Y Yamada

Summary

Country: Japan

Publications

  1. ncbi Association of a G994 --> T (Val279 --> Phe) polymorphism of the plasma platelet-activating factor acetylhydrolase gene with myocardial damage in Japanese patients with nonfamilial hypertrophic cardiomyopathy
    Y Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Yagi Memorial Park, Kani gun, Japan
    J Hum Genet 46:436-41. 2001
  2. ncbi Association of polymorphisms of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis
    Y Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology and Institute of Applied Biochemistry, Mitake, Gifu, Japan
    Pharmacogenetics 11:765-71. 2001
  3. ncbi Association of the C-509-->T polymorphism, alone of in combination with the T869-->C polymorphism, of the transforming growth factor-beta1 gene with bone mineral density and genetic susceptibility to osteoporosis in Japanese women
    Y Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Mitake, Japan
    J Mol Med (Berl) 79:149-56. 2001
  4. ncbi [Association of polymorphisms of the transforming growth factor-beta 1 gene with genetic susceptibility to osteoporosis]
    Y Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Kani-gun, Gifu-prf. 505-0116
    Rinsho Byori 49:900-5. 2001
  5. ncbi Transfer of Acetobacter oboediens Sokollek et al 1998 and Acetobacter intermedius Boesch et al. 1998 to the genus Gluconacetobacter as Gluconacetobacter oboediens comb. nov. and Gluconacetobacter intermedius comb. nov
    Y Yamada
    Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture, Japan
    Int J Syst Evol Microbiol 50:2225-7. 2000
  6. ncbi Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis
    M Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Yagi Memorial Park, Gifu, 505 0116, Mitake, Japan
    Mech Ageing Dev 116:65-76. 2000
  7. ncbi Genomic variation in pancreatic ion channel genes in Japanese type 2 diabetic patients
    Y Yamada
    Department of Metabolism and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Diabetes Metab Res Rev 17:213-6. 2001
  8. ncbi Association between a polymorphism of the transforming growth factor-beta1 gene and genetic susceptibility to ossification of the posterior longitudinal ligament in Japanese patients
    M Kamiya
    Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Japan
    Spine (Phila Pa 1976) 26:1264-6; discussion 1266-7. 2001
  9. ncbi Identification of the G994--> T missense in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men
    Y Yamada
    Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Aichi, Japan
    Metabolism 47:177-81. 1998
  10. ncbi Association of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women
    Y Yamada
    Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Aichi, Japan
    J Bone Miner Res 13:1569-76. 1998

Detail Information

Publications64

  1. ncbi Association of a G994 --> T (Val279 --> Phe) polymorphism of the plasma platelet-activating factor acetylhydrolase gene with myocardial damage in Japanese patients with nonfamilial hypertrophic cardiomyopathy
    Y Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Yagi Memorial Park, Kani gun, Japan
    J Hum Genet 46:436-41. 2001
    ....
  2. ncbi Association of polymorphisms of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis
    Y Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology and Institute of Applied Biochemistry, Mitake, Gifu, Japan
    Pharmacogenetics 11:765-71. 2001
    ....
  3. ncbi Association of the C-509-->T polymorphism, alone of in combination with the T869-->C polymorphism, of the transforming growth factor-beta1 gene with bone mineral density and genetic susceptibility to osteoporosis in Japanese women
    Y Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Mitake, Japan
    J Mol Med (Berl) 79:149-56. 2001
    ....
  4. ncbi [Association of polymorphisms of the transforming growth factor-beta 1 gene with genetic susceptibility to osteoporosis]
    Y Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Kani-gun, Gifu-prf. 505-0116
    Rinsho Byori 49:900-5. 2001
    ....
  5. ncbi Transfer of Acetobacter oboediens Sokollek et al 1998 and Acetobacter intermedius Boesch et al. 1998 to the genus Gluconacetobacter as Gluconacetobacter oboediens comb. nov. and Gluconacetobacter intermedius comb. nov
    Y Yamada
    Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture, Japan
    Int J Syst Evol Microbiol 50:2225-7. 2000
    ..The significance of growth on mannitol agar and the presence of a ubiquinone isoprenologue composed of Q-10 is discussed for characterization of the genus Gluconacetobacter...
  6. ncbi Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis
    M Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Yagi Memorial Park, Gifu, 505 0116, Mitake, Japan
    Mech Ageing Dev 116:65-76. 2000
    ..This genotype is likely to confer resistance to adult-onset diseases by suppressing obesity and atherosclerosis...
  7. ncbi Genomic variation in pancreatic ion channel genes in Japanese type 2 diabetic patients
    Y Yamada
    Department of Metabolism and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Diabetes Metab Res Rev 17:213-6. 2001
    ..Because type 2 diabetes is characterized by pancreatic beta-cell insensitivity to glucose, the genes responsible for glucose metabolism and calcium signaling in pancreatic beta-cells are candidate type 2 diabetes susceptibility genes...
  8. ncbi Association between a polymorphism of the transforming growth factor-beta1 gene and genetic susceptibility to ossification of the posterior longitudinal ligament in Japanese patients
    M Kamiya
    Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Japan
    Spine (Phila Pa 1976) 26:1264-6; discussion 1266-7. 2001
    ..A study was conducted to determine the association between polymorphism of the transforming growth factor-beta1 (TGF-beta1) gene and ossification of the posterior longitudinal ligament (OPLL) prevalence...
  9. ncbi Identification of the G994--> T missense in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men
    Y Yamada
    Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Aichi, Japan
    Metabolism 47:177-81. 1998
    ..These results indicate that the G994--> T missense mutation in exon 9 of the plasma PAF acetylhydrolase gene is an independent risk factor for CAD in Japanese men, especially low-risk individuals, but not in women...
  10. ncbi Association of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women
    Y Yamada
    Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Aichi, Japan
    J Bone Miner Res 13:1569-76. 1998
    ..Thus, analysis of the TGF-beta1 genotype may be useful in the prevention and management of osteoporosis...
  11. ncbi Antiatherogenic mitochondrial genotype in patients with type 2 diabetes
    H Matsunaga
    Department of Medicine, Metabolism and Endocrinology, Juntendo University, Tokyo, Japan
    Diabetes Care 24:500-3. 2001
    ..CONCLUSIONS: The Mt5178A genotype may be unrelated to the etiology of type 2 diabetes. However, Mt5178A seems to have an antiatherogenic effect, at least in type 2 diabetic individuals...
  12. ncbi Transforming growth factor-beta1 gene polymorphism and bone mineral density
    Y Yamada
    JAMA 285:167-8. 2001
  13. ncbi Genetic risk for metabolic syndrome: examination of candidate gene polymorphisms related to lipid metabolism in Japanese people
    Y Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie 514 8507, Japan
    J Med Genet 45:22-8. 2008
    ..The aim of this study was to identify genetic polymorphisms that confer susceptibility to metabolic syndrome, to allow prediction of genetic risk for this condition...
  14. ncbi Genetic risk for myocardial infarction determined by polymorphisms of candidate genes in a Japanese population
    Y Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie 514 8507, Japan
    J Med Genet 45:216-21. 2008
    ..Although several environmental factors influence the development of myocardial infarction (MI), genetic factors have been shown to contribute to individual susceptibility to this condition...
  15. ncbi Loss of activity of plasma platelet-activating factor acetylhydrolase due to a novel Gln281-->Arg mutation
    Y Yamada
    Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Aichi, Japan
    Biochem Biophys Res Commun 236:772-5. 1997
    ..Site-directed mutagenesis in vitro showed that the corresponding recombinant mutant protein lacked PAF acetylhydrolase activity. Thus, the Gln281-->Arg substitution appears responsible for the loss of plasma PAF acetylhydrolase activity...
  16. ncbi Impact of genetic polymorphisms of 17-hydroxylase cytochrome P-450 (CYP17) and steroid 5alpha-reductase type II (SRD5A2) genes on prostate-cancer risk among the Japanese population
    Y Yamada
    Second Department of Pathology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514, Japan
    Int J Cancer 92:683-6. 2001
    ..Regarding the A49T polymorphism of SRD5A2, we could not detect the T allele in any of the examined samples. These data suggest a significant association between the CYP17 polymorphism and prostate-cancer risk among the Japanese...
  17. ncbi Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells
    H Watanabe
    Craniofacial Developmental Biology and Regeneration Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:14466-73. 2001
    ....
  18. ncbi Identification of the varR gene as a transcriptional regulator of virginiamycin S resistance in Streptomyces virginiae
    W Namwat
    Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan
    J Bacteriol 183:2025-31. 2001
    ..4-kb transcript and that VS acted as an inducer of bicistronic transcription. Deletion analysis of the varS promoter region clarified two adjacent VarR binding sites in the varS promoter...
  19. ncbi Synergistic effect of polymorphisms of uncoupling protein 1 and beta3-adrenergic receptor genes on autonomic nervous system activity
    N Shihara
    The Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Int J Obes Relat Metab Disord 25:761-6. 2001
    ....
  20. ncbi Reduced myocardial sarcoplasmic reticulum Ca(2+)-ATPase mRNA expression and biphasic force-frequency relations in patients with hypertrophic cardiomyopathy
    F Somura
    Cardiovascular Division, Department of Clinical Pathophysiology, The First Department of Internal Medicine, Nagoya University, Japan
    Circulation 104:658-63. 2001
    ....
  21. ncbi Oxidative stress and DNA hypermethylation status in renal cell carcinoma arising in patients on dialysis
    Y Hori
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pathol 212:218-26. 2007
    ..The overexpression of iNOS, COX-2, and 8-OHdG in dialysis RCC suggests that patients on dialysis are affected by oxidative stress and that this effect plays an important role in the genesis of dialysis RCC...
  22. ncbi Genetic variations and haplotype structures of the ABCB1 gene in a Japanese population: an expanded haplotype block covering the distal promoter region, and associated ethnic differences
    K Sai
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, 158 8501, USA
    Ann Hum Genet 70:605-22. 2006
    ..Our updated analysis of ABCB1 haplotype blocks will assist pharmacogenetic and disease-association studies carried out using Asian subjects...
  23. ncbi Sensitive and rapid diagnosis of human parvovirus B19 infection by loop-mediated isothermal amplification
    Y Yamada
    First Department of Dermatology, School of Medicine, and Sakura Hospital, Toho University, Tokyo, Japan
    Br J Dermatol 155:50-5. 2006
    ..CONCLUSIONS: Detection of B19 DNA by LAMP in serum and especially in the pharynx is a rapid and convenient method for the diagnosis of acute B19 infection...
  24. ncbi No effect of fluvastatin on the bone mineral density of children with minimal change glomerulonephritis and some focal mesangial cell proliferation, other than an ameliorating effect on their proteinuria
    K Kano
    Department of Pediatrics, Dokkyo University School of Medicine, Tochigi, Japan
    Clin Nephrol 63:74-9. 2005
    ....
  25. ncbi Mutations in the hypoxanthine guanine phosphoribosyltransferase gene (HPRT1) in Asian HPRT deficient families
    Y Yamada
    Department of Genetics, Inst Developmental Res, Aichi Human Service Center, Aichi, Japan
    Nucleosides Nucleotides Nucleic Acids 23:1169-72. 2004
    ....
  26. ncbi Significantly higher incidence of carotid atherosclerosis found in Japanese type 2 diabetic patients with early nephropathy
    M Nomura
    Center for Diabetes Mellitus, Osaka Rosai Hospital, 1179 3, Nagasone cho, Sakai, Osaka, 591 8025, Japan
    Diabetes Res Clin Pract 66:S161-3. 2004
    ..And it was suggested that the age, lipid levels, presence of hypertension would be important clinical risk factors for carotid atherosclerosis found in diabetic patients with early nephropathy...
  27. ncbi Comparison of the efficacy, toxicity, and pharmacokinetics of a uracil/tegafur (UFT) plus oral leucovorin (LV) regimen between Japanese and American patients with advanced colorectal cancer: joint United States and Japan study of UFT/LV
    K Shirao
    Division of Gastrointestinal Oncology, National Cancer Center Hospital, Tokyo, Japan
    J Clin Oncol 22:3466-74. 2004
    ....
  28. ncbi Insulin secretion and insulin sensitivity at different stages of glucose tolerance: a cross-sectional study of Japanese type 2 diabetes
    M Fukushima
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Metabolism 53:831-5. 2004
    ..Japanese type 2 diabetic patients are characterized by a larger decrease in insulin secretion and show less attribution of insulin resistance...
  29. ncbi Detection of Legionella DNA by PCR of whole-blood samples in a mouse model
    S Aoki
    Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan
    J Med Microbiol 52:325-9. 2003
    ..These results indicate that PCR using blood samples may be a useful, convenient and non-invasive method for the diagnosis of Legionella pneumonia...
  30. ncbi Variation during the week in the incidence of acute myocardial infarction: increased risk for Japanese women on Saturdays
    K Kinjo
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    Heart 89:398-403. 2003
    ..Confirmation of this finding in other communities may help identify triggers of acute myocardial infarction and be useful in prevention...
  31. ncbi Genetic differences in ethanol metabolizing enzymes and blood pressure in Japanese alcohol consumers
    Y Yamada
    Department of Hygiene, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293 Japan
    J Hum Hypertens 16:479-86. 2002
    ..Thus it is concluded that the genetic polymorphisms in ethanol-metabolizing enzymes do not greatly influence the alcohol-BP relationship in Japanese men...
  32. ncbi Failure of ureteric bud invasion: a new model of renal agenesis in mice
    T Kamba
    Department of Pathology and Biology of Diseases, Kyoto University Graduate School of Medicine, Kyoto Saitama, Japan
    Am J Pathol 159:2347-53. 2001
    ..Studies of fubi1 congenic mice indicated that interaction of two or more loci is essential for the FUBI phenotype...
  33. ncbi Genetic factors for human obesity
    S Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie, Japan
    Cell Mol Life Sci 65:1086-98. 2008
    ..Identification of the underlying genetic causes of obesity will likely provide a basis both for the development of new therapeutic agents and for the personalized prevention of this condition...
  34. ncbi A rare case of complete human erythrocyte AMP deaminase deficiency due to two novel missense mutations in AMPD3
    Y Yamada
    Department of Genetics, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi 480 0392, Japan
    Hum Mutat 17:78. 2001
    ..As the frequency of carriers heterozygous for these mutations seems to be very low, identifying them may lead to a better understanding of the genetic background of populations in Japan...
  35. ncbi Lack of association with interleukin 1 receptor antagonist and interleukin-1beta gene polymorphisms in sarcoidosis patients
    T Niimi
    Second Department of Internal Medicine, Nagoya City University, Medical School, Nagoya, Japan
    Respir Med 94:1038-42. 2000
    ..In conclusion, there is no bias in the IL-1ra and IL-1beta genotype in Japanese sarcoidosis patients...
  36. ncbi Recombinant laminin G domain mediates myoblast adhesion and heparin binding
    P D Yurchenco
    Department of Pathology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854
    J Biol Chem 268:8356-65. 1993
    ..Finally rG did not inhibit laminin polymerization. These data support the role of G domain in cell and heparin binding, but not laminin self-assembly, and the approach provides a means to further characterize these functions...
  37. ncbi Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms
    Y Yamada
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637
    Genomics 15:449-52. 1993
    ..1, respectively. Highly informative simple tandem repeat DNA polymorphisms were identified in SSTR1 and SSTR2...
  38. ncbi A cloned rat CD38-homologous protein and its expression in pancreatic islets
    Q Li
    Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine, Japan
    Biochem Biophys Res Commun 202:629-36. 1994
    ..The presence of rat CD38H in the pancreatic islets suggests that CD38H may be involved in insulin secretion by synthesizing cADP-ribose...
  39. ncbi Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein
    S Kagimoto
    Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine, Japan
    Biochem Biophys Res Commun 202:1188-95. 1994
    ..These results indicate that human SSTR2 is functionally coupled to Gi alpha 1 protein but not to Gi alpha 2 or Gi alpha 3 when expressed in CHO cells...
  40. ncbi Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells
    Y Ihara
    Department of Metabolism and Clinical Nutrition Kyoto University Faculty of Medicine, Japan
    Mol Endocrinol 9:121-30. 1995
    ..Furthermore, the present study suggests that the expression of the beta-subunit as well as the alpha 1-subunit may participate in the regulation of insulin secretion...
  41. ncbi Identification of a novel mutant transcript of laminin alpha 2 chain gene responsible for muscular dystrophy and dysmyelination in dy2J mice
    Y Sunada
    Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City 52242, USA
    Hum Mol Genet 4:1055-61. 1995
    ..Thus, the mutant alpha 2 chain could disrupt the formation of the laminin network and lead to muscle cell degeneration. Our results provide a molecular basis of muscular dystrophy and dysmyelination of peripheral nerve...
  42. ncbi Mucopolysaccharidosis type II (Hunter disease): identification and characterization of eight point mutations in the iduronate-2-sulfatase gene in Japanese patients
    K Sukegawa
    Department of Pediatrics, Gifu University School of Medicine, Japan
    Hum Mutat 6:136-43. 1995
    ..Furthermore, expression of the eight mutant cDNAs resulted in severe reductions of iduronate-2-sulfatase enzyme activity in comparison with a normal cDNA...
  43. ncbi The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes
    Y Yamada
    Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine, Japan
    Genomics 27:312-9. 1995
    ..The determination of the structures of the human CACNL1A2 and CACNLB3 genes should facilitate study of the role of these genes in the development of NIDDM and also other genetic diseases such as long QT syndrome...
  44. ncbi Isolation and partial characterization of genomic clones coding for a human pro-alpha 1 (II) collagen chain and demonstration of restriction fragment length polymorphism at the 3' end of the gene
    A M Nunez
    Biochemistry 24:6343-8. 1985
    ..5-kb RNA for the rat type II procollagen chain. Finally, studies of genomic DNAs from normal individuals reveal the presence of a HindIII and a BamHI polymorphic site at the 3' end of the gene...
  45. ncbi Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms
    K J Doege
    Shriner s Hospital for Crippled Children, Oregon Health Sciences University, Portland 97201
    J Biol Chem 266:894-902. 1991
    ....
  46. ncbi Identification of two independent Japanese mutant HPRT genes using the PCR technique
    Y Yamada
    Department of Genetics, Institute for Developmental Research, Aichi, Japan
    Adv Exp Med Biol 309:121-4. 1991
  47. ncbi Mucopolysaccharidosis type VII: characterization of mutations and molecular heterogeneity
    S Tomatsu
    Department of Pediatrics, Gifu University School of Medicine, Japan
    Am J Hum Genet 48:89-96. 1991
    ..Each of these two amino acid changes reduced the beta G1 activity of the corresponding mutant beta G1 expressed following transfection of COS cells with expression vectors harboring the mutated cDNAs...
  48. ncbi Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney
    Y Yamada
    Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637
    Proc Natl Acad Sci U S A 89:251-5. 1992
    ..Thus, the biological effects of somatostatin are mediated by a family of receptors that are expressed in a tissue-specific manner...
  49. ncbi A single EGF-like motif of laminin is responsible for high affinity nidogen binding
    U Mayer
    Max Planck Institut fur Biochemie, Martinsried, Germany
    EMBO J 12:1879-85. 1993
    ..This identifies repeat 4 as the only binding structure. The sequence of repeat 4 is well conserved in the human and in part in the Drosophila laminin B2 chain.(ABSTRACT TRUNCATED AT 250 WORDS)..
  50. ncbi Polymorphism in ALDH2-genotype in Japanese men and the alcohol-blood pressure relationship
    I Tsuritani
    Department of Hygiene, Kanazawa Medical University, Ishikawa, Japan
    Am J Hypertens 8:1053-9. 1995
    ..It can be concluded that polymorphism in the ALDH2-genotype found in Japanese men does not affect the individual sensitivity to the pressor effect of alcohol...
  51. ncbi Cloning, characterization, and expression analysis of mouse enamelysin
    J Caterina
    Matrix Metalloproteinase Unit, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892 4380, USA
    J Dent Res 79:1697-703. 2000
    ..Characterization of mouse enamelysin demonstrated that it is highly conserved in both its sequence content and pattern of expression relative to the porcine, human, and bovine homologues previously described...
  52. ncbi Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression
    N Ban
    Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Japan
    Diabetes 49:1142-8. 2000
    ..These results suggest a mechanism in which ATF-2 regulates insulin gene expression in pancreatic beta-cells, with the transcriptional activity of ATF-2 being increased by an elevated concentration of calcium ions...
  53. ncbi In vitro synthesis of hyaluronan by a single protein derived from mouse HAS1 gene and characterization of amino acid residues essential for the activity
    M Yoshida
    Institute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Aichi 480 1195, Japan
    J Biol Chem 275:497-506. 2000
    ....
  54. ncbi A novel missense mutation (G209R) in exon 8 of the presenilin 1 gene in a Japanese family with presenile familial Alzheimer's disease. Mutation in brief no. 254. Online
    N Sugiyama
    Department of Psychiatry, Yokohama City University School of Medicine, Yokohama, Japan
    Hum Mutat 14:90. 1999
    ..These findings may suggest the possible existence of other genetic and/or environmental factors or the possibility that these two different Gly209 mutations may underlie different pathomechanisms in the development of presenile FAD...
  55. ncbi The MH1 domains of smad2 and smad3 are involved in the regulation of the ALK7 signals
    R Watanabe
    Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Kyoto, 606 8507, Japan
    Biochem Biophys Res Commun 254:707-12. 1999
    ..These results indicate that the ALK7 signal regulates nuclear localization and activation of Smad2 and Smad3, and the MH1 domain of Smad2 has inhibitory effects on the nuclear localization...
  56. ncbi Roles of plasma platelet-activating factor acetylhydrolase in allergic, inflammatory, and atherosclerotic diseases
    Y Yamada
    Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Aichi, Japan
    Jpn Circ J 62:328-35. 1998
    ..Such studies have provided insight into the functions of PAF and oxidized phospholipids as well as into the etiology of allergic, inflammatory, and atherosclerotic diseases...
  57. ncbi Lack of association of angiotensin converting enzyme gene polymorphism or serum enzyme activity with coronary artery disease in Japanese subjects
    T Fujimura
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Am J Hypertens 10:1384-90. 1997
    ..These results indicate that the ACE I/D polymorphism and genotype associated variation in serum ACE activity are not risk factors for CAD in Japanese men or women...
  58. ncbi The C-terminal domain V of perlecan promotes beta1 integrin-mediated cell adhesion, binds heparin, nidogen and fibulin-2 and can be modified by glycosaminoglycans
    J C Brown
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Eur J Biochem 250:39-46. 1997
    ..05-0.2 microM and about 2 microM). Perlecan domain V therefore seems to participate in the supramolecular assembly and cell connections of basement membranes...
  59. ncbi The alpha chain of laminin-1 is independently secreted and drives secretion of its beta- and gamma-chain partners
    P D Yurchenco
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 94:10189-94. 1997
    ..Such an alpha-chain-dependent mechanism could allow for the regulation of laminin export into a nascent basement membrane, and might serve an important role in controlling basement membrane formation...
  60. ncbi Lack of association of polymorphisms of the angiotensin converting enzyme and angiotensinogen genes with nonfamilial hypertrophic or dilated cardiomyopathy
    Y Yamada
    Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Aichi, Japan
    Am J Hypertens 10:921-8. 1997
    ....
  61. ncbi Mutations in the proteolipid protein gene in Japanese families with Pelizaeus-Merzbacher disease
    K Inoue
    Department of Psychiatry, Yokohama City University, School of Medicine, Japan
    Neurology 48:283-5. 1997
    ..Since linkage analysis has shown homogeneity at the PLP locus in patients with PMD, our findings suggest that there may be genetic abnormalities other than exonic mutations that cause milder forms of PMD...
  62. ncbi Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences
    A Utani
    Laboratory of Developmental Biology, NIDR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:2814-20. 1997
    ..Together these results suggest that fibulin-2 functions to bridge laminin-1 and laminin-5 with other extracellular matrix proteins, providing a linkage between the cell surface and the basement membrane...
  63. ncbi Genetic and epigenetic resistance of SL/Ni mice to lymphomas
    H Shisa
    Laboratory of Pathology, Saitama Cancer Center Research Institute
    Jpn J Cancer Res 87:258-62. 1996
    ..4. We named this gene nir-1 (SL/Ni-lymphoma resistance-1). Thus, we have demonstrated epigenetic and genetic mechanisms of lymphoma resistance of the SL/Ni mouse with the high expression of endogenous ETV...
  64. ncbi Assignment of the gene encoding the alpha 1 subunit of the neuroendocrine/brain-type calcium channel (CACNL1A2) to human chromosome 3, band p14.3
    S Seino
    Department of Medicine, University of Chicago, Illinois 60637
    Genomics 13:1375-7. 1992