Research Topics


Shigenobu Shibata


Affiliation: Waseda University
Country: Japan


  1. Akter S, Sasaki H, Uddin K, Ikeda Y, Miyakawa H, Shibata S. Anxiolytic effects of γ-oryzanol in chronically- stressed mice are related to monoamine levels in the brain. Life Sci. 2019;216:119-128 pubmed publisher
    ..Taken together, our studies suggested that 0.5% GORZ is a potential therapeutic drug candidate against anxiety under chronic stress conditions. ..
  2. Takahashi M, Ozaki M, Kang M, Sasaki H, Fukazawa M, Iwakami T, et al. Effects of Meal Timing on Postprandial Glucose Metabolism and Blood Metabolites in Healthy Adults. Nutrients. 2018;10: pubmed publisher
    ..In addition, this study provides insight into the difference of incretion and blood metabolites between breakfast and dinner, indicating that the total metabolic responses tends to be higher in the morning. ..
  3. Yokota S, Nakamura K, Ando M, Haraguchi A, Omori K, Shibata S. A low-protein diet eliminates the circadian rhythm of serum insulin and hepatic lipid metabolism in mice. J Nutr Biochem. 2019;63:177-185 pubmed publisher
  4. Aoyama S, Kojima S, Sasaki K, Ishikawa R, Tanaka M, Shimoda T, et al. Day-Night Oscillation of Atrogin1 and Timing-Dependent Preventive Effect of Weight-Bearing on Muscle Atrophy. EBioMedicine. 2018;37:499-508 pubmed publisher
    ..FUND: Council for Science, Technology, and Innovation, SIP, "Technologies for creating next-generation agriculture, forestry, and fisheries". ..
  5. Aoki N, Yoshida D, Ishikawa R, Ando M, Nakamura K, Tahara Y, et al. A single daily meal at the beginning of the active or inactive period inhibits food deprivation-induced fatty liver in mice. Nutr Res. 2014;34:613-22 pubmed publisher
    ..This is the first study to demonstrate that feeding patterns affect FD-induced TG accumulation in the mouse liver. ..
  6. Takahashi M, Tahara Y, Tsubosaka M, Fukazawa M, Ozaki M, Iwakami T, et al. Chronotype and social jetlag influence human circadian clock gene expression. Sci Rep. 2018;8:10152 pubmed publisher
  7. Hamaguchi Y, Tahara Y, Hitosugi M, Shibata S. Impairment of Circadian Rhythms in Peripheral Clocks by Constant Light Is Partially Reversed by Scheduled Feeding or Exercise. J Biol Rhythms. 2015;30:533-42 pubmed publisher
    ..The broad distribution of clock phases was clearly reversed by scheduled feeding, suggesting the importance of scheduled feeding as an entraining stimulus for impaired peripheral clocks. ..
  8. Moriya S, Tahara Y, Sasaki H, Ishigooka J, Shibata S. Housing under abnormal light-dark cycles attenuates day/night expression rhythms of the clock genes Per1, Per2, and Bmal1 in the amygdala and hippocampus of mice. Neurosci Res. 2015;99:16-21 pubmed publisher
    ..The present results suggest that the presence of a depressive state around the early active phase of activity may be related to impairment of rhythmicity and expression levels of Per1 and Per2 genes under abnormal light-dark conditions. ..
  9. Yokota S, Ando M, Aoyama S, Nakamura K, Shibata S. Leucine restores murine hepatic triglyceride accumulation induced by a low-protein diet by suppressing autophagy and excessive endoplasmic reticulum stress. Amino Acids. 2016;48:1013-21 pubmed publisher
    ..This study contributes to understanding the mechanisms of hepatic disorders of lipid metabolism. ..

More Information


  1. Moriya S, Tahara Y, Sasaki H, Ishigooka J, Shibata S. Phase-delay in the light-dark cycle impairs clock gene expression and levels of serotonin, norepinephrine, and their metabolites in the mouse hippocampus and amygdala. Sleep Med. 2015;16:1352-1359 pubmed publisher
    ..The present results suggest that misalignment of the internal and external clocks by continuous shifting of the light-dark cycle affects the circadian clocks and monoamine metabolism in the amygdala and hippocampus of mice. ..
  2. Tahara Y, Shibata S. Entrainment of the mouse circadian clock: Effects of stress, exercise, and nutrition. Free Radic Biol Med. 2018;119:129-138 pubmed publisher
    ..Here, we focus on the central and peripheral clocks mostly in rodents' studies and review the findings of recent investigations of the effects of stress, exercise, and food on the entrainment system. ..
  3. Haraguchi A, Fukuzawa M, Iwami S, Nishimura Y, Motohashi H, Tahara Y, et al. Night eating model shows time-specific depression-like behavior in the forced swimming test. Sci Rep. 2018;8:1081 pubmed publisher
    ..The present study suggests that the NES feeding pattern causes phase shift of peripheral clocks and malfunction of the monoamine system, which may contribute to the development of time-specific depression. ..
  4. Tahara Y, Yamazaki M, Sukigara H, Motohashi H, Sasaki H, Miyakawa H, et al. Gut Microbiota-Derived Short Chain Fatty Acids Induce Circadian Clock Entrainment in Mouse Peripheral Tissue. Sci Rep. 2018;8:1395 pubmed publisher
    ..SCFA oral gavage and prebiotic supplementation can facilitate peripheral clock adjustment, suggesting prebiotics as novel therapeutic candidates for misalignment. ..
  5. Ikeda Y, Kamagata M, Hirao M, Yasuda S, Iwami S, Sasaki H, et al. Glucagon and/or IGF-1 Production Regulates Resetting of the Liver Circadian Clock in Response to a Protein or Amino Acid-only Diet. EBioMedicine. 2018;28:210-224 pubmed publisher
    ..Our findings suggest that glucagon and/or IGF-1 production are additional key factors in food-induced entrainment. ..
  6. Tahara Y, Aoyama S, Shibata S. The mammalian circadian clock and its entrainment by stress and exercise. J Physiol Sci. 2017;67:1-10 pubmed publisher
    ..Therefore, using exercise to maintain the circadian clock at an appropriate phase and amplitude might be effective for preventing obesity, diabetes, and cardiovascular disease. ..
  7. Wada M, Orihara K, Kamagata M, Hama K, Sasaki H, Haraguchi A, et al. Circadian clock-dependent increase in salivary IgA secretion modulated by sympathetic receptor activation in mice. Sci Rep. 2017;7:8802 pubmed publisher
    ..We speculate that activation of sympathetic nerves during sleep may protect from bacterial access to the epithelial surface through enhanced secretion of IgA. ..
  8. Motohashi H, Sukigara H, Tahara Y, Saito K, Yamazaki M, Shiraishi T, et al. Polyporus and Bupleuri radix effectively alter peripheral circadian clock phase acutely in male mice. Nutr Res. 2017;43:16-24 pubmed publisher
    ..These crude drugs may be therefore good modulators of the circadian peripheral clocks including liver and kidney, and circadian clock genes become new molecular targets for these crude drugs. ..