Noriko Yoshimura

..Future research should be required to evaluate the types and quantity of physical activity needed for the prevention of osteoporosis...

..Smoking cessation is effective to decrease the risk for both osteoporosis and osteoporotic fractures. Future research should be required to evaluate the alcohol consumption and osteoporosis...

..The following risk factors for hip fractures were identified using multivariate analysis: past history of stroke with hemiplegia, sleep disturbance, sleeping in a Western-style bed, and drinking more than 3 cups of coffee daily...

..Data in 1990 and in 2000 showed significant improvements for men in their sixties and for women in their fifties, suggesting that future problems of osteoporosis might be less severe than has previously been predicted in Japan...

..These results indicate that fast bone loss is a transient phenomenon rather than a fixed status, although individuals who have been categorized as fast bone losers at some stage continue to display low BMD in the lumbar spine...

..pylori eradication. Subjects with highly active gastritis identified by the two serological tests and endoscopic RHG constitute a group at high risk of cancer development with H. pylori-infected nonatrophic stomach...

..pylori eradication is beneficial to most PG test-negative subjects with mild CAG as defined by the aforementioned criteria...

..0 had the lowest risk; none of these subjects developed cancer. Thus, serum PG levels and/or H. pylori antibody levels can be used to predict the risk of cancer in individuals with H. pylori-related gastritis from the general population...

..These results strongly suggest that chemoprevention of cancer in the metaplastic stomach is possible by controlling COX-2 expression...

..Knowing the H. pylori-related chronic gastritis stage will probably be useful for evaluation of risk for colorectal neoplasia...

..Thus, it is probable that a highly efficient gastric cancer screening system can be implemented by combining the two screening methods. Such a screening program would be beneficial in a population at high risk for gastric cancer...

..It would, however, be difficult to predict bone loss in middle-aged and elderly Japanese women over a 3-year period using these indices alone...

..Because the long-term outcomes of cancer development in extensive atrophic gastritis detected by pepsinogen test are unclear, test-positive and test-negative subjects were investigated in a longitudinal cohort study...

..2). After age-adjustment using the Japanese Model Population in 1985, differences of Parkinson disease incidence became attenuated and adjusted rates (95% CIs) turned to 10.8(9.1-12.7), 10.4(8.6-12.2), and 9.9(6.9-12.9), respectively...

..The review revealed that increased measurements could predict fractures among elderly and peri- and postmenopausal women, and elderly men...

..A population-based magnetic resonance imaging (MRI) study of the cervical spine...

..Development of treatment guidelines requires further knowledge about the etiology and natural history of DNDLS in the elderly...

..Previous injury to the knee and occupational factors are also associated with knee OA in both Britain and Japan, although characteristic activities for work vary...

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..CONCLUSION: Our results indicate the importance of CYP19 and the enzymes regulating the oestrone sulfate metabolism as factors of disease-free survival in breast cancer, in addition to the well-known factors ER and ERBB2...

..Physical work is associated with knee OA, demonstrating the influence of working activity on the development of OA. The present study suggests that risk factors for knee OA in men resemble those in women...

..The aim of this study was to identify lifestyle factors associated with BMD...

..Fracture, especially hip fracture and vertebral fracture, is associated with mortality. Thus, prevention for fracture in the elderly is very important issue...

..007; R2 = 0.25), and lifting (P = 0.014, R2 = 0.27), and those at the femoral neck were significantly correlated with decreased abilities in lifting (P = 0.001, R2 = 0.33)...

..It is encouraging that both men and women in later birth cohorts showed higher BMDs in middle-age, for this may predict a decrease in the incidence and prevalence of osteoporosis in the near future in Japan...

..However, further epidemiological research is needed to facilitate the development of affordable strategies using bone turnover markers for the early identification of high-risk individuals...

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..Indications for surgical intervention in PDB include unstable fractures, osteoarthritis, malignant soft-tissue tumor, osteosarcoma, and bone deformity...

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