M Daimon

Summary

Affiliation: Yamagata University
Country: Japan

Publications

  1. ncbi request reprint Association of the ABCA1 gene polymorphisms with type 2 DM in a Japanese population
    Makoto Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Biochem Biophys Res Commun 329:205-10. 2005
  2. doi request reprint Thyroid dysfunction in patients treated with tyrosine kinase inhibitors, sunitinib, sorafenib and axitinib, for metastatic renal cell carcinoma
    Makoto Daimon
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan
    Jpn J Clin Oncol 42:742-7. 2012
  3. ncbi request reprint Serum glycerophosphate levels are increased in Japanese men with type 2 diabetes
    Makoto Daimon
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology DNHMED, Yamagata University School of Medicine, Japan
    Intern Med 51:545-51. 2012
  4. doi request reprint Higher plasma renin activity is a risk factor for total mortality in older Japanese individuals: the Takahata study
    Makoto Daimon
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, Yamagata, Japan
    Metabolism 61:504-11. 2012
  5. doi request reprint Association of the clusterin gene polymorphisms with type 2 diabetes mellitus
    Makoto Daimon
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata 990 9585, Japan
    Metabolism 60:815-22. 2011
  6. ncbi request reprint Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese Population: the Funagata study
    Makoto Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Diabetes Care 26:2015-20. 2003
  7. ncbi request reprint Calpain 10 gene polymorphisms are related, not to type 2 diabetes, but to increased serum cholesterol in Japanese
    Makoto Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Diabetes Res Clin Pract 56:147-52. 2002
  8. ncbi request reprint Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM
    Makoto Daimon
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Biochem Biophys Res Commun 374:576-80. 2008
  9. ncbi request reprint Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM
    Makoto Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Biochem Biophys Res Commun 386:26-9. 2009
  10. ncbi request reprint Association of nephrin gene polymorphisms with type 2 diabetes in a Japanese population: The Funagata study
    Makoto Daimon
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology DNHMED, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Diabetes Care 29:1117-9. 2006

Collaborators

Detail Information

Publications73

  1. ncbi request reprint Association of the ABCA1 gene polymorphisms with type 2 DM in a Japanese population
    Makoto Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Biochem Biophys Res Commun 329:205-10. 2005
    ..0001), with an odds ratio (OR) of 2.53 (95%CI:1.62-4.12). Diplotype analysis also showed a significant association of the diplotypes with the haplotype 2 (OR:2.59, 95%CI:1.48-4.54, p = 0.0013)...
  2. doi request reprint Thyroid dysfunction in patients treated with tyrosine kinase inhibitors, sunitinib, sorafenib and axitinib, for metastatic renal cell carcinoma
    Makoto Daimon
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan
    Jpn J Clin Oncol 42:742-7. 2012
    ..As a result, unusual adverse effects, including thyroid dysfunction, have become important clinical issues...
  3. ncbi request reprint Serum glycerophosphate levels are increased in Japanese men with type 2 diabetes
    Makoto Daimon
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology DNHMED, Yamagata University School of Medicine, Japan
    Intern Med 51:545-51. 2012
    ..To identify metabolites showing changes in serum levels among Japanese male with diabetes...
  4. doi request reprint Higher plasma renin activity is a risk factor for total mortality in older Japanese individuals: the Takahata study
    Makoto Daimon
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, Yamagata, Japan
    Metabolism 61:504-11. 2012
    ..0 ng/[mL h]) PRA (1.97, 1.37-2.83). Higher PRA was a significant and independent risk factor for increased total mortality in this Japanese population and may be a marker for subjects at an increased risk of total mortality...
  5. doi request reprint Association of the clusterin gene polymorphisms with type 2 diabetes mellitus
    Makoto Daimon
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata 990 9585, Japan
    Metabolism 60:815-22. 2011
    ..0332). The CLU gene was associated with diabetes, probably through an increase in insulin resistance primarily and through an impairment of insulin secretion secondarily...
  6. ncbi request reprint Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese Population: the Funagata study
    Makoto Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Diabetes Care 26:2015-20. 2003
    ..To examine whether decreased serum levels of adiponectin are an independent risk factor for the progression to type 2 diabetes in a Japanese population...
  7. ncbi request reprint Calpain 10 gene polymorphisms are related, not to type 2 diabetes, but to increased serum cholesterol in Japanese
    Makoto Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Diabetes Res Clin Pract 56:147-52. 2002
    ..6 +/- 34.3 vs. 198.5 +/- 29.9, P=0.020). The genotype combination might be a risk factor, not for DM, obesity and hypertension, but for increased serum cholesterol...
  8. ncbi request reprint Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM
    Makoto Daimon
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Biochem Biophys Res Commun 374:576-80. 2008
    ..44 g/day) (p=0.002). A case-control association study also showed a significant association with diabetes only in subjects with low salt consumption (p=0.006)...
  9. ncbi request reprint Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM
    Makoto Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Biochem Biophys Res Commun 386:26-9. 2009
    ..010)...
  10. ncbi request reprint Association of nephrin gene polymorphisms with type 2 diabetes in a Japanese population: The Funagata study
    Makoto Daimon
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology DNHMED, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Diabetes Care 29:1117-9. 2006
  11. ncbi request reprint Large-scale search of SNPs for type 2 DM susceptibility genes in a Japanese population
    Makoto Daimon
    The Third Department of Internal Medicine, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Biochem Biophys Res Commun 302:751-8. 2003
    ..Six genes (met proto-oncogene, ATP-binding cassette transporter A1, fatty acid binding protein 2, LDL receptor defect C complementing, aldolase B, and sulfonylurea receptor) were shown to be associated with DM...
  12. ncbi request reprint Fine structure of the human translocation protein 1 (HTP1/TLOC1) gene
    M Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, Japan
    IUBMB Life 48:619-24. 1999
    ..Therefore, this gene may be one such gene...
  13. ncbi request reprint A novel mutation of the ceruloplasmin gene in a patient with heteroallelic ceruloplasmin gene mutation (HypoCPGM)
    M Daimon
    The Third Department of Internal Medicine, Yamagata University School of Medicine, Japan
    Tohoku J Exp Med 191:119-25. 2000
    ..PCR-restriction analysis with restriction enzyme Tsp EI for the mutation revealed that both the patient and her son were heterozygotes for the mutation...
  14. ncbi request reprint Identification of a human cDNA homologue to the Drosophila translocation protein 1 (Dtrp1)
    M Daimon
    The Third Department of Internal Medicine, Yamagata University School of Medicine, Japan
    Biochem Biophys Res Commun 230:100-4. 1997
    ..Northern blot analysis showed two HTP1 transcripts of about 2.8 and 5.5 kb, which were expressed concomitantly in various human tissues such as heart, brain, placenta, liver and pancreas...
  15. ncbi request reprint Hyperglycemia is a factor for an increase in serum ceruloplasmin in type 2 diabetes
    M Daimon
    Third Department of Internal Medicine, Yamagata University, School of Medicine, Japan
    Diabetes Care 21:1525-8. 1998
    ..To examine if there is a correlation between high blood glucose and serum ceruloplasmin (Cp) levels...
  16. ncbi request reprint Hypocaeruloplasminaemia with heteroallelic caeruloplasmin gene mutation: MRI of the brain
    M Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, Japan
    Neuroradiology 41:185-7. 1999
    ..These patients had diabetes mellitus and tremor of the hands, respectively. T2-weighted fast spin-echo MRI showed mildly reduced intensity of the putamen, much more marked on echo-planar imaging...
  17. ncbi request reprint Insulin activates p38 mitogen-activated protein (MAP) kinase via a MAP kinase kinase (MKK) 3/MKK 6 pathway in vascular smooth muscle cells
    M Igarashi
    Third Department of Internal Medicine, Yamagata University School of Medicine, Japan
    Eur J Clin Invest 30:668-77. 2000
    ..In this study, we investigated the effect of insulin on p38 mitogen-activated protein (MAP) kinase activation in cultured rat vascular smooth muscle cells (VSMC)...
  18. ncbi request reprint Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample
    T Oizumi
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Diabetes Care 24:1579-83. 2001
    ..We examined the associations in a large population-based sample...
  19. pmc Angiotensin-converting enzyme gene and retinal arteriolar narrowing: the Funagata Study
    Y Tanabe
    Department of Ophthalmology and Visual Science, Yamagata University, Yamagata, Japan
    J Hum Hypertens 23:788-93. 2009
    ..49 microm, 95% confidence interval (CI): -12.86 microm, -0.11 microm). Our study suggests that the ACE I/D polymorphism may be associated with subclinical structural arteriolar changes related to chronic hypertension...
  20. ncbi request reprint Characterization of platelet-derived growth factor-induced p38 mitogen-activated protein kinase activation in vascular smooth muscle cells
    H Yamaguchi
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Eur J Clin Invest 31:672-80. 2001
    ....
  21. ncbi request reprint Candesartan inhibits carotid intimal thickening and ameliorates insulin resistance in balloon-injured diabetic rats
    M Igarashi
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Hypertension 38:1255-9. 2001
    ..We conclude that candesartan could be effective for the suppression of vascular smooth muscle cell growth dose-dependently in Wistar fatty and lean rats. Furthermore, the agent could improve insulin resistance in Wistar fatty rats...
  22. ncbi request reprint Platelet-derived growth factor BB-induced p38 mitogen-activated protein kinase activation causes cell growth, but not apoptosis, in vascular smooth muscle cells
    H Yamaguchi
    Third Department of Internal Medicine, Yamagata University School of Medicine, Japan
    Endocr J 48:433-42. 2001
    ....
  23. ncbi request reprint A point mutation, C to T, in exon 8 of the porphobilinogen deaminase gene in a Japanese family with acute intermittent porphyria
    Y Morita
    Third Department of Internal Medicine, Yamagata University School of Medicine, Japan
    Jpn J Hum Genet 40:207-13. 1995
    ..This mutation resulted in an Arg116 to Trp substitution. Four carriers in the family were successfully diagnosed by detecting the mutation using restriction analysis of PCR products...
  24. ncbi request reprint Acute intermittent porphyria caused by a G to C mutation in exon 12 of the porphobilinogen deaminase gene that results in exon skipping
    M Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, Japan
    Hum Genet 92:549-53. 1993
    ..Analysis of the cDNA fragments amplified by PCR revealed that the patient has the abnormal PBG-D mRNA, which does not have exon 12 and exists in an approximately equal amount to the normal mRNA...
  25. ncbi request reprint Two new polymorphisms in introns 2 and 3 of the human porphobilinogen deaminase gene
    M Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, Japan
    Hum Genet 92:115-6. 1993
    ..The frequencies of these alleles are presented...
  26. ncbi request reprint Characterization of an inhibitory effect of pioglitazone on balloon-injured vascular smooth muscle cell growth
    M Igarashi
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Metabolism 50:955-62. 2001
    ..Pioglitazone also inhibited the phosphorylation of Pyk2. We conclude that pioglitazone itself could be effective for suppressing the growth of VSMC and consequent carotid intimal thickening...
  27. ncbi request reprint Fine structure of the human ceruloplasmin gene
    M Daimon
    Third Department of Internal Medicine, Yamagata University, School of Medicine, Japan
    Biochem Biophys Res Commun 208:1028-35. 1995
    ..Putative lariat sequences were identified between -17 and -42 nucleotides from the 3' splice junction for all 18 introns...
  28. doi request reprint Association of the G-protein β3 subunit gene polymorphism with the incidence of cardiovascular disease independent of hypertension: the Funagata study
    M Daimon
    1 Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology DNHMED, Yamagata University School of Medicine, Yamagata, Japan 2 Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan
    J Hum Hypertens 27:612-6. 2013
    ..The TT genotype of the C825T GNB3 gene polymorphism was found to be a significant risk factor for the incidence of CVD and stroke independent of hypertension and other established CVD risk factors in a Japanese population. ..
  29. ncbi request reprint A polymorphism of the aldehyde dehydrogenase 2 gene is a risk factor for multiple lacunar infarcts in Japanese men: the Takahata Study
    H Nagasawa
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Eur J Neurol 14:428-34. 2007
    ..The present study revealed that the ALDH2 *1/*1 genotype was significantly associated with the prevalence of multiple lacunar infarcts in Japanese men...
  30. ncbi request reprint Identification of a novel mutation of the CPO gene in a Japanese hereditary coproporphyria family
    S Susa
    The Third Department of Internal Medicine, Yamagata University School of Medicine, Japan
    Am J Med Genet 80:204-6. 1998
    ..MaeI restriction analysis showed two other carriers in the family. The C-T mutation is located within a recently proposed putative alternative translation initiation codon (TIC-1), supporting that TIC-1 is the real TIC rather than TIC-2...
  31. pmc Nifedipine suppresses neointimal thickening by its inhibitory effect on vascular smooth muscle cell growth via a MEK-ERK pathway coupling with Pyk2
    A Hirata
    Department of Laboratory Medicine, Yamagata University School of Medicine, 2 2 2, Iida Nishi, Yamagata 990 9585, Japan
    Br J Pharmacol 131:1521-30. 2000
    ....
  32. doi request reprint Cystatin C as an index of cerebral small vessel disease: results of a cross-sectional study in community-based Japanese elderly
    M Wada
    Department of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University, Iida Nishi, Yamagata, Japan
    Eur J Neurol 17:383-90. 2010
    ....
  33. ncbi request reprint Lateral and medial medullary infarction: a comparative analysis of 214 patients
    W Kameda
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Stroke 35:694-9. 2004
    ..The aim of this study was to investigate them through the use of cooperatively collected cases...
  34. ncbi request reprint The metabolic syndrome and retinal microvascular signs in a Japanese population: the Funagata study
    R Kawasaki
    Department of Ophthalmology and Visual Science, Yamagata University Faculty of Medicine, Yamagata, Japan
    Br J Ophthalmol 92:161-6. 2008
    ..To determine the relationship of metabolic syndrome and its components with retinopathy and other retinal microvascular signs in a Japanese population...
  35. ncbi request reprint Association of the common fat mass and obesity associated (FTO) gene polymorphism with obesity in a Japanese population
    Shigeru Karasawa
    Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan
    Endocr J 57:293-301. 2010
    ..19-4.80]) in the Low-PA group but not in the High- PA group (p=0.650). The FTO gene, rs9939609, was associated with obesity, and the association was evident in subjects with low-PA, suggesting a PA-dependent association...
  36. ncbi request reprint A novel missense mutation in exon 4 of the human coproporphyrinogen oxidase gene in two patients with hereditary coproporphyria
    M Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, Japan
    Hum Genet 99:199-201. 1997
    ..This mutation results in a glycine to arginine substitution at amino acid 180. Two carriers in the family were successfully diagnosed by detecting the mutation using restriction analysis of the PCR products...
  37. ncbi request reprint Insulin inhibits glucagon-induced glycogenolysis in perivenous hepatocytes specifically
    Y Ikezawa
    Third Department of Internal Medicine, Yamagata University School of Medicine, Japan
    J Lab Clin Med 138:387-92. 2001
    ..The specific effect of insulin on PVHs might depend on the differences in intracellular characteristics between PPHs and PVHs rather than hormone binding...
  38. doi request reprint Impaired glucose tolerance is a risk factor for stroke in a Japanese sample--the Funagata study
    Toshihide Oizumi
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology DNHMED, Yamagata University School of Medicine, Yamagata 90 9585, Japan
    Metabolism 57:333-8. 2008
    ..51 [95% confidence interval, 1.02-2.24], P = .039) but not for CHD (1.21 [0.69-2.313], .509). Impaired glucose tolerance is a risk factor for future stroke in a Japanese population...
  39. ncbi request reprint Galectin-1 is a component of neurofilamentous lesions in sporadic and familial amyotrophic lateral sclerosis
    T Kato
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Biochem Biophys Res Commun 282:166-72. 2001
    ..Since galectin-1 has axonal regeneration-enhancing activity, the abnormal accumulation of galectin-1 to the lesions seems to be related to the pathological process of ALS...
  40. doi request reprint Prevalence and risk factors for age-related macular degeneration in an adult Japanese population: the Funagata study
    Ryo Kawasaki
    Yamagata University Faculty of Medicine, Yamagata, Japan
    Ophthalmology 115:1376-81, 1381.e1-2. 2008
    ..To describe the prevalence and risk factors for age-related macular degeneration (AMD) in a Japanese population and to compare these with data from a white population...
  41. ncbi request reprint Mechanisms of inhibitory effects of cerivastatin on rat vascular smooth muscle cell growth
    Masahiko Igarashi
    Third Department of Internal Medicine and Department of Laboratory Medicine, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    J Cardiovasc Pharmacol 40:277-87. 2002
    ..These results indicate that cerivastatin suppresses cell survival and activates the apoptotic cellular signaling in VSMCs, suggesting that it could be effective for preventing the progression of restenosis after angioplasty...
  42. ncbi request reprint Cerebral small vessel disease and C-reactive protein: results of a cross-sectional study in community-based Japanese elderly
    Manabu Wada
    Department of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    J Neurol Sci 264:43-9. 2008
    ..We assessed whether higher C-reactive protein (CRP) levels were associated with an increased number of lacunar infarcts or severity of white matter lesions...
  43. ncbi request reprint Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population
    Makoto Daimon
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology DNHMED, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Biochem Biophys Res Commun 365:466-71. 2008
    ..In the NGT subjects, serum fasting insulin levels in the at-risk genotype group of SNP 4 were significantly lower than those in the others (TT, TC, and CC, 4.9+/-2.6, 5.4+/-3.0, and 5.6+/-3.4muU/ml, respectively; p=0.029)...
  44. doi request reprint Impact of metabolic syndrome on elevated serum alanine aminotransferase levels in the Japanese population
    Takafumi Saito
    Department of Gastroenterology, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Metabolism 58:1067-75. 2009
    ..These results suggest that elevated ALT levels in the Japanese population older than 40 years have a strong association with metabolic syndrome-related features including obesity and insulin resistance...
  45. ncbi request reprint Cardiovascular risk factors and retinal microvascular signs in an adult Japanese population: the Funagata Study
    Ryo Kawasaki
    Centre for Vision Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia
    Ophthalmology 113:1378-84. 2006
    ..To describe the prevalence of retinal vascular signs and their association with cardiovascular risk factors in a Japanese population...
  46. ncbi request reprint Association of decrease in serum dehydroepiandrosterone sulfate levels with the progression to type 2 diabetes in men of a Japanese population: the Funagata Study
    Wataru Kameda
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Metabolism 54:669-76. 2005
    ..410 (95% confidence interval [CI], 1.020-1.948, P = .038), independently from age, height, and 2-hour plasma glucose in men. A decrease in serum DHEAS levels seems to be associated with the progression to DM in Japanese men...
  47. ncbi request reprint Mechanism of an inhibitory effect of nipradilol on rat vascular smooth muscle cell growth
    Masahiko Igarashi
    Department of Laboratory Medicine, Yamagata School of Medicine, Yamagata, Japan
    J Atheroscler Thromb 10:226-33. 2003
    ..These results indicate that nipradilol suppresses cell growth without apoptosis in rat VSMCs, suggesting that it could be effective for preventing the progression of restenosis after angioplasty...
  48. ncbi request reprint Female preponderance of Parkinson's disease in Japan
    H Kimura
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Neuroepidemiology 21:292-6. 2002
    ..0/100,000 women, showing that women were significantly more affected by PD than men (p < 0.001). Contrary to the findings in Europe and the USA, the results indicate a female preponderance of PD among the Japanese population...
  49. ncbi request reprint The D allele of the angiotensin-converting enzyme insertion/ deletion (I/D) polymorphism is a risk factor for type 2 diabetes in a population-based Japanese sample
    Makoto Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Endocr J 50:393-8. 2003
    ..49, 95% CI 1.01-2.21). The D allele of the ACE gene I/D polymorphism is a risk factor for DM...
  50. ncbi request reprint Type 2 diabetes is not a risk factor for asymptomatic ischemic brain lesion--the Funagata study
    Tamotsu Saitoh
    Third Department of Internal Medicine, Yamagata University School of Medicine
    Intern Med 41:351-6. 2002
    ..The purpose of this study is to clarify whether type 2 diabetes (DM) is a risk factor for asymptomatic (silent) ischemic brain lesion, which is controversial at present...
  51. doi request reprint Asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on MRI (AVIM) in the elderly: a prospective study in a Japanese population
    Chifumi Iseki
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology DNHMED, Yamagata University School of Medicine, Yamagata, Japan
    J Neurol Sci 277:54-7. 2009
    ..The prevalence of possible iNPH was 0.51% (4/790) among Japanese elderly (>61 years of age). Asymptomatic ventriculomegaly with the iNPH features on MRI (AVIM) may represent a preclinical stage of iNPH...
  52. doi request reprint A functional polymorphism of the TNF-alpha gene that is associated with type 2 DM
    Shinji Susa
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Biochem Biophys Res Commun 369:943-7. 2008
    ..The functional analyses showed that YY1 transcription factor bound allele-specifically to the SNP region and, the IVS1+123A allele had an increase in luciferase expression compared with the G allele...
  53. doi request reprint Relationship between alcohol consumption and serum adiponectin levels: the Takahata study--a cross-sectional study of a healthy Japanese population
    Yuko Nishise
    Department of Gastroenterology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    J Clin Endocrinol Metab 95:3828-35. 2010
    ..The relationship between alcohol consumption and serum adiponectin levels has not been fully explored in an Asian population...
  54. doi request reprint Retinal arteriolar narrowing predicts 5-year risk of hypertension in Japanese people: the Funagata study
    Yusuke Tanabe
    Department of Ophthalmology and Visual Science, Yamagata University, Yamagata, Japan
    Microcirculation 17:94-102. 2010
    ..To determine whether retinal arteriolar narrowing, possibly reflecting peripheral arteriolar vasoconstriction, predicts risk of hypertension in Japanese persons...
  55. ncbi request reprint Microalbuminuria is a risk factor for cerebral small vessel disease in community-based elderly subjects
    Manabu Wada
    Department of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    J Neurol Sci 255:27-34. 2007
    ..15 per one log UACR increase). The present study revealed that levels of urinary albumin are associated with cerebral SVD, independently of traditional cerebrovascular risk factors, in community-based elderly...
  56. ncbi request reprint A palatinose-based balanced formula improves glucose tolerance, serum free fatty acid levels and body fat composition
    Toshihide Oizumi
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, Japan
    Tohoku J Exp Med 212:91-9. 2007
    ..5 vs 11.2 +/- 30.2% change, p = 0.024). PBF also had the beneficial effects on serum free fatty acids levels and visceral fat area. In conclusion, PBF consumption has beneficial effects on metabolic syndrome-related parameters in humans...
  57. ncbi request reprint Genetic association between aldehyde dehydrogenase 2 (ALDH2) variation and high-density lipoprotein cholesterol (HDL-C) among non-drinkers in two large population samples in Japan
    Manabu Wada
    Department of Neurology, Faculty of Medicine, Yamagata University, Japan
    J Atheroscler Thromb 15:179-84. 2008
    ..We undertook a large-scale correlation study between HDL-C levels and ALDH2 genotype among Japanese non-drinkers to investigate the possibility that HDL-C levels could be associated with ALDH2 genotype...
  58. ncbi request reprint Progression of diabetic nephropathy enhances the plasma osteopontin level in type 2 diabetic patients
    Hiroshi Yamaguchi
    Third Department of Internal Medicine, Yamagata University School of Medicine, Japan
    Endocr J 51:499-504. 2004
    ..The results established that the plasma OPN was elevated in proportion to the progression of diabetic nephropathy, indicating that the plasma concentration may be a potential diagnostic predictor of diabetic end-stage renal disease...
  59. doi request reprint Cerebral small vessel disease and chronic kidney disease (CKD): results of a cross-sectional study in community-based Japanese elderly
    Manabu Wada
    Department of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    J Neurol Sci 272:36-42. 2008
    ..This is the first study showing the relationship between silent SVD-related brain lesions and the presence of CKD, independently of conventional cardiovascular risk factors, in community-based elderly...
  60. ncbi request reprint Correlation between change in body weight rather than current body weight and change in serum adiponectin levels in a Japanese population -- the Funagata study
    Nobuko Arawaka
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Metabolism 55:324-30. 2006
    ..In conclusion, we showed here that the deltaBW was strongly associated with the deltaAdiponectin in both sexes, whereas the BW at the baseline examinations was not associated with the deltaAdiponectin, at least in women...
  61. ncbi request reprint Association of an intronic haplotype of the LIPC gene with hyperalphalipoproteinemia in two independent populations
    Hiroshi Iijima
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetes, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, Japan
    J Hum Genet 53:193-200. 2008
    ..00011), indicating that H2 haplotype elevates plasma HDLc levels. This association was validated in the second population (n = 1,638) (P = 0.00070). The results provide convincing evidence that the LIPC locus influences HDL metabolism...
  62. ncbi request reprint Increased urinary levels of pentosidine, pyrraline and acrolein adduct in type 2 diabetes
    Makoto Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Endocr J 50:61-7. 2003
    ..The urinary levels of pentosidine, pyrraline and acrolein adduct were increased in DM and were significantly correlated with glycemic control levels. In addition, smoking habit seems to increase the urinary levels of acrolein adduct...
  63. ncbi request reprint Insulin inhibits glucagon-induced glycogenolysis normally in perivenous hepatocytes of Wistar fatty rats
    Yoshihiro Ikezawa
    Third Department of Internal Medicine, Yamagata University School of Medicine, 2 2 2 Iidanishi, Yamagata 990 9585, Japan
    Diabetes Res Clin Pract 69:120-3. 2005
    ..7+/-13.3% and to 46.1+/-7.5%, respectively. Thus, the antagonizing effect of insulin on glucagon-induced increase in glycogenolysis was preserved in PVH of hyperinsulinemic and hyperglycemic WF rats...
  64. doi request reprint Ghrelin infused into the portal vein inhibits glucose-stimulated insulin secretion in Wistar rats
    Can Cui
    Department of Neurology, Hematology, Endocrinology, Metabolism and Diabetology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Peptides 29:1241-6. 2008
    ..The decrease in ghrelin level after a meal is important for the occurrence of the incretin effect in rats...
  65. ncbi request reprint The long, but not the short, presequence of human coproporphyrinogen oxidase is essential for its import and sorting to mitochondria
    Shinji Susa
    The Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Tohoku J Exp Med 200:39-45. 2003
    ..This correction revealed that mouse pCPO has also a longer presequence, which are very similar to the long presequence of human. These results indicate that the long, but not short, presequence is the real one...
  66. ncbi request reprint Glucagon-like peptide-1 inhibits glucagon-induced glycogenolysis in perivenous hepatocytes specifically
    Yoshihiro Ikezawa
    The Third Department of Internal Medicine, Yamagata University School of Medicine, 2 2 2 Iidanishi, Yamagata 990 9585, Japan
    Regul Pept 111:207-10. 2003
    ..Insulin binding did not differ between PPH and PVH of fed rats. GLP-1 did not displace [125I]-glucagon binding to the purified hepatic cell membrane. Thus, it is directly confirmed that GLP-1 has an insulin-like activity in the liver...
  67. ncbi request reprint [Decreased serum levels of adiponectin as a risk factor for development of type 2 diabetes]
    Makoto Daimon
    Division of Metabolism, Endocrinology and Diabetes, DNHMED, Yamagata University Graduate School of Medicine
    Nihon Rinsho 63:642-5. 2005
  68. ncbi request reprint Combined use of fasting plasma glucose and glycated hemoglobin A1c in a stepwise fashion to detect undiagnosed diabetes mellitus
    Tomoko Nakagami
    Diabetes Center, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Tohoku J Exp Med 213:25-32. 2007
    ..In conclusion, the screening test scenario, in which an OGTT would be followed by the combined use of FPG and HbA1c in a stepwise fashion according to the JNDSP guideline, was not effective in identifying people with undiagnosed DM...
  69. ncbi request reprint [A family of acute intermittent porphyria]
    Masaki Igarashi
    Division of Hematology, NTT Kanto Medical Center
    Rinsho Ketsueki 45:562-7. 2004
    ..Four of his seven children were successfully diagnosed as AIP carriers. This is the ninth AIP family report, in which a mutation in the PBGD gene was revealed by DNA analysis...
  70. ncbi request reprint Heme inhibits the mitochondrial import of coproporphyrinogen oxidase
    Shinji Susa
    Blood 100:4678-9. 2002
  71. ncbi request reprint Is the measurement of glycated hemoglobin A1c alone an efficient screening test for undiagnosed diabetes? Japan National Diabetes Survey
    Tomoko Nakagami
    Diabetes Center, Tokyo Women s Medical University, 8 1, Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Diabetes Res Clin Pract 76:251-6. 2007
    ..The measurement of HbA1c alone may be efficient to screen undiagnosed DM and the cut-off point of 5.6% might be proper with respect to screening tests properties for undiagnosed DM, and prediction of vascular complications in Japan...
  72. ncbi request reprint A proposal for the cutoff point of waist circumference for the diagnosis of metabolic syndrome in the Japanese population
    Toshihide Oizumi
    Circ J 70:1663. 2006
  73. doi request reprint A novel 12-base pair deletion mutation in exon 15 of the porphobilinogen deaminase gene in a Taiwanese patient with acute intermittent porphyria
    Jun Ichi Sakabe
    Blood Cells Mol Dis 41:202. 2008