H Yamaue

Summary

Affiliation: Wakayama Medical University
Country: Japan

Publications

  1. pmc Specific T-cell immunity against Ki-ras peptides in patients with pancreatic and colorectal cancers
    Y Shono
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Japan
    Br J Cancer 88:530-6. 2003
  2. pmc Identification of HLA-A24-restricted novel T Cell epitope peptides derived from P-cadherin and kinesin family member 20A
    Ryuji Osawa
    Second Department of Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    J Biomed Biotechnol 2012:848042. 2012
  3. pmc Identification of an HLA-A2-restricted epitope peptide derived from hypoxia-inducible protein 2 (HIG2)
    Sachiko Yoshimura
    Second Department of Surgery, Wakayama Medical University, Wakayama, Japan OncoTherapy Science Inc, Research and Development Division, Kanagawa, Japan
    PLoS ONE 9:e85267. 2014
  4. doi request reprint Isolated Roux-en-Y anastomosis of the pancreatic stump in a duct-to-mucosa fashion in patients with distal pancreatectomy with en-bloc celiac axis resection
    Ken Ichi Okada
    Second Department of Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 8510, Japan
    J Hepatobiliary Pancreat Sci 21:193-8. 2014
  5. doi request reprint Phase II clinical study of alternate-day oral therapy with S-1 as first-line chemotherapy for locally advanced and metastatic pancreatic cancer
    Hiroki Yamaue
    Second Department of Surgery, Wakayama Medical University, 10 31 Kimiidera, Wakayama City, Wakayama, 641 8510, Japan
    Cancer Chemother Pharmacol 73:97-102. 2014
  6. pmc Endoscopically observable white nodule caused by distal intramural lymphatic spread of rectal cancer: a case report
    Ayako Tsumura
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    World J Surg Oncol 10:216. 2012
  7. doi request reprint Effect of Daikenchuto (TJ-100) on postoperative bowel motility and on prevention of paralytic ileus after pancreaticoduodenectomy: a multicenter, randomized, placebo-controlled phase II trial (the JAPAN-PD study)
    Ken Ichi Okada
    Second Department of Surgery, Wakayama Medical University, Wakayama, Japan
    Jpn J Clin Oncol 43:436-8. 2013
  8. pmc Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway
    Shinya Hayami
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Mol Cancer 9:59. 2010
  9. pmc Hemangiopericytoma in the sacrococcygeal space: a case report
    Yuji Kitahata
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Kimiidera, Wakayama, 641 8510, Japan
    J Med Case Reports 4:8. 2010
  10. pmc Moderately differentiated colorectal adenocarcinoma as a lymph node metastatic phenotype: comparison with well differentiated counterparts
    Shozo Yokoyama
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    BMC Surg 10:8. 2010

Collaborators

Detail Information

Publications114 found, 100 shown here

  1. pmc Specific T-cell immunity against Ki-ras peptides in patients with pancreatic and colorectal cancers
    Y Shono
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Japan
    Br J Cancer 88:530-6. 2003
    ..However, pancreatic and colorectal cancer patients have T-cell immunity against Ki-ras-peptides, and this provides potential target for cancer immunotherapy...
  2. pmc Identification of HLA-A24-restricted novel T Cell epitope peptides derived from P-cadherin and kinesin family member 20A
    Ryuji Osawa
    Second Department of Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    J Biomed Biotechnol 2012:848042. 2012
    ..Our results demonstrated that CDH3-10-807 peptide and KIF20A-10-66 peptide are novel HLA-A24-restricted tumor-associated antigens and would be applicable for CTL-inducing cancer therapies...
  3. pmc Identification of an HLA-A2-restricted epitope peptide derived from hypoxia-inducible protein 2 (HIG2)
    Sachiko Yoshimura
    Second Department of Surgery, Wakayama Medical University, Wakayama, Japan OncoTherapy Science Inc, Research and Development Division, Kanagawa, Japan
    PLoS ONE 9:e85267. 2014
    ..Taken together, these findings indicate that the HIG2-9-4 peptide is a novel HLA-A2 supertype-restricted epitope peptide that could be useful for peptide-based immunotherapy against cancer cells with HIG2 expression. ..
  4. doi request reprint Isolated Roux-en-Y anastomosis of the pancreatic stump in a duct-to-mucosa fashion in patients with distal pancreatectomy with en-bloc celiac axis resection
    Ken Ichi Okada
    Second Department of Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 8510, Japan
    J Hepatobiliary Pancreat Sci 21:193-8. 2014
    ..Therefore, a procedure to decrease the incidence of postoperative pancreatic fistula is urgently needed...
  5. doi request reprint Phase II clinical study of alternate-day oral therapy with S-1 as first-line chemotherapy for locally advanced and metastatic pancreatic cancer
    Hiroki Yamaue
    Second Department of Surgery, Wakayama Medical University, 10 31 Kimiidera, Wakayama City, Wakayama, 641 8510, Japan
    Cancer Chemother Pharmacol 73:97-102. 2014
    ..We therefore conducted a multicenter cooperative prospective study to compare daily with alternate-day administration of S-1 for advanced pancreatic cancer...
  6. pmc Endoscopically observable white nodule caused by distal intramural lymphatic spread of rectal cancer: a case report
    Ayako Tsumura
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    World J Surg Oncol 10:216. 2012
    ..Small white nodules near a primary rectal cancer should be suspected of being intramural spreading. Endoscopic detection of white nodules may be useful for the diagnosis of distal intramural spread...
  7. doi request reprint Effect of Daikenchuto (TJ-100) on postoperative bowel motility and on prevention of paralytic ileus after pancreaticoduodenectomy: a multicenter, randomized, placebo-controlled phase II trial (the JAPAN-PD study)
    Ken Ichi Okada
    Second Department of Surgery, Wakayama Medical University, Wakayama, Japan
    Jpn J Clin Oncol 43:436-8. 2013
    ..Two hundred and twenty patients are required in the study (110 patients per group)...
  8. pmc Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway
    Shinya Hayami
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Mol Cancer 9:59. 2010
    ..Cell cycle-dependent characteristics of KDM5B were identified by immunofluorescence and FACS...
  9. pmc Hemangiopericytoma in the sacrococcygeal space: a case report
    Yuji Kitahata
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Kimiidera, Wakayama, 641 8510, Japan
    J Med Case Reports 4:8. 2010
    ..Hemangiopericytomas can occur wherever there are vascular capillaries. However, there are no previous reports of a hemangiopericytoma in the sacrococcygeal space...
  10. pmc Moderately differentiated colorectal adenocarcinoma as a lymph node metastatic phenotype: comparison with well differentiated counterparts
    Shozo Yokoyama
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    BMC Surg 10:8. 2010
    ..Since Mod is unable to form complete acini, therefore an epithelial-mesenchymal transition (EMT) can occur in that structure. Herein, we hypothesized that Mod metastasizes more easily than the Wel counterparts...
  11. pmc Endoscopic resection of duodenal bulb neuroendocrine tumor larger than 10 mm in diameter
    Shozo Yokoyama
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    BMC Gastroenterol 11:67. 2011
    ..This report presents four cases successfully treated with endosonography (EUS)-assisted endoscopic mucosal resection (EMR) procedure for duodenal bulb neuroendocrine tumor larger than 10 mm in diameter...
  12. ncbi request reprint Locoregional chemotherapy for patients with pancreatic cancer intra-arterial adjuvant chemotherapy after pancreatectomy with portal vein resection
    Hiroki Yamaue
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Pancreas 25:366-72. 2002
    ....
  13. ncbi request reprint Solid and cystic tumor of the pancreas: clinicopathologic and genetic studies of four cases
    H Yamaue
    Second Department of Surgery, Wakayama Medical School, Japan
    Int J Pancreatol 27:69-76. 2000
    ..Solid and cystic tumor (SCT) of the pancreas can be distinguished from other pancreatic neoplasms by its nearly exclusive occurrence in young women, and its favorable prognosis after complete resection...
  14. ncbi request reprint Multidisciplinary treatment for gastric cancer patients by chemoimmunotherapy
    H Yamaue
    Second Department of Surgery, Wakayama Medical School, Japan
    Hepatogastroenterology 46:620-5. 1999
    ..Gastric cancer is a virulent disease with a poor prognosis despite multidisciplinary treatment. The present study was designed to clarify the clinical effects of chemoimmunotherapy for patients with advanced gastric cancer...
  15. ncbi request reprint Pancreatic dissection in the procedure of pancreaticoduodenectomy (with videos)
    Hiroki Yamaue
    Second Department of Surgery, Wakayama Medical University, Wakayama, Japan
    J Hepatobiliary Pancreat Sci 19:95-9. 2012
    ....
  16. ncbi request reprint Adenosquamous carcinoma of the pancreas: successful treatment with extended radical surgery, intraoperative radiation therapy, and locoregional chemotherapy
    H Yamaue
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Japan
    Int J Pancreatol 29:53-8. 2001
    ..Adenosquamous carcinoma of the pancreas is a rare tumor with an extremely poor survival rate. No obvious evidence that multidisciplinary treatments improves the prognosis and survival has been reported...
  17. ncbi request reprint Clinical efficacy of doxifluridine and correlation to in vitro sensitivity of anticancer drugs in patients with colorectal cancer
    Hiroki Yamaue
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1, Kimiidera, Wakayama 641 8510, Japan
    Anticancer Res 23:2559-64. 2003
    ..We examined thymidine phosphorylase (TP) expression and sensitivity to anticancer drugs and compared the findings with the efficacy of 5'-deoxy-5-fluorouridine (5'-DFUR), an intermediate metabolite of capecitabine...
  18. pmc C-Reactive protein is an independent surgical indication marker for appendicitis: a retrospective study
    Shozo Yokoyama
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    World J Emerg Surg 4:36. 2009
    ..This study is an attempt to clarify the role of C-reactive protein (CRP) as a surgical indication marker for appendicitis...
  19. ncbi request reprint In vitro augmentation of antitumor effect in combination with CPT-11 and CDDP for human colorectal cancer
    T Tsunoda
    Second Department of Surgery, Wakayama Medical School, Wakayama, Japan
    J Surg Oncol 73:6-11. 2000
    ....
  20. ncbi request reprint Complete response of highly advanced gastric cancer with peritoneal dissemination after new combined chemotherapy of S-1 and low-dose cisplatin: report of a case
    M Iwahashi
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Oncology 61:16-22. 2001
    ..Further studies are necessary to evaluate the efficacy of this therapy...
  21. ncbi request reprint In vitro antitumor effect of topoisomerase-I inhibitor, CPT-11, on freshly isolated human gastric and colorectal cancer
    T Tsunoda
    Second Department of Surgery, Wakayama Medical School, Japan
    Anticancer Res 19:5451-5. 1999
    ..It was demonstrated that the MTT assay was appropriate for the analysis of the antitumor effects of CPT-11 and SN-38, and that CPT-11 may be a worthwhile choice as an anticancer agent against gastric and colorectal cancer...
  22. pmc Fibronectin promotes the proliferation of cytotoxic T lymphocytes generated from cancer patients
    S Mizobata
    Second Department of Surgery, Wakayama Medical School, Japan
    Br J Cancer 74:1598-604. 1996
    ..05). Thus, CTLs generated by FN might have both killer and helper functions, since they could lyse autologous tumour cells and secrete various cytokines, including IL-2...
  23. ncbi request reprint Tumor specific CTL therapy for advanced cancer and development for cancer vaccine
    T Tsunoda
    Second Department of Surgery, Wakayama Medical School, Japan
    Hepatogastroenterology 46:1287-92. 1999
    ..The present study was designed to clarify the clinical effects of tumor specific cytotoxic T Lymphocyte (CTL) therapy as multidisciplinary treatment for patients with advanced cancer...
  24. ncbi request reprint Overexpression of pyrimidine nucleoside phosphorylase enhances the sensitivity to 5'-deoxy-5-fluorouridine in tumour cells in vitro and in vivo
    T Nagata
    Second Department of Surgery, Wakayama Medical School, Kimiidera, Japan
    Eur J Cancer 38:712-7. 2002
    ..These findings demonstrate that PyNPase gene transfection increases the sensitivity to 5'-DFUR, and thereby decreases the toxicity of the agent...
  25. ncbi request reprint Carcinoembryonic antigen-specific suicide gene therapy of cytosine deaminase/5-fluorocytosine enhanced by the cre/loxP system in the orthotopic gastric carcinoma model
    K Ueda
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama 641-8510, Japan
    Cancer Res 61:6158-62. 2001
    ..01). These results suggested that application of the Cre/loxP system could provide a new approach for enhanced selective suicide gene therapy of CD/5-FC for the treatment of advanced gastric carcinoma...
  26. pmc Mapping the HLA-A24-restricted T-cell epitope peptide from a tumour-associated antigen HER2 / neu: possible immunotherapy for colorectal carcinomas
    H Tanaka
    Department of Surgery II, Wakayama Medical School, Wakayama, 641 0012, Japan
    Br J Cancer 84:94-9. 2001
    ..In summary, HER2 / neu peptide, RWGLLLALL, may contribute to the induction of antitumour immunity with the peptide-based immunotherapy for the colorectal carcinomas...
  27. doi request reprint Liver metastasis as an initial recurrence has no impact on the survival of patients with resectable pancreatic adenocarcinoma
    Masaji Tani
    Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan
    Langenbecks Arch Surg 394:249-53. 2009
    ..Prognosis of the patients with pancreatic adenocarcinoma is still poor due to a recurrence, and liver metastasis is a distant metastasis that is foreboded the short survival period...
  28. pmc Clonal and functional analysis for the augmentation of tumour-infiltrating lymphocytes by interleukin 4
    T Tsunoda
    Second Department of Surgery, Wakayama Medical School, Japan
    Br J Cancer 74:1085-9. 1996
    ..Furthermore, binding IL-2 internalised rapidly into the cells. Thus, it is suggested that signal transduction is augmented and proliferation of TILs is enhanced by IL-4 via the action of IL-2/IL-2 receptor system...
  29. ncbi request reprint Individualized adjuvant chemotherapy guided by chemosensitivity test sequential to extended surgery for advanced gastric cancer
    Makoto Iwahashi
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Anticancer Res 25:3453-9. 2005
    ..In this study, the feasibility and efficacy of a strategy of extended surgery combined with individualized adjuvant chemotherapy for advanced gastric cancer with serosal invasion and nodal involvement was examined...
  30. ncbi request reprint Preoperative evaluation of the extrahepatic bile duct structure for laparoscopic cholecystectomy
    K Uchiyama
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama, 641 8510, Japan
    Surg Endosc 20:1119-23. 2006
    ..This study aimed to clarify the types of normal cystic ducts and the incidence of aberrant extrahepatic bile ducts, and to search for a method of avoiding injuries during LC...
  31. ncbi request reprint Repeat reduction surgery after an initial hepatectomy for patients with colorectal cancer
    Kenji Matsuda
    Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama 641 8510, Japan
    Oncol Rep 18:189-94. 2007
    ..Patients with a longer DFI and with negative lymph node findings at the primary site may therefore be considered to be good candidates for repeat reduction surgery...
  32. pmc Generation of cytotoxic T cell responses to an HLA-A24 restricted epitope peptide derived from wild-type p53
    Y Umano
    Second Department of Surgery, Wakayama Medical School
    Br J Cancer 84:1052-7. 2001
    ..The identification of this novel p53 epitope for CTL offers the possibility to design and develop specific immunotherapeutic approaches for treating tumours with p53 mutation in HLA-A24-positive patients...
  33. ncbi request reprint Clinical features and imaging diagnosis of biliary cystadenocarcinoma of the liver
    H Kinoshita
    Second Department of Surgery, Wakayama Medical School, 811-1 Kimiidera, Wakayama 641-0012, Japan
    Hepatogastroenterology 48:250-2. 2001
    ..Systematic hepatectomy was recommended as the initial treatment in consideration of the features of cystadenocarcinoma...
  34. doi request reprint Combination of p53 codon 72 polymorphism and inactive p53 mutation predicts chemosensitivity to 5-fluorouracil in colorectal cancer
    Toshiji Tominaga
    Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan
    Int J Cancer 126:1691-701. 2010
    ..The combination of the p53 codon 72 polymorphism and p53 mutation status is a potential predictive marker of sensitivity to 5-FU in CRC...
  35. ncbi request reprint Evaluation of chemosensitivity testing with highly purified tumor cells in 435 patients with gastric carcinoma using an MTT assay
    Kohei Noguchi
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Anticancer Res 25:931-7. 2005
    ..We evaluated the results of chemosensitivity testing for gastric cancer using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay in terms of the correlation of chemosensitivity and clinicopathological findings...
  36. ncbi request reprint Potential predictors of long-term survival after surgery for patients with stage IV colorectal cancer
    Tsukasa Hotta
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Anticancer Res 26:1377-83. 2006
    ..In this study, the potential predictors, including chemotherapy regimens for survival after surgery, in patients with stage IV colorectal cancer are presented...
  37. ncbi request reprint Does postoperative chemotherapy have a survival benefit for patients with pancreatic cancer?
    Masaji Tani
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Japan
    J Surg Oncol 93:485-90. 2006
    ..6 months (P < 0.01). Since pancreatic cancer is characterized by an aggressive tumor with a high recurrent rate, postoperative chemotherapy is effective for an improvement of survival...
  38. ncbi request reprint Gender differences in postoperative pain after laparoscopic cholecystectomy
    K Uchiyama
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Surg Endosc 20:448-51. 2006
    ..This study investigated gender differences in postoperative pain after laparoscopic cholecystectomy (LC) on the basis of visual analog pain scale (VAS) scores and the clinical course...
  39. ncbi request reprint Clinical features and management of hepatic portal venous gas: four case reports and cumulative review of the literature
    H Kinoshita
    Critical Care Medical Center, School of Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8510, Japan
    Arch Surg 136:1410-4. 2001
    ..The underlying disease associated with HPVG determines the clinical features and prognosis of the patients. The treatment of patients with HPVG should be directed to the underlying disease...
  40. ncbi request reprint Focal fatty liver after pancreaticoduodenectomy: a case report of a rare entity of intrahepatic tumor
    Masaji Tani
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Hepatogastroenterology 49:1087-9. 2002
    ..The tumor was a soft yellow mass, and histological examination indicated focal fatty liver. It was thought that the fatty liver was caused by localized low blood supply and dysabsorption of lipoprotein after pancreaticoduodenectomy...
  41. doi request reprint Pylorus-preserving pancreaticoduodenectomy versus conventional pancreaticoduodenectomy for pancreatic adenocarcinoma
    Masaji Tani
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama, 641 8510, Japan
    Surg Today 39:219-24. 2009
    ..However, the characteristics of pancreatic cancer are remarkably different from those of other periampullary cancers, so the outcomes of PD and PpPD for pancreatic cancer are being re-evaluated...
  42. ncbi request reprint Clinical impact of adjuvant chemotherapy on patients with stage III colorectal cancer: l-LV/5FU chemotherapy as a modified RPMI regimen is an independent prognostic factor for survival
    Tsukasa Hotta
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Anticancer Res 26:1425-32. 2006
    ..1-LV/5FU for patients with stage III colorectal cancer may play an important role, as an adjuvant chemotherapy, in improving survival...
  43. ncbi request reprint A collision tumor composed of cancers of the bile duct and ampulla of Vater--immunohistochemical analysis of a rare entity of double cancer
    Seiko Hirono
    Second Department of Surgery, Wakayama Medical University School of Medicine, Wakayama, Japan
    Hepatogastroenterology 55:861-4. 2008
    ..As a result, it was concluded that this was a case of collision cancer of the middle bile duct and the papilla of Vater...
  44. ncbi request reprint The ratio between metastatic and examined lymph nodes is an independent prognostic factor for patients with resectable middle and distal bile duct carcinoma
    Manabu Kawai
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Am J Surg 199:447-52. 2010
    ....
  45. ncbi request reprint Indication of hepatopancreatoduodenectomy for biliary tract cancer
    Seiko Hirono
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, 641 8510 Wakayama, Japan
    World J Surg 30:567-73; discussion 574-5. 2006
    ..In this study, we review our experience with HPD for advanced biliary tract cancer, and seek to define the indication for HPD...
  46. ncbi request reprint Brachytherapy technique for abdominal wall metastases of colorectal cancer: ultrasound-guided insertion of applicator needle and a skin preservation method
    K Kishi
    Department of Radiology, Wakayama Medical College, Wakayama City, Japan
    Acta Radiol 47:157-61. 2006
    ..To report a technique of interstitial brachytherapy for the treatment of subcutaneous metastatic abdominal wall tumors...
  47. ncbi request reprint Upregulated expression of angiogenesis genes and down regulation of cell cycle genes in human colorectal cancer tissue determined by cDNA macroarray
    T Tsunoda
    Second Department of Surgery, Wakayama Medical School, 811-1 Kimiidera, Wakayama, 641-0012, Japan
    Anticancer Res 21:137-43. 2001
    ..The expression profile was quite different between these two patients. This approach may eventually provide a mean of selecting target-based drugs in individual colon cancer patients...
  48. ncbi request reprint Effectiveness of the clinical pathway to decrease length of stay and cost for laparoscopic surgery
    K Uchiyama
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Surg Endosc 16:1594-7. 2002
    ..The aim of this study was to investigate the effect of clinical pathways for laparoscopic surgeries on cost and length of hospital stay...
  49. doi request reprint Half clamping of the infrahepatic inferior vena cava reduces bleeding during a hepatectomy by decreasing the central venous pressure
    Kazuhisa Uchiyama
    Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan
    Langenbecks Arch Surg 394:243-7. 2009
    ..Bleeding from the hepatic vein is closely related to central venous pressure (CVP). To evaluate the effect of low central venous pressure during a hepatectomy, the infrahepatic inferior vena cava (IVC) was half clamped...
  50. ncbi request reprint Survival in colorectal cancer patients with urinary tract invasion
    Tsukasa Hotta
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Dis Colon Rectum 49:1399-409. 2006
    ..We compared overall survival and disease-free survival in colorectal cancer patients with and without invasion of urinary organs...
  51. ncbi request reprint Prognostic impact of treatment modalities on patients with single nodular recurrence of hepatocellular carcinoma
    Masaki Ueno
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Surg Today 39:675-81. 2009
    ....
  52. ncbi request reprint Transection using bipolar scissors reduces pancreatic fistula after distal pancreatectomy
    Manabu Kawai
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    J Hepatobiliary Pancreat Surg 15:366-72. 2008
    ..However, appropriate surgical stump closure after DP is still controversial. We aimed to clarify whether using bipolar scissors in DP reduces pancreatic fistula compared to hand-sewn suture of surgical stump closure...
  53. ncbi request reprint A pancreaticoduodenectomy is acceptable for periampullary tumors in the elderly, even in patients over 80 years of age
    Masaji Tani
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama, 641 8510, Japan
    J Hepatobiliary Pancreat Surg 16:675-80. 2009
    ..Although the mortality rates for pancreaticoduodenectomy have been reported to be low for periampullary tumors at high-volume centers, postoperative results still remain unclear for elderly patients over 80 years of age...
  54. ncbi request reprint A central pancreatectomy for benign or low-grade malignant neoplasms
    Seiko Hirono
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    J Gastrointest Surg 13:1659-65. 2009
    ..A central pancreatectomy is a parenchyma-sparing procedure that is performed to reduce long-term endocrine and exocrine insufficiency...
  55. ncbi request reprint Rectal cancer surgery in the elderly: analysis of consecutive 158 patients with stage III rectal cancer
    Tsukasa Hotta
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1, Kimiidera, Wakayama, 641 8510, Japan
    Langenbecks Arch Surg 392:549-58. 2007
    ..It is difficult to establish a clear-cut indication for rectal surgery in elderly patients because of greater risk. We tried to clarify the factors associated with the short-term and long-term outcomes between elderly and younger patients...
  56. ncbi request reprint Complications with reconstruction procedures in pylorus-preserving pancreaticoduodenectomy
    Masaji Tani
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    World J Surg 29:881-4. 2005
    ....
  57. ncbi request reprint Clinicopathological features of malignant intraductal papillary mucinous tumors of the pancreas: the differential diagnosis from benign entities
    Manabu Kawai
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Arch Surg 139:188-92. 2004
    ..The accurate differential diagnosis of malignant intraductal papillary mucinous tumors (IPMTs) of the pancreas from benign IPMTs remains unclear...
  58. ncbi request reprint Indications for extended hepatectomy in the management of stage IV hilar cholangiocarcinoma
    Kazuhisa Uchiyama
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Arch Surg 138:1012-6. 2003
    ..However, the effect of extended operations for stage IV hilar cholangiocarcinoma on survival is still unclear...
  59. ncbi request reprint Toxicity during l-LV/5FU adjuvant chemotherapy as a modified RPMI regimen for patients with colorectal cancer
    Tsukasa Hotta
    Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Oncol Rep 14:433-9. 2005
    ..Thus, we clarified the attentive point of side effect of l-LV/5FU adjuvant chemotherapy for colorectal cancer...
  60. ncbi request reprint Clinical benefit of chemosensitivity test for patients with regional lymph node-positive esophageal squamous cell carcinoma
    Mikihito Nakamori
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    J Surg Oncol 84:10-6. 2003
    ..The present study was designed to determine whether the chemosensitivity test in fresh human esophageal squamous cell carcinoma, using highly purified tumor cells, correlates with the clinical response...
  61. ncbi request reprint Randomized clinical trial of isolated Roux-en-Y versus conventional reconstruction after pancreaticoduodenectomy
    M Tani
    Second Department of Surgery, School of Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 8510, Japan
    Br J Surg 101:1084-91. 2014
    ..This randomized clinical trial compared the incidence of pancreatic fistula between the isolated Roux-en-Y (IsoRY) and conventional reconstruction (CR) methods...
  62. doi request reprint Long-term comorbidity of diabetes mellitus is a risk factor for perineal wound complications after an abdominoperineal resection
    Kenji Matsuda
    Second Department of Surgery, School of Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama, 641 8510, Japan
    Langenbecks Arch Surg 394:65-70. 2009
    ....
  63. ncbi request reprint Improvement of carcinoembryonic antigen-specific prodrug gene therapy for experimental colon cancer
    Kentaro Ueda
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Surgery 133:309-17. 2003
    ..We used the Cre/loxP system for enhancing carcinoembryonic antigen (CEA)-specific prodrug gene therapy of cytosine (CD)/5-fluorocytosine (5-FC) for the treatment of a colon cancer model accompanied with liver metastases...
  64. ncbi request reprint Prognostic factors of intrahepatic cholangiocarcinoma after surgical treatment
    Hiroyuki Kinoshita
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama 641 8510, Japan
    Oncol Rep 9:97-101. 2002
    ..859; p<0.01). Aggressive surgical therapy may allow long-term survival if the tumor spread is limited to local regions and tumors are the intraductal growth type...
  65. doi request reprint Influence of overweight on patients with gastric cancer after undergoing curative gastrectomy: an analysis of 689 consecutive cases managed by a single center
    Toshiyasu Ojima
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Kimiidera, Wakayama, Japan
    Arch Surg 144:351-8; discussion 358. 2009
    ..0) has an effect on surgical results, postoperative complications, and long-term survival in patients with gastric cancer who underwent curative gastrectomy...
  66. ncbi request reprint CLIP method (preoperative CT image-assessed ligation of inferior pancreaticoduodenal artery) reduces intraoperative bleeding during pancreaticoduodenectomy
    Manabu Kawai
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama, 641 8510, Japan
    World J Surg 32:82-7. 2008
    ..The aim of this study was to clarify whether the new operative approach reduces intraoperative bleeding compared with classical PD...
  67. doi request reprint A new prediction model of postoperative complications after major hepatectomy for hepatocellular carcinoma
    Masaki Ueno
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Dig Surg 26:392-9. 2009
    ..Serum hyaluronic acid (HA) concentrations reflect the degree of hepatic dysfunction and may have potential for predicting postoperative complications in a major hepatectomy for hepatocellular carcinoma (HCC)...
  68. ncbi request reprint [Selection of therapy from the prognosis for stage IV hilar cholangiocarcinoma--extended hepatectomy vs stenting]
    Kazuhisa Uchiyama
    Second Department of Surgery, Wakayama Medical University
    Nihon Rinsho 64:555-9. 2006
  69. ncbi request reprint Potential predictors of survival after surgery for colorectal cancer patients with synchronous unresectable liver metastases
    Tsukasa Hotta
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Oncol Rep 16:1369-74. 2006
    ..492, P=0.053; y=17.388-3.733x). Thus, we clarified some of the predictors of survival for MBCLM, and the usefulness of serum CEA...
  70. ncbi request reprint The relationship between survival and the expression of dihydropyrimidine dehydrogenase in patients with colorectal cancer
    Tsukasa Hotta
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Oncol Rep 16:177-82. 2006
    ..390, P = 0.073). Based on these findings, we demonstrated the importance of DPD expression in tumor tissue as a prognostic factor in patients with colorectal cancer...
  71. doi request reprint Identifying molecular markers for chemosensitivity to gemcitabine in pancreatic cancer: increased expression of interferon-stimulated gene 15 kd is associated with intrinsic chemoresistance
    Shinomi Ina
    Second Department of Surgery, Wakayama Medical University, Wakayama, Japan
    Pancreas 39:473-85. 2010
    ..Nevertheless, the prognosis of pancreatic cancer patients is still poor. Evaluating the mechanisms of chemoresistance to gemcitabine will be helpful for the improvement of the therapeutic outcome...
  72. ncbi request reprint Impact of lymph node metastasis on survival in patients with pathological T1 carcinoma of the ampulla of Vater
    Hiroshi Terasawa
    Second Department of Surgery, Wakayama Medical University, Wakayama, Japan
    J Gastrointest Surg 10:823-8. 2006
    ..017). As for survival after the operation, there was no significant difference between pancreatoduodenectomy and pylorus-preserving pancreatoduodenectomy...
  73. ncbi request reprint Indication and procedure for treatment of hepatolithiasis
    Kazuhisa Uchiyama
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Arch Surg 137:149-53. 2002
    ..Because of its complicated clinicopathologic features, hepatolithiasis is difficult to treat, and there is no established method of treating patients with intrahepatic stones...
  74. ncbi request reprint Phase 2 trial of oral S-1 combined with low-dose cisplatin for unresectable advanced pancreatic cancer
    Shinomi Ina
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Anticancer Res 28:2373-7. 2008
    ..A phase 2 trial of S-1 combined with cisplatin was conducted for unresectable pancreatic cancer...
  75. ncbi request reprint [Clinical characteristics of invasive ductal carcinomas of the pancreas according to the histological differentiation]
    Hiroki Yamaue
    Second Department of Surgery, Wakayama Medical University, School of Medicine
    Nihon Rinsho 64:48-51. 2006
  76. doi request reprint Assessment of liver function for successful hepatectomy in patients with hepatocellular carcinoma with impaired hepatic function
    Kazuhisa Uchiyama
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama, 641 8510, Japan
    J Hepatobiliary Pancreat Surg 15:596-602. 2008
    ..This study aimed to construct a formula for assessing liver function in order to prevent post-hepatectomy liver failure...
  77. doi request reprint Xanthogranulomatous cholecystitis: the use of preoperative CT findings to differentiate it from gallbladder carcinoma
    Kazuhisa Uchiyama
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama, 641 8510, Japan
    J Hepatobiliary Pancreat Surg 16:333-8. 2009
    ..A retrospective analysis was performed on 32 patients with histologically confirmed xanthogranulomatous cholecystitis (XGC) and 21 patients with gallbladder carcinoma who underwent surgical treatment between 1998 and 2007...
  78. doi request reprint Treatment strategy for intraductal papillary mucinous neoplasm of the pancreas based on malignant predictive factors
    Seiko Hirono
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Kimiidera, Wakayama, Japan
    Arch Surg 144:345-9; discussion 349-50. 2009
    ..Identification of predictive factors for differentiating IPMC from benign IPMNs would assist in providing appropriate treatment...
  79. pmc Early removal of prophylactic drains reduces the risk of intra-abdominal infections in patients with pancreatic head resection: prospective study for 104 consecutive patients
    Manabu Kawai
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Ann Surg 244:1-7. 2006
    ..The aim of this study was designed to determine whether the period of drain insertion influences the incidence of postoperative complications...
  80. ncbi request reprint Dendritic cells transduced with tumor-associated antigen gene elicit potent therapeutic antitumor immunity: comparison with immunodominant peptide-pulsed DCs
    Masaki Nakamura
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama, Japan
    Oncology 68:163-70. 2005
    ..These results suggested that vaccine therapy using DCs adenovirally transduced with TAA gene can elicit potent antitumor immunity, and may be useful for clinical application...
  81. ncbi request reprint Preoperative evaluation of pelvic lateral lymph node of patients with lower rectal cancer: comparison study of MR imaging and CT in 53 patients
    Kazuo Arii
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Langenbecks Arch Surg 391:449-54. 2006
    ..Preoperative assessment of the lateral pelvic lymph nodes is important for treatment strategy to patients with lower rectal cancer...
  82. ncbi request reprint Reducing residual and recurrent stones by hepatectomy for hepatolithiasis
    Kazuhisa Uchiyama
    Second Department of Surgery, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    J Gastrointest Surg 11:626-30. 2007
    ..In PTCSL procedures, favorable results have been obtained when the stones were completely cleared; however, the incidence of recurrent stones is high in patients after PTCSL...
  83. doi request reprint A prospective randomized controlled trial of internal versus external drainage with pancreaticojejunostomy for pancreaticoduodenectomy
    Masaji Tani
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Am J Surg 199:759-64. 2010
    ..A stent often is placed across the pancreaticojejunostomy. However, there is no report compared between internal drainage and external drainage...
  84. ncbi request reprint Recurrence of primary hepatocellular carcinoma after hepatectomy--differences related to underlying hepatitis virus species
    Kazuhisa Uchiyama
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Hepatogastroenterology 52:591-5. 2005
    ..Studies on post-hepatectomy prognoses by infecting viral species have only been rarely reported...
  85. ncbi request reprint The evaluation of duct-to-mucosal pancreaticojejunostomy in pancreaticoduodenectomy
    Masaji Tani
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    World J Surg 29:76-9. 2005
    ..01). The duct-to-mucosal anastomosis was more effective pancreaticojejunostomy than the external stent in terms of prevention of pancreatic duct dilatation, and it should be the surgical procedure of choice in pancreaticoduodenectomy...
  86. ncbi request reprint Effect of normothermic perfusion using fructose-1,6-bisphosphate for maintenance of liver function during in situ extended hepatectomy by the total hepatic vascular exclusion technique
    Ryuichiro Uemura
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    J Surg Res 137:89-95. 2007
    ..We evaluated the effect of normothermic liver perfusion with the addition of fructose-1, 6-bisphosphate (FBP) and oxygenation to maintain liver parenchymal, non-parenchymal, and Kupffer cell function...
  87. ncbi request reprint Prognostic factors for long-term survival in patients with locally invasive pancreatic cancer
    Masaji Tani
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama, 641 8510, Japan
    J Hepatobiliary Pancreat Surg 14:545-50. 2007
    ..We aimed to investigate predictors of survival in patients with resectable locally invasive pancreatic cancer...
  88. ncbi request reprint Omental torsion secondary to right inguinal hernia: case report and cumulative review of the English literature
    Seiko Hirono
    Department of Surgery, Naga Hospital, Naga Country, Wakayama, Japan
    Int Surg 92:187-91. 2007
    ....
  89. ncbi request reprint An analysis of the factors contributing to a reduction in the incidence of pulmonary complications following an esophagectomy for esophageal cancer
    Masaki Nakamura
    Second Department of Surgery, School of Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 8510, Japan
    Langenbecks Arch Surg 393:127-33. 2008
    ....
  90. doi request reprint Analysis of the prognostic factors and evaluation of surgical treatment for synchronous liver metastases from gastric cancer
    Kentaro Ueda
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama, 641 8510, Japan
    Langenbecks Arch Surg 394:647-53. 2009
    ..We identify the significant prognostic factors and clarify the beneficial effect on the survival of liver surgical treatment...
  91. ncbi request reprint Nonhepatocytic malignant mixed tumor of the liver in adults: report of a long surviving case
    Yoshiharu Shono
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Kimiidera, Wakayama, Japan
    Int Surg 93:55-8. 2008
    ..Diagnosis was established after surgery. The patient is still alive 11 years after surgery, and to our knowledge is the longest surviving patient with a primary nonhepatocytic malignant mixed primary tumor of the liver...
  92. ncbi request reprint SNAIL induces epithelial-to-mesenchymal transition in a human pancreatic cancer cell line (BxPC3) and promotes distant metastasis and invasiveness in vivo
    Ryohei Nishioka
    Second Department of Surgery, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Exp Mol Pathol 89:149-57. 2010
    ..These results indicate that SNAIL-mediated EMT may be relevant in the progression of pancreatic cancer, and SNAIL could be a molecular target for a pancreatic cancer intervention...
  93. ncbi request reprint Bacillus Calmette-Guérin cell-wall skeleton enhances the killing activity of cytotoxic lymphocyte-activated human dendritic cells transduced with the prostate-specific antigen gene
    Reona Fujii
    Departments of Urology, Wakayama Medical University, Wakayama, Japan
    BJU Int 104:1766-73. 2009
    ..The maturation of DC-PSA stimulated by BCG-CWS was assayed by flow cytometry. The cytotoxic activity enhanced by BCG-CWS was assessed by the 51Cr-release assay...
  94. ncbi request reprint Benefits of gene transduction of granulocyte macrophage colony-stimulating factor in cancer vaccine using genetically modified dendritic cells
    Toshiyasu Ojima
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Kimiidera, Wakayama 641 8510, Japan
    Int J Oncol 31:931-9. 2007
    ....
  95. ncbi request reprint [Bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents--special references to bacteria isolated between April 2002 and March 2003]
    Nagao Shinagawa
    Department of Surgery, Nagoya Midori Municipal Hospital
    Jpn J Antibiot 57:33-69. 2004
    ..We noticed no vancomycin-resistant Gram-positive cocci nor P. aeruginosa producing metallo-beta-lactamase. But we noticed cefazolin-resistant E. coli probably producing extended spectrum beta-lactamase...
  96. ncbi request reprint Enhancement of cytotoxic T-lymphocyte responses in patients with gastrointestinal malignancies following vaccination with CEA peptide-pulsed dendritic cells
    Kenji Matsuda
    Second Department of Surgery, Wakayama Medical University, Wakayama, Japan
    Cancer Immunol Immunother 53:609-16. 2004
    ..Three patients have shown stabilization of the disease after vaccinations. In conclusion, our results clearly demonstrated that our vaccination protocol was safe and might develop a CEA-specific CTL response in cancer patients...
  97. ncbi request reprint Preoperative antimicrobial administration for prevention of postoperative infection in patients with laparoscopic cholecystectomy
    Kazuhisa Uchiyama
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Dig Dis Sci 48:1955-9. 2003
    ..05). The above results demonstrate that administration of SBT/CPZ before LC suppressed the level of bacteria in the bile, resulting in a significant reduction in complications induced by postoperative infection...
  98. ncbi request reprint Differential gene expression profiles and identification of the genes relevant to clinicopathologic factors in colorectal cancer selected by cDNA array method in combination with principal component analysis
    Takuya Tsunoda
    Department of Surgery and Bioengineering Advanced Clinical Research Center, Institute of Medical Science of Tokyo, Shiroganedai 4 6 1, Minato ku, Tokyo 108 8639, Japan
    Int J Oncol 23:49-59. 2003
    ..We conclude that, with PCA method, we successfully selected the genes relevant to clinicopathologic factors using limited population of clinical samples...
  99. ncbi request reprint Prediction of distant metastasis by using reverse transcriptase-polymerase chain reaction for epithelial and variant CD44 mRNA in the peripheral blood of patients with colorectal cancer
    Shozo Yokoyama
    Second Department of Surgery, Wakayama Medical University, School of Medicine 811 1 Kimiidera, Wakayama 641 8510, Japan
    Arch Surg 137:1069-73. 2002
    ..Molecular detection is thought to provide useful information for the clinical management of postoperative adjuvant therapy regimens...
  100. ncbi request reprint Clinical features of ciliated foregut cyst of the gallbladder: a rare entity of cystic lesion in the gallbladder
    Seiko Hirono
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Japan
    Dig Dis Sci 47:1817-20. 2002
  101. ncbi request reprint Dose of adenoviral vectors expressing interleukin-2 plays an important role in combined gene therapy with cytosine deaminase/5-fluorocytosine: preclinical consideration
    Mikihito Nakamori
    Second Department of Surgery, Wakayama Medical University School of Medicine, Wakayama 641 8510
    Jpn J Cancer Res 93:706-15. 2002
    ....