Wataru Kagawa

Summary

Affiliation: Waseda University
Country: Japan

Publications

  1. doi request reprint From meiosis to postmeiotic events: uncovering the molecular roles of the meiosis-specific recombinase Dmc1
    Wataru Kagawa
    Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku ku, Tokyo, Japan
    FEBS J 277:590-8. 2010
  2. pmc Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2
    Naoki Horikoshi
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan
    Acta Crystallogr D Biol Crystallogr 69:2431-9. 2013
  3. ncbi request reprint Crystal structure of the human centromeric nucleosome containing CENP-A
    Hiroaki Tachiwana
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan
    Nature 476:232-5. 2011
  4. doi request reprint Structures of human nucleosomes containing major histone H3 variants
    Hiroaki Tachiwana
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo 162 8480, Japan
    Acta Crystallogr D Biol Crystallogr 67:578-83. 2011
  5. doi request reprint Current progress on structural studies of nucleosomes containing histone H3 variants
    Hitoshi Kurumizaka
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan
    Curr Opin Struct Biol 23:109-15. 2013
  6. ncbi request reprint Comparison between the CENP-A and histone H3 structures in nucleosomes
    Hiroaki Tachiwana
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan
    Nucleus 3:6-11. 2012
  7. pmc Functional analyses of the C-terminal half of the Saccharomyces cerevisiae Rad52 protein
    Wataru Kagawa
    Department of Interdisciplinary Science and Engineering, Program in Chemistry and Life Science, School of Science and Engineering, Meisei University, 2 1 1 Hodokubo, Hino shi, Tokyo 191 8506, Japan, Department of Applied Biological Science, Nihon University College of Bioresource Sciences, Fujisawa shi, Kanagawa 252 0880, Japan, Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan and Cellular and Molecular Biology Laboratory, RIKEN, Wako Shi, Saitama 351 0198, Japan
    Nucleic Acids Res 42:941-51. 2014
  8. pmc Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair
    Koichi Sato
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan
    EMBO J 31:3524-36. 2012
  9. doi request reprint Comprehensive structural analysis of mutant nucleosomes containing lysine to glutamine (KQ) substitutions in the H3 and H4 histone-fold domains
    Wakana Iwasaki
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku ku, Tokyo 162 8480, Japan
    Biochemistry 50:7822-32. 2011
  10. doi request reprint Purification and characterization of the fission yeast telomere clustering factors, Bqt1 and Bqt2
    Yuichi Ichikawa
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan
    Protein Expr Purif 88:207-13. 2013

Collaborators

Detail Information

Publications15

  1. doi request reprint From meiosis to postmeiotic events: uncovering the molecular roles of the meiosis-specific recombinase Dmc1
    Wataru Kagawa
    Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku ku, Tokyo, Japan
    FEBS J 277:590-8. 2010
    ..Recent structural, biochemical, and genetic findings are now revealing the molecular mechanisms of Dmc1-mediated homologous recombination and its regulation by various recombination mediators...
  2. pmc Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2
    Naoki Horikoshi
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan
    Acta Crystallogr D Biol Crystallogr 69:2431-9. 2013
    ..Z.1 and H2A.Z.2. These findings provide important new information for understanding the differences in the regulation and functions of H2A.Z.1 and H2A.Z.2 in cells. ..
  3. ncbi request reprint Crystal structure of the human centromeric nucleosome containing CENP-A
    Hiroaki Tachiwana
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan
    Nature 476:232-5. 2011
    ..The structure provides the first atomic-resolution picture of the centromere-specific nucleosome...
  4. doi request reprint Structures of human nucleosomes containing major histone H3 variants
    Hiroaki Tachiwana
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo 162 8480, Japan
    Acta Crystallogr D Biol Crystallogr 67:578-83. 2011
    ..1 nucleosome. Since the amino-acid residues specific for H3.2 and H3.3 are located on the accessible surface of the H3/H4 tetramer, they may be potential interaction sites for H3.2- and H3.3-specific chaperones...
  5. doi request reprint Current progress on structural studies of nucleosomes containing histone H3 variants
    Hitoshi Kurumizaka
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan
    Curr Opin Struct Biol 23:109-15. 2013
    ..In this review, we survey the current progress in the studies of nucleosomes containing H3 variants, and discuss their implications for the architecture and dynamics of chromatin domains...
  6. ncbi request reprint Comparison between the CENP-A and histone H3 structures in nucleosomes
    Hiroaki Tachiwana
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan
    Nucleus 3:6-11. 2012
    ..In this Extra View article, we provide a detailed structural comparison between CENP-A and H3 in nucleosomes and describe their distinctions and similarities...
  7. pmc Functional analyses of the C-terminal half of the Saccharomyces cerevisiae Rad52 protein
    Wataru Kagawa
    Department of Interdisciplinary Science and Engineering, Program in Chemistry and Life Science, School of Science and Engineering, Meisei University, 2 1 1 Hodokubo, Hino shi, Tokyo 191 8506, Japan, Department of Applied Biological Science, Nihon University College of Bioresource Sciences, Fujisawa shi, Kanagawa 252 0880, Japan, Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan and Cellular and Molecular Biology Laboratory, RIKEN, Wako Shi, Saitama 351 0198, Japan
    Nucleic Acids Res 42:941-51. 2014
    ..Our studies suggested that phenylalanine-349 and tyrosine-409 are key residues in the C-terminal half of Rad52 and probably play an important role in the mediator activity. ..
  8. pmc Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair
    Koichi Sato
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan
    EMBO J 31:3524-36. 2012
    ..Although FANCI by itself lacked nucleosome-assembly activity, it significantly stimulated FANCD2-mediated nucleosome assembly. These observations suggest that FANCD2-FANCI may regulate chromatin dynamics during DNA repair...
  9. doi request reprint Comprehensive structural analysis of mutant nucleosomes containing lysine to glutamine (KQ) substitutions in the H3 and H4 histone-fold domains
    Wakana Iwasaki
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku ku, Tokyo 162 8480, Japan
    Biochemistry 50:7822-32. 2011
    ..These results provide an important structural basis for understanding how histone modifications and mutations affect chromatin structure and function...
  10. doi request reprint Purification and characterization of the fission yeast telomere clustering factors, Bqt1 and Bqt2
    Yuichi Ichikawa
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan
    Protein Expr Purif 88:207-13. 2013
    ..The expression and purification procedures established here will facilitate further biophysical studies of the Bqt1-Bqt2 complex...
  11. pmc Structural and functional analyses of the DMC1-M200V polymorphism found in the human population
    Juri Hikiba
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan
    Nucleic Acids Res 36:4181-90. 2008
    ....
  12. doi request reprint Structural and biochemical analyses of the human PAD4 variant encoded by a functional haplotype gene
    Naoki Horikoshi
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjyuku ku, Tokyo 162 8480, Japan
    Acta Crystallogr D Biol Crystallogr 67:112-8. 2011
    ....
  13. ncbi request reprint The putative nuclear localization signal of the human RAD52 protein is a potential sumoylation site
    Kengo Saito
    Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan
    J Biochem 147:833-42. 2010
    ..These results suggest the possibility of sumoylation playing an important role in the nuclear transport of RAD52...
  14. doi request reprint Structural basis for the DNA-binding activity of the bacterial β-propeller protein YncE
    Wataru Kagawa
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan
    Acta Crystallogr D Biol Crystallogr 67:1045-53. 2011
    ....
  15. pmc Structural basis of instability of the nucleosome containing a testis-specific histone variant, human H3T
    Hiroaki Tachiwana
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku ku, Tokyo 162 8480, Japan
    Proc Natl Acad Sci U S A 107:10454-9. 2010
    ..These physical and structural properties of the H3T-containing nucleosome may provide the basis of chromatin reorganization during spermatogenesis...