Junichi Fujii


Affiliation: Yamagata University
Country: Japan


  1. Fujii J, Homma T, Kobayashi S, Seo H. Mutual interaction between oxidative stress and endoplasmic reticulum stress in the pathogenesis of diseases specifically focusing on non-alcoholic fatty liver disease. World J Biol Chem. 2018;9:1-15 pubmed publisher
  2. Konno T, Otsuki N, Kurahashi T, Kibe N, Tsunoda S, Iuchi Y, et al. Reactive oxygen species exacerbate autoimmune hemolytic anemia in New Zealand Black mice. Free Radic Biol Med. 2013;65:1378-1384 pubmed publisher
    ..These results were consistent with the hypothetical role of reactive oxygen species in triggering the autoimmune reaction in RBCs and may provide a novel approach to mitigating the progression of AIHA by reducing oxidative stress. ..
  3. Ito J, Otsuki N, Zhang X, Konno T, Kurahashi T, Takahashi M, et al. Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice. Life Sci. 2014;95:1-8 pubmed publisher
    ..Pentobarbital action is increased under conditions of ascorbic acid deficiency, and this may have to be taken into account when anesthetizing malnourished patients. ..
  4. Lee J, Homma T, Kobayashi S, Ishii N, Fujii J. Unveiling systemic organ disorders associated with impaired lipid catabolism in fasted SOD1-deficient mice. Arch Biochem Biophys. 2018;654:163-171 pubmed publisher
    ..These collective data suggest that the lipid-catabolizing system is the sensitive target of oxidative stress triggered by fasting conditions in the KO mice. ..
  5. Kurahashi T, Hamashima S, Shirato T, Lee J, Homma T, Kang E, et al. An SOD1 deficiency enhances lipid droplet accumulation in the fasted mouse liver by aborting lipophagy. Biochem Biophys Res Commun. 2015;467:866-71 pubmed publisher
  6. Fujii J, Ikeda Y, Kurahashi T, Homma T. Physiological and pathological views of peroxiredoxin 4. Free Radic Biol Med. 2015;83:373-9 pubmed publisher
    ..Elucidation of these PRDX4 functions under in vivo situations is expected to show the whole picture of how PRDX4 has evolved in multicellular organisms. ..
  7. Lee J, Homma T, Kurahashi T, Kang E, Fujii J. Oxidative stress triggers lipid droplet accumulation in primary cultured hepatocytes by activating fatty acid synthesis. Biochem Biophys Res Commun. 2015;464:229-35 pubmed publisher
    ..Levels of enzymes involved in lipogenesis were elevated. It thus appears that lipogenesis is activated by oxidative stress, which is more prominent in the case of Sod1 deficiency, and appears to participate in liver steatosis. ..
  8. Homma T, Kurahashi T, Lee J, Kang E, Fujii J. SOD1 deficiency decreases proteasomal function, leading to the accumulation of ubiquitinated proteins in erythrocytes. Arch Biochem Biophys. 2015;583:65-72 pubmed publisher
    ..We conclude that an oxidative stress-induced malfunction in the scavenging activity of proteasomes accelerates the accumulation of damaged proteins, leading to a shortened lifespan of RBCs and, hence, anemia. ..
  9. Guo X, Noguchi H, Ishii N, Homma T, Hamada T, Hiraki T, et al. The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma. Antioxid Redox Signal. 2018;: pubmed publisher

More Information


  1. Otsuki N, Homma T, Fujiwara H, Kaneko K, Hozumi Y, Shichiri M, et al. Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase. Regul Toxicol Pharmacol. 2016;79:83-90 pubmed publisher
    ..Taken together, these data indicate that SOD1 plays a pivotal role in protecting motor neuron function against TCE toxicity. ..
  2. Shirato T, Homma T, Lee J, Kurahashi T, Fujii J. Oxidative stress caused by a SOD1 deficiency ameliorates thioacetamide-triggered cell death via CYP2E1 inhibition but stimulates liver steatosis. Arch Toxicol. 2017;91:1319-1333 pubmed publisher
    ..We conclude that elevated TAA metabolites and reactive oxygen species that are produced by CYP-mediated drug metabolism trigger lipogenesis as well as liver damage via ER stress and determine the fate of the mice. ..
  3. Kurahashi T, Lee J, Nabeshima A, Homma T, Kang E, Saito Y, et al. Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy. Arch Biochem Biophys. 2016;604:36-46 pubmed publisher
  4. Homma T, Okano S, Lee J, Ito J, Otsuki N, Kurahashi T, et al. SOD1 deficiency induces the systemic hyperoxidation of peroxiredoxin in the mouse. Biochem Biophys Res Commun. 2015;463:1040-6 pubmed publisher
  5. Homma T, Fujii J. Heat stress promotes the down-regulation of IRE1? in cells: An atypical modulation of the UPR pathway. Exp Cell Res. 2016;349:128-138 pubmed publisher
    ..These collective results suggest that heat stress simultaneously activates both the UPR and autophagy, followed by the activation of a negative feedback system in UPR by modulating the responses related to the IRE1?-XBP-1 axis. ..
  6. Ito J, Ishii N, Akihara R, Lee J, Kurahashi T, Homma T, et al. A high-fat diet temporarily renders Sod1-deficient mice resistant to an oxidative insult. J Nutr Biochem. 2017;40:44-52 pubmed publisher
  7. Homma T, Akihara R, Okano S, Shichiri M, Yoshida Y, Yamada K, et al. Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a). Behav Brain Res. 2017;319:219-224 pubmed publisher
    ..These results suggest that Akr1a might be involved in the metabolism of steroids and other carbonyl-containing compounds and, hence, the absence of Akr1a results in heightened aggression via a malfunction in a metabolic pathway. ..
  8. Kobayashi S, Lee J, Takao T, Fujii J. Increased ophthalmic acid production is supported by amino acid catabolism under fasting conditions in mice. Biochem Biophys Res Commun. 2017;491:649-655 pubmed publisher
    ..Thus the consumption of Cys and the parallel elevation of 2AB under fasting conditions appeared to force ?-glutamylcysteine synthetase to form ?-glutamyl-2AB, despite the fact that the enzyme has a higher Km value for 2AB than Cys. ..
  9. Fujii J, Iuchi Y, Okada F. Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system. Reprod Biol Endocrinol. 2005;3:43 pubmed
    ..Thus, many antioxidative and redox enzyme genes are expressed and aggressively protect gametes and embryos in reproductive systems. ..
  10. Lee J, Kang E, Kobayashi S, Homma T, Sato H, Seo H, et al. The viability of primary hepatocytes is maintained under a low cysteine-glutathione redox state with a marked elevation in ophthalmic acid production. Exp Cell Res. 2017;361:178-191 pubmed publisher
    ..Thus, OPT may become a marker for Cys insufficiency and might be used to predict pathological conditions of cells with elevated oxidative stress...
  11. Lee J, Homma T, Fujii J. Mice in the early stage of liver steatosis caused by a high fat diet are resistant to thioacetamide-induced hepatotoxicity and oxidative stress. Toxicol Lett. 2017;277:92-103 pubmed publisher
  12. Akihara R, Homma T, Lee J, Yamada K, Miyata S, Fujii J. Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress. Biochem Biophys Res Commun. 2016;478:765-71 pubmed publisher
    ..Based on these collective results, we conclude that Akr1a exerts a protective effect against CCl4-induced hepatic steatosis by replenishing AsA via its antioxidative properties. ..