W Kimura

..There have been only a few reports on follow-up results of serous cystic neoplasm (SCN) of the pancreas. The frequency of malignancy and surgical indication of SCN are not determined yet...

..Benign lesions as well as low-grade malignancy of the body and tail of the pancreas may be a possible indication for this procedure...

..Therefore, a classification system for epithelial atypism, which can be used for all of the ducts and ductules of the pancreas, regardless of their diameter, should be developed as a "common world language"...

..If the anastomosis leaks, the massive flow of pancreatic juice around the anastomosis is prevented because of the pancreatic juice flowing out of the pancreatic tube...

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..To evaluate the expression and role of c-kit protein in the neoplasia of pancreatic neoplasms and its relationship to prognosis in invasive ductal carcinoma (IDC) of the pancreas...

..This may explain why there are few reports of the co-existence of IPMN and pancreatic stones (Kimura in Kan Tan Sui 58:485-492, 2009)...

..This type of carcinoma should be classified as a new disease entity of carcinoma of the pancreas...

..The aim of this study was to identify which epithelial lesion was a precursor of duct cell carcinoma and to determine how many millimeters atypical epithelia spread intraductally before beginning to infiltrate...

..Spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein is easy and safe, and should be performed for some patients with intraductal papillary mucinous tumor of the pancreas...

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..Gallbladder carcinoma develops in more than 90% of pancreaticobiliary maljunction without bile duct dilatation...

..The aim of this study was to investigate the clinicopathological features of and therapeutic strategy for this ailment...

..Knowledge of transversely oriented arterial systems within the pancreas that would need to be ligated in most forms of pancreatic surgery is clinically important. We studied the anatomy of arteries running transversely in the pancreas...

..Akt/PKB promotes cell proliferation and rescues cells from apoptosis...

..The proposed entity of the direct, long descending pathway will influence the selection and modification of lymphadenectomy methods in cancer surgery in the pancreaticoduodenal region...

..Therefore, patients with this unusual disease entity should be carefully followed up after resection of the primary tumor...

..6 and 1.1 cm, respectively, in diameter on computed tomography...

..The diagnostic values of the expression of Survivin, p53, and Bcl-2 and the apoptotic index (AI) and Ki-67 labeling index (Ki-67 LI) in IPMT were also examined...

..02). These suggest that in carcinoma of the papilla of Vater, TP production by tumor cells is correlated with tumor progression through its regulatory effect on neovascularization...

..Recently, two-staged pancreatoduodenectomy including exteriorization of the pancreatic juice and second-look pancreaticojejunostomy was performed in high-risk patients...

..Therefore, in patients with small HCCs and good liver function, the first choice treatment should not be ethanol injection, but surgical resection...

..The histone-modifying enzymes histone deacetylase (HDAC) and histone acetyltransferase (HAT) control gene transcriptional activation and repression in human malignancies...

..We classified IPMNs at our institute and used this classification to determine the clinicopathological features, prognosis, and malignant potential of the 4 types...

..Although this procedure is somewhat complicated, it is not technically difficult and can be safely performed by any surgeon. This procedure is indicated for some cases with chronic pancreatitis and IPMT...

..The positive results in this patient suggest that resection of the confluence of the hepatic duct may be an effective surgical treatment for noncirrhotic PSC patients who have dominant extrahepatic strictures...

..Perineural invasion is regarded as a factor associated with local recurrence of pancreatic cancer...

..However, the collateral of the recR and its direct drainage to the venous system suggested that the recR involvement often corresponds to a systemic disease...

..The current case is very rare, however, if patients with carcinoma of the papilla of Vater have localized liver metastases and no local recurrence, liver metastases should be resected to improve the chances for long-term survival...

..Therefore, we suggest that de novo IDC may occur in IPMT patients, especially those with multiple tumor recurrence. The present case may be helpful in understanding the pathogenesis of pancreatic duct lesions...

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..Just after the operation, normal saline is added through the feeding tube and the Faycon drainage tube is suctioned continuously. Irrigation is necessary for more than two weeks...

..The results support the reliability of the extended D2 lymphadenectomy (D2 + group 16b1 nodes + group 16a2-inter node) for curative cancer surgery in the pancreaticoduodenal region...

..Such indication of the direction of differentiation seemed to appear in PanIN1-2, even before abnormalities of HER2/neu, Akt/PKB, DPC4/Smad4, p53, and cyclin A expression began to be detected...

..With the operative procedure and postoperative controls described above, operative mortality was zero in 114 consecutive patients in our series who underwent pancreaticoduodenectomy...

..An increased survival benefit was obtained by repeat hepatectomy for recurrent hepatic metastases. Preoperative portal embolization extended the indication for hepatectomy and provided postoperative safety...

..Conservative treatment options include endoscopic stenting of the minor papilla, but long-term outcomes remain unclear. Pancreatoduodenectomy is a rational treatment for symptomatic groove pancreatitis...

..Therefore, we conclude that PTEN does not participate in gastric carcinogenesis as a tumor suppressor gene...

..The aim of the present study was to compare the expression levels of the cyclins and the differentiation-related factors in pancreatic neoplasms...

..Such organ-preserving procedures are: duodenum-preserving pancreas head resection, spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein, and so on...

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..01). These results indicate that DCC is frequently silenced, probably by epigenetic mechanisms instead of sequence mutations in gastric cancer...

..We limited the drainage operation for pancreatic trauma. As a result, the pancreatic body and tail were preserved, which is thought to be a much better long-term result for this patient...

..2. These data indicate that bi-allelic hypermethylation of the TSLC1 promoter and resulting gene silencing occur in a subset of primary gastric cancers...

..To date, there has been reporting of extended lymph node dissection and adjuvant chemotherapy in patients with carcinoma of the papilla of Vater. Further studies will be necessary to resolve these problems...

..Adjuvant chemotherapy with TS-1 was administered on an out-patient basis 6 weeks after the operation. The patient is well and has now been free of symptoms of recurrence and metastasis for 8 months...

..Hilar bile duct cancer progresses slowly but easily invades the nearby portal vein or hepatic artery. Thus, in some cases, curative resection is impossible, so we need to determine the best non-surgical treatments for this tumor...

..In addition, we investigated the influence of E-cadherin and matrix metalloproteinase (MMP)-7 expression on the development of micrometastases...

..Hypermethylation of DAP-kinase appears to be a significant prognostic factor in primary biliary tract carcinomas...

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..CONCLUSIONS: Spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein is easy and safe, and should be performed for some of the patients with intraductal papillary mucinous tumor of the pancreas...

..Margin-positive or negative resection has often been reported to correlate with the prognosis. Moreover, the value of combined vessel resection for hilar bile duct cancer is still obscure...

..The reason is that it is impossible to completely investigate positive or negative carcinoma in the cut end of the nerve plexus after surgery, since the cut end is long and some specimens are deformed by formalin fixation...

..Yet the pathophysiological significance is controversial, because previous in vitro studies have shown that the enzyme has little cytotoxicity or ability to activate the arachidonic acid cascade by itself in contrast to other isozymes...

..There are three possible origins of endocrine tumors of the pancreas: Langerhans islets cells, ductular cells, and acinar cells...

..The aim of this study is to assess the postoperative outcome of the two reconstruction methods using both a free jejunal graft and a venous-reconstructed gastric tube or a gastric tube alone after total pharyngolaryngoesophagectomy...

..Furthermore, the role of p53 expression in tumor neovascularization was also examined in this study...

..The aim of this study was to investigate MUC5AC and MUC6 expressions in IDC with special reference to clinicopathological factors and patient prognosis...

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..We suggest that total papillectomy can be performed for an intestinal, borderline malignant tumor...

..Consequenly, the filtration function of most of Virchow's node seemed to be quite limited...

..In conclusion, we treated a rare AFP-producing pancreatic cancer with radiotherapy, which was effective. However, care is needed to avoid external beam radiation-induced gastrointestinal ulceration...

..Whenever possible, biliary drainage should not be performed in the lobe undergoing hepatectomy. (99m)Tc-GSA SPECT scintigraphy is useful for the evaluation of postoperative liver failure...

..The hanging maneuver by an anterior approach without mobilization is convenient for right or left hepatectomy for large tumors or hardened liver...

..CONCLUSIONS: TXA(2) synthesis by circulating pancreatic PLA(2) contributes to metabolic acidosis and thrombocytopenia during acute pancreatitis...

..It is therefore suggested that alterations in biliary bilirubin subfractions might accurately reflect the energy state of the remnant liver following hepatectomy...

..The inferior vena cava ligament is a fibrous membrane located around the inferior vena cava. Few reports exist on the ligament's location, attachment to the liver, or the inferior vena cava...

..Histological examination of the resected stomach and lymph nodes revealed no remaining viable cancer cells. The patient has been doing well without any recurrence for 1 year since the start of treatment...

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..Preparation for postoperative respiratory complications and cardiovascular diseases might help to save lives of the elderly...

..However, early postoperative liver function and long-term regeneration of segment 6 after IRHV-preserving hepatectomy remains unclear...

..Surgery and chemotherapy for elderly patients are also increasing. We evaluated the characteristics of elderly colorectal cancer to clarify issues related to surgical therapy for elderly patients...

..5% in invasive carcinoma cases. In conclusion, IPMT and MCT show distinct clinicopathologic and prognostic differences. The results from this study may contribute to the diagnosis and treatment of IPMT and MCT...

..To our knowledge, this is the first reported case of UC in situ without evident extraductal invasion in English literature...

..Pancreatic serous cystadenomas that include a mucinous-cystadenoma component are extremely rare, and the difference between serous and mucinous cystadenomas is not always distinct...