Kazuhito Hayakawa

Summary

Affiliation: Yakult Central Institute for Microbiological Research
Country: Japan

Publications

  1. ncbi request reprint Mechanism underlying gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats
    Kazuhito Hayakawa
    Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi shi, Tokyo 186 8650, Japan
    Eur J Pharmacol 438:107-13. 2002
  2. ncbi request reprint Effect of a gamma-aminobutyric acid-enriched dairy product on the blood pressure of spontaneously hypertensive and normotensive Wistar-Kyoto rats
    Kazuhito Hayakawa
    Yakult Central Institute for Microbiological Research, Tokyo, Japan
    Br J Nutr 92:411-7. 2004
  3. ncbi request reprint Role of the renal nerves in gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats
    Kazuhito Hayakawa
    Yakult Central Institute for Microbiological Research, Kunitachi shi, Tokyo, Japan
    Eur J Pharmacol 524:120-5. 2005
  4. ncbi request reprint Involvement of gamma-aminobutyric acid (GABA) B receptors in the hypotensive effect of systemically administered GABA in spontaneously hypertensive rats
    Masayuki Kimura
    Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan
    Jpn J Pharmacol 89:388-94. 2002
  5. ncbi request reprint Roles of nuclear receptors in the up-regulation of hepatic cholesterol 7alpha-hydroxylase by cholestyramine in rats
    Shinya Shibata
    Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi, Tokyo 186 8650, Japan
    Life Sci 80:546-53. 2007
  6. ncbi request reprint Hypocholesterolemic mechanism of Chlorella: Chlorella and its indigestible fraction enhance hepatic cholesterol catabolism through up-regulation of cholesterol 7alpha-hydroxylase in rats
    Shinya Shibata
    Yakult Central Institute for Microbiological Research, Tokyo, Japan
    Biosci Biotechnol Biochem 71:916-25. 2007
  7. ncbi request reprint Repeated-batch production of galactooligosaccharides from lactose at high concentration by using alginate-immobilized cells of Sporobolomyces singularis YIT 10047
    Takafumi Sakai
    Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan
    J Gen Appl Microbiol 54:285-93. 2008
  8. pmc Direct evidence for interferon-gamma production by effector-memory-type intraepidermal T cells residing at an effector site of immunopathology in fixed drug eruption
    Yoshiko Mizukawa
    Department of Dermatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Am J Pathol 161:1337-47. 2002

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Mechanism underlying gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats
    Kazuhito Hayakawa
    Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi shi, Tokyo 186 8650, Japan
    Eur J Pharmacol 438:107-13. 2002
    ..These results suggest that, in spontaneously hypertensive rats, GABA has an antihypertensive effect due to its inhibition of noradrenaline release from sympathetic nerves in the mesenteric arterial bed via presynaptic GABA(B) receptors...
  2. ncbi request reprint Effect of a gamma-aminobutyric acid-enriched dairy product on the blood pressure of spontaneously hypertensive and normotensive Wistar-Kyoto rats
    Kazuhito Hayakawa
    Yakult Central Institute for Microbiological Research, Tokyo, Japan
    Br J Nutr 92:411-7. 2004
    ..The present results suggest that low-dose oral GABA has a hypotensive effect in SHR/Izm and that the hypotensive effect of FMG is due to GABA...
  3. ncbi request reprint Role of the renal nerves in gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats
    Kazuhito Hayakawa
    Yakult Central Institute for Microbiological Research, Kunitachi shi, Tokyo, Japan
    Eur J Pharmacol 524:120-5. 2005
    ..These results suggest that a reduction in the effects induced by the renal nerves may play an important role in the hypotensive effect induced in spontaneously hypertensive rats by chronic dietary administration of GABA...
  4. ncbi request reprint Involvement of gamma-aminobutyric acid (GABA) B receptors in the hypotensive effect of systemically administered GABA in spontaneously hypertensive rats
    Masayuki Kimura
    Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan
    Jpn J Pharmacol 89:388-94. 2002
    ..In conclusion, in SHR, low-dose (0.3 to 1.0 mg/kg, i.d.) GABA had a hypotensive effect, which may result from attenuation of sympathetic transmission through the activation of GABA(B) receptors at presynaptic or ganglionic sites...
  5. ncbi request reprint Roles of nuclear receptors in the up-regulation of hepatic cholesterol 7alpha-hydroxylase by cholestyramine in rats
    Shinya Shibata
    Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi, Tokyo 186 8650, Japan
    Life Sci 80:546-53. 2007
    ..These results suggest that cholestyramine up-regulates the expression of CYP7A1 independently via LXR- or FXR-mediated pathways in rats...
  6. ncbi request reprint Hypocholesterolemic mechanism of Chlorella: Chlorella and its indigestible fraction enhance hepatic cholesterol catabolism through up-regulation of cholesterol 7alpha-hydroxylase in rats
    Shinya Shibata
    Yakult Central Institute for Microbiological Research, Tokyo, Japan
    Biosci Biotechnol Biochem 71:916-25. 2007
    ..These results suggest that the hypocholesterolemic effect of CP involves enhancement of cholesterol catabolism through up-regulation of hepatic CYP7A1 expression and that CIF contributes to the hypocholesterolemic effect...
  7. ncbi request reprint Repeated-batch production of galactooligosaccharides from lactose at high concentration by using alginate-immobilized cells of Sporobolomyces singularis YIT 10047
    Takafumi Sakai
    Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan
    J Gen Appl Microbiol 54:285-93. 2008
    ..The repeated-batch reaction with IM-SS would be an ideal system for GOS production because of its stability and high productivity...
  8. pmc Direct evidence for interferon-gamma production by effector-memory-type intraepidermal T cells residing at an effector site of immunopathology in fixed drug eruption
    Yoshiko Mizukawa
    Department of Dermatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Am J Pathol 161:1337-47. 2002
    ..This study provides the first in situ description of the detrimental effects specifically mediated by effector-memory T cells residing at the effector site of immunopathology...