Toshiaki Yagi

Summary

Country: Japan

Publications

  1. ncbi request reprint Subcutaneous emphysema after tonsillectomy: a case report
    Ken ichi Watanabe
    Department of Otorhinolaryngology, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa 211 8533, Japan
    J Nippon Med Sch 71:111-3. 2004
  2. ncbi request reprint Expression of myeloperoxidase and cochlear dysfunction in the lipopolysaccharide-treated guinea pig
    K Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Tokyo, Japan
    Eur Arch Otorhinolaryngol 258:164-7. 2001
  3. ncbi request reprint Detection of apoptotic change in the lipopolysaccharide (LPS)-treated cochlea of guinea pigs
    K Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Tokyo, Japan
    Hear Res 158:116-22. 2001
  4. ncbi request reprint Expression of inducible nitric oxide synthase (iNOS/NOS II) in the hydropic vestibule after injection of keyhole limpet hemocyanin into the endolymphatic sac of guinea pigs
    K Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Sendagi 1 1 5, Bunkyo ku, Tokyo 113 8603, Japan
    J Vestib Res 11:67-71. 2001
  5. ncbi request reprint Local injection of OK-432 in the treatment of ranula: a case report
    Ken ichi Watanabe
    Department of Otorhinolaryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyoku, Tokyo 113 8603, Japan
    Ear Nose Throat J 81:97-8. 2002
  6. ncbi request reprint Induction of apoptotic pathway in the vestibule of cisplatin (CDDP)-treated guinea pigs
    K Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Tokyo, Japan
    Anticancer Res 21:3929-32. 2001
  7. ncbi request reprint Carboplatin induces less apoptosis in the cochlea of guinea pigs than cisplatin
    Ken chi Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Tokyo, Japan
    Chemotherapy 48:82-7. 2002
  8. ncbi request reprint Expression of caspase-activated deoxyribonuclease (CAD) and caspase 3 (CPP32) in the hydropic cochlea of guinea pigs - second report
    Kenichi Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Eur Arch Otorhinolaryngol 259:257-61. 2002
  9. ncbi request reprint Expression of caspase-activated deoxyribonuclease (CAD) and caspase 3 (CPP32) in the cochlea of cisplatin (CDDP)-treated guinea pigs
    Ken ichi Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Kawasaki, Tokyo 113 8603, Japan
    Auris Nasus Larynx 30:219-25. 2003
  10. ncbi request reprint Induction of apoptosis in the vestibule of guinea pigs after middle ear inoculation with lipopolysaccharide (LPS)
    Ken ichi Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, 113 8603, Tokyo, Japan
    Auris Nasus Larynx 30:355-61. 2003

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Subcutaneous emphysema after tonsillectomy: a case report
    Ken ichi Watanabe
    Department of Otorhinolaryngology, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa 211 8533, Japan
    J Nippon Med Sch 71:111-3. 2004
    ..To avoid this kind of complication, we should pay attention to carefully separate the tonsil from its fossa and to make appropriate selection of surgical equipments...
  2. ncbi request reprint Expression of myeloperoxidase and cochlear dysfunction in the lipopolysaccharide-treated guinea pig
    K Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Tokyo, Japan
    Eur Arch Otorhinolaryngol 258:164-7. 2001
    ..These results suggest that MPO and reactive oxygen species are involved in cochlea dysfunction under inflammatory conditions...
  3. ncbi request reprint Detection of apoptotic change in the lipopolysaccharide (LPS)-treated cochlea of guinea pigs
    K Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Tokyo, Japan
    Hear Res 158:116-22. 2001
    ..These results suggest that the activation of CPP32 and fragmentation of DNA are involved in the dysfunction of the cochlea observed under inflammatory conditions...
  4. ncbi request reprint Expression of inducible nitric oxide synthase (iNOS/NOS II) in the hydropic vestibule after injection of keyhole limpet hemocyanin into the endolymphatic sac of guinea pigs
    K Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Sendagi 1 1 5, Bunkyo ku, Tokyo 113 8603, Japan
    J Vestib Res 11:67-71. 2001
    ..Our results suggest that the occurrence of inducible nitric oxide synthase immunoreactivity parallels the inner ear disturbance as seen in endolymphatic hydrops...
  5. ncbi request reprint Local injection of OK-432 in the treatment of ranula: a case report
    Ken ichi Watanabe
    Department of Otorhinolaryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyoku, Tokyo 113 8603, Japan
    Ear Nose Throat J 81:97-8. 2002
    ..Our experience suggests that OK-432 injection is an effective treatment for ranula. However, because this treatment causes the cyst to collapse rather than disappear completely, patients should be regularly monitored over the long term...
  6. ncbi request reprint Induction of apoptotic pathway in the vestibule of cisplatin (CDDP)-treated guinea pigs
    K Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Tokyo, Japan
    Anticancer Res 21:3929-32. 2001
    ..We immunohistochemically examined the apoptotic changes induced by cisplatin in the vestibule of guinea pigs...
  7. ncbi request reprint Carboplatin induces less apoptosis in the cochlea of guinea pigs than cisplatin
    Ken chi Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Tokyo, Japan
    Chemotherapy 48:82-7. 2002
    ..We examined apoptotic changes in the cochlea of guinea pigs after injection of CDDP or CBDCA using immunohistochemical and electrophysiological techniques...
  8. ncbi request reprint Expression of caspase-activated deoxyribonuclease (CAD) and caspase 3 (CPP32) in the hydropic cochlea of guinea pigs - second report
    Kenichi Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Eur Arch Otorhinolaryngol 259:257-61. 2002
    ..These findings suggest that apoptosis is involved in the pathogenesis of endolymphatic hydrops. This phenomenon could lead to cochlear dysfunction, as seen in endolymphatic hydrops...
  9. ncbi request reprint Expression of caspase-activated deoxyribonuclease (CAD) and caspase 3 (CPP32) in the cochlea of cisplatin (CDDP)-treated guinea pigs
    Ken ichi Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Kawasaki, Tokyo 113 8603, Japan
    Auris Nasus Larynx 30:219-25. 2003
    ..These findings suggest that apoptosis is involved in the cochlear damage observed in cancer patients treated with cisplatin...
  10. ncbi request reprint Induction of apoptosis in the vestibule of guinea pigs after middle ear inoculation with lipopolysaccharide (LPS)
    Ken ichi Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, 113 8603, Tokyo, Japan
    Auris Nasus Larynx 30:355-61. 2003
    ..We immunohistochemically examined the apoptotic changes induced by endotoxin in the vestibule of guinea pigs...
  11. ncbi request reprint Traumatic perilymph fistula in infants: a case report
    Ken ichi Watanabe
    Department of Otorhinolaryngology, Nippon Medical School, Kawasaki, Kanagawa, Japan
    J Nippon Med Sch 70:519-21. 2003
    ..The perforation of the tympanic membrane was closed with temporal fascia. After surgery, the spontaneous nystagmus disappeared. The patient is under observation as an outpatient and is growing normally...
  12. ncbi request reprint Brain abscess secondary to the middle ear cholesteatoma: a report of two cases
    Ken ichi Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Kosugi cho 1 396, Nakahara ku, Kawasaki, Kanagawa 211 8533, Japan
    Auris Nasus Larynx 31:433-7. 2004
    ..The abscess was drained and the cholesteatoma was removed using the canal down procedure under general anesthesia. The patient has been under observation for 1 year already and has presented no signs of recurrence...
  13. ncbi request reprint Detection of single-stranded DNA (ssDNA) in the vestibule of guinea pigs after the application of cisplatinum (CDDP)
    K Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Anticancer Res 21:1135-8. 2001
    ..Cisplatinum (CDDP) has a toxic effect on the inner ear. CDDP reacts with DNA and leads to apoptotic cell death. In this study, the presence of single-stranded DNA (ssDNA) was examined immunohistochemically...
  14. ncbi request reprint Inhibition of inducible nitric oxide synthase lowers the cochlear damage by lipopolysaccharide in guinea pigs
    K Watanabe
    Department of Oto Rhino Laryngology, University of Cologne, Germany
    Free Radic Res 32:363-70. 2000
    ..These results indicate that LPS has an ototoxic effect on the cochlea and that this effect could be mediated by iNOS produced high nitric oxide under inflammatory conditions...
  15. ncbi request reprint Nitric oxide synthase inhibitor reduces the apoptotic change in the cisplatin-treated cochlea of guinea pigs
    K Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Tokyo, Japan
    Anticancer Drugs 11:731-5. 2000
    ..High NO levels lead to inner ear dysfunction under pathological conditions. Our results indicate that NO mediates the ototoxicity of cisplatin...
  16. ncbi request reprint Expression of myeloperoxidase in the inner ear of cisplatin-treated guinea pigs
    K Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Tokyo, Japan
    Anticancer Drugs 11:727-30. 2000
    ..These results suggest that MPO and reactive oxygen species are involved in the inner ear dysfunction after the application of cisplatin...
  17. ncbi request reprint Apoptosis in the hydropic cochlea of guinea pigs following immune reaction of the endolymphatic sac: immunohistochemical analysis
    K Watanabe
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Eur Arch Otorhinolaryngol 258:296-9. 2001
    ..Apoptosis is the process of the cell death. Our findings imply that apoptotic changes are involved in endolymphatic hydrops. These phenomena could lead to cochlear dysfunction as seen in endolymphatic hydrops...
  18. ncbi request reprint Detection of single-stranded DNA in the hydropic vestibule after the direct injection of antigen into the endolymphatic sac of guinea pigs
    K I Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Tokyo, Japan
    Neurosci Lett 293:57-60. 2000
    ..ssDNA is accompanied with the apoptotic change in the vestibule. Our results suggest that apoptotic changes could be involved in the hydropic vestibule and these phenomena lead inner ear disturbance as seen in endolymphatic hydrops...
  19. ncbi request reprint Nitric oxide synthase inhibitor suppresses the ototoxic side effect of cisplatin in guinea pigs
    K I Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Tokyo, Japan
    Anticancer Drugs 11:401-6. 2000
    ..iNOS catalyzed high NO levels lead to inner ear dysfunction. Our results indicate that iNOS mediates the ototoxicity of cisplatin...
  20. ncbi request reprint Expression of inducible nitric oxide synthase (iNOS/NOS II) in the vestibule of guinea pigs after the application of cisplatin
    K Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Tokyo, Japan
    Anticancer Drugs 11:29-32. 2000
    ..Increased NO levels lead to inner ear dysfunction. Therefore, our results indicate that iNOS could also mediate the vestibulo-toxicity of cisplatin...
  21. ncbi request reprint Changes of the compound action potential (CAP) and the expression of inducible nitric oxide synthase (iNOS/NOS II) in the cochlea under the inflammatory condition(1)
    K Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Tokyo, Japan
    Hear Res 145:149-55. 2000
    ..These changes became evident first at higher frequency (8 kHz). These results suggest that iNOS-generated NO is involved in the cochlea dysfunction under inflammatory conditions...
  22. doi request reprint Expression of cochlin mRNA splice variants in the inner ear
    Kuwon Sekine
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Audiol Neurootol 15:88-96. 2010
    ..The short mRNA was detected only in the inner ear, and this variant may provide a clue to understanding the formation and function of cochlin isoforms...
  23. doi request reprint Cochlin-tomoprotein (CTP) detection test identifies traumatic perilymphatic fistula due to penetrating middle ear injury
    Tetsuo Ikezono
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Acta Otolaryngol 131:937-44. 2011
    ..The cochlin-tomoprotein (CTP) detection test can be used to make a definite, objective diagnosis of traumatic perilymphatic fistula (PLF), and therefore offers valuable information on patient selection for surgical treatment...
  24. doi request reprint Molecular cloning of the Coch gene of guinea pig inner ear and its expression analysis in cultured fibrocytes of the spiral ligament
    Lishu Li
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Acta Otolaryngol 130:868-80. 2010
    ..Proper Coch gene expression appears to be dependent on the unique extracellular micro-environment of the inner ear in vivo. These results provide insight into the Coch gene expression and its regulation...
  25. doi request reprint Synergistic induction of thymic stromal lymphopoietin by tumor necrosis factor alpha and Th2 cytokine in nasal polyp fibroblasts
    Manabu Nonaka
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Am J Rhinol Allergy 24:e14-8. 2010
    ..We investigated the expression of TSLP in cytokine-treated nasal polyp fibroblasts...
  26. ncbi request reprint Expression of cochlin in the vestibular organ of rats
    Tetsuo Ikezono
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    ORL J Otorhinolaryngol Relat Spec 67:252-8. 2005
    ..These findings support the theory that deposition of acidophilic substance in the inner ear caused by mutation of cochlin can induce a secondary retrograde dendritic degeneration of the vestibular nerves...
  27. doi request reprint The performance of Cochlin-tomoprotein detection test in the diagnosis of perilymphatic fistula
    Tetsuo Ikezono
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Audiol Neurootol 15:168-74. 2010
    ..To establish a definite diagnostic test for PLF using CTP as a biochemical marker, we examined the diagnostic performance of the CTP detection test...
  28. ncbi request reprint Subjective evaluation of post-tympanoplasty hearing in relation to the pure tone threshold
    Shunkichi Baba
    Department of Otolaryngology, Nippon Medical School Chiba Hokusoh Hospital, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Auris Nasus Larynx 31:347-51. 2004
    ..Thus, it is essential to study the relationship between the subjective evaluation of post-operative hearing based on the patient's own assessment and the objective assessment by audiometry...
  29. doi request reprint Cochlin-tomoprotein: a novel perilymph-specific protein and a potential marker for the diagnosis of perilymphatic fistula
    Tetsuo Ikezono
    Department of Otorhinolaryngology, Nippon Medical School, Sendagi, Tokyo 113 8603, Japan
    Audiol Neurootol 14:338-44. 2009
    ..The aim of this study was to determine whether CTP, a novel perilymph-specific protein, could be used as a marker for the diagnosis of PLF...
  30. doi request reprint Cochlin expression in the rat perilymph during postnatal development
    Kyoko Shiiba
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Acta Otolaryngol 132:1134-9. 2012
    ..The changes in the cochlin isoforms in the perilymph may provide important insights to the understanding of cochlin function and the pathogenesis of related inner ear diseases...
  31. ncbi request reprint Nuclear-factor kappa B (NF-kappa B)-inducible nitric oxide synthase (iNOS/NOS II) pathway damages the stria vascularis in cisplatin-treated mice
    Ken ichi Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, Sendagi 1 1 5, Bunkyo ku, Tokyo 113 8603, Japan
    Anticancer Res 22:4081-5. 2002
    ..The induction of inducible nitric oxide synthase is regulated by nuclear-factor kappa B (NF-kappa B). We examined the damage of the stria vascularis by immunohistochemical techniques...
  32. doi request reprint CTP (Cochlin-tomoprotein) detection in the profuse fluid leakage (gusher) from cochleostomy
    Tetsuo Ikezono
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Acta Otolaryngol 130:881-7. 2010
    ..Cochleostomy might have suddenly decreased the perilymph pressure, allowing the influx of CSF into the inner ear resulting in profuse fluid leakage, first perilymph then CSF...
  33. ncbi request reprint Expression of full-length Cochlin p63s is inner ear specific
    Lishu Li
    Department of Otorhinolaryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Auris Nasus Larynx 32:219-23. 2005
    ..To study the specificity of expression of Cochlin isoforms in various organs, here we have investigated expression of the COCH gene at both the transcriptional and translational level...
  34. doi request reprint Combined stimulation with Poly(I:C), TNF-alpha and Th2 cytokines induces TARC production by human fibroblasts from the nose, bronchioles and lungs
    Manabu Nonaka
    Department of Otolaryngology, Nippon Medical School, Tokyo, Japan
    Int Arch Allergy Immunol 152:327-41. 2010
    ..Resident fibroblasts are thought to contribute to inflammatory cell infiltration through chemokine production. We compared the abilities of nasal, bronchiolar and lung fibroblasts to produce TARC...
  35. doi request reprint Toll-like receptor 2, 3, 4, 5 ligands and interleukin-4 synergistically induce TARC production in nasal polyp fibroblasts
    Manabu Nonaka
    Department of Otorhinolaryngology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo, Japan
    Auris Nasus Larynx 35:515-20. 2008
    ..We investigated whether nasal polyp fibroblasts produce TARC when stimulated with the breakdown products of microorganisms (TLR ligands) and a Th2 cytokine (IL-4)...
  36. doi request reprint Combined stimulation of nasal polyp fibroblasts with poly IC, interleukin 4, and tumor necrosis factor alpha potently induces production of thymus- and activation-regulated chemokine
    Manabu Nonaka
    Department of Otolaryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Arch Otolaryngol Head Neck Surg 134:630-5. 2008
    ..To examine the effects of cytokines and poly IC on the expression of thymus- and activation-regulated chemokine (TARC), a potent chemoattractant for helper T-cell type 2 (T(H)2) cells, in nasal polyp fibroblasts...
  37. doi request reprint Spatiotemporal expression of cochlin in the inner ear of rats during postnatal development
    Susumu Shindo
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Neurosci Lett 444:148-52. 2008
    ..This is the first to report about the spatiotemporal expression of cochlin in the developing rat inner ear...
  38. ncbi request reprint Immunoreactivity for myeloperoxidase (MPO) in the vestibule after the injection of bacterial lipopolysaccharide into the middle ear
    Ken ichi Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Auris Nasus Larynx 29:241-5. 2002
    ..In this study, the effect of endotoxin on the vestibule of the ear of guinea pigs was immunohistochemically examined...
  39. ncbi request reprint Significance of preserving the posterior branch of the great auricular nerve in parotidectomy
    Kazuhiko Yokoshima
    Department of Otolaryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    J Nippon Med Sch 71:323-7. 2004
    ..In order to reduce the postoperative discomfort of the pinna, we tried to preserve the posterior branch of the great auricular nerve...
  40. doi request reprint Nasal polyp fibroblasts produce MIP-3alpha in response to toll-like receptor ligands and cytokine stimulation
    Manabu Nonaka
    Department of Otolaryngology, Nippon Medical School, Sendagi, Tokyo, Japan
    Rhinology 48:41-6. 2010
    ....
  41. ncbi request reprint Pathological localization of so-called posterior canal BPPV
    Toshiaki Yagi
    Department of Otolaryngology, Nippon Medical School, 1 1 5 Sendagi, Tokyo, Japan
    Auris Nasus Larynx 33:391-5. 2006
    ..To clarify the anatomical origin of positioning nystagmus in BPPV patients, we analyzed the positioning nystagmus of benign paroxysmal positioning vertigo (BPPV) patients three-dimensionally...
  42. doi request reprint 3D analysis of cough-induced nystagmus in a patient with superior semicircular canal dehiscence
    Toshiaki Yagi
    Department of Otolaryngology, Nippon Medical School, Sendagi, Bunkyo ku, Japan
    Auris Nasus Larynx 36:590-3. 2009
    ..In conjunction with the temporal bone CT study, the pathological localization in the inner ear in this patient was confirmed to be in the right superior semicircular canal...
  43. ncbi request reprint Congenital malformations of the middle ear with an intact external ear: a review of 38 cases
    Shunkichi Baba
    Department of Otolaryngology, Nippon Medical School, Tokyo, Japan
    ORL J Otorhinolaryngol Relat Spec 66:74-9. 2004
    ..Therefore, in patients with multiple middle ear malformations, the surgeon should know that the prospect of an improvement in the hearing threshold is rather low even after surgical reconstruction...
  44. pmc Synergistic Induction of Macrophage Inflammatory Protein-3α;/CCL20 Production by Interleukin-17A and Tumor Necrosis Factor-α; in Nasal Polyp Fibroblasts
    Manabu Nonaka
    From the Department of Otolaryngology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo, Japan
    World Allergy Organ J 2:218-23. 2009
    ..The objective of this study was to demonstrate the expression of MIP-3α;/CCL20 in nasal polyp fibroblasts after stimulation with proinflammatory cytokines such as interleukin-17 (IL-17) and tumor necrosis factor-α; (TNF-α;)...
  45. ncbi request reprint Foreign body in the maxillary sinus--possible plastic tube: a case report
    Jun Hasegawa
    Department of Oto Rhino Laryngology, Nippon Medical School, Kosugi cho 1 396, Nakahara ku, Kawasaki, Kanagawa 211 8533, Japan
    Auris Nasus Larynx 30:299-301. 2003
    ..However, the patient did not remember having been subjected to a treatment using such kind of tube. After the surgical removal, the patient became free from the nasal symptoms...
  46. pmc Expression and Roles of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 in Allergic Nasal Mucosa
    Sachiko Mori
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Allergy Asthma Immunol Res 4:231-9. 2012
    ..We analyzed the expression of MMPs and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs), in allergic nasal mucosa after nasal allergen challenge (NAC) and determined their relationship to inflammatory cells...
  47. ncbi request reprint A comparative study on the observation of spontaneous nystagmus with Frenzel glasses and an infrared CCD camera
    Shunkichi Baba
    Department of Otolaryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    J Nippon Med Sch 71:25-9. 2004
    ....
  48. ncbi request reprint Preliminary study of the role of endothelin-1 in the homeostasis of the inner ear
    K Jinnouchi
    Department of Otolaryngology, Nippon Medical School, Tokyo, Japan
    Acta Otolaryngol Suppl 528:10-4. 1997
    ..On day 7, ET-1-like activity recovered as a consequence of the decrease of inflammatory cells and reduction of EH. These findings suggest that ET-1 may play an important role as one of the regulators maintaining the fluid balance...
  49. ncbi request reprint Pathophysiologic mechanisms of chronic rhinosinusitis
    Ruby Pawankar
    Department of Otolaryngology, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo, 113 8603, Japan
    Immunol Allergy Clin North Am 24:75-85. 2004
  50. pmc Decreased Expression of FOXP3 in Nasal Polyposis
    Kannika Roongrotwattanasiri
    Rhinology and Allergy, Nippon Medical School, Tokyo, Japan
    Allergy Asthma Immunol Res 4:24-30. 2012
    ..Decreased expression of FOXP3 has been reported in allergic diseases. The present study was designed to evaluate the presence and potential roles of Tregs, defined by the expression of FOXP3 protein, in NP...
  51. ncbi request reprint Expression of inducible nitric oxide synthase in the cochlea following immune response in the endolymphatic sac of guinea pigs
    K Watanabe
    Department of Oto-Rhino-Laryngology, Nippon Medical School, Tokyo, Japan
    ORL J Otorhinolaryngol Relat Spec 63:155-9. 2001
    ..It is known that high levels of nitric oxide can lead to inner ear dysfunction. Our results suggest that iNOS may mediate the inner ear disturbance as seen in endolymphatic hydrops...
  52. doi request reprint Rotation vectors of slow and quick phase of caloric nystagmus
    Toshiaki Yagi
    Department of Otolaryngology, Nippon Medical School 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
    Auris Nasus Larynx 39:475-8. 2012
    ..The purpose of this study was to elucidate the rotation axes of the slow and quick phase of the caloric nystagmus using the video-oculographic technique...
  53. pmc Increased expression and role of thymic stromal lymphopoietin in nasal polyposis
    Satoko Kimura
    Department of Otolaryngology, Nippon Medical School, Tokyo, Japan
    Allergy Asthma Immunol Res 3:186-93. 2011
    ..Here, we investigated the expression of TSLP in nasal polyps from atopics and non-atopics in comparison with the nasal mucosa and its potential role in nasal polyposis...
  54. ncbi request reprint Expression of MCP-4 by TLR ligand-stimulated nasal polyp fibroblasts
    Manabu Nonaka
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Acta Otolaryngol 127:1304-9. 2007
    ..These results indicate that nasal polyp fibroblasts contribute to innate immunity and eosinophilic inflammation such as nasal polyposis...
  55. ncbi request reprint Subjective evaluation and overall satisfaction after tympanoplasty for chronic simple suppurative otitis media
    Shunkichi Baba
    Department of Otorhinolaringology, Chiba Hokuso Hospital, Nippon Medical School, 1715 Kamagari, Inba, Chiba 270 1694, Japan
    J Nippon Med Sch 71:17-24. 2004
    ..VAS is considered a useful method to evaluate the degree of satisfaction of patients after surgery...
  56. ncbi request reprint Utility of sonography for evaluation of clinical T1 and T2 glottic carcinoma
    Shigehiko Kuribayashi
    Department of Radiology, Nippon Medical School Hospital, Tokyo, Japan
    J Ultrasound Med 28:1429-40. 2009
    ..The aim of this study was to evaluate the prognostic impact of sonographically determined tumor features in relation to local control of clinical T1 and T2 glottic carcinoma treated by definitive radiation therapy...
  57. ncbi request reprint Use of free flaps for reconstruction in head and neck surgery: a retrospective study of 182 cases
    Munenaga Nakamizo
    Department of Otolaryngology, Head and Neck Surgery, Nippon Medical School, 1 1 5 Sendagi Bunkyo ku, Tokyo 113 8603, Japan
    Auris Nasus Larynx 31:269-73. 2004
    ..In order to clarify the factors affecting the survival of flaps, we performed a retrospective study on free flaps (187) used for reconstruction in head and neck surgery in 182 patients...
  58. ncbi request reprint Ultrasonographic demonstration of retropharyngeal lymph nodes: preliminary report
    Tsuguhiro Miyashita
    Department of Radiology, Nippon Medical School, Tokyo, Japan
    Ultrasound Med Biol 29:633-6. 2003
    ..5 cm and from 0.0 cm to 1.0 cm, respectively. RPNs that are 1.5 cm or more in size can be demonstrated with percutaneous US using CT guidance. This technique should be utilized for the purpose of monitoring in a radiation therapy setting...
  59. ncbi request reprint Mast cell-IgE-and mast cell-structural cell interactions in allergic airway disease
    Ruby Pawankar
    Department of Otolaryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Curr Drug Targets Inflamm Allergy 2:303-12. 2003
    ....
  60. ncbi request reprint Identification of a novel Cochlin isoform in the perilymph: insights to Cochlin function and the pathogenesis of DFNA9
    Tetsuo Ikezono
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Biochem Biophys Res Commun 314:440-6. 2004
    ..The pathogenesis of DFNA9 is not fully clarified as yet, and this novel perilymph-associated CTP isoform might provide mechanistic clues to how mutations in the COCH gene damage the inner ear function...
  61. ncbi request reprint Passive transfer of experimental autoimmune labyrinthitis
    T Ikezono
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Audiol Neurootol 5:292-9. 2000
    ..These findings suggest that the experimentally induced labyrinthitis observed in this animal model was probably due to an autoimmune reaction to the IEAg and was passively transferred by a cell-mediated immune reaction...
  62. ncbi request reprint The effect of gravity on the stability of human eye orientation
    Mio Aoyagi
    Department of Otolaryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, 113 8603, Tokyo, Japan
    Auris Nasus Larynx 30:363-7. 2003
    ..Therefore, in the present study, we examined the gaze stability of healthy human subjects in the three dimensions in the tilted position using a video image analysis system (VIAS)...
  63. ncbi request reprint IL-5 and eotaxin levels in middle ear effusion and blood from asthmatics with otitis media with effusion
    Manabu Nonaka
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Acta Otolaryngol 123:383-7. 2003
    ....
  64. ncbi request reprint Incidence and characteristics of otosclerosis in the Japanese population
    Toshiaki Yagi
    Department of Otolaryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Auris Nasus Larynx 29:257-60. 2002
    ..However, in recent years the incidence of this disease seems to have increased. Here we report about the characteristics and incidence of this disease in the Japanese population who underwent stapes surgery in our department...
  65. ncbi request reprint Role of dorsal neck proprioceptive inputs to vestibular compensation in humans
    T Yagi
    Department of Otolaryngology, Nippon Medical School, Tokyo, Japan
    Nihon Ika Daigaku Zasshi 65:291-7. 1998
    ..These results indicate that manipulation of the neck afferents causes discompensation in subjects whose vestibular dysfunction has already been compensated by multisensory inputs including neck afferents...
  66. ncbi request reprint Distinct expression of RANTES and GM-CSF by lipopolysaccharide in human nasal fibroblasts but not in other airway fibroblasts
    M Nonaka
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Int Arch Allergy Immunol 119:314-21. 1999
    ..These findings suggest that nasal fibroblasts may play an important role in the recruitment and activation of eosinophils into nasal polyps through the release of RANTES and GM-CSF...
  67. ncbi request reprint Experimental autoimmune labyrinthitis induced by cell-mediated immune reaction
    S Tomiyama
    Department of Otolaryngology, Nippon Medical School, Tokyo, Japan tomiyama
    Acta Otolaryngol 119:665-70. 1999
    ..These results suggest that the inner ear may possess cross-species organ-specific antigen and that a cell-mediated immune reaction may play an important role in the induction of autoimmune labyrinthitis...
  68. ncbi request reprint Induction of eotaxin production by interleukin-4, interleukin-13 and lipopolysaccharide by nasal fibroblasts
    M Nonaka
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Clin Exp Allergy 34:804-11. 2004
    ....