analysis for the expression of intracellular proteins between regressive and progressive cancer cell lines
    Eiko Hayashi
    Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine, Ube, Japan
    Proteomics 5:1024-32. 2005
  9. ncbi Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1
    Makoto Hiromura
    Division of Cancer Biology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    J Biol Chem 279:53407-18. 2004
  10. ncbi Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: implication of inflammation-associated carcinogenesis and tumor progression
    Hiroshi Tazawa
    Divisions of Cancer Pathobiology and Cancer-Related Genes Research, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Am J Pathol 163:2221-32. 2003

Collaborators

  • Hiroshi Tazawa
  • Junichi Fujii
  • Mary Dinauer
  • Takashige Abe
  • Yoshihito Iuchi
  • Masanobu Kobayashi
  • Wenli Zhao
  • Mitsuteru Natsuizaka
  • Kunishige Onuma
  • Takuya Yamanobe
  • Koji Nakagawa
  • Masahiro Asaka
  • Yoshihiko Tomita
  • Takeshi Kondo
  • Hiroki Tanaka
  • Stephanie Darmanin
  • Jun-ichi Hamada
  • Tatsuya Ishii
  • Yuki Nagaoka
  • Eiko Hayashi
  • Makoto Hiromura
  • Hisakazu Fujita
  • Jingxin Wang
  • Tokushige Kobayashi
  • Masuo Hosokawa
  • Wakako Suhara
  • Mariko Ozasa
  • Kiyoshi Aita
  • Masanobu Shindoh
  • Suguru Kamada
  • Hideyuki Koide
  • Fumihiro Higashino
  • Satoshi Kondo
  • Masaki Miyamoto
  • Hironobu Asao
  • Tadashi Onoda
  • Jun ichi Hamada
  • Hongjiang Qiao
  • Noboru Kuzumaki
  • Masato Takimoto
  • Reza Shirkoohi
  • Satoshi Kuzumaki
  • Yoshiya Ueyama
  • Yuu-ichi Hattori
  • Yoshitaka Ikeda
  • Xiulian Zhang
  • Naoki Kotani
  • Kazuaki Sato
  • Jian Chen
  • Kaoru Otsu
  • Masanori Fujimoto
  • Shinjiro Toyosaki
  • Qiang Fu
  • Yoshihiro Ohba
  • Norio Iizuka
  • Junji Hamuro
  • Shingo Matsuki
  • Hongyan Cui
  • Yasuhiro Kuramitsu
  • Kazuyuki Nakamura
  • Daniel Auguin
  • Masayuki Noguchi
  • Christian Roumestand
  • Takeshi Shibata
  • Toshiyuki Obata
  • Santoso Cornain
  • Masonobu Kobayashi
  • Toshiyuki Shibata
  • Sung Ki Choi
  • Wei Ding
  • Tetsuya Aoyama
  • Satoru Ito
  • Prem Seth
  • Naoko Tomita
  • Nobuyuki Fujii
  • Lan Yuan

Detail Information

Publications19

  1. ncbi Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system
    Junichi Fujii
    Department of Biomolecular Function, Yamagata University Graduate School of Medicine, 2 2 2 Iidanishi, Yamagata 990 9585, Japan
    Reprod Biol Endocrinol 3:43. 2005
    ..Thus, many antioxidative and redox enzyme genes are expressed and aggressively protect gametes and embryos in reproductive systems...
  2. ncbi Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase
    F Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, 2 2 2, Iidanishi, Yamagata 990 9585, Japan
    Br J Cancer 94:854-62. 2006
    ..These results suggested that the orally active SOD derivative prevented tumour progression promoted by inflammation, which is thought to be through scavenging inflammatory cell-derived superoxide anion...
  3. ncbi Involvement of reactive nitrogen oxides for acquisition of metastatic properties of benign tumors in a model of inflammation-based tumor progression
    Futoshi Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Yamagata 990 9585, Japan
    Nitric Oxide 14:122-9. 2006
    ..These results showed that nitric oxide and its reactive nitrogen oxide species cooperatively play a pivotal role in the progression of benign tumor cells in inflamed lesions...
  4. ncbi Deterioration of ischemia/reperfusion-induced acute renal failure in SOD1-deficient mice
    Takuya Yamanobe
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, 2 2 2 Iidanishi, Yamagata, 990 9585, Japan
    Free Radic Res 41:200-7. 2007
    ..Thus, the increased ARF in SOD1-/- mice appears to be mainly attributable to a deficiency in CuZnSOD. These data support the view that ROS are exacerbating factors in ischemia/reperfusion-induced ARF...
  5. ncbi Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production
    Yoshihito Iuchi
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Yamagata, Japan
    Biochem J 402:219-27. 2007
    ....
  6. ncbi Thymosin-beta4 regulates motility and metastasis of malignant mouse fibrosarcoma cells
    Tokushige Kobayashi
    Division of Cancer Pathobiology, Research Section of Pathophysiology, Hokkaido University, Sapporo, Japan
    Am J Pathol 160:869-82. 2002
    ..These findings indicate that thymosin-beta4 molecule regulates fibrosarcoma cell tumorigenicity and metastasis through actin-based cytoskeletal organization...
  7. ncbi Beyond foreign-body-induced carcinogenesis: impact of reactive oxygen species derived from inflammatory cells in tumorigenic conversion and tumor progression
    Futoshi Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Yamagata, Japan
    Int J Cancer 121:2364-72. 2007
    ....
  8. ncbi Proteomic profiling for cancer progression: Differential display analysis for the expression of intracellular proteins between regressive and progressive cancer cell lines
    Eiko Hayashi
    Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine, Ube, Japan
    Proteomics 5:1024-32. 2005
    ..The results suggest an important complementary role for proteomics in identification of molecular abnormalities in tumor progression...
  9. ncbi Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1
    Makoto Hiromura
    Division of Cancer Biology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    J Biol Chem 279:53407-18. 2004
    ..This observation will facilitate the design of specific inhibitors for Akt, a core intracellular survival factor underlying various human neoplastic diseases...
  10. ncbi Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: implication of inflammation-associated carcinogenesis and tumor progression
    Hiroshi Tazawa
    Divisions of Cancer Pathobiology and Cancer-Related Genes Research, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Am J Pathol 163:2221-32. 2003
    ..These results suggested that inflammation, especially when neutrophils infiltrate into tumor tissue, is primarily important for benign tumor cells to acquire metastatic phenotype...
  11. ncbi Synergistic up-regulation of Hexokinase-2, glucose transporters and angiogenic factors in pancreatic cancer cells by glucose deprivation and hypoxia
    Mitsuteru Natsuizaka
    Department of Pathological Oncology, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, Japan
    Exp Cell Res 313:3337-48. 2007
    ..Our results thus suggest that the enhanced expressions of those genes mediated by the activation of AMPK and HIF-1 therefore play a pivotal role in the tumor formation of pancreatic cancers...
  12. ncbi Suppression of in vivo tumorigenicity of rat hepatoma cell line KDH-8 cells by soluble TGF-beta receptor type II
    Wenli Zhao
    Division of Cancer Pathobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, Hokkaido 060-0815, Japan
    Cancer Immunol Immunother 51:381-8. 2002
    ....
  13. ncbi Inflammation and free radicals in tumor development and progression
    Futoshi Okada
    Division of Cancer Pathobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Redox Rep 7:357-68. 2002
    ..This article reviews the current findings linking inflammation and cancer, and shed light on inflammatory cell-derived free radicals as major endogenous reactive substances for tumor development and progression...
  14. ncbi The role of nicotinamide adenine dinucleotide phosphate oxidase-derived reactive oxygen species in the acquisition of metastatic ability of tumor cells
    Futoshi Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, 2 2 2, Iidanishi, Yamagata 990 9585 Japan
    Am J Pathol 169:294-302. 2006
    ....
  15. ncbi Establishment and characterization of human urothelial cancer xenografts in severe combined immunodeficient mice
    Takashige Abe
    Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Urol 13:47-57. 2006
    ..To establish and characterize a murine xenograft model of human urothelial cancer in severe combined immunodeficient (SCID) mice for therapeutic simulation...
  16. ncbi Hypoxia suppresses the production of matrix metalloproteinases and the migration of human monocyte-derived dendritic cells
    Wenli Zhao
    Department of Pathological Oncology, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Eur J Immunol 35:3468-77. 2005
    ..Our results suggest that the hypoxic microenvironment in solid tumor tissues may suppress the function of DC...
  17. ncbi siRNA gelsolin knockdown induces epithelial-mesenchymal transition with a cadherin switch in human mammary epithelial cells
    Hiroki Tanaka
    Division of Cancer Gene Regulation, Research Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Int J Cancer 118:1680-91. 2006
    ....
  18. ncbi Accelerated impairment of spermatogenic cells in SOD1-knockout mice under heat stress
    Tatsuya Ishii
    Department of Urology, Yamagata University School of Medicine, 2 2 2 Iidanishi, Yamagata, 990 9585, Japan
    Free Radic Res 39:697-705. 2005
    ..Alternatively, since even a short exposure triggers harmful damage to spermatogenic cells, generated ROS may function as a type of signal for cell death rather than directly causing oxidative damage to cells...
  19. ncbi Specific inactivation of cysteine protease-type cathepsin by singlet oxygen generated from naphthalene endoperoxides
    Yuki Nagaoka
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Japan
    Biochem Biophys Res Commun 331:215-23. 2005
    ..These data suggest that singlet oxygen oxidatively modifies an amino acid residue essential for catalysis and consequently results in the irreversible inactivation of cysteine protease-type cathepsin...